BR112023003366A2 - Moléculas multiespecíficas de ligação ao antígeno que têm como alvo hiv e métodos de uso - Google Patents
Moléculas multiespecíficas de ligação ao antígeno que têm como alvo hiv e métodos de usoInfo
- Publication number
- BR112023003366A2 BR112023003366A2 BR112023003366A BR112023003366A BR112023003366A2 BR 112023003366 A2 BR112023003366 A2 BR 112023003366A2 BR 112023003366 A BR112023003366 A BR 112023003366A BR 112023003366 A BR112023003366 A BR 112023003366A BR 112023003366 A2 BR112023003366 A2 BR 112023003366A2
- Authority
- BR
- Brazil
- Prior art keywords
- binding molecules
- methods
- specific antigen
- hiv
- molecules targeting
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 230000008685 targeting Effects 0.000 title abstract 2
- 239000000427 antigen Substances 0.000 abstract 3
- 102000036639 antigens Human genes 0.000 abstract 3
- 108091007433 antigens Proteins 0.000 abstract 3
- 108010039334 HIV Envelope Protein gp120 Proteins 0.000 abstract 1
- 208000031886 HIV Infections Diseases 0.000 abstract 1
- 208000037357 HIV infectious disease Diseases 0.000 abstract 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1036—Retroviridae, e.g. leukemia viruses
- C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
- C07K16/1063—Lentiviridae, e.g. HIV, FIV, SIV env, e.g. gp41, gp110/120, gp160, V3, PND, CD4 binding site
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70514—CD4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063070141P | 2020-08-25 | 2020-08-25 | |
| US202163163713P | 2021-03-19 | 2021-03-19 | |
| PCT/US2021/047165 WO2022046644A1 (en) | 2020-08-25 | 2021-08-23 | Multi-specific antigen binding molecules targeting hiv and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112023003366A2 true BR112023003366A2 (pt) | 2023-05-09 |
Family
ID=77775012
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112023003366A BR112023003366A2 (pt) | 2020-08-25 | 2021-08-23 | Moléculas multiespecíficas de ligação ao antígeno que têm como alvo hiv e métodos de uso |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20230056252A1 (es) |
| EP (1) | EP4204092A1 (es) |
| JP (1) | JP2023539196A (es) |
| KR (1) | KR20230054456A (es) |
| CN (1) | CN116157416A (es) |
| AU (1) | AU2021333577A1 (es) |
| BR (1) | BR112023003366A2 (es) |
| CA (1) | CA3187085A1 (es) |
| CL (1) | CL2023000539A1 (es) |
| CO (1) | CO2023002034A2 (es) |
| CR (1) | CR20230101A (es) |
| DO (1) | DOP2023000039A (es) |
| IL (1) | IL300256A (es) |
| MX (1) | MX2023002194A (es) |
| PE (1) | PE20231105A1 (es) |
| TW (1) | TW202348625A (es) |
| WO (1) | WO2022046644A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021062119A1 (en) * | 2019-09-26 | 2021-04-01 | Regents Of The University Of Minnesota | Nk engager compounds that bind viral antigens and methods of use |
Family Cites Families (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5156840A (en) | 1982-03-09 | 1992-10-20 | Cytogen Corporation | Amine-containing porphyrin derivatives |
| US5057313A (en) | 1986-02-25 | 1991-10-15 | The Center For Molecular Medicine And Immunology | Diagnostic and therapeutic antibody conjugates |
| WO1988007089A1 (en) | 1987-03-18 | 1988-09-22 | Medical Research Council | Altered antibodies |
| US6174666B1 (en) | 1992-03-27 | 2001-01-16 | The United States Of America As Represented By The Department Of Health And Human Services | Method of eliminating inhibitory/instability regions from mRNA |
