BR112023000730A2 - Método para induzir e/ou ativar uma resposta imune, forma de dosagem, kit, vetor, célula hospedeira, partículas do vetor lentiviral pseudotipada e composição imunogênica - Google Patents
Método para induzir e/ou ativar uma resposta imune, forma de dosagem, kit, vetor, célula hospedeira, partículas do vetor lentiviral pseudotipada e composição imunogênicaInfo
- Publication number
- BR112023000730A2 BR112023000730A2 BR112023000730A BR112023000730A BR112023000730A2 BR 112023000730 A2 BR112023000730 A2 BR 112023000730A2 BR 112023000730 A BR112023000730 A BR 112023000730A BR 112023000730 A BR112023000730 A BR 112023000730A BR 112023000730 A2 BR112023000730 A2 BR 112023000730A2
- Authority
- BR
- Brazil
- Prior art keywords
- immune response
- inducing
- dosage form
- kit
- activating
- Prior art date
Links
- 230000028993 immune response Effects 0.000 title abstract 4
- 239000002552 dosage form Substances 0.000 title abstract 3
- 230000001939 inductive effect Effects 0.000 title abstract 3
- 239000002245 particle Substances 0.000 title abstract 3
- -1 KIT Substances 0.000 title abstract 2
- 230000003213 activating effect Effects 0.000 title abstract 2
- 230000002163 immunogen Effects 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 241000008904 Betacoronavirus Species 0.000 abstract 2
- 201000003176 Severe Acute Respiratory Syndrome Diseases 0.000 abstract 2
- 230000001681 protective effect Effects 0.000 abstract 2
- 210000002345 respiratory system Anatomy 0.000 abstract 2
- 229940096437 Protein S Drugs 0.000 abstract 1
- 101710198474 Spike protein Proteins 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/215—Coronaviridae, e.g. avian infectious bronchitis virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/544—Mucosal route to the airways
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/20011—Coronaviridae
- C12N2770/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
- C12N2810/60—Vectors comprising as targeting moiety peptide derived from defined protein from viruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
método para induzir e/ou ativar uma resposta imune, forma de dosagem, kit, vetor, célula hospedeira, partículas do vetor lentiviral pseudotipada e composição imunogênica. método de indução de uma resposta imune de proteção contra o beta-coronavírus 2 da síndrome respiratória aguda grave (sars-cov-2), compreendendo administrar ao trato respiratório superior de um indivíduo uma quantidade eficaz de um agente que induz uma resposta imune de proteção contra sars-cov-2. uma forma de dosagem para administração ao trato respiratório superior de uma partícula do vetor lentiviral pseudotipada que codifica uma proteína de pico do beta-coronavírus 2 da síndrome respiratória aguda grave (sars-cov-2) (s) ou um derivado ou fragmento da mesma.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063052264P | 2020-07-15 | 2020-07-15 | |
US202063130202P | 2020-12-23 | 2020-12-23 | |
PCT/IB2021/000293 WO2022167831A1 (en) | 2021-02-02 | 2021-02-02 | Sars-cov-2 immunogenic compositions, vaccines, and methods |
PCT/EP2021/069890 WO2022013405A1 (en) | 2020-07-15 | 2021-07-15 | Sars-cov-2 immunogenic compositions, vaccines, and methods |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112023000730A2 true BR112023000730A2 (pt) | 2023-10-03 |
Family
ID=77104030
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112023000730A BR112023000730A2 (pt) | 2020-07-15 | 2021-07-15 | Método para induzir e/ou ativar uma resposta imune, forma de dosagem, kit, vetor, célula hospedeira, partículas do vetor lentiviral pseudotipada e composição imunogênica |
Country Status (8)
Country | Link |
---|---|
US (1) | US20230256084A1 (pt) |
EP (1) | EP4181954A1 (pt) |
JP (1) | JP2023535163A (pt) |
KR (1) | KR20230041028A (pt) |
AU (1) | AU2021308424A1 (pt) |
BR (1) | BR112023000730A2 (pt) |
CA (1) | CA3185952A1 (pt) |
WO (1) | WO2022013405A1 (pt) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN117120085A (zh) * | 2020-07-15 | 2023-11-24 | 巴斯德研究所 | Sars-cov-2免疫原性组合物、疫苗和方法 |
WO2023135439A1 (en) * | 2022-01-17 | 2023-07-20 | Institut Pasteur | Boosting sars-cov-2 immunity with a lentiviral-based nasal vaccine |
WO2023166054A1 (en) * | 2022-03-02 | 2023-09-07 | ISR Immune System Regulation Holding AB (publ) | Vaccine composition comprising an antigen and a tlr3 agonist |
PL442478A1 (pl) * | 2022-10-10 | 2024-04-15 | Politechnika Warszawska | Kompozycja szczepionki do zastosowania w profilaktyce chorób zakaźnych |
WO2024091694A1 (en) * | 2022-10-28 | 2024-05-02 | Mary Hitchcock Memorial Hospital, For Itself And On Behalf Of Dartmouth-Hitchcock Clinic | Chimeric human receptor for pathogenic viruses |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1092779B1 (en) | 1999-10-11 | 2009-11-25 | Institut Pasteur | Lentiviral vectors for the preparation of immunotherapeutical compositions |
US10906944B2 (en) * | 2020-06-29 | 2021-02-02 | The Scripps Research Institute | Stabilized coronavirus spike (S) protein immunogens and related vaccines |
-
2021
- 2021-07-15 BR BR112023000730A patent/BR112023000730A2/pt unknown
- 2021-07-15 US US18/005,146 patent/US20230256084A1/en active Pending
- 2021-07-15 WO PCT/EP2021/069890 patent/WO2022013405A1/en unknown
- 2021-07-15 KR KR1020237005288A patent/KR20230041028A/ko unknown
- 2021-07-15 JP JP2023503013A patent/JP2023535163A/ja active Pending
- 2021-07-15 EP EP21746673.9A patent/EP4181954A1/en active Pending
- 2021-07-15 CA CA3185952A patent/CA3185952A1/en active Pending
- 2021-07-15 AU AU2021308424A patent/AU2021308424A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US20230256084A1 (en) | 2023-08-17 |
CA3185952A1 (en) | 2022-01-20 |
WO2022013405A1 (en) | 2022-01-20 |
JP2023535163A (ja) | 2023-08-16 |
AU2021308424A1 (en) | 2023-02-09 |
EP4181954A1 (en) | 2023-05-24 |
KR20230041028A (ko) | 2023-03-23 |
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