BR112015031589A2 - método para a fabricação de um produto moldado de ácido hialurônico reticulado - Google Patents
método para a fabricação de um produto moldado de ácido hialurônico reticuladoInfo
- Publication number
- BR112015031589A2 BR112015031589A2 BR112015031589A BR112015031589A BR112015031589A2 BR 112015031589 A2 BR112015031589 A2 BR 112015031589A2 BR 112015031589 A BR112015031589 A BR 112015031589A BR 112015031589 A BR112015031589 A BR 112015031589A BR 112015031589 A2 BR112015031589 A2 BR 112015031589A2
- Authority
- BR
- Brazil
- Prior art keywords
- hyaluronic acid
- molded product
- manufacturing
- cross
- acid molded
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F9/00—Artificial filaments or the like of other substances; Manufacture thereof; Apparatus specially adapted for the manufacture of carbon filaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/91—Injection
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Birds (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- Dispersion Chemistry (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Textile Engineering (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Inorganic Chemistry (AREA)
Abstract
resumo método para a fabricação de um produto moldado de ácido hialurônico reticulado. um método para a fabricação de um produto moldado de ácido hialurônico reticulado, que compreende a etapa de submeter um substrato de ácido hialurônico precipitado não-reticulado na forma desejada a uma única reação de reticulação em um meio líquido com um ph de 11,5 ou superior e que compreende um ou mais agente(s) de reticulação polifuncional e uma quantidade de um ou mais solvente(s) orgânicos que dá condições de precipitação ao ácido hialurônico, sob condições adequadas para obter um produto moldado de ácido hialurônico reticulado precipitado, com um grau de modificação de 1-40 unidades de agente de reticulação por 1000 unidades de dissacarídeo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/EP2013/063716 WO2014206500A1 (en) | 2013-06-28 | 2013-06-28 | Method for manufacturing a shaped cross-linked hyaluronic acid product |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112015031589A2 true BR112015031589A2 (pt) | 2017-07-25 |
Family
ID=48703545
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015031589A BR112015031589A2 (pt) | 2013-06-28 | 2013-06-28 | método para a fabricação de um produto moldado de ácido hialurônico reticulado |
Country Status (12)
Country | Link |
---|---|
US (4) | US10077321B2 (pt) |
EP (2) | EP3013865B1 (pt) |
JP (1) | JP6434003B2 (pt) |
KR (1) | KR102048395B1 (pt) |
CN (2) | CN105473622B (pt) |
AU (1) | AU2013396752B2 (pt) |
BR (1) | BR112015031589A2 (pt) |
CA (1) | CA2916119A1 (pt) |
HK (1) | HK1224314A1 (pt) |
MX (1) | MX369409B (pt) |
RU (1) | RU2640865C2 (pt) |
WO (1) | WO2014206500A1 (pt) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
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MX2017010383A (es) * | 2015-02-13 | 2018-11-12 | Endo Derma Co Ltd | Microestructura usando hidrogel de ácido hialurónico reticulado y método para preparar el mismo. |
US11021580B2 (en) | 2015-07-27 | 2021-06-01 | Galderma Holding SA | Process for efficient cross-linking of hyaluronic acid |
KR101709608B1 (ko) * | 2015-09-03 | 2017-03-09 | (주)진우바이오 | 용융 방사에 의한 히알루론산염 파이버의 제조방법 및 이로부터 제조된 히알루론산염 파이버 |
EP3350240B1 (en) * | 2015-09-18 | 2023-08-09 | Arkema, Inc. | Polyol pre-mixes having improved shelf life |
KR20170090965A (ko) * | 2016-01-29 | 2017-08-08 | 한미약품 주식회사 | 복합 히알루론산 가교물 및 그 제조방법 |
US20190247547A1 (en) * | 2016-10-18 | 2019-08-15 | Aarhus Universitet | Printed hyaluronic acid scaffolds |
WO2018122342A1 (en) * | 2016-12-29 | 2018-07-05 | Nestlé Skin Health Sa | Micro- or nanoparticular multilamellar vesicles, compositions comprising the same and method for their use in skin care |
WO2018122343A1 (en) | 2016-12-29 | 2018-07-05 | Nestlé Skin Health Sa | Micro- or nanoparticular vesicles comprising crosslinked hyaluronic acid, compositions comprising the same and method for their use in skin care |
WO2018122344A1 (en) | 2016-12-29 | 2018-07-05 | Nestlé Skin Health Sa | Composition comprising a crosslinked hyaluronic acid (ha) in combination with a low-molecular ha and/or an agent stimulating endogenous ha synthesis |
EP3600441A1 (en) | 2017-03-22 | 2020-02-05 | Genentech, Inc. | Hydrogel cross-linked hyaluronic acid prodrug compositions and methods |
WO2019073364A1 (en) * | 2017-10-12 | 2019-04-18 | Solyplus Berlin Gmbh | CROSSLINKING BIOPOLYMERS IN A SEMI-SOLID STATE |
JP2022527503A (ja) * | 2019-03-24 | 2022-06-02 | アラーガン ファーマシューティカルズ インターナショナル リミテッド | 複数の形態のヒアルロン酸を含む注射可能で均質なゲルおよびその製造方法 |
WO2020234167A1 (en) * | 2019-05-17 | 2020-11-26 | ETH Zürich | Printable hydrogel, method for generating a printable hydrogel, lyophilizate, printed product and 3d printing method |
CN112147029A (zh) * | 2019-06-28 | 2020-12-29 | 杭州协合医疗用品有限公司 | 一种交联透明质酸钠凝胶溶胀度的测定方法 |
US20220298310A1 (en) * | 2019-09-27 | 2022-09-22 | Lg Chem, Ltd. | A method of preparing polymeric microparticles, polymeric microparticles, medical composition, cosmetic composition, medical articles and cosmetic articles using the same |
KR102173790B1 (ko) * | 2020-02-26 | 2020-11-03 | (주) 제이피케어즈 | 가교 히알루론산을 이용한 약물 전달 조성물 및 이의 제조방법 |
EP4171671A4 (en) * | 2020-06-24 | 2024-07-24 | Anika Therapeutics Inc | MEDICAL COMPOSITE TEXTILE WITH NON-RESORBABLE FIBERS AND BIORESORBABLE HYALURONATE-BASED FIBERS |
KR102527095B1 (ko) | 2020-12-18 | 2023-04-28 | 충남대학교산학협력단 | 가교 처리된 히알루론산 조성물의 가교율 측정방법 |
CN113045779B (zh) * | 2021-03-22 | 2022-09-02 | 华熙生物科技股份有限公司 | 一种交联透明质酸凝胶粗品及其制备方法 |
WO2023064618A1 (en) * | 2021-10-15 | 2023-04-20 | Prohibix Llc | Crosslinked hyaluronic acid precipitates |
CN114404355B (zh) * | 2021-12-28 | 2024-05-24 | 常州药物研究所有限公司 | 透明质酸钠凝胶及其制备方法、应用 |
WO2023148619A1 (en) | 2022-02-01 | 2023-08-10 | Galderma Holding SA | Methods of producing crosslinked hyaluronic acid hydrogels |
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US4605691A (en) * | 1984-12-06 | 1986-08-12 | Biomatrix, Inc. | Cross-linked gels of hyaluronic acid and products containing such gels |
US4582865A (en) * | 1984-12-06 | 1986-04-15 | Biomatrix, Inc. | Cross-linked gels of hyaluronic acid and products containing such gels |
AU619760B2 (en) | 1987-12-10 | 1992-02-06 | Genzyme Biosurgery Corporation | Hylan preparation and method of recovery thereof from animal tissues |
JPH01197501A (ja) | 1988-02-02 | 1989-08-09 | Mitsubishi Acetate Co Ltd | 精製サイリウムガムの製造方法 |
US5827937A (en) * | 1995-07-17 | 1998-10-27 | Q Med Ab | Polysaccharide gel composition |
GB9902412D0 (en) * | 1999-02-03 | 1999-03-24 | Fermentech Med Ltd | Process |
TW574301B (en) * | 2001-05-02 | 2004-02-01 | Ind Tech Res Inst | Manufacturing method of epoxide crosslinked polysaccharides matrix |
DE10223310A1 (de) * | 2002-05-24 | 2003-12-11 | Biotronik Mess & Therapieg | Verfahren zum Beschichten von Implantaten mit einer Polysaccharid-Lage |
TWI251596B (en) * | 2002-12-31 | 2006-03-21 | Ind Tech Res Inst | Method for producing a double-crosslinked hyaluronate material |
