BR112016029756A2 - ?método para produzir um composto? - Google Patents
?método para produzir um composto?Info
- Publication number
- BR112016029756A2 BR112016029756A2 BR112016029756A BR112016029756A BR112016029756A2 BR 112016029756 A2 BR112016029756 A2 BR 112016029756A2 BR 112016029756 A BR112016029756 A BR 112016029756A BR 112016029756 A BR112016029756 A BR 112016029756A BR 112016029756 A2 BR112016029756 A2 BR 112016029756A2
- Authority
- BR
- Brazil
- Prior art keywords
- formula
- amino
- represented
- producing
- reacting
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Natural products N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 3
- LPXQDHBKGPBRMI-UHFFFAOYSA-N 2-amino-6-methylpyridine-3-carboxamide Chemical compound CC1=CC=C(C(N)=O)C(N)=N1 LPXQDHBKGPBRMI-UHFFFAOYSA-N 0.000 abstract 2
- XQBYYQRWYONQLM-UHFFFAOYSA-N 2-amino-6-methylpyridine-3-carboxylic acid Chemical compound CC1=CC=C(C(O)=O)C(N)=N1 XQBYYQRWYONQLM-UHFFFAOYSA-N 0.000 abstract 2
- YSBNBAYNISAUIT-UHFFFAOYSA-N 2-chloro-6-methylpyridine-3-carbonitrile Chemical compound CC1=CC=C(C#N)C(Cl)=N1 YSBNBAYNISAUIT-UHFFFAOYSA-N 0.000 abstract 1
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonium chloride Substances [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 abstract 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 235000011114 ammonium hydroxide Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/803—Processes of preparation
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pest Control & Pesticides (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Agronomy & Crop Science (AREA)
- Epidemiology (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
a presente invenção provê um método para produzir ácido 2-amino-6-metilnicotínico representado pela fórmula [i], em que o método de produção compreende: (a) reagir 2-cloro-3-ciano-6-metilpiridina representada pela fórmula [ii] em uma solução aquosa de amônia para obter uma solução de reação contendo 2-amino-6-metil-nicotinamida representada pela fórmula [iii]; e (b) remover a amônia da solução de reação, então reagir a 2-amino-6-metilnicotinamida representada pela fórmula [iii] com uma base para produzir o ácido 2-amino-6-metilnicotínico representado pela fórmula [i].
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/JP2014/067260 WO2015198486A1 (ja) | 2014-06-27 | 2014-06-27 | 2-アミノ-6-メチルニコチン酸の製造方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112016029756A2 true BR112016029756A2 (pt) | 2017-08-22 |
BR112016029756B1 BR112016029756B1 (pt) | 2021-05-04 |
Family
ID=54937605
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112016029756-3A BR112016029756B1 (pt) | 2014-06-27 | 2014-06-27 | método para produzir um composto |
Country Status (10)
Country | Link |
---|---|
US (1) | US9902697B2 (pt) |
EP (1) | EP3162796B1 (pt) |
JP (1) | JP6219516B2 (pt) |
KR (1) | KR101849274B1 (pt) |
CN (1) | CN106458908B (pt) |
BR (1) | BR112016029756B1 (pt) |
RU (1) | RU2658916C1 (pt) |
TW (1) | TWI565696B (pt) |
WO (1) | WO2015198486A1 (pt) |
ZA (1) | ZA201700478B (pt) |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4327219A (en) * | 1980-04-21 | 1982-04-27 | The Lummus Company | Nicotinamide production |
US4963561A (en) * | 1990-02-28 | 1990-10-16 | Sterling Drug Inc. | Imidazopyridines, their preparation and use |
CN1173949C (zh) * | 1996-02-09 | 2004-11-03 | 莱利工业公司 | 在基本上绝热的条件下氰基吡啶类水解的连续式方式 |
US7932272B2 (en) | 2003-09-30 | 2011-04-26 | Eisai R&D Management Co., Ltd. | Antifungal agent containing heterocyclic compound |
US20090227799A1 (en) | 2004-08-09 | 2009-09-10 | Kazutaka Nakamoto | Novel Antimalarial Agent Containing Heterocyclic Compound |
KR20060071812A (ko) * | 2004-12-22 | 2006-06-27 | 주식회사 엘지생명과학 | 신규한 3-(2-아미노-6-피리디닐)-4-히드록시페닐 아민유도체 |
CN102702194A (zh) | 2005-12-21 | 2012-10-03 | 雅培制药有限公司 | 抗病毒化合物 |
JP2009521479A (ja) | 2005-12-21 | 2009-06-04 | アボット・ラボラトリーズ | 抗ウイルス化合物 |
WO2007081517A2 (en) | 2005-12-21 | 2007-07-19 | Abbott Laboratories | Anti-viral compounds |
TWI399380B (zh) | 2006-12-20 | 2013-06-21 | Abbott Lab | 抗病毒化合物 |
KR20100015673A (ko) | 2007-04-20 | 2010-02-12 | 론자 아게 | 수성 유체 중 헤테로방향족 니트릴의 가수분해 방법 |
