BR112022020203A2 - Composição de nanopartículas lipídicas - Google Patents

Composição de nanopartículas lipídicas

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Publication number
BR112022020203A2
BR112022020203A2 BR112022020203A BR112022020203A BR112022020203A2 BR 112022020203 A2 BR112022020203 A2 BR 112022020203A2 BR 112022020203 A BR112022020203 A BR 112022020203A BR 112022020203 A BR112022020203 A BR 112022020203A BR 112022020203 A2 BR112022020203 A2 BR 112022020203A2
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BR
Brazil
Prior art keywords
lipid nanoparticles
composition
lipids
lipid
prophylactic
Prior art date
Application number
BR112022020203A
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English (en)
Inventor
Ying Bo
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Suzhou Abogen Biosciences Co Ltd
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Publication date
Application filed by Suzhou Abogen Biosciences Co Ltd filed Critical Suzhou Abogen Biosciences Co Ltd
Publication of BR112022020203A2 publication Critical patent/BR112022020203A2/pt

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    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
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    • C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
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    • C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
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Abstract

COMPOSIÇÃO DE NANOPARTÍCULAS LIPÍDICAS. A presente invenção refere-se a lipídios que podem ser usados em combinação com outros componentes lipídicos, como lipídios neutros, colesterol e lipídios conjugados com polímero, para formar nanopartículas lipídicas para distribuição de agentes terapêuticos (por exemplo, moléculas de ácido nucleico) para fins terapêuticos ou profiláticos, incluindo vacinação.
BR112022020203A 2020-04-09 2021-04-08 Composição de nanopartículas lipídicas BR112022020203A2 (pt)

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PCT/CN2021/085879 WO2021204175A1 (en) 2020-04-09 2021-04-08 Lipid nanoparticle composition

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