BR112023019951A2 - Linhagens hematopoiéticas derivadas de células-tronco pluripotentes - Google Patents
Linhagens hematopoiéticas derivadas de células-tronco pluripotentesInfo
- Publication number
- BR112023019951A2 BR112023019951A2 BR112023019951A BR112023019951A BR112023019951A2 BR 112023019951 A2 BR112023019951 A2 BR 112023019951A2 BR 112023019951 A BR112023019951 A BR 112023019951A BR 112023019951 A BR112023019951 A BR 112023019951A BR 112023019951 A2 BR112023019951 A2 BR 112023019951A2
- Authority
- BR
- Brazil
- Prior art keywords
- cells
- hematopoietic
- pluripotent stem
- stem cells
- present
- Prior art date
Links
- 230000003394 haemopoietic effect Effects 0.000 title abstract 5
- 210000001778 pluripotent stem cell Anatomy 0.000 title abstract 2
- 210000004027 cell Anatomy 0.000 abstract 5
- 238000000034 method Methods 0.000 abstract 4
- 210000001978 pro-t lymphocyte Anatomy 0.000 abstract 2
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 238000011467 adoptive cell therapy Methods 0.000 abstract 1
- 210000003719 b-lymphocyte Anatomy 0.000 abstract 1
- 210000001772 blood platelet Anatomy 0.000 abstract 1
- 238000002659 cell therapy Methods 0.000 abstract 1
- 210000003743 erythrocyte Anatomy 0.000 abstract 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 abstract 1
- 210000004263 induced pluripotent stem cell Anatomy 0.000 abstract 1
- 210000005210 lymphoid organ Anatomy 0.000 abstract 1
- 210000002540 macrophage Anatomy 0.000 abstract 1
- 210000003593 megakaryocyte Anatomy 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 210000001616 monocyte Anatomy 0.000 abstract 1
- 210000000822 natural killer cell Anatomy 0.000 abstract 1
- 210000000440 neutrophil Anatomy 0.000 abstract 1
- 210000005259 peripheral blood Anatomy 0.000 abstract 1
- 239000011886 peripheral blood Substances 0.000 abstract 1
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4613—Natural-killer cells [NK or NK-T]
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- A61K39/46—Cellular immunotherapy
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- A61K39/4631—Chimeric Antigen Receptors [CAR]
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- C12N5/0602—Vertebrate cells
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
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Abstract
linhagens hematopoiéticas derivadas de células-tronco pluripotentes. a presente invenção refere-se, em vários aspectos, a métodos para geração de células de linhagem hematopoiética para terapia com células hematopoiéticas. as várias linhagens hematopoiéticas incluem linfócitos t incluindo células t progenitoras, células assassinas naturais, linfócitos b, neutrófilos, monócitos e/ou macrófagos; glóbulos vermelhos, megacariócitos e plaquetas. em várias modalidades, a invenção provê processos ex vivo eficientes para desenvolvimento de linhagens hematopoiéticas, incluindo, mas não limitado a, células t progenitoras e linhagens de células t, a partir de células-tronco pluripotentes induzidas por humano (ipscs). as células geradas de acordo com a invenção em várias modalidades são funcionais e/ou se assemelham mais à linhagem correspondente isolada de sangue periférico ou órgãos linfoides. a presente invenção em alguns aspectos provê células isoladas e composições de células produzidas através dos métodos revelados na presente invenção, bem como métodos para terapia com células adotivas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202163168360P | 2021-03-31 | 2021-03-31 | |
PCT/US2022/022562 WO2022212514A1 (en) | 2021-03-31 | 2022-03-30 | Pluripotent stem cell-derived hematopoietic lineages |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112023019951A2 true BR112023019951A2 (pt) | 2023-11-14 |
Family
ID=83459917
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112023019951A BR112023019951A2 (pt) | 2021-03-31 | 2022-03-30 | Linhagens hematopoiéticas derivadas de células-tronco pluripotentes |
Country Status (11)
Country | Link |
---|---|
US (1) | US20240180961A1 (pt) |
EP (1) | EP4313082A1 (pt) |
JP (1) | JP2024514091A (pt) |
KR (1) | KR20240037179A (pt) |
CN (1) | CN117597435A (pt) |
AU (1) | AU2022252247A1 (pt) |
BR (1) | BR112023019951A2 (pt) |
CA (1) | CA3214216A1 (pt) |
IL (1) | IL307219A (pt) |
MX (1) | MX2023011658A (pt) |
WO (1) | WO2022212514A1 (pt) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2024077146A2 (en) * | 2022-10-05 | 2024-04-11 | Garuda Therapeutics, Inc. | Erythroid lineages derived from pluripotent cells |
CN116574672B (zh) * | 2023-07-11 | 2023-10-20 | 北京北启生物医药有限公司 | 一种诱导化学诱导多能干细胞向生血内皮细胞分化的培养基及方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG10202101358XA (en) * | 2015-01-26 | 2021-03-30 | Fate Therapeutics Inc | Methods and compositions for inducing hematopoietic cell differentiation |
US20180325947A1 (en) * | 2015-10-27 | 2018-11-15 | Children's Hospital Medical Center | Use of mapk inhibitors to reduce loss of hematopoietic stem cells during ex vivo culture and/or genetic manipulation |
JP6928604B2 (ja) * | 2015-11-04 | 2021-09-01 | フェイト セラピューティクス,インコーポレイテッド | 万能性細胞のゲノム改変 |
JP6995750B2 (ja) * | 2015-12-03 | 2022-02-04 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド | 機能的造血幹細胞を生成するための方法 |
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2022
- 2022-03-30 EP EP22782098.2A patent/EP4313082A1/en active Pending
- 2022-03-30 US US18/284,577 patent/US20240180961A1/en active Pending
- 2022-03-30 IL IL307219A patent/IL307219A/en unknown
- 2022-03-30 CN CN202280038941.7A patent/CN117597435A/zh active Pending
- 2022-03-30 JP JP2023560011A patent/JP2024514091A/ja active Pending
- 2022-03-30 WO PCT/US2022/022562 patent/WO2022212514A1/en active Application Filing
- 2022-03-30 BR BR112023019951A patent/BR112023019951A2/pt unknown
- 2022-03-30 CA CA3214216A patent/CA3214216A1/en active Pending
- 2022-03-30 AU AU2022252247A patent/AU2022252247A1/en active Pending
- 2022-03-30 MX MX2023011658A patent/MX2023011658A/es unknown
- 2022-03-30 KR KR1020237037357A patent/KR20240037179A/ko unknown
Also Published As
Publication number | Publication date |
---|---|
CN117597435A (zh) | 2024-02-23 |
IL307219A (en) | 2023-11-01 |
JP2024514091A (ja) | 2024-03-28 |
KR20240037179A (ko) | 2024-03-21 |
EP4313082A1 (en) | 2024-02-07 |
MX2023011658A (es) | 2023-12-14 |
US20240180961A1 (en) | 2024-06-06 |
AU2022252247A1 (en) | 2023-10-26 |
WO2022212514A1 (en) | 2022-10-06 |
CA3214216A1 (en) | 2022-10-06 |
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