BR112021023957A2 - Peptídeos - Google Patents
PeptídeosInfo
- Publication number
- BR112021023957A2 BR112021023957A2 BR112021023957A BR112021023957A BR112021023957A2 BR 112021023957 A2 BR112021023957 A2 BR 112021023957A2 BR 112021023957 A BR112021023957 A BR 112021023957A BR 112021023957 A BR112021023957 A BR 112021023957A BR 112021023957 A2 BR112021023957 A2 BR 112021023957A2
- Authority
- BR
- Brazil
- Prior art keywords
- seq
- amino acids
- peptide
- positions
- fragment
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 8
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 239000012634 fragment Substances 0.000 abstract 6
- 150000001413 amino acids Chemical class 0.000 abstract 5
- 102000008300 Mutant Proteins Human genes 0.000 abstract 1
- 108010021466 Mutant Proteins Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000037433 frameshift Effects 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
- G01N33/505—Cells of the immune system involving T-cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
peptídeos. a presente invenção revela um peptídeo compreendendo um fragmento de seq id no:2 ou seq id no:8. o fragmento compreende pelo menos 8 aminoácidos consecutivos de seq id no:8, incluindo pelo menos uma das posições 121 e 135 de seq id no:8. alternativamente, o fragmento compreende as posições 6 a 13 da seq id no:3 e o peptídeo compreende não mais do que 21 aminoácidos, o fragmento compreende as posições 7 a 22 da seq id no:3 e o peptídeo não compreende mais do que 40 aminoácidos, ou o fragmento compreende as posições 18 a 33 da seq id no:3, e o peptídeo não compreende mais do que 33 aminoácidos. alternativamente, o fragmento compreende a sequência de aminoácidos de seq id no:29, e o peptídeo compreende não mais do que 21 aminoácidos e é para uso no tratamento e/ou profilaxia do câncer. o peptídeo é capaz de induzir uma resposta imune contra uma proteína mutante de alteração do quadro de leitura de tgfßr2 -1a.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP19177444 | 2019-05-29 | ||
PCT/EP2020/064893 WO2020239937A1 (en) | 2019-05-29 | 2020-05-28 | Peptides |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112021023957A2 true BR112021023957A2 (pt) | 2022-02-01 |
Family
ID=66677029
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112021023957A BR112021023957A2 (pt) | 2019-05-29 | 2020-05-28 | Peptídeos |
Country Status (22)
Country | Link |
---|---|
US (1) | US20220213170A1 (pt) |
EP (2) | EP4276463A3 (pt) |
JP (1) | JP2022535784A (pt) |
KR (1) | KR20220012938A (pt) |
CN (1) | CN113891723A (pt) |
AU (1) | AU2020281912A1 (pt) |
BR (1) | BR112021023957A2 (pt) |
CA (1) | CA3141951A1 (pt) |
CO (1) | CO2021017664A2 (pt) |
DK (1) | DK3840767T3 (pt) |
ES (1) | ES2970223T3 (pt) |
FI (1) | FI3840767T3 (pt) |
HR (1) | HRP20240017T1 (pt) |
HU (1) | HUE065269T2 (pt) |
IL (1) | IL288412A (pt) |
LT (1) | LT3840767T (pt) |
MX (1) | MX2021014497A (pt) |
PL (1) | PL3840767T3 (pt) |
PT (1) | PT3840767T (pt) |
SG (1) | SG11202113125QA (pt) |
SI (1) | SI3840767T1 (pt) |
WO (1) | WO2020239937A1 (pt) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN115916251A (zh) | 2020-05-28 | 2023-04-04 | 休博治疗有限公司 | 肽混合物 |