| EP0714409A1 (en) | 1993-06-16 | 1996-06-05 | Celltech Therapeutics Limited | Antibodies |
| US5834597A (en) | 1996-05-20 | 1998-11-10 | Protein Design Labs, Inc. | Mutated nonactivating IgG2 domains and anti CD3 antibodies incorporating the same |
| DK1068241T3 (da) | 1998-04-02 | 2008-02-04 | Genentech Inc | Antistofvarianter og fragmenter deraf |
| GB9809951D0 (en) | 1998-05-08 | 1998-07-08 | Univ Cambridge Tech | Binding molecules |
| US7658921B2 (en) | 2000-12-12 | 2010-02-09 | Medimmune, Llc | Molecules with extended half-lives, compositions and uses thereof |
| JP4568896B2 (ja) | 2003-12-16 | 2010-10-27 | 財団法人くまもとテクノ産業財団 | 抗ｈｉｖ抗体 |
| US7700099B2 (en) | 2005-02-14 | 2010-04-20 | Merck & Co., Inc. | Non-immunostimulatory antibody and compositions containing the same |
| US8673307B1 (en) | 2009-03-09 | 2014-03-18 | The Rockefeller University | HIV-1 anti-core neutralizing antibodies that target a conformational epitope within the ALPHA5-helix of GP120 |
| SI3260136T1 (sl) | 2009-03-17 | 2021-05-31 | Theraclone Sciences, Inc. | Humani imunodeficientni virus (HIV)-nevtralizirajoča protitelesa |
| FR2945538B1 (fr) | 2009-05-12 | 2014-12-26 | Sanofi Aventis | Anticorps humanises specifiques de la forme protofibrillaire du peptide beta-amyloide. |
| EP2477658A2 (en) | 2009-09-16 | 2012-07-25 | Duke University | Hiv-1 antibodies |
| CN103403026B (zh) | 2009-09-25 | 2016-05-11 | 美国政府(由卫生和人类服务部的部长所代表) | Hiv-1中和抗体及其用途 |
| WO2011046623A2 (en) | 2009-10-16 | 2011-04-21 | Duke University | Hiv-1 antibodies |
| WO2011146891A2 (en) | 2010-05-21 | 2011-11-24 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | High-affinity fully functional soluble single-domain human cd4, antibodies, and related fusion proteins |
| EP3556396B1 (en) | 2010-08-31 | 2022-04-20 | Theraclone Sciences, Inc. | Human immunodeficiency virus (hiv)-neutralizing antibodies |
| WO2012154312A1 (en) | 2011-05-09 | 2012-11-15 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Neutralizing antibodies to hiv-1 and their use |
| MX358099B (es) | 2011-05-17 | 2018-08-06 | Univ Rockefeller | Anticuerpos que neutralizan el virus de inmunodeficiencia humano y metodos de uso de ellos. |
| US9890207B2 (en) | 2011-07-25 | 2018-02-13 | California Institute Of Technology | Highly active agonistic CD4 binding site anti-HIV antibodies (HAADS) comprising modified CDRH2 regions that improve contact with GP120 |
| US9493549B2 (en) | 2011-07-25 | 2016-11-15 | The Rockefeller University | Antibodies directed toward the HIV-1 GP120 CD4 binding site with increased potency and breadth |
| RU2624046C2 (ru) | 2011-11-07 | 2017-06-30 | Дзе Юнайтед Стейтс Оф Америка, Эз Репрезентед Бай Дзе Секретэри, Департмент Оф Хелт Энд Хьюман Сервисиз | Gp41-нейтрализующие антитела и их применение |
| US9695230B2 (en) | 2011-12-08 | 2017-07-04 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Broadly neutralizing HIV-1 VRC07 antibodies that bind to the CD4-binding site of the envelope protein |
| WO2013090644A2 (en) | 2011-12-13 | 2013-06-20 | California Institute Of Technology | Anti-hiv antibodies having increased potency and breadth |
| EP2828294A1 (en) | 2012-03-23 | 2015-01-28 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Neutralizing antibodies to hiv-1 and their use |