FR2928070A1 (fr) | 2008-02-27 | 2009-09-04 | Sumitomo Chemical Co | Composition agricole, utilisation d'un compose pour sa production et procede pour matriser ou prevenir les maladies des plantes. |
CN101812016B (zh) | 2009-02-23 | 2013-01-16 | 浙江海翔药业股份有限公司 | 一种制备依托昔布中间体-6-甲基烟酸及其酯的方法 |
PT2871180T (pt) | 2012-07-04 | 2018-05-08 | Agro Kanesho Co Ltd | Derivado de éster do ácido 2-aminonicotínico e bactericida que o contém como ingrediente ativo |
-
2014
- 2014-06-27 CN CN201480080171.8A patent/CN106458908B/zh active Active
- 2014-06-27 RU RU2017102327A patent/RU2658916C1/ru active
- 2014-06-27 WO PCT/JP2014/067260 patent/WO2015198486A1/ja active Application Filing
- 2014-06-27 US US15/317,255 patent/US9902697B2/en active Active
- 2014-06-27 EP EP14895551.1A patent/EP3162796B1/en active Active
- 2014-06-27 JP JP2016528966A patent/JP6219516B2/ja active Active
- 2014-06-27 KR KR1020177000235A patent/KR101849274B1/ko active IP Right Grant
- 2014-06-27 BR BR112016029756-3A patent/BR112016029756B1/pt active IP Right Grant
-
2015
- 2015-04-23 TW TW104113086A patent/TWI565696B/zh active
-
2017
- 2017-01-20 ZA ZA2017/00478A patent/ZA201700478B/en unknown
Also Published As
Publication number | Publication date |
---|---|
ZA201700478B (en) | 2018-04-25 |
KR101849274B1 (ko) | 2018-04-16 |
BR112016029756B1 (pt) | 2021-05-04 |
US9902697B2 (en) | 2018-02-27 |
CN106458908B (zh) | 2018-11-06 |
EP3162796A4 (en) | 2018-01-03 |
TW201600509A (zh) | 2016-01-01 |
US20170129858A1 (en) | 2017-05-11 |
CN106458908A (zh) | 2017-02-22 |
JPWO2015198486A1 (ja) | 2017-04-20 |
WO2015198486A1 (ja) | 2015-12-30 |
JP6219516B2 (ja) | 2017-10-25 |
RU2658916C1 (ru) | 2018-06-26 |
EP3162796B1 (en) | 2021-06-09 |
EP3162796A1 (en) | 2017-05-03 |
TWI565696B (zh) | 2017-01-11 |
KR20170015864A (ko) | 2017-02-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112014018756A8 (pt) | Processo para preparo de etil éster de ácido n-(4-ciclo-hexil-3-trifluorometil-benziloxi)-acetimídico | |
MX2014014138A (es) | Procedimiento nuevo para la preparacion de acido 2-ciclopentil-6-metoxi-isonicotinico. | |
MX2016000390A (es) | Proceso para fabricar haloacetamidas. | |
UA111333C2 (uk) | Спосіб одержання l-аргінінової солі периндроприлу | |
SA519401362B1 (ar) | بوليمرات تحتوي على أمين أولي مفيدة كمثبطات للقشور | |
BR112014015962B8 (pt) | Métodos para produzir 4-amino-3-cloro-6-(4-cloro-2-flúor-3-metóxi-fenil)piridina-2-carboxilato de metila | |
NZ720106A (en) | A process for the preparation of regadenoson | |
PH12016500913A1 (en) | Soap bar | |
MX2014004823A (es) | Colorantes acidos de trisazo. | |
CY1121351T1 (el) | Μεθοδος για την παρασκευη οξυκωδονης | |
PH12016501704A1 (en) | Method for producing 2-acyliminopyridine derivative | |
MY174153A (en) | Processes for the preparation of pyrimidinylcyclopentane compounds | |
AR095548A1 (es) | Preparación de ácido 4-amino-2,4-dioxobutanoico | |
GB2523674A (en) | Compounds as inhibitor of DNA double-strand break repair, methods and applications thereof | |
EP3492479A3 (en) | Crystal of cyclic phosphonic acid sodium salt and method for manufacturing same | |
MX361998B (es) | Procedimiento de preparacion de derivados de acido 4-haloalquil-3-mercapto-2 sustituido-hidroxibenzoico. | |
MX2015017640A (es) | Proceso para preparar compuestos de piridilpirazol y sus derivados de piridilhidrazina. | |
UA111329C2 (uk) | Спосіб синтезу івабрадину і його адитивних солей з фармацевтично прийнятною кислотою | |
BR112016029756A2 (pt) | ?método para produzir um composto? | |
MX2017004815A (es) | Metodo para la polimeracion de acido (met)acrilico en solucion. | |
MY175821A (en) | Microorganism having ability to produce o-succinylhomoserine or succinic acid, and method for producing succinic acid or o-succinylhomoserine by using same | |
MX353410B (es) | Tinturas ácidas, proceso para su producción y su uso. | |
BR112015028751A2 (pt) | processo para a preparação de derivados de 3,5-bis (fluoralquil)pirazol a partir de alfa,alfa-dihaloaminas | |
MX2015007372A (es) | Proceso mejorado para la preparacion de [n-ciano-s-[1-(piridin-3-i l) etil]-s-metilsulfiliminas. | |
MX2015017747A (es) | Proceso para producir 2-fenil-1, 3-benzoxazoles. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 27/06/2014, OBSERVADAS AS CONDICOES LEGAIS. |