BR112022025631A2 - Derivados de 4-(pirazol-5-il)-indol macrocíclico n-ligados como inibidores de mcl-1 - Google Patents

Derivados de 4-(pirazol-5-il)-indol macrocíclico n-ligados como inibidores de mcl-1

Info

Publication number
BR112022025631A2
BR112022025631A2 BR112022025631A BR112022025631A BR112022025631A2 BR 112022025631 A2 BR112022025631 A2 BR 112022025631A2 BR 112022025631 A BR112022025631 A BR 112022025631A BR 112022025631 A BR112022025631 A BR 112022025631A BR 112022025631 A2 BR112022025631 A2 BR 112022025631A2
Authority
BR
Brazil
Prior art keywords
mcl
inhibitors
pyrazol
indole derivatives
linked macrocyclic
Prior art date
Application number
BR112022025631A
Other languages
English (en)
Inventor
Peschiulli Aldo
Jan Rita Rombouts Frederik
Velter Adriana-Ingrid
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BR112022025631A2 publication Critical patent/BR112022025631A2/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • A61K31/41621,2-Diazoles condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D515/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

DERIVADOS DE 4-(PIRAZOL-5-IL)-INDOL MACROCÍCLICO N-LIGADOS COMO INIBIDORES DE MCL-1. A presente invenção refere-se a agentes farmacêuticos úteis para terapia e/ou profilaxia em um indivíduo, composição farmacêutica compreendendo tais compostos e seu uso como inibidores de MCL-1, úteis para o tratamento de doenças como câncer.
BR112022025631A 2020-06-19 2021-06-18 Derivados de 4-(pirazol-5-il)-indol macrocíclico n-ligados como inibidores de mcl-1 BR112022025631A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP20181144 2020-06-19
PCT/EP2021/066655 WO2021255258A1 (en) 2020-06-19 2021-06-18 N-linked macrocyclic 4-(pyrazol-5-yl)-indole derivatives as inhibitors of mcl-1

Publications (1)

Publication Number Publication Date
BR112022025631A2 true BR112022025631A2 (pt) 2023-01-17

Family

ID=71119928

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022025631A BR112022025631A2 (pt) 2020-06-19 2021-06-18 Derivados de 4-(pirazol-5-il)-indol macrocíclico n-ligados como inibidores de mcl-1

Country Status (10)

Country Link
US (1) US20230234965A1 (pt)
EP (1) EP4168413A1 (pt)
JP (1) JP2023530148A (pt)
KR (1) KR20230027153A (pt)
CN (1) CN115943146A (pt)
AU (1) AU2021294273A1 (pt)
BR (1) BR112022025631A2 (pt)
CA (1) CA3181816A1 (pt)
MX (1) MX2022015998A (pt)
WO (1) WO2021255258A1 (pt)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017182625A1 (en) 2016-04-22 2017-10-26 Astrazeneca Ab Macrocyclic mcl1 inhibitors for treating cancer
TW201904976A (zh) 2017-03-31 2019-02-01 瑞典商阿斯特捷利康公司 Mcl-1抑制劑及其使用方法
TWI781996B (zh) 2017-03-31 2022-11-01 瑞典商阿斯特捷利康公司 合成mcl-1抑制劑之方法
AU2019347963A1 (en) 2018-09-30 2021-05-27 Jiangsu Hengrui Medicine Co., Ltd. Indole macrocyclic derivative, preparation method therefor and application thereof in medicine
WO2020103864A1 (en) 2018-11-22 2020-05-28 Ascentage Pharma (Suzhou) Co., Ltd. Macrocyclic indoles as mcl-1 inhibitors

Also Published As

Publication number Publication date
AU2021294273A1 (en) 2023-02-23
EP4168413A1 (en) 2023-04-26
CA3181816A1 (en) 2021-12-23
JP2023530148A (ja) 2023-07-13
US20230234965A1 (en) 2023-07-27
KR20230027153A (ko) 2023-02-27
CN115943146A (zh) 2023-04-07
WO2021255258A1 (en) 2021-12-23
MX2022015998A (es) 2023-04-12

Similar Documents

Publication Publication Date Title
BR112022000251A2 (pt) Derivados macrocíclicos de espirociclo como inibidores de mcl-1
BR112023000212A2 (pt) Éter macrocíclico contendo derivados de indol como inibidores de mcl-1
DOP2022000266A (es) 2-amino-3-cianotiofenos anulados y derivados para el tratamiento del cáncer
BR112022002532A2 (pt) Compostos heterocíclicos como inibidores de quinase
NI201900099A (es) Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue
ECSP18073366A (es) Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue
BR112015028879A8 (pt) compostos derivados heterocíclicos, composição farmacêutica compreendendo os referidos compostos e usos dos mesmos
DOP2010000064A (es) 2-anilinopurin 8-onas como inhibidores de ttk/mps1 para el tratamiento de trastornos proliferativos
ECSP18073293A (es) Derivados de indolina sustituidos como inhibidores de la replicación viral del dengue
BR112012021086A2 (pt) composições farmacêuticas de composto espiro-oxindole para administração tópica e seu uso como agentes terapêuticos
ECSP19083640A (es) Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue
BR112015029401A8 (pt) derivados de pirazolo-pirrolidin-4-ona, seus usos, e composição e combinação farmacêuticas
BR112021025732A2 (pt) Inibidores macrocíclicos de mcl-1
EA202191801A1 (ru) Гетероциклические ингибиторы mat2a и способы применения для лечения рака
BR112015029353A2 (pt) derivados de pirazolo-pirrolidin-4-ona e seu uso no tratamento de doenças
BR112017016817A2 (pt) derivados heterocíclicos formilados como inibidores de fgfr4
BR112022025117A2 (pt) 2-amino-3-fluoro-but-3-enamidas macrocíclicas como inibidores de mcl-1
BR112018070536A2 (pt) composto, composição farmacêutica, combinação, uso de um composto ou um sal farmaceuticamente aceitável do mesmo, e, método de tratamento de uma doença ou condição
BR112014006223A8 (pt) 3-(quinolin-6-iltio)-[1,2,4-triazol[4,3-a] piradinas 6-substituídas, seus usos, composições farmacêuticas, e combinação
BR112021025764A2 (pt) Derivado de pirimidina que inibe o crescimento de células cancerígenas e uso medicinal do mesmo
BR112018070514A2 (pt) composto, composição farmacêutica, combinação, uso de um composto ou um sal farmaceuticamente aceitável do mesmo, e, método de tratamento de uma doença ou condição
BR112019007863A2 (pt) derivados de naftiridinona inovadores e seu uso no tratamento de arritmia
BR112022009142A2 (pt) Derivados de indol macrocíclicos como inibidores de mcl-1
BR112019005578A2 (pt) compostos de indazol para uso em lesões no tendão e/ou ligamento
BR112022009754A2 (pt) Derivados macrocíclicos de sulfonila como inibidores de mcl-1