BR112022010069A2 - Anticorpo biespecífico, molécula de ácido nucleico isolada, vetor, célula hospedeira, conjugado, kit, uso do anticorpo biespecífico e composição farmacêutica - Google Patents
Anticorpo biespecífico, molécula de ácido nucleico isolada, vetor, célula hospedeira, conjugado, kit, uso do anticorpo biespecífico e composição farmacêuticaInfo
- Publication number
- BR112022010069A2 BR112022010069A2 BR112022010069A BR112022010069A BR112022010069A2 BR 112022010069 A2 BR112022010069 A2 BR 112022010069A2 BR 112022010069 A BR112022010069 A BR 112022010069A BR 112022010069 A BR112022010069 A BR 112022010069A BR 112022010069 A2 BR112022010069 A2 BR 112022010069A2
- Authority
- BR
- Brazil
- Prior art keywords
- antibody
- vegfa
- bispecific antibody
- conjugate
- kit
- Prior art date
Links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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- A—HUMAN NECESSITIES
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6845—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a cytokine, e.g. growth factors, VEGF, TNF, a lymphokine or an interferon
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
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- A61P35/02—Antineoplastic agents specific for leukemia
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
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- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
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- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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Abstract
ANTICORPO BIESPECÍFICO, MOLÉCULA DE ÁCIDO NUCLEICO ISOLADA, VETOR, CÉLULA HOSPEDEIRA, CONJUGADO, KIT, USO DO ANTICORPO BIESPECÍFICO E COMPOSIÇÃO. FARMACÊUTICA. São providos um anticorpo biespecífico anti-VEGFA-anti-PD-1 e o uso do mesmo. Especificamente, o anticorpo biespecífico anti-VEGFA-anti-PD-1 compreende: uma primeira região funcional de proteína direcionada a PD-1 e uma segunda região funcional de proteína direcionada a VEGFA. De acordo com um sistema de numeração EU, a mutação ocorre em duas posições das posições 234 e 235 de uma região constante de cadeia pesada da imunoglobulina contida no anticorpo biespecífico, e após a mutação, uma constante de afinidade do anticorpo biespecífico com FcYRI, FcYRIIa, FcYRIIIa, e/ou C1q está diminuído em comparação com aquele antes da mutação. O anticorpo biespecífico pode se ligar especificamente a VEGFA e PD-1, aliviar especificamente a imunossupressão de VEGFA e PD-1 em um organismo e inibir a angiogênese induzida por tumor e, portanto, tem boas perspectivas de aplicação.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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CN201911164156 | 2019-11-25 | ||
PCT/CN2020/131447 WO2021104302A1 (zh) | 2019-11-25 | 2020-11-25 | 抗pd-1-抗vegfa的双特异性抗体、其药物组合物及其用途 |
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BR112022010069A2 true BR112022010069A2 (pt) | 2022-09-06 |
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BR112022010069A BR112022010069A2 (pt) | 2019-11-25 | 2020-11-25 | Anticorpo biespecífico, molécula de ácido nucleico isolada, vetor, célula hospedeira, conjugado, kit, uso do anticorpo biespecífico e composição farmacêutica |
Country Status (12)
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US (1) | US20230027029A1 (pt) |
EP (1) | EP4067387A4 (pt) |
JP (1) | JP2023504003A (pt) |
KR (1) | KR20220104033A (pt) |
CN (1) | CN112830972A (pt) |
AU (1) | AU2020390967A1 (pt) |
BR (1) | BR112022010069A2 (pt) |
CA (1) | CA3162748A1 (pt) |
IL (1) | IL293241A (pt) |
MX (1) | MX2022006330A (pt) |
WO (1) | WO2021104302A1 (pt) |
