BR112018011327A2 - usos de populações expandidas de células-tronco/progenitoras hematopoiéticas - Google Patents

usos de populações expandidas de células-tronco/progenitoras hematopoiéticas

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Publication number
BR112018011327A2
BR112018011327A2 BR112018011327A BR112018011327A BR112018011327A2 BR 112018011327 A2 BR112018011327 A2 BR 112018011327A2 BR 112018011327 A BR112018011327 A BR 112018011327A BR 112018011327 A BR112018011327 A BR 112018011327A BR 112018011327 A2 BR112018011327 A2 BR 112018011327A2
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BR
Brazil
Prior art keywords
hematopoietic stem
stem cell
expanded hematopoietic
progenitor populations
reducing
Prior art date
Application number
BR112018011327A
Other languages
English (en)
Inventor
Delaney Colleen
Original Assignee
Hutchinson Fred Cancer Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hutchinson Fred Cancer Res filed Critical Hutchinson Fred Cancer Res
Publication of BR112018011327A2 publication Critical patent/BR112018011327A2/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/51—Umbilical cord; Umbilical cord blood; Umbilical stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/001—Preparations to induce tolerance to non-self, e.g. prior to transplantation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/12—Animals modified by administration of exogenous cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0381—Animal model for diseases of the hematopoietic system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Reproductive Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

são descritos usos de células-tronco/progenitoras hematopoiéticas (hspc) do sangue do cordão umbilical expandido. exemplos incluem reduzir a rejeição ao transplante, induzir imunotolerância, reduzir a alimentação por nutrição parenteral total (tpn), o uso de opiáceos, mucosite e hospitalização após um procedimento médico, e reduzir a doença do enxerto contra o hospedeiro (gvhd) após um transplante alogênico.
BR112018011327A 2015-12-04 2016-12-05 usos de populações expandidas de células-tronco/progenitoras hematopoiéticas BR112018011327A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562263573P 2015-12-04 2015-12-04
US201562263470P 2015-12-04 2015-12-04
PCT/US2016/064908 WO2017096347A1 (en) 2015-12-04 2016-12-05 Uses of expanded populations of hematopoietic stem/progenitor cells

Publications (1)

Publication Number Publication Date
BR112018011327A2 true BR112018011327A2 (pt) 2018-12-04

Family

ID=58797992

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018011327A BR112018011327A2 (pt) 2015-12-04 2016-12-05 usos de populações expandidas de células-tronco/progenitoras hematopoiéticas

Country Status (11)

Country Link
US (1) US10813949B2 (pt)
EP (1) EP3384006A4 (pt)
JP (2) JP2018537472A (pt)
KR (1) KR20180085018A (pt)
CN (1) CN108473949A (pt)
AU (1) AU2016364934A1 (pt)
BR (1) BR112018011327A2 (pt)
CA (1) CA3005767A1 (pt)
MX (1) MX2018006828A (pt)
RU (1) RU2747728C2 (pt)
WO (1) WO2017096347A1 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018170335A1 (en) 2017-03-15 2018-09-20 Orca Biosystems Inc. Compositions and methods for hematopoietic stem cell transplants
CA3064055A1 (en) 2017-05-16 2018-11-22 Gamida-Cell Ltd. Selection and use of umbilical cord cell fractions suitable for transplantation
BR112019024113A2 (pt) * 2017-05-16 2020-06-02 Gamida-Cell Ltd. Métodos para selecionar uma unidade de sangue do cordão umbilical e frações de célula sanguínea do cordão umbilical e para preparar uma unidade de sangue do cordão umbilical.
US11697799B2 (en) 2019-04-15 2023-07-11 Ossium Health, Inc. System and method for extraction and cryopreservation of bone marrow
CN110564687B (zh) * 2019-11-05 2020-04-03 诺未科技（北京）有限公司 用于扩增造血干细胞的组合物、培养基、方法和试剂盒
EP4181675A4 (en) 2020-07-18 2024-04-24 Ossium Health Inc PERMEATION OF WHOLE VERTEBRAL BODY WITH CRYOPROTECTIVE USING VACUUM-ASSISTED DIFFUSION
CN116583594A (zh) * 2020-10-14 2023-08-11 奥瑟姆健康公司 用于骨髓的提取和低温保藏的***和方法
WO2022081909A1 (en) * 2020-10-14 2022-04-21 Ossium Health, Inc. Systems and methods for extraction and cryopreservation of bone marrow
EP4262831A1 (en) 2020-12-18 2023-10-25 Ossium Health, Inc. Methods of cell therapies
WO2023283404A1 (en) * 2021-07-09 2023-01-12 Temple University - Of The Commonwealth System Of Higher Education Myocardial wound healing post ischemic injury

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IL101728A (en) 1991-05-03 2007-08-19 Univ Yale Human Abandonment and Delta, Restrictive Areas of Effect in Tophoric Proteins, and Methods Based on Them
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WO1993012141A1 (en) 1991-12-11 1993-06-24 Yale University Nucleotide and protein sequences of the serrate gene and methods based thereon
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WO1996014853A1 (en) 1994-11-10 1996-05-23 University Of Washington Intrathymic stem cell implantation
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US20120269774A1 (en) * 2006-09-21 2012-10-25 Medistem Laboratories, Inc Allogeneic stem cell transplants in non-conditioned recipients
AU2008216749B2 (en) * 2007-02-12 2014-03-13 Celularity Inc. Treatment of inflammatory diseases using placental stem cells
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EP3097917B1 (en) * 2010-04-09 2019-08-14 Fred Hutchinson Cancer Research Center Compositions and methods for providing hematopoietic function without hla matching
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MX370404B (es) * 2011-12-22 2019-12-11 Yeda Res & Dev Uso de una terapia de combinación para inducir un injerto estable y a largo plazo.
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Also Published As

Publication number Publication date
WO2017096347A1 (en) 2017-06-08
JP2018537472A (ja) 2018-12-20
JP2022088551A (ja) 2022-06-14
CA3005767A1 (en) 2017-06-08
EP3384006A1 (en) 2018-10-10
RU2018124303A3 (pt) 2020-08-06
RU2747728C2 (ru) 2021-05-13
US20180353541A1 (en) 2018-12-13
MX2018006828A (es) 2018-08-09
RU2018124303A (ru) 2020-01-13
US10813949B2 (en) 2020-10-27
KR20180085018A (ko) 2018-07-25
EP3384006A4 (en) 2019-06-12
CN108473949A (zh) 2018-08-31
AU2016364934A1 (en) 2018-06-07

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Legal Events

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B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]