IL309738A (en) | 2021-07-09 | 2024-02-01 | Hubro Therapeutics As | Primer |
EP4223782A1 (en) * | 2022-02-07 | 2023-08-09 | Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft | Novel t cell receptors and immune therapy using the same for the treatment of cancer |
WO2024052542A2 (en) | 2022-09-09 | 2024-03-14 | Hubro Therapeutics As | A peptide cocktail |
WO2024149791A1 (en) | 2023-01-11 | 2024-07-18 | Hubro Therapeutics As | A primer |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NO315238B1 (no) * | 1998-05-08 | 2003-08-04 | Gemvax As | Peptider som stammer fra leserammeforskyvingsmutasjoner i TBF<beta>II- eller BAX-genet, og farmasöytiske sammensetninger inneholdende disse,nukleinsyresekvenser som koder for slike peptider, plasmider og virusvektoreromfattende slikenukleinsy |
AU2003232485A1 (en) | 2002-04-18 | 2003-10-27 | Mtm Laboratories Ag | Neopeptides and methods useful for detection and treatment of cancer |
ATE439383T1 (de) * | 2005-09-20 | 2009-08-15 | Peter Jon Nelson | Gewebeinhibitor für metalloproteinasen (timp) gebunden an ein glycosylphosphatidylinositol (gpi-) anker zur behandlung von krebs |
RU2012147590A (ru) * | 2010-04-09 | 2014-05-20 | Онкотерапи Сайенс, Инк. | Пептиды cdca5 и содержащие их вакцины |
EP2571512B1 (en) * | 2010-05-17 | 2017-08-23 | Sangamo BioSciences, Inc. | Novel dna-binding proteins and uses thereof |
US20200188496A1 (en) * | 2017-06-02 | 2020-06-18 | Arizona Board Of Regents On Behalf Of Arizona State University | Universal cancer vaccines and methods of making and using same |
-
2020
- 2020-05-28 FI FIEP20728497.7T patent/FI3840767T3/fi active
- 2020-05-28 ES ES20728497T patent/ES2970223T3/es active Active
- 2020-05-28 SI SI202030322T patent/SI3840767T1/sl unknown
- 2020-05-28 WO PCT/EP2020/064893 patent/WO2020239937A1/en unknown
- 2020-05-28 MX MX2021014497A patent/MX2021014497A/es unknown
- 2020-05-28 HU HUE20728497A patent/HUE065269T2/hu unknown
- 2020-05-28 SG SG11202113125QA patent/SG11202113125QA/en unknown
- 2020-05-28 HR HRP20240017TT patent/HRP20240017T1/hr unknown
- 2020-05-28 DK DK20728497.7T patent/DK3840767T3/da active
- 2020-05-28 BR BR112021023957A patent/BR112021023957A2/pt unknown
- 2020-05-28 CA CA3141951A patent/CA3141951A1/en active Pending
- 2020-05-28 PT PT207284977T patent/PT3840767T/pt unknown
- 2020-05-28 PL PL20728497.7T patent/PL3840767T3/pl unknown
- 2020-05-28 EP EP23185952.1A patent/EP4276463A3/en active Pending
- 2020-05-28 CN CN202080039516.0A patent/CN113891723A/zh active Pending
- 2020-05-28 EP EP20728497.7A patent/EP3840767B1/en active Active
- 2020-05-28 JP JP2021571354A patent/JP2022535784A/ja active Pending
- 2020-05-28 LT LTEPPCT/EP2020/064893T patent/LT3840767T/lt unknown
- 2020-05-28 AU AU2020281912A patent/AU2020281912A1/en active Pending
- 2020-05-28 KR KR1020217042578A patent/KR20220012938A/ko unknown
- 2020-05-28 US US17/614,272 patent/US20220213170A1/en active Pending
-
2021
- 2021-11-25 IL IL288412A patent/IL288412A/en unknown
- 2021-12-22 CO CONC2021/0017664A patent/CO2021017664A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
AU2020281912A1 (en) | 2022-01-20 |
US20220213170A1 (en) | 2022-07-07 |
PL3840767T3 (pl) | 2024-03-04 |
FI3840767T3 (fi) | 2024-01-31 |
ES2970223T3 (es) | 2024-05-27 |
