BR112017022505A2 - sal de sódio de inibidor de transportador de ácido úrico e forma cristalina do mesmo - Google Patents
sal de sódio de inibidor de transportador de ácido úrico e forma cristalina do mesmoInfo
- Publication number
- BR112017022505A2 BR112017022505A2 BR112017022505-0A BR112017022505A BR112017022505A2 BR 112017022505 A2 BR112017022505 A2 BR 112017022505A2 BR 112017022505 A BR112017022505 A BR 112017022505A BR 112017022505 A2 BR112017022505 A2 BR 112017022505A2
- Authority
- BR
- Brazil
- Prior art keywords
- crystalline form
- sodium salt
- uric acid
- acid carrier
- present
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/36—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Abstract
a presente invenção refere-se a um sal de sódio de um inibidor de transportador de ácido úrico e a forma cristalina do mesmo. em particular, a presente invenção refere-se ao sal de sódio de um inibidor de transportador de ácido úrico (urat1), e o cristal tipo i e o método de preparação do mesmo. a presente invenção refere-se formato de 1-((6-bromo-quinolina-4-il)tio)ciclobutila de sódio (o composto da fórmula (i)), e o cristal tipo i e o método de preparação do mesmo. o cristal tipo i do composto da fórmula (i) obtido na presente invenção tem uma boa estabilidade da forma cristalina e estabilidade química, e o solvente de cristalização usado tem uma baixa toxicidade e baixo resíduo, e pode ser usado melhor em tratamento clínico. (i)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510280720.2 | 2015-05-27 | ||
| CN201510280720 | 2015-05-27 | ||
| PCT/CN2016/083423 WO2016188444A1 (zh) | 2015-05-27 | 2016-05-26 | 一种尿酸转运蛋白抑制剂的钠盐及其结晶形式 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112017022505A2 true BR112017022505A2 (pt) | 2018-07-17 |
Family
ID=57393793
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112017022505-0A BR112017022505A2 (pt) | 2015-05-27 | 2016-05-26 | sal de sódio de inibidor de transportador de ácido úrico e forma cristalina do mesmo |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US10196361B2 (pt) |
| EP (1) | EP3305768B1 (pt) |
| JP (1) | JP6738350B2 (pt) |
| KR (1) | KR20180006441A (pt) |
| CN (1) | CN107001276B (pt) |
| AU (1) | AU2016269359B2 (pt) |
| BR (1) | BR112017022505A2 (pt) |
| CA (1) | CA2984961C (pt) |
| CY (1) | CY1123262T1 (pt) |
| DK (1) | DK3305768T3 (pt) |
| ES (1) | ES2811325T3 (pt) |
| HR (1) | HRP20201178T1 (pt) |
| HU (1) | HUE051640T2 (pt) |
| LT (1) | LT3305768T (pt) |
| MX (1) | MX2017014319A (pt) |
| PL (1) | PL3305768T3 (pt) |
| PT (1) | PT3305768T (pt) |
| RS (1) | RS60749B1 (pt) |
| RU (1) | RU2719484C2 (pt) |
| SI (1) | SI3305768T1 (pt) |
| WO (1) | WO2016188444A1 (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3305768T3 (da) * | 2015-05-27 | 2020-08-10 | Jiangsu Hengrui Medicine Co | Natriumsalt fra urinsyretransportinhibitor og krystallisk form deraf |
| CN108201529B (zh) * | 2016-12-16 | 2021-10-08 | 江苏恒瑞医药股份有限公司 | 一种含有尿酸转运蛋白抑制剂的药物组合物及其制备方法 |
| CN110467571B (zh) * | 2018-05-11 | 2021-02-26 | 江苏恒瑞医药股份有限公司 | 一种制备环烷基甲酸类衍生物或其可药用盐的方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SA04250253B1 (ar) * | 2003-08-21 | 2009-11-10 | استرازينيكا ايه بي | احماض فينوكسي اسيتيك مستبدلة باعتبارها مركبات صيدلانية لعلاج الامراض التنفسية مثل الربو ومرض الانسداد الرئوي المزمن |
