BR112018015034A2 - sistema de marcação de massa carregada - Google Patents

sistema de marcação de massa carregada

Info

Publication number
BR112018015034A2
BR112018015034A2 BR112018015034A BR112018015034A BR112018015034A2 BR 112018015034 A2 BR112018015034 A2 BR 112018015034A2 BR 112018015034 A BR112018015034 A BR 112018015034A BR 112018015034 A BR112018015034 A BR 112018015034A BR 112018015034 A2 BR112018015034 A2 BR 112018015034A2
Authority
BR
Brazil
Prior art keywords
mass
marking
affinity reagent
unit
charged
Prior art date
Application number
BR112018015034A
Other languages
English (en)
Inventor
Hollerbach Adam
Pugia Michael
Graham Cooks Robert
Ayrton Stephen
Baird Zane
Original Assignee
Purdue Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Purdue Research Foundation filed Critical Purdue Research Foundation
Publication of BR112018015034A2 publication Critical patent/BR112018015034A2/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5748—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving oncogenic proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biophysics (AREA)
  • Hospice & Palliative Care (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

a invenção, em geral, se refere às carregado marcação de massa composições e métodos de uso das mesmas para detectar um analito alvo em uma amostra. em certos aspectos, a invenção fornece uma composição de marcação de massa carregada, incluindo um reagente de afinidade e um precursor de marcação de massa ligado ao reagente de afinidade. o precursor de marcação de massa inclui uma unidade de ligação de marcação e uma marcação de massa. a unidade de ligação de marcação liga de forma reversível a marcação de massa ao reagente de afinidade. a marcação de massa inclui uma unidade de carga e uma unidade de marcação de massa que apresenta um valor de massa/carga pré-definido em um espectro de massas.
BR112018015034A 2016-01-22 2017-01-20 sistema de marcação de massa carregada BR112018015034A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662286115P 2016-01-22 2016-01-22
PCT/US2017/014320 WO2017127670A1 (en) 2016-01-22 2017-01-20 Charged mass labeling system

Publications (1)

Publication Number Publication Date
BR112018015034A2 true BR112018015034A2 (pt) 2019-02-12

Family

ID=59362118

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018015034A BR112018015034A2 (pt) 2016-01-22 2017-01-20 sistema de marcação de massa carregada

Country Status (8)

Country Link
US (2) US11061035B2 (pt)
EP (2) EP4012416A1 (pt)
JP (2) JP6902036B2 (pt)
KR (1) KR102641264B1 (pt)
CN (2) CN113970589A (pt)
BR (1) BR112018015034A2 (pt)
CA (1) CA3012121C (pt)
WO (1) WO2017127670A1 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8207497B2 (en) 2009-05-08 2012-06-26 Ionsense, Inc. Sampling of confined spaces
US8822949B2 (en) 2011-02-05 2014-09-02 Ionsense Inc. Apparatus and method for thermal assisted desorption ionization systems
US9337007B2 (en) 2014-06-15 2016-05-10 Ionsense, Inc. Apparatus and method for generating chemical signatures using differential desorption
WO2017127670A1 (en) * 2016-01-22 2017-07-27 Purdue Research Foundation Charged mass labeling system
US10636640B2 (en) 2017-07-06 2020-04-28 Ionsense, Inc. Apparatus and method for chemical phase sampling analysis
WO2019231859A1 (en) 2018-06-01 2019-12-05 Ionsense Inc. Apparatus and method for reducing matrix effects when ionizing a sample
JP2022553600A (ja) 2019-10-28 2022-12-26 イオンセンス インコーポレイテッド 拍動流大気リアルタイムイオン化
US11913861B2 (en) 2020-05-26 2024-02-27 Bruker Scientific Llc Electrostatic loading of powder samples for ionization

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
WO1991019813A1 (en) 1990-06-11 1991-12-26 The University Of Colorado Foundation, Inc. Nucleic acid ligands
US5270163A (en) 1990-06-11 1993-12-14 University Research Corporation Methods for identifying nucleic acid ligands
US5182213A (en) 1991-03-18 1993-01-26 Miles Inc. Method for detecting the presence of peroxidatively active substance in basic media
BR9707060A (pt) * 1996-01-23 1999-12-28 Rapigene Inc Métodos e composições para detectar o ligamento de par ligante usando indicador não-fluorescente.
US20050042625A1 (en) * 1997-01-15 2005-02-24 Xzillion Gmbh & Co. Mass label linked hybridisation probes
US6379971B1 (en) * 1998-02-24 2002-04-30 Target Discovery, Inc. Methods for sequencing proteins
EP1105517B2 (en) 1998-08-25 2009-09-30 University Of Washington Rapid quantitative analysis of proteins or protein function in complex mixtures
US6649351B2 (en) 1999-04-30 2003-11-18 Aclara Biosciences, Inc. Methods for detecting a plurality of analytes by mass spectrometry
US6818395B1 (en) 1999-06-28 2004-11-16 California Institute Of Technology Methods and apparatus for analyzing polynucleotide sequences
US7244559B2 (en) 1999-09-16 2007-07-17 454 Life Sciences Corporation Method of sequencing a nucleic acid
US7211390B2 (en) 1999-09-16 2007-05-01 454 Life Sciences Corporation Method of sequencing a nucleic acid
US20020164649A1 (en) 2000-10-25 2002-11-07 Rajendra Singh Mass tags for quantitative analysis
EP1368497A4 (en) 2001-03-12 2007-08-15 California Inst Of Techn METHOD AND DEVICE FOR ANALYZING POLYNUCLEOTIDE SEQUENCES BY ASYNCHRONOUS BASE EXTENSION
CA2728746C (en) 2003-01-29 2018-01-16 454 Corporation Methods of amplifying and sequencing nucleic acids
US20070082019A1 (en) * 2003-02-21 2007-04-12 Ciphergen Biosystems Inc. Photocrosslinked hydrogel surface coatings
WO2005042559A2 (en) * 2003-06-06 2005-05-12 President And Fellows Of Harvard College Capture and release based isotope tagged peptides and methods for using the same
GB0314209D0 (en) * 2003-06-19 2003-07-23 Amersham Biosciences Ab Novel MS reagents
US7169560B2 (en) 2003-11-12 2007-01-30 Helicos Biosciences Corporation Short cycle methods for sequencing polynucleotides
US7335897B2 (en) 2004-03-30 2008-02-26 Purdue Research Foundation Method and system for desorption electrospray ionization
US20090053817A1 (en) * 2004-08-16 2009-02-26 Ludwig Institute For Cancer Research Fixed charge reagents
EP1824516A4 (en) * 2004-10-29 2008-11-05 Target Discovery Inc GLYCAN ANALYSIS WITH DEUTERATED GLUCOSE
GB0518585D0 (en) * 2005-09-12 2005-10-19 Electrophoretics Ltd Mass labels
AU2007226582B2 (en) * 2006-03-13 2012-07-05 Perkinelmer Health Sciences, Inc. Substrates and internal standards for mass spectroscopy detection
US20090075252A1 (en) 2006-04-14 2009-03-19 Helicos Biosciences Corporation Methods for increasing accuracy of nucleic acid sequencing
US7282337B1 (en) 2006-04-14 2007-10-16 Helicos Biosciences Corporation Methods for increasing accuracy of nucleic acid sequencing
EP1918714A1 (en) * 2006-11-02 2008-05-07 Koninklijke Philips Electronics N.V. Compounds and methods for double labelling of polypeptides to allow multiplexing in mass spectrometric analysis
CN101274909B (zh) * 2007-03-27 2011-06-08 中国科学院化学研究所 溴化1-[3-(4-马来酰亚胺基苯氧基)丙基]三甲铵及其制备方法与应用
EP2160235B1 (en) 2007-06-01 2016-11-30 Purdue Research Foundation Discontinuous atmospheric pressure interface
US7767400B2 (en) 2008-02-03 2010-08-03 Helicos Biosciences Corporation Paired-end reads in sequencing by synthesis
CN101946300B (zh) 2008-02-12 2015-11-25 普度研究基金会 低温等离子体探针及其使用方法
CA2759987C (en) 2009-04-30 2018-10-02 Purdue Research Foundation Ion generation using wetted porous material
US20120196297A1 (en) * 2009-07-14 2012-08-02 Yost Richard A Mass tags for mass spectrometric analysis of immunoglobulins
US20110294952A1 (en) 2010-05-25 2011-12-01 SynDevRX Optimized Drug Conjugates
EP2666182B1 (en) 2011-01-20 2019-11-13 Purdue Research Foundation (Prf) Synchronization of ion generation with cycling of a discontinuous atmospheric interface
EP3667702A1 (en) 2011-09-22 2020-06-17 Purdue Research Foundation Differentially pumped dual linear quadrupole ion trap mass spectrometer
US20140264004A1 (en) 2013-03-15 2014-09-18 Purdue Research Foundation Systems and methods for analyzing a sample using a mass spectrometry probe configured to contact the sample
ES2796259T3 (es) * 2014-05-29 2020-11-26 Siemens Healthcare Diagnostics Inc Detección de moléculas raras
US10656157B2 (en) 2014-09-24 2020-05-19 Purdue Research Foundation Rare event detection using mass tags
KR102609564B1 (ko) * 2015-09-24 2023-12-05 제인 베어드 희유 세포 및 무세포 분자를 위한 질량 태그 분석
WO2017127670A1 (en) * 2016-01-22 2017-07-27 Purdue Research Foundation Charged mass labeling system