MX2021014497A (es) | 2022-02-11 |
LT3840767T (lt) | 2024-02-26 |
EP3840767A1 (en) | 2021-06-30 |
CN113891723A (zh) | 2022-01-04 |
KR20220012938A (ko) | 2022-02-04 |
WO2020239937A1 (en) | 2020-12-03 |
CA3141951A1 (en) | 2020-12-03 |
EP4276463A3 (en) | 2024-01-10 |
SI3840767T1 (sl) | 2024-04-30 |
HRP20240017T1 (hr) | 2024-04-26 |
EP3840767B1 (en) | 2023-11-15 |
DK3840767T3 (da) | 2024-02-12 |
HUE065269T2 (hu) | 2024-05-28 |
SG11202113125QA (en) | 2021-12-30 |
JP2022535784A (ja) | 2022-08-10 |
CO2021017664A2 (es) | 2022-01-17 |
EP4276463A2 (en) | 2023-11-15 |
PT3840767T (pt) | 2024-01-29 |
IL288412A (en) | 2022-01-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112021023957A2 (pt) | Peptídeos | |
AR105485A1 (es) | Derivado de glucagón y una composición que comprende un conjugado de acción prolongada del mismo | |
PE20120358A1 (es) | Mutantes fgf21 y usos de los mismos | |
BRPI0607097B8 (pt) | uso de um peptídeo imunogênico para a fabricação de um medicamento para o tratamento, prevenção ou redução de infecção por papilomavírus | |
BR112013013548B8 (pt) | Proteína de fusão anticancerígena | |
BR112016013138A2 (pt) | mistura de peptídeos | |
WO2018067217A3 (en) | COMPOSITIONS COMPRISING SHORT PEPTIDES DERIVED FROM PEDF AND USES THEREOF | |
EP3939606A3 (en) | Improved methods and compounds for eliminating immune responses to therapeutic agents | |
BR112018000660A2 (pt) | peptídeos anti-inflamatórios e seu uso | |
BRPI0510016A (pt) | vetor lentiviral recombinante para expressão de uma proteìna de flaviviridae e aplicações do mesmo como vacina | |
BR112022024074A2 (pt) | Coquetel de peptídeos | |
EA202190310A1 (ru) | Белок для лечения воспалительных заболеваний | |
MX2020013296A (es) | Composiciones que contienen inhibidor de proteasa recombinante, metodos para producir las mismas y usos de las mismas. | |
BR112014015390A2 (pt) | vírus da estomatite vesicular para vacinas iniciais e de reforço | |
EP4253419A3 (en) | A vaccine in combination with an immune checkpoint inhibitor for use in treating cancer | |
BR112015032556A2 (pt) | Proteína matriz (m) modificada de um vírus da estomatite vesicular (vsv); sequência de nucleotídeos que codifica uma proteína matriz modificada de um vírus da estomatite vesicular; vírus da estomatite vesicular recombinante (rvsv); vacina; vacina de combinação de preparação e reforço; kit; peptídeo isolado; sequências de nucleotídeos isoladas; uso da vacina; uso da vacina de combinação de preparação e reforço; método para induzir uma resposta imunológica em um indivíduo | |
BR112022012470A2 (pt) | Proteína rsv f mutante e uso da mesma | |
BR112018071215A2 (pt) | peptídeo para uso no tratamento, melhora ou prevenção de osteoartrite | |
WO2019094938A3 (en) | Methods and compositions for the treatment of wounds | |
NZ736652A (en) | Short synthetic peptide for treating diseases and/or conditions related to angiogenesis | |
BR112013025975A2 (pt) | proteína de fusão anticancerígena | |
JP2017519763A5 (pt) | ||
BR112022020438A2 (pt) | Composições compreendendo três proteínas de fusão ospa para uso médico | |
BR112017022390A2 (pt) | composição farmacêutica | |
CL2020003220A1 (es) | Nueva proteína con propiedades antiinflamatorias |