BR112023019951A2 - Linhagens hematopoiéticas derivadas de células-tronco pluripotentes - Google Patents

Linhagens hematopoiéticas derivadas de células-tronco pluripotentes

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Publication number
BR112023019951A2
BR112023019951A2 BR112023019951A BR112023019951A BR112023019951A2 BR 112023019951 A2 BR112023019951 A2 BR 112023019951A2 BR 112023019951 A BR112023019951 A BR 112023019951A BR 112023019951 A BR112023019951 A BR 112023019951A BR 112023019951 A2 BR112023019951 A2 BR 112023019951A2
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cells
hematopoietic
pluripotent stem
stem cells
present
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BR112023019951A
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English (en)
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Dhvanit Shah
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Garuda Therapeutics Inc
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Publication of BR112023019951A2 publication Critical patent/BR112023019951A2/pt

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Abstract

linhagens hematopoiéticas derivadas de células-tronco pluripotentes. a presente invenção refere-se, em vários aspectos, a métodos para geração de células de linhagem hematopoiética para terapia com células hematopoiéticas. as várias linhagens hematopoiéticas incluem linfócitos t incluindo células t progenitoras, células assassinas naturais, linfócitos b, neutrófilos, monócitos e/ou macrófagos; glóbulos vermelhos, megacariócitos e plaquetas. em várias modalidades, a invenção provê processos ex vivo eficientes para desenvolvimento de linhagens hematopoiéticas, incluindo, mas não limitado a, células t progenitoras e linhagens de células t, a partir de células-tronco pluripotentes induzidas por humano (ipscs). as células geradas de acordo com a invenção em várias modalidades são funcionais e/ou se assemelham mais à linhagem correspondente isolada de sangue periférico ou órgãos linfoides. a presente invenção em alguns aspectos provê células isoladas e composições de células produzidas através dos métodos revelados na presente invenção, bem como métodos para terapia com células adotivas.
BR112023019951A 2021-03-31 2022-03-30 Linhagens hematopoiéticas derivadas de células-tronco pluripotentes BR112023019951A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202163168360P 2021-03-31 2021-03-31
PCT/US2022/022562 WO2022212514A1 (en) 2021-03-31 2022-03-30 Pluripotent stem cell-derived hematopoietic lineages

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BR112023019951A2 true BR112023019951A2 (pt) 2023-11-14

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US (1) US20240180961A1 (pt)
EP (1) EP4313082A1 (pt)
JP (1) JP2024514091A (pt)
KR (1) KR20240037179A (pt)
CN (1) CN117597435A (pt)
AU (1) AU2022252247A1 (pt)
BR (1) BR112023019951A2 (pt)
CA (1) CA3214216A1 (pt)
IL (1) IL307219A (pt)
MX (1) MX2023011658A (pt)
WO (1) WO2022212514A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024077146A2 (en) * 2022-10-05 2024-04-11 Garuda Therapeutics, Inc. Erythroid lineages derived from pluripotent cells
CN116574672B (zh) * 2023-07-11 2023-10-20 北京北启生物医药有限公司 一种诱导化学诱导多能干细胞向生血内皮细胞分化的培养基及方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10202101358XA (en) * 2015-01-26 2021-03-30 Fate Therapeutics Inc Methods and compositions for inducing hematopoietic cell differentiation
US20180325947A1 (en) * 2015-10-27 2018-11-15 Children's Hospital Medical Center Use of mapk inhibitors to reduce loss of hematopoietic stem cells during ex vivo culture and/or genetic manipulation
JP6928604B2 (ja) * 2015-11-04 2021-09-01 フェイト セラピューティクス，インコーポレイテッド 万能性細胞のゲノム改変
JP6995750B2 (ja) * 2015-12-03 2022-02-04 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド 機能的造血幹細胞を生成するための方法

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CN117597435A (zh) 2024-02-23
IL307219A (en) 2023-11-01
JP2024514091A (ja) 2024-03-28
KR20240037179A (ko) 2024-03-21
EP4313082A1 (en) 2024-02-07
MX2023011658A (es) 2023-12-14
US20240180961A1 (en) 2024-06-06
AU2022252247A1 (en) 2023-10-26
WO2022212514A1 (en) 2022-10-06
CA3214216A1 (en) 2022-10-06

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