BR122020011180B8 - formulações injetáveis de compostos de tetraciclina - Google Patents

formulações injetáveis de compostos de tetraciclina

Info

Publication number
BR122020011180B8
BR122020011180B8 BR122020011180A BR122020011180A BR122020011180B8 BR 122020011180 B8 BR122020011180 B8 BR 122020011180B8 BR 122020011180 A BR122020011180 A BR 122020011180A BR 122020011180 A BR122020011180 A BR 122020011180A BR 122020011180 B8 BR122020011180 B8 BR 122020011180B8
Authority
BR
Brazil
Prior art keywords
injectable formulations
tetracycline compounds
formulations
tetracycline compound
injectable
Prior art date
Application number
BR122020011180A
Other languages
English (en)
Other versions
BR122020011180B1 (pt
Inventor
Johnston Sean
Original Assignee
Paratek Pharm Innc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41114256&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR122020011180(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Paratek Pharm Innc filed Critical Paratek Pharm Innc
Publication of BR122020011180B1 publication Critical patent/BR122020011180B1/pt
Publication of BR122020011180B8 publication Critical patent/BR122020011180B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

são descritas formulações injetáveis e orais de um composto de tetraciclina. em uma modalidade, a invenção se refere a uma formulação oral de um composto de 9-aminometil tetraciclina, ou de um sal do mesmo, em forma de comprimido ou cápsula. as formulações podem ser usadas, por exemplo, para tratar infecções.
BR122020011180A 2008-03-28 2009-03-30 formulações injetáveis de compostos de tetraciclina BR122020011180B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US4039808P 2008-03-28 2008-03-28
US61/040,398 2008-03-28
PI0909211-0 2009-03-30
PCT/US2009/001973 WO2009120389A1 (en) 2008-03-28 2009-03-30 Oral and injectable formulations of tetracycline compounds
BRPI0909211A BRPI0909211B8 (pt) 2008-03-28 2009-03-30 formulação oral em forma de comprimido de compostos de tetraciclina

Publications (2)

Publication Number Publication Date
BR122020011180B1 BR122020011180B1 (pt) 2021-03-23
BR122020011180B8 true BR122020011180B8 (pt) 2021-07-27

Family

ID=41114256

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0909211A BRPI0909211B8 (pt) 2008-03-28 2009-03-30 formulação oral em forma de comprimido de compostos de tetraciclina
BR122020011180A BR122020011180B8 (pt) 2008-03-28 2009-03-30 formulações injetáveis de compostos de tetraciclina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BRPI0909211A BRPI0909211B8 (pt) 2008-03-28 2009-03-30 formulação oral em forma de comprimido de compostos de tetraciclina

Country Status (31)