| AR051780A1 (es) * | 2004-11-29 | 2007-02-07 | Japan Tobacco Inc | Compuestos en anillo fusionados que contienen nitrogeno y utilizacion de los mismos |
| MX362747B (es) * | 2013-05-13 | 2019-02-05 | Shanghai hengrui pharmaceutical co ltd | Derivado de ácido cicloalquilo, método de preparación del mismo, y aplicación farmacéutica del mismo. |
| DK3305768T3 (da) * | 2015-05-27 | 2020-08-10 | Jiangsu Hengrui Medicine Co | Natriumsalt fra urinsyretransportinhibitor og krystallisk form deraf |
-
2016
- 2016-05-26 DK DK16799331.0T patent/DK3305768T3/da active
- 2016-05-26 SI SI201630871T patent/SI3305768T1/sl unknown
- 2016-05-26 PL PL16799331T patent/PL3305768T3/pl unknown
- 2016-05-26 PT PT167993310T patent/PT3305768T/pt unknown
- 2016-05-26 HU HUE16799331A patent/HUE051640T2/hu unknown
- 2016-05-26 US US15/574,328 patent/US10196361B2/en active Active
- 2016-05-26 AU AU2016269359A patent/AU2016269359B2/en active Active
- 2016-05-26 CA CA2984961A patent/CA2984961C/en active Active
- 2016-05-26 RS RS20200924A patent/RS60749B1/sr unknown
- 2016-05-26 CN CN201680003846.8A patent/CN107001276B/zh active Active
- 2016-05-26 MX MX2017014319A patent/MX2017014319A/es unknown
- 2016-05-26 EP EP16799331.0A patent/EP3305768B1/en active Active
- 2016-05-26 LT LTEP16799331.0T patent/LT3305768T/lt unknown
- 2016-05-26 RU RU2017142996A patent/RU2719484C2/ru active
- 2016-05-26 BR BR112017022505-0A patent/BR112017022505A2/pt not_active Application Discontinuation
- 2016-05-26 JP JP2017555478A patent/JP6738350B2/ja active Active
- 2016-05-26 WO PCT/CN2016/083423 patent/WO2016188444A1/zh active Application Filing
- 2016-05-26 ES ES16799331T patent/ES2811325T3/es active Active
- 2016-05-26 KR KR1020177035949A patent/KR20180006441A/ko not_active Application Discontinuation
-
2018
- 2018-10-11 US US16/157,696 patent/US10358424B2/en active Active
-
2020
- 2020-07-28 HR HRP20201178TT patent/HRP20201178T1/hr unknown
- 2020-08-04 CY CY20201100720T patent/CY1123262T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2811325T3 (es) | 2021-03-11 |
| EP3305768A1 (en) | 2018-04-11 |
| CA2984961C (en) | 2023-08-01 |
| US10196361B2 (en) | 2019-02-05 |
| PL3305768T3 (pl) | 2020-12-28 |
| RU2017142996A3 (pt) | 2019-11-20 |
| AU2016269359B2 (en) | 2020-02-06 |
| CN107001276B (zh) | 2020-03-13 |
| WO2016188444A1 (zh) | 2016-12-01 |
| DK3305768T3 (da) | 2020-08-10 |
| SI3305768T1 (sl) | 2020-10-30 |
| US20190040015A1 (en) | 2019-02-07 |
| RU2017142996A (ru) | 2019-06-27 |
| EP3305768A4 (en) | 2019-02-13 |
| LT3305768T (lt) | 2020-08-25 |
| CN107001276A (zh) | 2017-08-01 |
| MX2017014319A (es) | 2018-03-07 |
| EP3305768B1 (en) | 2020-07-01 |
| AU2016269359A1 (en) | 2017-11-23 |
| RU2719484C2 (ru) | 2020-04-17 |
| CY1123262T1 (el) | 2021-12-31 |
| HRP20201178T1 (hr) | 2020-11-13 |
| CA2984961A1 (en) | 2016-12-01 |
| JP6738350B2 (ja) | 2020-08-12 |
| KR20180006441A (ko) | 2018-01-17 |
| HUE051640T2 (hu) | 2021-03-01 |
| JP2018515454A (ja) | 2018-06-14 |
| US20180134663A1 (en) | 2018-05-17 |
| US10358424B2 (en) | 2019-07-23 |
| RS60749B1 (sr) | 2020-10-30 |
| PT3305768T (pt) | 2020-08-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |