BR112022003451A2 - Sistemas e métodos para processamento de imagens de lâminas para inferir biomarcadores - Google Patents

Sistemas e métodos para processamento de imagens de lâminas para inferir biomarcadores

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Publication number
BR112022003451A2
BR112022003451A2 BR112022003451A BR112022003451A BR112022003451A2 BR 112022003451 A2 BR112022003451 A2 BR 112022003451A2 BR 112022003451 A BR112022003451 A BR 112022003451A BR 112022003451 A BR112022003451 A BR 112022003451A BR 112022003451 A2 BR112022003451 A2 BR 112022003451A2
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BR
Brazil
Prior art keywords
biomarker
images
interest
region
systems
Prior art date
Application number
BR112022003451A
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English (en)
Inventor
Christopher Kanan
Leo Grady
Ran Godrich
Supriya Kapur
Thomas Fuchs
Original Assignee
Paige Ai Inc
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Publication date
Application filed by Paige Ai Inc filed Critical Paige Ai Inc
Publication of BR112022003451A2 publication Critical patent/BR112022003451A2/pt

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    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G06T7/0012—Biomedical image inspection
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F18/00—Pattern recognition
    • G06F18/20—Analysing
    • G06F18/21—Design or setup of recognition systems or techniques; Extraction of features in feature space; Blind source separation
    • G06F18/214—Generating training patterns; Bootstrap methods, e.g. bagging or boosting
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/10—Segmentation; Edge detection
    • G06T7/11—Region-based segmentation
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V10/00—Arrangements for image or video recognition or understanding
    • G06V10/20—Image preprocessing
    • G06V10/255—Detecting or recognising potential candidate objects based on visual cues, e.g. shapes
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G06V20/695—Preprocessing, e.g. image segmentation
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G06V20/698—Matching; Classification
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
    • G16H10/40—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H30/00—ICT specially adapted for the handling or processing of medical images
    • G16H30/40—ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10024—Color image
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10056—Microscopic image
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/20—Special algorithmic details
    • G06T2207/20021—Dividing image into blocks, subimages or windows
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/20—Special algorithmic details
    • G06T2207/20076—Probabilistic image processing
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/20—Special algorithmic details
    • G06T2207/20081—Training; Learning
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/20—Special algorithmic details
    • G06T2207/20084—Artificial neural networks [ANN]
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30024—Cell structures in vitro; Tissue sections in vitro
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30061—Lung
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30068—Mammography; Breast
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30096—Tumor; Lesion
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V2201/00—Indexing scheme relating to image or video recognition or understanding
    • G06V2201/03—Recognition of patterns in medical or anatomical images

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  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Theoretical Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Epidemiology (AREA)
  • Primary Health Care (AREA)
  • Data Mining & Analysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Multimedia (AREA)
  • Molecular Biology (AREA)
  • Quality & Reliability (AREA)
  • Pathology (AREA)
  • Databases & Information Systems (AREA)
  • Evolutionary Computation (AREA)
  • Evolutionary Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Artificial Intelligence (AREA)
  • General Engineering & Computer Science (AREA)
  • Image Analysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

sistemas e métodos para processamento de imagens de lâminas para inferir biomarcadores. sistemas e métodos são divulgados para receber uma imagem eletrônica alvo correspondente a um espécime alvo, o espécime alvo compreendendo uma amostra de tecido de um paciente, aplicar um sistema de aprendizado de máquina à imagem eletrônica alvo para identificar uma região de interesse do espécime alvo e determinar um nível de expressão de, categoria de, e/ou presença de um biomarcador na região de interesse, o biomarcador compreendendo pelo menos um dentre um biomarcador de receptor de fator de crescimento epitelial (egfr) e/ou um biomarcador de deficiência de reparo de incompatibilidade de dna (mmr), o sistema de aprendizado de máquina foi gerado pelo processamento de uma pluralidade de imagens de treinamento para prever se uma região de interesse está presente na imagem eletrônica alvo, as imagens de treinamento compreendendo imagens de tecido humano e/ou imagens que são geradas algoritmicamente, e saída do nível de expressão determinado, categoria e/ou presença do biomarcador na região de interesse.
BR112022003451A 2019-09-09 2020-09-09 Sistemas e métodos para processamento de imagens de lâminas para inferir biomarcadores BR112022003451A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962897734P 2019-09-09 2019-09-09
PCT/US2020/049968 WO2021050567A1 (en) 2019-09-09 2020-09-09 Systems and methods for processing images of slides to infer biomarkers

Publications (1)

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BR112022003451A2 true BR112022003451A2 (pt) 2022-05-24

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Country Status (9)

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US (3) US20210073986A1 (pt)
EP (1) EP4028990A1 (pt)
JP (1) JP2022546596A (pt)
KR (1) KR20220064379A (pt)
CN (1) CN114341952A (pt)
AU (1) AU2020345841A1 (pt)
BR (1) BR112022003451A2 (pt)
CA (1) CA3146711A1 (pt)
WO (1) WO2021050567A1 (pt)

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WO2022093906A1 (en) * 2020-10-29 2022-05-05 Paige Ai, Inc. Systems and methods for processing images to determine image-based computational biomarkers from liquid specimens
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CN113239924B (zh) * 2021-05-21 2022-04-26 上海交通大学 一种基于迁移学习的弱监督目标检测方法及***
US11830622B2 (en) * 2021-06-11 2023-11-28 International Business Machines Corporation Processing multimodal images of tissue for medical evaluation
KR20230056175A (ko) * 2021-10-20 2023-04-27 주식회사 뷰노 의료 영상 분석 방법
KR20230056174A (ko) * 2021-10-20 2023-04-27 주식회사 뷰노 딥러닝 기반의 의료 영상 분석 방법
WO2023106546A1 (ko) * 2021-12-09 2023-06-15 재단법인대구경북과학기술원 상향식 인스턴스 세분화 방법 및 장치
WO2023172929A1 (en) * 2022-03-08 2023-09-14 The Regents Of The University Of California Artificial intelligence architecture for predicting cancer biomarkers
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Publication number Publication date
KR20220064379A (ko) 2022-05-18
US20220335607A1 (en) 2022-10-20
JP2022546596A (ja) 2022-11-04
EP4028990A1 (en) 2022-07-20
US20210073986A1 (en) 2021-03-11
CN114341952A (zh) 2022-04-12
WO2021050567A1 (en) 2021-03-18
CA3146711A1 (en) 2021-03-18
US20230245309A1 (en) 2023-08-03
US11741604B2 (en) 2023-08-29
AU2020345841A1 (en) 2022-03-17

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