Country Link
US (2) US9314475B2 (pt)
EP (3) EP2271348B1 (pt)
JP (7) JP2011515473A (pt)
KR (3) KR101835574B1 (pt)
CN (1) CN102046177B (pt)
AU (1) AU2009229174A1 (pt)
BR (2) BRPI0909211B8 (pt)
CA (2) CA2719751C (pt)
CL (1) CL2010000281A1 (pt)
CO (1) CO6300935A2 (pt)
CY (2) CY1120240T1 (pt)
DK (2) DK2271348T3 (pt)
EC (1) ECSP10010576A (pt)
ES (2) ES2836448T3 (pt)
HK (1) HK1257928A1 (pt)
HR (2) HRP20180836T1 (pt)
HU (2) HUE038257T2 (pt)
IL (1) IL208440A0 (pt)
LT (2) LT2271348T (pt)
MA (1) MA32275B1 (pt)
MX (1) MX2010010585A (pt)
NO (1) NO2271348T3 (pt)
NZ (1) NZ588428A (pt)
PL (2) PL2271348T3 (pt)
PT (2) PT2271348T (pt)
RU (1) RU2010144130A (pt)
SI (2) SI3348258T1 (pt)
TR (1) TR201806893T4 (pt)
UA (2) UA122762C2 (pt)
WO (1) WO2009120389A1 (pt)
ZA (1) ZA201007013B (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2010009693A (es) * 2008-03-05 2010-12-20 Paratek Pharm Innc Compuestos de monociclina y metodos de uso de la misma.
TW202332671A (zh) * 2008-05-23 2023-08-16 美商Ｐｒｔｋ Ｓｐｖ２公司 四環素化合物之甲苯磺酸鹽及同素異形體
KR101799304B1 (ko) 2010-05-12 2017-11-20 렘펙스 파머수티클스 인코퍼레이티드 테트라사이클린 조성물
CN109414445A (zh) * 2016-05-02 2019-03-01 帕拉特克药品公司 9-氨基甲基米诺环素化合物及其在泌尿道感染(uti)治疗中的应用方法
US10166912B2 (en) 2016-08-19 2019-01-01 Sl Corporation Automotive LED driving apparatus
CN110087655A (zh) 2016-11-01 2019-08-02 帕拉特克药品公司 9-氨基甲基米诺环素化合物及其在治疗社区获得性细菌性肺炎(cabp)中的用途
CA3111447A1 (en) * 2018-09-04 2020-03-12 Paratek Pharmaceuticals, Inc. Methods of treating mycobacterial infections using tetracycline compounds
PT117254B (pt) 2021-05-26 2024-04-18 Hovione Farm S A Método de síntese de compostos 9-aminometil tetraciclinas