ZA (1) | ZA202206885B (pt) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112023018457A2 (pt) * | 2021-03-12 | 2023-10-10 | Akeso Biopharma Inc | Combinação farmacêutica contendo anticorpo biespecífico anti-pd-1-anti-vegfa e uso da mesma |
KR20230170648A (ko) * | 2021-04-14 | 2023-12-19 | 아케소 바이오파마, 인크. | 항-cd47 단일클론 항체 및 이의 용도 |
CN115558029B (zh) * | 2021-10-22 | 2024-01-30 | 立凌生物制药(苏州)有限公司 | 靶向pd-1的双特异性抗体、及其制备和应用 |
CN114181310B (zh) * | 2022-02-14 | 2022-07-05 | 中山康方生物医药有限公司 | 抗tigit抗体、其药物组合物及用途 |
CN116731188A (zh) * | 2022-03-02 | 2023-09-12 | 三优生物医药(上海)有限公司 | 抗pd-l1和vegf双特异性抗体及其应用 |
CN114736303A (zh) * | 2022-03-17 | 2022-07-12 | 英诺湖医药(杭州)有限公司 | 抗pd-l1和4-1bb的双功能抗体及其医药用途 |
CN117257934A (zh) | 2022-06-22 | 2023-12-22 | 中山康方生物医药有限公司 | 药物组合物及其用途 |
WO2024051223A1 (zh) | 2022-09-09 | 2024-03-14 | 中山康方生物医药有限公司 | 药物组合及用途 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
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US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US5747654A (en) | 1993-06-14 | 1998-05-05 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant disulfide-stabilized polypeptide fragments having binding specificity |
DE69829891T2 (de) | 1997-04-07 | 2005-10-06 | Genentech, Inc., South San Francisco | Anti-VEGF Antikörper |
US20040132101A1 (en) * | 2002-09-27 | 2004-07-08 | Xencor | Optimized Fc variants and methods for their generation |
PT2215117E (pt) * | 2007-10-30 | 2015-04-01 | Genentech Inc | Purificação de anticorpo por cromatografia de troca de catiões |
CN105175545B (zh) * | 2015-10-20 | 2019-01-25 | 安徽瀚海博兴生物技术有限公司 | 一种抗vegf-抗pd-1双功能抗体及其应用 |
MX2017016851A (es) * | 2016-03-04 | 2018-04-30 | Sichuan Kelun Biotech Biopharmaceutical Co Ltd | Anticuerpo para el ligando del factor 1 de muerte celular programada (pdl-1), composicion farmaceutica del mismo y uso de los mismos. |
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WO2018223923A1 (zh) * | 2017-06-05 | 2018-12-13 | 江苏恒瑞医药股份有限公司 | Pd-1抗体与vegf配体或vegf受体抑制剂联合在制备***的药物中的用途 |
TW202116811A (zh) * | 2017-12-29 | 2021-05-01 | 圓祥生命科技股份有限公司 | 調節免疫檢查點作為癌症治療的單特異性蛋白質、其醫藥組成物、其核酸、及其用途 |
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CN110563849B (zh) * | 2019-08-09 | 2022-09-09 | 安徽瀚海博兴生物技术有限公司 | 一种抗vegf-抗pd1双特异性抗体 |
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CN110960543A (zh) * | 2019-12-10 | 2020-04-07 | 安徽瀚海博兴生物技术有限公司 | 一种联合抗vegf-抗pd1双特异性抗体用于制备抗癌药物 |
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2020
- 2020-11-25 CN CN202011341655.7A patent/CN112830972A/zh active Pending
- 2020-11-25 AU AU2020390967A patent/AU2020390967A1/en active Pending
- 2020-11-25 EP EP20892544.6A patent/EP4067387A4/en active Pending
- 2020-11-25 MX MX2022006330A patent/MX2022006330A/es unknown
- 2020-11-25 CA CA3162748A patent/CA3162748A1/en active Pending
- 2020-11-25 JP JP2022530820A patent/JP2023504003A/ja active Pending
- 2020-11-25 US US17/779,425 patent/US20230027029A1/en active Pending
- 2020-11-25 BR BR112022010069A patent/BR112022010069A2/pt unknown
- 2020-11-25 KR KR1020227021354A patent/KR20220104033A/ko unknown
- 2020-11-25 WO PCT/CN2020/131447 patent/WO2021104302A1/zh active Application Filing
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US20230027029A1 (en) | 2023-01-26 |
MX2022006330A (es) | 2022-08-17 |
IL293241A (en) | 2022-07-01 |
CN112830972A (zh) | 2021-05-25 |
EP4067387A4 (en) | 2023-12-27 |
KR20220104033A (ko) | 2022-07-25 |
ZA202206885B (en) | 2023-04-26 |
AU2020390967A1 (en) | 2022-06-23 |
CA3162748A1 (en) | 2021-06-03 |
EP4067387A1 (en) | 2022-10-05 |
JP2023504003A (ja) | 2023-02-01 |
WO2021104302A1 (zh) | 2021-06-03 |
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