| WO2013163427A1 (en) * | 2012-04-25 | 2013-10-31 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Antibodies to treat hiv-1 infection |
| WO2013192589A1 (en) | 2012-06-21 | 2013-12-27 | California Institute Of Technology | Antibodies targeting hiv escape mutants |
| IL301018A (en) | 2012-10-18 | 2023-05-01 | Univ Rockefeller | Broad-spectrum neutralizing antibodies against the AIDS virus |
| WO2014089152A1 (en) | 2012-12-04 | 2014-06-12 | University Of Maryland, Baltimore | Hiv-1 env-binding antibodies, fusion proteins, and methods of use |
| WO2014159940A1 (en) * | 2013-03-14 | 2014-10-02 | Macrogenics, Inc. | Bispecific molecules that are immunoreactive with immune effector cells that express an activating receptor |
| EP2968453B1 (en) | 2013-03-15 | 2019-12-04 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Stabilized single human cd4 domains and fusion proteins |
| KR20230073341A (ko) | 2013-07-05 | 2023-05-25 | 젠맵 에이/에스 | 인간화 또는 키메라 cd3 항체 |
| US20160244510A1 (en) | 2013-09-27 | 2016-08-25 | Duke University | Human monoclonal antibodies |
| EP3176185A1 (en) | 2013-11-04 | 2017-06-07 | Glenmark Pharmaceuticals S.A. | Production of t cell retargeting hetero-dimeric immunoglobulins |
| WO2015103549A1 (en) | 2014-01-03 | 2015-07-09 | The United States Of America, As Represented By The Secretary Department Of Health And Human Services | Neutralizing antibodies to hiv-1 env and their use |
| US10421803B2 (en) | 2014-01-31 | 2019-09-24 | The Rockefeller University | Broadly neutralizing glycan-dependent 8ANC195 antibody variants that bind to an epitope spanning both HIV-1 Env subunits |
| US10093720B2 (en) * | 2014-06-11 | 2018-10-09 | International Aids Vaccine Initiative | Broadly neutralizing antibody and uses thereof |
| US10676521B2 (en) | 2014-07-21 | 2020-06-09 | The Rockefeller University | Combination of broadly neutralizing HIV antibodies and viral inducers |
| PE20171103A1 (es) | 2014-11-26 | 2017-08-07 | Xencor Inc | Anticuerpos heterodimericos que se unen a cd3 y cd38 |
| WO2016149710A2 (en) | 2015-03-19 | 2016-09-22 | Duke University | Hiv-1 neutralizing antibodies and uses thereof |
| US10344077B2 (en) | 2015-03-19 | 2019-07-09 | Duke University | HIV-1 neutralizing antibodies and uses thereof (V3 antibodies) |
| SI3271389T1 (sl) | 2015-03-20 | 2020-09-30 | The United States Of America, As Represented By The Secretary Department Of Health And Human Services | Nevtralizirajoča protitelesa proti GP120 in njihova uporaba |
| WO2016153572A1 (en) | 2015-03-25 | 2016-09-29 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Bispecific multivalent fusion proteins |
| WO2016168758A1 (en) * | 2015-04-17 | 2016-10-20 | Igm Biosciences, Inc. | Multi-valent human immunodeficiency virus antigen binding molecules and uses thereof |
| WO2016196975A1 (en) | 2015-06-03 | 2016-12-08 | The United States Of America, As Represented By The Secretary Department Of Health & Human Services | Neutralizing antibodies to hiv-1 env and their use |
| IL301140A (en) * | 2015-10-25 | 2023-05-01 | The Usa As Represented By The Sec Dep Of Health And Human Services | Trispecific and/or terrivalent binding proteins for the prevention or treatment of HIV infection |
| EP4011911A1 (en) | 2015-11-03 | 2022-06-15 | The United States of America as represented by The Secretary Department of Health and Human Services | Neutralizing antibodies to hiv-1 gp41 and their use |