Also Published As

Publication number Publication date
EP4012416A1 (en) 2022-06-15
CN108780072A (zh) 2018-11-09
CN113970589A (zh) 2022-01-25
EP3405783A1 (en) 2018-11-28
JP2019510204A (ja) 2019-04-11
JP2021167820A (ja) 2021-10-21
US20210293826A1 (en) 2021-09-23
CA3012121C (en) 2023-09-26
CN108780072B (zh) 2021-11-05
EP3405783A4 (en) 2019-09-18
US20190128897A1 (en) 2019-05-02
JP7305709B2 (ja) 2023-07-10
CA3012121A1 (en) 2017-07-27
US11061035B2 (en) 2021-07-13
KR20180102654A (ko) 2018-09-17
KR102641264B1 (ko) 2024-02-26
WO2017127670A1 (en) 2017-07-27
EP3405783B1 (en) 2022-03-09
JP6902036B2 (ja) 2021-07-14

Similar Documents

Publication Publication Date Title
BR112018015034A2 (pt) sistema de marcação de massa carregada
EP3635366A4 (en) NEW UNIVERSAL TEST SYSTEM FOR QUANTITATIVE ANALYSIS
BR112017017025A2 (pt) métodos e composições para analizar componentes celulares
GB201811292D0 (en) Instrument for analytical sample preparation
EP3636769A4 (en) TEST KIT FOR SAMPLE NUCLEIC ACID MEASUREMENT, REAGENT AND USE OF IT
HK1258925A1 (zh) 用於確定分析物濃度的套件
BR112014010955A2 (pt) sistema e método para processar amostras
BR112016007112A2 (pt) Anticorpos que se ligam a angiopoietina 2 (ang-2) humana, usos de um anticorpo que se liga a angiopoietina 2 (ang-2) humana e combinação
WO2014144822A3 (en) Methods and compositions for tagging and analyzing samples
EP3662271A4 (en) SYSTEM FOR DETERMINING THE PRESENCE OF A SUBSTANCE OF INTEREST IN A SAMPLE
SG11201504874QA (en) Sample analysis for mass cytometry
BR112016019836A2 (pt) método para analisar uma amostra de um sujeito, dispositivo de diagnóstico para utilização no diagnóstico da endometriose, kit, uso de um biomarcador, e, método para aumentar uma resposta de anticorpos em um sujeito
BR112016029521A2 (pt) ?kit, dispositivo e método para a detecção de câncer de estômago?
BR112016025627A2 (pt) biomarcadores e combinações dos mesmos para diagnóstico de tuberculose
EP3310719A4 (en) Compositions and methods for analytical sample preparation
EP3240885A4 (en) STRUCTURED BIOLOGICAL SAMPLES FOR ANALYSIS BY A MASS CYTOMETER
EP3553528A4 (en) ANALYSIS DEVICE FOR BIOLOGICAL SAMPLES
EP3165923A4 (en) Marker, immunoassay method, immunoassay reagent, method for assaying analyte, kit for assaying analyte, and test strip for lateral flow chromatography
BR112017023726A2 (pt) detecção de fatores de virulência microbiana na cavidade oral
EP3382396A4 (en) SAMPLE ANALYSIS DEVICE
EP3515500A4 (en) FUNCTIONALIZED SUPPORT FOR ANALYTICAL SAMPLE PREPARATION
EP3165560A4 (en) Resin-metal composite, labeling substance, immunoassay method, immunoassay reagent, method for measuring analyte, analyte measurement kit, and lateral-flow chromatographic test strip
EP3258266A4 (en) Reagent kit used for detecting gastrin-17, and preparation method and application for reagent kit
EP3236243A4 (en) System for analyzing online-transferred assay samples
BR112016024730A2 (pt) dispositivo, método e conjunto de análise imunocromatográfica

Legal Events

Date Code Title Description
B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2706 DE 16-11-2022 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.