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2699054A (en) 1953-10-09 1955-01-11 Lloyd H Conover Tetracycline
US2712517A (en) 1954-03-03 1955-07-05 Bristol Lab Inc Production of tetracycline and substituted tetracyclines
US3019173A (en) 1956-06-04 1962-01-30 American Cyanamid Co Method for preparing tetracycline
US2990331A (en) 1956-11-23 1961-06-27 Pfizer & Co C Stable solutions of salts of tetracyclines for parenteral administration
US3005023A (en) 1957-04-05 1961-10-17 American Cyanamid Co Production of tetracycline
US2980584A (en) 1957-10-29 1961-04-18 Pfizer & Co C Parenteral magnesium oxytetracycline acetic or lactic acid carboxamide vehicle preparation
US2886595A (en) 1958-09-30 1959-05-12 Bristol Lab Inc Tetracycline recovery
US3062717A (en) 1958-12-11 1962-11-06 Pfizer & Co C Intramuscular calcium tetracycline acetic or lactic acid carboxamide vehicle preparation
US3019260A (en) 1959-05-13 1962-01-30 American Cyanamid Co Process for the catalytic reduction of 6-hydroxy hydronaphthacenes
FR1430859A (pt) 1960-05-23 1966-05-25
US3165531A (en) 1962-03-08 1965-01-12 Pfizer & Co C 13-substituted-6-deoxytetracyclines and process utilizing the same
US3301899A (en) 1963-11-27 1967-01-31 Bristol Myers Co Purification of tetracycline
US3454697A (en) 1965-06-08 1969-07-08 American Cyanamid Co Tetracycline antibiotic compositions for oral use
NL6607516A (pt) 1966-05-31 1967-12-01
DE1767891C3 (de) 1968-06-28 1980-10-30 Pfizer Verfahren zur Herstellung von wäßrigen arzneilichen Lösungen für die parenterale, perorale und lokale Anwendung mit einem Gehalt an einem Tetracyclinderivat
US3957980A (en) 1972-10-26 1976-05-18 Pfizer Inc. Doxycycline parenteral compositions
DE2442829A1 (de) 1974-09-06 1976-03-18 Merck Patent Gmbh Tetracyclische verbindungen und verfahren zu ihrer herstellung
US4018889A (en) 1976-01-02 1977-04-19 Pfizer Inc. Oxytetracycline compositions
US4126680A (en) 1977-04-27 1978-11-21 Pfizer Inc. Tetracycline antibiotic compositions
US4837030A (en) * 1987-10-06 1989-06-06 American Cyanamid Company Novel controlled release formulations of tetracycline compounds
DE69232302T4 (de) 1991-10-04 2003-02-13 American Cyanamid Co., Wayne 7-Substituierte-9-substituierte Amino-6-Demethyl-6-Deoxy-Tetracycline
US5494903A (en) 1991-10-04 1996-02-27 American Cyanamid Company 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
US6465431B1 (en) * 1999-11-17 2002-10-15 Boston Life Sciences, Inc. Pharmaceutical compositions comprising troponin subunits, fragments and homologs thereof and methods of their use to inhibit angiogenesis
WO1999011261A1 (en) 1997-08-29 1999-03-11 Dsm N.V. Granules free of excipients
KR100252699B1 (ko) * 1998-03-17 2000-12-01 강재헌 치주염 치료용 미노사이클린 조성물
EP1743632A1 (en) 1998-11-18 2007-01-17 Collagenex Pharmaceuticals, Inc. Novel 4-dedimethy laminotetracycline derivatives
US6448323B1 (en) 1999-07-09 2002-09-10 Bpsi Holdings, Inc. Film coatings and film coating compositions based on polyvinyl alcohol
WO2001047554A1 (fr) * 1999-12-28 2001-07-05 Chugai Seiyaku Kabushiki Kaisha Compositions d'anticorps stables et preparations pour injection
CN1690047B (zh) 2000-07-07 2010-10-06 塔夫茨大学信托人 9-取代的二甲胺四环素化合物
BR0116935A (pt) 2001-03-13 2005-04-12 Paratek Pharm Innc Composto de tetraciclina, método para tratar um estado responsivo à tetraciclina em um indivìduo, e, composição farmacêutica
US7553828B2 (en) 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
JP2005504722A (ja) * 2001-03-14 2005-02-17 パラテック ファーマシューティカルズ インコーポレイテッド 相乗的抗真菌薬剤としての置換テトラサイクリン化合物
AU2002256092C1 (en) 2001-04-05 2009-10-15 Collagenex Pharmaceuticals, Inc. Controlled delivery of tetracycline compounds and tetracycline derivatives
US8088820B2 (en) * 2001-04-24 2012-01-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
EP2332550A1 (en) * 2001-07-13 2011-06-15 Paratek Pharmaceuticals, Inc. Tetracyclines for the treatment of neurodegenerative diseases
AU2003220123B2 (en) 2002-03-08 2009-05-07 Paratek Pharmaceuticals, Inc. Amino-methyl substituted tetracycline compounds
CN1390550A (zh) * 2002-07-25 2003-01-15 于航 盐酸米诺环素冻干粉针剂及其制备方法
EP1562608A4 (en) * 2002-10-24 2010-09-01 Paratek Pharm Innc METHOD OF USE OF SUBSTITUTED TETRACYCLINE COMPOUNDS FOR MODULATING THE RNA
AU2003287218C1 (en) * 2002-10-24 2010-07-15 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
US20040121003A1 (en) * 2002-12-19 2004-06-24 Acusphere, Inc. Methods for making pharmaceutical formulations comprising deagglomerated microparticles
WO2004064728A2 (en) * 2003-01-16 2004-08-05 Paratek Pharmaceuticals, Inc. Use of specific tetracycline compounds in therapy
EA200501252A1 (ru) * 2003-02-03 2006-02-24 Неофарм, Инк. Липосомальная композиция, способ ее получения и лекарственное средство на ее основе (варианты)
WO2004078111A2 (en) * 2003-03-06 2004-09-16 Ranbaxy Laboratories Limited Extended release minocycline compositions and processes for their preparation
WO2004091513A2 (en) * 2003-04-10 2004-10-28 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
CA2531728A1 (en) * 2003-07-09 2005-02-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
US20060287283A1 (en) 2003-07-09 2006-12-21 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
CA2531732C (en) * 2003-07-09 2012-04-10 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
US7786099B2 (en) * 2004-01-15 2010-08-31 Paratek Pharmaceuticals, Inc. Aromatic a-ring derivatives of tetracycline compounds
GB2414668B (en) * 2004-06-03 2009-07-29 Dexcel Ltd Tetracycline modified release delivery system
KR101354093B1 (ko) * 2005-03-14 2014-01-24 와이어쓰 엘엘씨 티게사이클린 조성물 및 이의 제조방법
EP1991236A2 (en) 2006-01-24 2008-11-19 Paratek Pharmaceuticals, Inc. Methods of increasing oral bioavailability of tetracyclines
US20090246276A1 (en) * 2008-01-28 2009-10-01 Graham Jackson Pharmaceutical Compositions
MX2010009693A (es) * 2008-03-05 2010-12-20 Paratek Pharm Innc Compuestos de monociclina y metodos de uso de la misma.

