BR112017013420A2 - anticorpo adam17 humanizado - Google Patents
anticorpo adam17 humanizadoInfo
- Publication number
- BR112017013420A2 BR112017013420A2 BR112017013420A BR112017013420A BR112017013420A2 BR 112017013420 A2 BR112017013420 A2 BR 112017013420A2 BR 112017013420 A BR112017013420 A BR 112017013420A BR 112017013420 A BR112017013420 A BR 112017013420A BR 112017013420 A2 BR112017013420 A2 BR 112017013420A2
- Authority
- BR
- Brazil
- Prior art keywords
- humanized antibody
- adam17
- humanized
- antibody
- binding
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
a presente invenção se relaciona a um novo anticorpo humanizado capaz de se ligar a adam17, e também as sequências de amino e ácido nucleico que codificam para referido anticorpo. de um aspecto, a invenção se relaciona a um novo anticorpo humanizado, ou fragmentos de ligação de antígeno, capazes de se ligarem a adam17 com atividades antitumor. a invenção também compreende o uso de referido anticorpo humanizado como um fármaco para o tratamento de câncer. finalmente, a invenção compreende composições compreendendo referido anticorpo humanizado, sozinho, ou em combinação ou conjugação com outros compostos anticâncer, e ao uso do mesmo para o tratamento de câncer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14307185 | 2014-12-24 | ||
PCT/EP2016/050029 WO2016102716A1 (en) | 2014-12-24 | 2016-01-04 | Novel humanized adam17 antibody |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112017013420A2 true BR112017013420A2 (pt) | 2018-02-06 |
Family
ID=52396391
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112017013420A BR112017013420A2 (pt) | 2014-12-24 | 2016-01-04 | anticorpo adam17 humanizado |
Country Status (11)
Country | Link |
---|---|
US (1) | US20180057601A1 (pt) |
EP (1) | EP3237008A1 (pt) |
JP (1) | JP2018502096A (pt) |
KR (1) | KR20170099927A (pt) |
CN (1) | CN107250162A (pt) |
AU (1) | AU2016204625A1 (pt) |
BR (1) | BR112017013420A2 (pt) |
CA (1) | CA2971361A1 (pt) |
MX (1) | MX2017008475A (pt) |
RU (1) | RU2017125036A (pt) |
WO (1) | WO2016102716A1 (pt) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020021061A1 (en) | 2018-07-26 | 2020-01-30 | Pieris Pharmaceuticals Gmbh | Humanized anti-pd-1 antibodies and uses thereof |
DE102018124785A1 (de) | 2018-10-08 | 2020-04-09 | Schott Ag | Glas mit vorzugsweise erhöhter speicherbarer Zugspannung, chemisch vorgespannter Glasartikel mit vorzugsweise erhöhter speicherbarer Zugspannung, Verfahren zu dessen Herstellung sowie dessen Verwendung |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001036445A1 (en) * | 1999-11-18 | 2001-05-25 | The Brigham And Women's Hospital, Inc. | Compositions and methods for the improved diagnosis and treatment of germ cell tumors |
EP1449538A1 (en) * | 2003-02-21 | 2004-08-25 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Inhibition of TACE or amphiregulin for the modulation of EGF receptor signal transactivation |
EP1833964B1 (en) * | 2004-12-17 | 2013-05-22 | Monash University | Regulation of metalloprotease cleavage of cell surface proteins by adam10 |
CN103492413A (zh) * | 2011-02-01 | 2014-01-01 | 癌症研究技术有限公司 | 抗tace抗体分子及其应用 |
EP3495470A1 (en) * | 2011-06-29 | 2019-06-12 | The General Hospital Corporation | In vivo methods for enhancing bioenergetic status in female germ cells |
WO2014157229A1 (ja) * | 2013-03-28 | 2014-10-02 | 国立大学法人東北大学 | Taceペプチドエピトープ、抗ヒトtaceタンパク質抗体及び当該抗体を産生するハイブリドーマ |
-
2016
- 2016-01-04 EP EP16700011.6A patent/EP3237008A1/en not_active Withdrawn
- 2016-01-04 MX MX2017008475A patent/MX2017008475A/es unknown
- 2016-01-04 CN CN201680007889.3A patent/CN107250162A/zh active Pending
- 2016-01-04 US US15/538,331 patent/US20180057601A1/en not_active Abandoned
- 2016-01-04 AU AU2016204625A patent/AU2016204625A1/en not_active Abandoned
- 2016-01-04 KR KR1020177018568A patent/KR20170099927A/ko unknown
- 2016-01-04 WO PCT/EP2016/050029 patent/WO2016102716A1/en active Application Filing
- 2016-01-04 BR BR112017013420A patent/BR112017013420A2/pt not_active Application Discontinuation
- 2016-01-04 JP JP2017534270A patent/JP2018502096A/ja active Pending
- 2016-01-04 RU RU2017125036A patent/RU2017125036A/ru not_active Application Discontinuation
- 2016-01-04 CA CA2971361A patent/CA2971361A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20180057601A1 (en) | 2018-03-01 |
AU2016204625A1 (en) | 2017-07-13 |
CA2971361A1 (en) | 2016-06-30 |
MX2017008475A (es) | 2018-02-21 |
KR20170099927A (ko) | 2017-09-01 |
CN107250162A (zh) | 2017-10-13 |
WO2016102716A1 (en) | 2016-06-30 |
JP2018502096A (ja) | 2018-01-25 |
EP3237008A1 (en) | 2017-11-01 |
RU2017125036A (ru) | 2019-01-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |