BR112022009331A2 - Formas cristalinas do receptor de quimiocina c c antagonista tipo 4 e usos das mesmas - Google Patents
Formas cristalinas do receptor de quimiocina c c antagonista tipo 4 e usos das mesmasInfo
- Publication number
- BR112022009331A2 BR112022009331A2 BR112022009331A BR112022009331A BR112022009331A2 BR 112022009331 A2 BR112022009331 A2 BR 112022009331A2 BR 112022009331 A BR112022009331 A BR 112022009331A BR 112022009331 A BR112022009331 A BR 112022009331A BR 112022009331 A2 BR112022009331 A2 BR 112022009331A2
- Authority
- BR
- Brazil
- Prior art keywords
- crystalline forms
- chemokine
- receptor
- antagonist
- antagonist type
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
FORMAS CRISTALINAS DO RECEPTOR DE QUIMIOCINA C-C ANTAGONISTA TIPO 4 E USOS DAS MESMAS. São fornecidas formas cristalinas de um antagonista do receptor de quimiocina C-C tipo 4 (CCR4), formas de dosagem oral das mesmas e métodos de uso e preparação das mesmas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962935007P | 2019-11-13 | 2019-11-13 | |
PCT/US2020/060575 WO2021097339A1 (en) | 2019-11-13 | 2020-11-13 | Crystalline forms of c-c chemokine receptor type 4 antagonist and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112022009331A2 true BR112022009331A2 (pt) | 2022-08-09 |
Family
ID=73856569
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022009331A BR112022009331A2 (pt) | 2019-11-13 | 2020-11-13 | Formas cristalinas do receptor de quimiocina c c antagonista tipo 4 e usos das mesmas |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP4058456A1 (pt) |
JP (1) | JP2023501584A (pt) |
KR (1) | KR20220101099A (pt) |
CN (1) | CN114728972A (pt) |
AU (1) | AU2020383625A1 (pt) |
BR (1) | BR112022009331A2 (pt) |
CA (1) | CA3158521A1 (pt) |
IL (1) | IL292755A (pt) |
MX (1) | MX2022005795A (pt) |
TW (1) | TW202132303A (pt) |
WO (1) | WO2021097339A1 (pt) |
ZA (1) | ZA202204943B (pt) |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
US4911920A (en) | 1986-07-30 | 1990-03-27 | Alcon Laboratories, Inc. | Sustained release, comfort formulation for glaucoma therapy |
FR2588189B1 (fr) | 1985-10-03 | 1988-12-02 | Merck Sharp & Dohme | Composition pharmaceutique de type a transition de phase liquide-gel |
DE3815221C2 (de) | 1988-05-04 | 1995-06-29 | Gradinger F Hermes Pharma | Verwendung einer Retinol- und/oder Retinsäureester enthaltenden pharmazeutischen Zubereitung zur Inhalation zur Einwirkung auf die Schleimhäute des Tracheo-Bronchialtraktes einschließlich der Lungenalveolen |
JP2594486B2 (ja) | 1991-01-15 | 1997-03-26 | アルコン ラボラトリーズ インコーポレイテッド | 局所的眼薬組成物 |
US5212162A (en) | 1991-03-27 | 1993-05-18 | Alcon Laboratories, Inc. | Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions |
US5698155A (en) | 1991-05-31 | 1997-12-16 | Gs Technologies, Inc. | Method for the manufacture of pharmaceutical cellulose capsules |
EP1853260A1 (en) * | 2005-02-16 | 2007-11-14 | Merck & Co., Inc. | Substituted pyrazoles as modulators of chemokine receptors |
WO2010034740A1 (en) * | 2008-09-23 | 2010-04-01 | Palau Pharma, S.A. | (r)-3-(n,n-dimethylamino)pyrrolidine derivatives |
US8383812B2 (en) * | 2009-10-13 | 2013-02-26 | Bristol-Myers Squibb Company | N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-A][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide, a dual modulator of chemokine receptor activity, crystalline forms and processes |
JP2013031931A (ja) * | 2011-08-01 | 2013-02-14 | Hitachi Koki Co Ltd | 携帯式作業機 |
TW201311693A (zh) * | 2011-09-02 | 2013-03-16 | Kyowa Hakko Kirin Co Ltd | 化學激活激素受體活性調節劑 |
AR096758A1 (es) * | 2013-06-28 | 2016-02-03 | Abbvie Inc | Inhibidores cristalinos de bromodominios |
KR102566924B1 (ko) * | 2016-07-29 | 2023-08-11 | 랩트 테라퓨틱스, 인크. | 케모카인 수용체 조절제 및 이의 용도 |
WO2018049271A1 (en) * | 2016-09-09 | 2018-03-15 | Flx Bio, Inc. | Chemokine receptor modulators and uses thereof |
BR112020004697A2 (pt) * | 2017-09-12 | 2020-10-27 | Ardea Biosciences, Inc. | inibidores de cxcr-2 para tratamento de distúrbios |
IL274444B1 (en) * | 2017-11-06 | 2024-02-01 | Rapt Therapeutics Inc | Chemokine receptor modulators for the treatment of Epstein-Barr virus-positive cancer |
CN109796457B (zh) * | 2019-03-28 | 2020-03-06 | 苏州国匡医药科技有限公司 | 一种2-(3-(氮杂环丁烷-3-基)哌啶-1-基)乙基-1-醇的制备方法及其应用 |
-
2020
- 2020-11-13 EP EP20828597.3A patent/EP4058456A1/en active Pending
- 2020-11-13 BR BR112022009331A patent/BR112022009331A2/pt unknown
- 2020-11-13 CN CN202080076933.2A patent/CN114728972A/zh active Pending
- 2020-11-13 JP JP2022527735A patent/JP2023501584A/ja active Pending
- 2020-11-13 WO PCT/US2020/060575 patent/WO2021097339A1/en unknown
- 2020-11-13 CA CA3158521A patent/CA3158521A1/en active Pending
- 2020-11-13 MX MX2022005795A patent/MX2022005795A/es unknown
- 2020-11-13 KR KR1020227016282A patent/KR20220101099A/ko unknown
- 2020-11-13 TW TW109139744A patent/TW202132303A/zh unknown
- 2020-11-13 AU AU2020383625A patent/AU2020383625A1/en active Pending
-
2022
- 2022-05-03 IL IL292755A patent/IL292755A/en unknown
- 2022-05-05 ZA ZA2022/04943A patent/ZA202204943B/en unknown
Also Published As
Publication number | Publication date |
---|---|
CA3158521A1 (en) | 2021-05-20 |
MX2022005795A (es) | 2022-06-08 |
KR20220101099A (ko) | 2022-07-19 |
CN114728972A (zh) | 2022-07-08 |
US20210139487A1 (en) | 2021-05-13 |
TW202132303A (zh) | 2021-09-01 |
JP2023501584A (ja) | 2023-01-18 |
AU2020383625A1 (en) | 2022-05-05 |
WO2021097339A1 (en) | 2021-05-20 |
ZA202204943B (en) | 2023-11-29 |
IL292755A (en) | 2022-07-01 |
EP4058456A1 (en) | 2022-09-21 |
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