Also Published As

Publication number Publication date
ES2836448T3 (es) 2021-06-25
NO2271348T3 (pt) 2018-08-25
DK2271348T3 (en) 2018-06-14
JP6412521B2 (ja) 2018-10-24
BRPI0909211A2 (pt) 2016-11-29
NZ588428A (en) 2012-08-31
JP5940119B2 (ja) 2016-06-29
PL3348258T3 (pl) 2021-03-08
JP2019196408A (ja) 2019-11-14
JP2014221820A (ja) 2014-11-27
KR101746228B1 (ko) 2017-06-12
TR201806893T4 (tr) 2018-06-21
CN102046177B (zh) 2012-12-19
JP6577645B2 (ja) 2019-09-18
MA32275B1 (fr) 2011-05-02
DK3348258T3 (da) 2020-12-07
EP2271348A4 (en) 2011-05-25
ZA201007013B (en) 2013-11-27
PT2271348T (pt) 2018-04-16
PL2271348T3 (pl) 2018-08-31
CN102046177A (zh) 2011-05-04
CA2984301A1 (en) 2009-10-01
HUE038257T2 (hu) 2018-10-29
BRPI0909211B1 (pt) 2020-08-25
KR20180026799A (ko) 2018-03-13
WO2009120389A1 (en) 2009-10-01
LT2271348T (lt) 2018-06-25
EP3348258A1 (en) 2018-07-18
CA2719751A1 (en) 2009-10-01
EP3789030A1 (en) 2021-03-10
KR20110008057A (ko) 2011-01-25
MX2010010585A (es) 2010-11-09
CY1120240T1 (el) 2019-07-10
PT3348258T (pt) 2020-11-25
HK1257928A1 (zh) 2019-11-01
CA2984301C (en) 2020-10-27
RU2010144130A (ru) 2012-05-10
SI2271348T1 (en) 2018-08-31
CA2719751C (en) 2018-01-02
KR101835574B1 (ko) 2018-03-08
AU2009229174A1 (en) 2009-10-01
EP3348258B1 (en) 2020-09-09
JP2016145260A (ja) 2016-08-12
KR101893740B1 (ko) 2018-08-30
US20160279151A1 (en) 2016-09-29
UA122762C2 (uk) 2021-01-06
ECSP10010576A (es) 2010-12-30
JP2023144043A (ja) 2023-10-06
EP2271348A1 (en) 2011-01-12
JP2011515473A (ja) 2011-05-19
US9314475B2 (en) 2016-04-19
JP2018203778A (ja) 2018-12-27
SI3348258T1 (sl) 2020-12-31
BR122020011180B1 (pt) 2021-03-23
UA109627C2 (uk) 2015-09-25
CY1123382T1 (el) 2021-12-31
KR20160105532A (ko) 2016-09-06
US20100056638A1 (en) 2010-03-04
WO2009120389A8 (en) 2009-12-30
CL2010000281A1 (es) 2012-03-30
EP2271348B1 (en) 2018-03-28
ES2674708T3 (es) 2018-07-03
IL208440A0 (en) 2010-12-30
HRP20201883T1 (hr) 2021-01-22
LT3348258T (lt) 2020-12-10
HUE052201T2 (hu) 2021-04-28
CO6300935A2 (es) 2011-07-21
JP2021167355A (ja) 2021-10-21
HRP20180836T1 (hr) 2018-07-27
BRPI0909211B8 (pt) 2021-05-25

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