BR112023022224A2 - Urolitina para aumentar função de célula-tronco - Google Patents

Urolitina para aumentar função de célula-tronco

Info

Publication number
BR112023022224A2
BR112023022224A2 BR112023022224A BR112023022224A BR112023022224A2 BR 112023022224 A2 BR112023022224 A2 BR 112023022224A2 BR 112023022224 A BR112023022224 A BR 112023022224A BR 112023022224 A BR112023022224 A BR 112023022224A BR 112023022224 A2 BR112023022224 A2 BR 112023022224A2
Authority
BR
Brazil
Prior art keywords
stem cell
cell function
urolithine
increase stem
increase
Prior art date
Application number
BR112023022224A
Other languages
English (en)
Inventor
Mukul Girotra
Nicola Vannini
Original Assignee
Ludwig Inst For Cancer Res Ltd
Nestle Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ludwig Inst For Cancer Res Ltd, Nestle Sa filed Critical Ludwig Inst For Cancer Res Ltd
Publication of BR112023022224A2 publication Critical patent/BR112023022224A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A61K31/37—Coumarins, e.g. psoralen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/999—Small molecules not provided for elsewhere

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Primary Cells (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

urolitina para aumentar função de célula-tronco. uso de uma urolitina, caracterizado por ser para aumentar a função de célula-tronco em uma população de células-tronco e/ou células progenitoras hematopoiéticas (hspcs), sendo que a função de célula-tronco é aumentada durante pelo menos 40 semanas.
BR112023022224A 2021-05-05 2022-05-02 Urolitina para aumentar função de célula-tronco BR112023022224A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP21172290 2021-05-05
PCT/EP2022/061666 WO2022233767A1 (en) 2021-05-05 2022-05-02 Urolithin for increasing stem cell function

Publications (1)

Publication Number Publication Date
BR112023022224A2 true BR112023022224A2 (pt) 2024-02-06

Family

ID=75825544

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112023022224A BR112023022224A2 (pt) 2021-05-05 2022-05-02 Urolitina para aumentar função de célula-tronco

Country Status (7)

Country Link
EP (1) EP4333832A1 (pt)
JP (1) JP2024516187A (pt)
CN (1) CN117202903A (pt)
AU (1) AU2022270331A1 (pt)
BR (1) BR112023022224A2 (pt)
CA (1) CA3213384A1 (pt)
WO (1) WO2022233767A1 (pt)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5723315A (en) 1996-08-23 1998-03-03 Genetics Institute, Inc. Secreted proteins and polynucleotides encoding them
US6118001A (en) 1996-08-07 2000-09-12 Darwin Discovery, Ltd. Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity
US6126939A (en) 1996-09-03 2000-10-03 Yeda Research And Development Co. Ltd. Anti-inflammatory dipeptide and pharmaceutical composition thereof
WO2019163437A1 (ja) * 2018-02-21 2019-08-29 株式会社ダイセル ウロリチン類を含有する破骨細胞分化抑制剤
WO2019211294A1 (en) * 2018-04-30 2019-11-07 Amazentis Sa Urolithin a as immune enhancer
CN113260360A (zh) * 2019-01-18 2021-08-13 雀巢产品有限公司 用于增加干细胞功能的试剂和方法

Also Published As

Publication number Publication date
JP2024516187A (ja) 2024-04-12
AU2022270331A1 (en) 2023-10-12
WO2022233767A1 (en) 2022-11-10
CA3213384A1 (en) 2022-11-10
CN117202903A (zh) 2023-12-08
EP4333832A1 (en) 2024-03-13
AU2022270331A9 (en) 2023-10-19

Similar Documents

Publication Publication Date Title
BRPI0406389A (pt) Interface de usuário de mensagens integrada com registro baseado em mensagens
BR112022011169A2 (pt) Métodos para geração de células-tronco hematopoiéticas
BR112022007950A2 (pt) Integração direcionada no locus de alfa-globina em células-tronco e células progenitoras hematopoiéticas humanas
AR113150A1 (es) Producción mejorada de etanol libre de glicerol
BR112023022224A2 (pt) Urolitina para aumentar função de célula-tronco
ATE539146T1 (de) Säugetier-megakaryozytenstammzelle
BR112015031679A8 (pt) conjugado de peptídeo-resina, seu uso, processo para sua produção, peptídeo e método para sua preparação
BR112018000658A2 (pt) recipiente para administração, armazenagem ou cultivo de células
CL2023001860A1 (es) Composiciones y métodos para reducir hla-a en una célula
BR112023005370A2 (pt) Composições e métodos para aumentar função das células-tronco
BR112022015953A2 (pt) Variante de mananase, polinucleotídeo que codifica a mananase, construto de expressão, célula hospedeira, métodos para expressar uma variante de mananase e para aumentar a estabilidade de fermentação, preparação enzimática líquida, formulação detergente, e, uso de uma mananase
BR112022003515A2 (pt) Tcr de alta afinidade para reconhecer antígeno ssx2
BR112023024231A2 (pt) Células t primárias rhd negativas hipoimunogênicas
Simmel Tendencies in German Life and thought since 1870
BR112023005375A2 (pt) Composições e métodos para aumentar a função de células-tronco
Usheva et al. Occupational stress sources and ways to cope with its consequences
Fernández et al. Attention to the needs and potential of the students of the Technical University of Babahoyo, Quevedo Extension, in the English language learning process
WO2024086792A3 (en) Methods for promoting homing and engraftment of hematopoietic stem cells
Edward Philosophy of History and Philosophy in History: A Critique of Quentin Skinner’s Contribution to Historical Theory
AR113149A1 (es) Producción mejorada de etanol libre de glicerol
Xiulian et al. Construction and Planning of Nuclear Engineering and NuclearTechnology Laboratory of Sichuan University
Galeano et al. Diagnóstico de HPN
Robertson Rise of the Spanish Empire in the Old World and in the New
BR112021024123A2 (pt) Dispositivo de mesa de instrumentos de veículo e veículo
JP1725948S (ja) 培養容器用アダプター