BR112021019328A2 - Métodos ex vivo para produzir um produto terapêutico de célula t e composições e métodos relacionados - Google Patents

Métodos ex vivo para produzir um produto terapêutico de célula t e composições e métodos relacionados

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Publication number
BR112021019328A2
BR112021019328A2 BR112021019328A BR112021019328A BR112021019328A2 BR 112021019328 A2 BR112021019328 A2 BR 112021019328A2 BR 112021019328 A BR112021019328 A BR 112021019328A BR 112021019328 A BR112021019328 A BR 112021019328A BR 112021019328 A2 BR112021019328 A2 BR 112021019328A2
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Brazil
Prior art keywords
methods
producing
therapeutic product
cell therapeutic
related compositions
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BR112021019328A
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English (en)
Inventor
Jacob Ceccarelli
J Langer Timothy
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Myst Therapeutics Llc
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Publication date
Application filed by Myst Therapeutics Llc filed Critical Myst Therapeutics Llc
Publication of BR112021019328A2 publication Critical patent/BR112021019328A2/pt

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
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    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
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    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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Abstract

métodos ex vivo para produzir um produto terapêutico de célula t e composições e métodos relacionados. a presente invenção refere-se a métodos para expansão das células t ex vivo incluindo células t reativas ao tumor, e composições contendo tais células t. são também fornecidos métodos para tratar doenças e condições, tal como câncer, usando composições da presente invenção.
BR112021019328A 2019-03-29 2020-03-27 Métodos ex vivo para produzir um produto terapêutico de célula t e composições e métodos relacionados BR112021019328A2 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201962826974P 2019-03-29 2019-03-29
US201962941610P 2019-11-27 2019-11-27
US202062978298P 2020-02-18 2020-02-18
PCT/US2020/025541 WO2020205662A1 (en) 2019-03-29 2020-03-27 Ex vivo methods for producing a t cell therapeutic and related compositions and methods

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BR112021019328A2 true BR112021019328A2 (pt) 2021-11-30

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Country Status (11)

Country Link
US (1) US20220177841A1 (pt)
EP (1) EP3946437A1 (pt)
JP (1) JP2022521355A (pt)
KR (1) KR20220002336A (pt)
CN (1) CN114269370A (pt)
AU (1) AU2020256125A1 (pt)
BR (1) BR112021019328A2 (pt)
CA (1) CA3134144A1 (pt)
IL (1) IL286679A (pt)
MX (1) MX2021011608A (pt)
WO (1) WO2020205662A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL293350A (en) * 2019-11-27 2022-07-01 Myst Therapeutics Llc A method for producing tumor-reactive t cells using modulatory substances
EP4355859A1 (en) * 2021-06-17 2024-04-24 Cbio A/S Multistep process for culturing tumor-infiltrating lymphocytes for therapeutic use
EP4359511A1 (en) * 2021-06-22 2024-05-01 Achilles Therapeutics UK Limited A method for producing antigen-specific t cells

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