| WO2017096221A1 (en) | 2015-12-02 | 2017-06-08 | The Rockefeller University | Bispecific anti-hiv broadly neutralizing antibodies |
| EA201891186A1 (ru) | 2015-12-15 | 2018-12-28 | Джилид Сайэнс, Инк. | Антитела, нейтрализующие вирус иммунодефицита человека |
| CN107022027B (zh) | 2016-02-02 | 2022-03-08 | 中国疾病预防控制中心性病艾滋病预防控制中心 | Hiv-1广谱中和抗体及其用途 |
| CN107033241B (zh) | 2016-02-03 | 2022-03-08 | 中国疾病预防控制中心性病艾滋病预防控制中心 | Hiv-1广谱中和抗体及其用途 |
| WO2018075564A1 (en) | 2016-10-17 | 2018-04-26 | University Of Maryland, College Park | Multispecific antibodies targeting human immunodeficiency virus and methods of using the same |
| EP3562505A4 (en) | 2016-12-27 | 2020-11-11 | The Rockefeller University | HIGHLY NEUTRALIZING ANTI-HIV-1 ANTIBODIES AND THEIR USE PROCEDURE |
| EP3642229A1 (en) | 2017-06-21 | 2020-04-29 | Gilead Sciences, Inc. | Multispecific antibodies that target hiv gp120 and cd3 |
| WO2019226829A1 (en) | 2018-05-22 | 2019-11-28 | Beth Israel Deaconess Medical Center, Inc. | Antibody therapies for human immunodeficiency virus (hiv) |
| CA3102859A1 (en) | 2018-07-03 | 2020-01-09 | Gilead Sciences, Inc. | Antibodies that target hiv gp120 and methods of use |
| EP3830108A4 (en) | 2018-07-27 | 2022-08-10 | International AIDS Vaccine Initiative | MODIFIED ANTIBODIES TOWARDS HIV ENVs |
| WO2020056145A1 (en) | 2018-09-14 | 2020-03-19 | The Rockefeller University | Anti-hiv antibody 10-1074 variants |
| US20210355197A1 (en) | 2018-10-22 | 2021-11-18 | International Aids Vaccine Initiative | Anti-hiv antibodies |
-
2021
- 2021-08-23 PE PE2023000528A patent/PE20231105A1/es unknown
- 2021-08-23 AU AU2021333577A patent/AU2021333577A1/en active Pending
- 2021-08-23 CR CR20230101A patent/CR20230101A/es unknown
- 2021-08-23 CA CA3187085A patent/CA3187085A1/en active Pending
- 2021-08-23 IL IL300256A patent/IL300256A/en unknown
- 2021-08-23 MX MX2023002194A patent/MX2023002194A/es unknown
- 2021-08-23 US US17/409,260 patent/US20230056252A1/en active Pending
- 2021-08-23 BR BR112023003366A patent/BR112023003366A2/pt unknown
- 2021-08-23 CN CN202180053297.6A patent/CN116157416A/zh active Pending
- 2021-08-23 EP EP21770379.2A patent/EP4204092A1/en active Pending
- 2021-08-23 KR KR1020237010068A patent/KR20230054456A/ko active Search and Examination
- 2021-08-23 JP JP2023513114A patent/JP2023539196A/ja active Pending
- 2021-08-23 WO PCT/US2021/047165 patent/WO2022046644A1/en active Application Filing
- 2021-08-24 TW TW112133115A patent/TW202348625A/zh unknown
-
2023
- 2023-02-23 DO DO2023000039A patent/DOP2023000039A/es unknown
- 2023-02-23 CO CONC2023/0002034A patent/CO2023002034A2/es unknown
- 2023-02-23 CL CL2023000539A patent/CL2023000539A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CL2023000539A1 (es) | 2023-09-01 |
| US20230056252A1 (en) | 2023-02-23 |
| MX2023002194A (es) | 2023-03-03 |
| CO2023002034A2 (es) | 2023-04-17 |
| AU2021333577A1 (en) | 2023-03-30 |
| JP2023539196A (ja) | 2023-09-13 |
| CR20230101A (es) | 2023-04-28 |
| WO2022046644A1 (en) | 2022-03-03 |
| IL300256A (en) | 2023-03-01 |
| PE20231105A1 (es) | 2023-07-19 |
| DOP2023000039A (es) | 2023-03-23 |
| KR20230054456A (ko) | 2023-04-24 |
| TW202348625A (zh) | 2023-12-16 |
| EP4204092A1 (en) | 2023-07-05 |
| TW202233665A (zh) | 2022-09-01 |
| CA3187085A1 (en) | 2022-03-03 |
| CN116157416A (zh) | 2023-05-23 |
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