BR112018017173A2 - composições e métodos para a produção e uso de formulações imunogênicas termoestáveis com compatibilidade aumentada de uso como vacinas contra um ou mais patógenos - Google Patents

composições e métodos para a produção e uso de formulações imunogênicas termoestáveis com compatibilidade aumentada de uso como vacinas contra um ou mais patógenos

Info

Publication number
BR112018017173A2
BR112018017173A2 BR112018017173A BR112018017173A BR112018017173A2 BR 112018017173 A2 BR112018017173 A2 BR 112018017173A2 BR 112018017173 A BR112018017173 A BR 112018017173A BR 112018017173 A BR112018017173 A BR 112018017173A BR 112018017173 A2 BR112018017173 A2 BR 112018017173A2
Authority
BR
Brazil
Prior art keywords
methods
immunogenic
pathogens
compositions
thermostable
Prior art date
Application number
BR112018017173A
Other languages
English (en)
Inventor
W Weimer Alan
Garcea Robert
W Randolph Theodore
Original Assignee
Univ Colorado Regents
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Colorado Regents filed Critical Univ Colorado Regents
Publication of BR112018017173A2 publication Critical patent/BR112018017173A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

a presente invenção refere-se a novas composições, métodos de uso e métodos para formulações únicas de composição de múltiplas doses termoestáveis. em certas modalidades, a presente divulgação fornece composições e métodos para a desidratação de agentes imunogênicos na presença de agentes de formação de vidro, e revestimento das partículas formadas pelos agentes de formação de vidro. em outras modalidades, a presente divulgação fornece a geração de composições para a administração de uma composição imunogênica a um indivíduo múltiplas vezes utilizando uma composição imunogênica única capaz de administração de liberação retardada. em outras modalidades, as partículas contendo agente imunogênico de dose única podem ser direcionadas a dois ou mais patógenos. em outras modalidades, os agentes imunogênicos incompatíveis contra dois ou mais patógenos diferentes de partículas contendo agente imunogênico aqui divulgadas, podem ser misturados entre si e revestidos para administração de liberação temporizada para produzir formulações de administração única capazes de produzir uma resposta imune aos dois ou mais patógenos em um indivíduo.
BR112018017173A 2016-02-23 2017-02-23 composições e métodos para a produção e uso de formulações imunogênicas termoestáveis com compatibilidade aumentada de uso como vacinas contra um ou mais patógenos BR112018017173A2 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662298912P 2016-02-23 2016-02-23
US201662381558P 2016-08-30 2016-08-30
US201662404408P 2016-10-05 2016-10-05
PCT/US2017/019163 WO2017147318A1 (en) 2016-02-23 2017-02-23 Compositions and methods for making and using thermostable immunogenic formulations with increased compatibility of use as vaccines against one or more pathogens

Publications (1)

Publication Number Publication Date
BR112018017173A2 true BR112018017173A2 (pt) 2019-01-02

Family

ID=58228591

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018017173A BR112018017173A2 (pt) 2016-02-23 2017-02-23 composições e métodos para a produção e uso de formulações imunogênicas termoestáveis com compatibilidade aumentada de uso como vacinas contra um ou mais patógenos

Country Status (4)

Country Link
US (3) US10751408B2 (pt)
EP (1) EP3419659A1 (pt)
BR (1) BR112018017173A2 (pt)
WO (1) WO2017147318A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3079151A1 (en) * 2017-10-16 2019-04-25 Serum Institute Of India Private Limited Stable vaccine compositions comprising inter alia live attenuated recombinant flavivirus and process for preparation thereof
BR102017023366A2 (pt) * 2017-10-30 2020-04-28 Univ Estadual Campinas Unicamp vacina anti-zika vírus
GB2585077A (en) 2019-06-28 2020-12-30 Nanexa Ab Apparatus
AU2019477328A1 (en) * 2019-12-06 2022-06-09 Nanexa Ab New composition

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EP1516615A3 (en) * 1994-08-04 2007-10-31 Quadrant Drug Delivery Limited Solid delivery systems for controlled release of molecules incorporated therein and methods of making same
GB0124710D0 (en) 2001-10-15 2001-12-05 Quadrant Healthcare Uk Ltd Therapeutic composition
US6982080B2 (en) 2002-03-15 2006-01-03 Wyeth Hydroxyethyl starch—containing polypeptide compositions
US9744227B2 (en) 2004-06-02 2017-08-29 Universal Stabilization Technologies, Inc. Compositions containing ambient-temperature stable, inactivated but therapeutically active biopharmaceuticals and methods for formulation thereof
WO2008043157A1 (en) 2006-10-12 2008-04-17 The University Of Queensland Compositions and methods for modulating immune responses
EP2113078A4 (en) 2007-01-29 2013-04-17 Nanexa Ab ACTIVE SENSOR SURFACE AND METHOD FOR MANUFACTURING THE SAME
DK2829282T3 (en) 2007-03-22 2018-01-02 Univ Colorado Regents Process for preparing an immunologically active adjuvant-linked dried vaccine composition
EP2173327A2 (en) * 2007-07-24 2010-04-14 Nexbio, Inc. Technology for the preparation of microparticles
US20110120943A1 (en) 2008-01-14 2011-05-26 Nanexa Ab Biocompatible filter member for body fluid dialysis and fabrication and use thereof
WO2011037533A1 (en) 2009-09-25 2011-03-31 Nanexa Ab Sers device
SG182317A1 (en) 2010-01-28 2012-08-30 Advanced Bionutrition Corp Dry glassy composition comprising a bioactive material
SE535732C2 (sv) 2010-09-17 2012-11-27 Nanexa Ab Polymerprodukt med skyddande lager som hindrar inväxning av svamp eller andra mikrobiella substanser
MX2013010002A (es) 2011-03-03 2013-12-06 Merck Patent Gmbh Preparacion farmaceutica solida recubierta.
US20120222979A1 (en) 2011-03-04 2012-09-06 Elwha LLC, a limited liability company of the State of Delaware Glassy compositions
FI126168B (en) 2012-09-18 2016-07-29 Novaldmedical Ltd Oy A method for coating pharmaceutical substrates
KR102266567B1 (ko) 2013-03-11 2021-06-21 크리스탈 딜리버리 비.브이. 백신접종 조성물
EP4091606A1 (en) 2013-05-24 2022-11-23 Nanexa AB A solid nanoparticle with inorganic coating
US20160184484A1 (en) 2013-06-10 2016-06-30 Nanexa Ab Low friction coating on vein catheter
BR112017000515A2 (pt) 2014-07-18 2017-11-14 Msd Wellcome Trust Hilleman Laboratories Pvt Ltd formulação de vacina contra rotavírus termoestável seca por liofilização e processo para preparação da mesma
NL2014348B1 (en) 2015-02-25 2016-10-13 Univ Delft Tech Controlled release from particles encapsulated by molecular layer deposition.
WO2016176558A1 (en) 2015-04-30 2016-11-03 The Regents Of The University Of California Adjuvant particles comprising adenosine receptor antagonists

Also Published As

Publication number Publication date
US20220265810A1 (en) 2022-08-25
US20200384100A1 (en) 2020-12-10
US11364293B2 (en) 2022-06-21
US20190046632A1 (en) 2019-02-14
US10751408B2 (en) 2020-08-25
WO2017147318A1 (en) 2017-08-31
EP3419659A1 (en) 2019-01-02

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B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]