BR112016014000A2 - Síntese de enantiômero de progesterona e intermediários do mesmo - Google Patents

Síntese de enantiômero de progesterona e intermediários do mesmo

Info

Publication number
BR112016014000A2
BR112016014000A2 BR112016014000A BR112016014000A BR112016014000A2 BR 112016014000 A2 BR112016014000 A2 BR 112016014000A2 BR 112016014000 A BR112016014000 A BR 112016014000A BR 112016014000 A BR112016014000 A BR 112016014000A BR 112016014000 A2 BR112016014000 A2 BR 112016014000A2
Authority
BR
Brazil
Prior art keywords
progesterone
intermediates
synthesis
enantiomer
enantiomers
Prior art date
Application number
BR112016014000A
Other languages
English (en)
Inventor
Emil Levy Daniel
Zhang Faliang
Zhan Xinxi
Original Assignee
Prevacus Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prevacus Inc filed Critical Prevacus Inc
Publication of BR112016014000A2 publication Critical patent/BR112016014000A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/26—Radicals substituted by doubly bound oxygen or sulfur atoms or by two such atoms singly bound to the same carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J15/00—Stereochemically pure steroids containing carbon, hydrogen, halogen or oxygen having a partially or totally inverted skeleton, e.g. retrosteroids, L-isomers
    • C07J15/005—Retrosteroids (9 beta 10 alfa)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general
    • C07J75/005—Preparation of steroids by cyclization of non-steroid compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

Abstract

SÍNTESE DE ENANTIÔMERO DE PROGESTERONA E INTERMEDIÁRIOS DO MESMO. A presente invenção refere-se à síntese de enantiômero de progesterona e intermediários do mesmo.
BR112016014000A 2013-12-20 2014-12-17 Síntese de enantiômero de progesterona e intermediários do mesmo BR112016014000A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361919420P 2013-12-20 2013-12-20
PCT/US2014/070879 WO2015095339A1 (en) 2013-12-20 2014-12-17 Synthesis of ent-progesterone and intermediates thereof

Publications (1)

Publication Number Publication Date
BR112016014000A2 true BR112016014000A2 (pt) 2017-08-08

Family

ID=53399300

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016014000A BR112016014000A2 (pt) 2013-12-20 2014-12-17 Síntese de enantiômero de progesterona e intermediários do mesmo

Country Status (18)

Country Link
US (1) US20150175650A1 (pt)
EP (1) EP3083656A1 (pt)
JP (1) JP2017502031A (pt)
CN (1) CN105980396B (pt)
AR (1) AR098879A1 (pt)
AU (1) AU2014364850A1 (pt)
BR (1) BR112016014000A2 (pt)
CA (1) CA2934466A1 (pt)
EA (1) EA201691074A1 (pt)
IL (1) IL246258A0 (pt)
MA (1) MA39126B1 (pt)
MX (1) MX2016008167A (pt)
PH (1) PH12016501201A1 (pt)
SG (1) SG11201604982XA (pt)
TN (1) TN2016000252A1 (pt)
TW (1) TW201538519A (pt)
UY (1) UY35909A (pt)
WO (1) WO2015095339A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017100988A (ja) * 2015-12-01 2017-06-08 アサヒグループホールディングス株式会社 光学活性なヒドロキシ脂肪酸の製造方法
IT201700004904A1 (it) * 2017-01-18 2018-07-18 Ind Chimica Srl PROCESSO PER LA PREPARAZIONE DI 9β,10α-PROGESTERONE (RETROPROGESTERONE)
WO2021025973A1 (en) * 2019-08-02 2021-02-11 Enterin, Inc. Human aminosterol ent-03 compounds, related compositions comprising the same, and methods of using the same
CA3149480A1 (en) * 2019-08-02 2021-02-11 Enterin, Inc. Human squalamine derivatives, related compositions comprising the same, and methods of using the same

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2009219230A1 (en) * 2008-02-26 2009-09-03 Emory University Steroid analogues for neuroprotection
US20110306579A1 (en) * 2009-01-30 2011-12-15 Emory University Methods of neuroprotection using neuroprotective steroids and a vitamin d
EP2763679A4 (en) * 2011-10-07 2016-06-01 Univ Florida State Res Found PROPHYLACTIC AND POSTACLE USE OF PROGESTERONE FOR BETTER TREATMENT RESULTS IN BRAIN DISORDER

Also Published As

Publication number Publication date
EP3083656A1 (en) 2016-10-26
MX2016008167A (es) 2017-04-27
AU2014364850A1 (en) 2016-07-07
CN105980396B (zh) 2019-03-22
TW201538519A (zh) 2015-10-16
MA39126A3 (fr) 2019-04-30
WO2015095339A1 (en) 2015-06-25
UY35909A (es) 2015-07-31
US20150175650A1 (en) 2015-06-25
MA39126A2 (fr) 2018-08-31
IL246258A0 (en) 2016-08-02
CA2934466A1 (en) 2015-06-25
CN105980396A (zh) 2016-09-28
SG11201604982XA (en) 2016-07-28
PH12016501201A1 (en) 2016-08-15
EA201691074A1 (ru) 2017-02-28
MA39126B1 (fr) 2020-03-31
AR098879A1 (es) 2016-06-22
JP2017502031A (ja) 2017-01-19
TN2016000252A1 (en) 2017-10-06

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]