US7323425B2 (en) * | 2004-08-27 | 2008-01-29 | Stony Brook Technology And Applied Research | Crosslinking of hyaluronan solutions and nanofiberous membranes made therefrom |
US20060105022A1 (en) | 2004-11-15 | 2006-05-18 | Shiseido Co., Ltd. | Process for preparing crosslinked hyaluronic acid gel |
JP4875988B2 (ja) | 2004-11-15 | 2012-02-15 | 株式会社 資生堂 | 架橋ヒアルロン酸ゲルの製造方法 |
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FR2908415B1 (fr) * | 2006-11-10 | 2009-01-23 | Abr Dev Sarl | Acide hyaluronique reticule et son procede de preparation |
KR20080062092A (ko) * | 2006-12-29 | 2008-07-03 | 주식회사 핸슨바이오텍 | 세포전달체로서의 히알루론산 유도체 및 이의 제조 방법 |
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US8318695B2 (en) * | 2007-07-30 | 2012-11-27 | Allergan, Inc. | Tunably crosslinked polysaccharide compositions |
FR2920786B1 (fr) * | 2007-09-07 | 2010-09-10 | Univ Claude Bernard Lyon | Fibres creuses, notamment multi membranaires, leur procede de preparation par filage et dispositif pour la mise en oeuvre dudit procede |
US8691957B2 (en) | 2007-09-28 | 2014-04-08 | Shiseido Company, Ltd. | Swellable crosslinked hyaluronan powder and method for producing the same |
ITMI20072416A1 (it) | 2007-12-21 | 2009-06-22 | Sigea Srl | Derivati polisaccaridici dell'acido lipoico, loro preparazione ed uso come dermocosmetici e presidi medicali |
WO2010115081A2 (en) * | 2009-04-02 | 2010-10-07 | Allergan, Inc. | Hair-like shaped hydrogels for soft tissue augmentation |
MX2012001204A (es) * | 2009-07-30 | 2012-08-03 | Carbylan Biosurgery Inc | Composiciones de polimero de acido hialuronico modificado y metodos relacionados. |
EP2979709B1 (en) * | 2010-10-20 | 2017-08-02 | Allergan Holdings France S.A.S. | Threads of cross-linked hyaluronic acid and use thereof |
CZ20101001A3 (cs) | 2010-12-31 | 2012-02-08 | Cpn S.R.O. | Hyaluronová vlákna, zpusob jejich prípravy a použití |
CN102552974A (zh) * | 2012-02-17 | 2012-07-11 | 上海白衣缘生物工程有限公司 | 皮肤注射填充用凝胶组合物及其制备 |
CN102660040B (zh) * | 2012-05-03 | 2014-03-12 | 杭州协合医疗用品有限公司 | 一种透明质酸钠凝胶的制备方法 |
CN102731801B (zh) * | 2012-07-13 | 2013-12-25 | 常州药物研究所有限公司 | 外科整形用交联透明质酸钠凝胶及其制备方法 |
CN102863631B (zh) * | 2012-09-29 | 2013-11-13 | 杭州嘉伟生物制品有限公司 | 外科整形用组织填充剂交联透明质酸钠凝胶及其制备方法 |
-
2013
- 2013-06-28 AU AU2013396752A patent/AU2013396752B2/en not_active Ceased
- 2013-06-28 EP EP13732529.6A patent/EP3013865B1/en active Active
- 2013-06-28 JP JP2016522286A patent/JP6434003B2/ja not_active Expired - Fee Related
- 2013-06-28 RU RU2016101734A patent/RU2640865C2/ru not_active IP Right Cessation
- 2013-06-28 CA CA2916119A patent/CA2916119A1/en not_active Abandoned
- 2013-06-28 CN CN201380079033.3A patent/CN105473622B/zh active Active
- 2013-06-28 MX MX2015017526A patent/MX369409B/es active IP Right Grant
- 2013-06-28 BR BR112015031589A patent/BR112015031589A2/pt not_active Application Discontinuation
- 2013-06-28 CN CN201910026542.9A patent/CN109734825B/zh active Active
- 2013-06-28 KR KR1020167002526A patent/KR102048395B1/ko active IP Right Grant
- 2013-06-28 US US14/901,546 patent/US10077321B2/en active Active
- 2013-06-28 EP EP19202714.2A patent/EP3617236B1/en active Active
- 2013-06-28 WO PCT/EP2013/063716 patent/WO2014206500A1/en active Application Filing
-
2016
- 2016-11-03 HK HK16112650.8A patent/HK1224314A1/zh unknown
-
2018
- 2018-08-24 US US16/111,561 patent/US20180362670A1/en not_active Abandoned
-
2020
- 2020-02-04 US US16/781,264 patent/US10982016B2/en active Active
-
2021
- 2021-03-29 US US17/216,084 patent/US11702484B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
EP3013865A1 (en) | 2016-05-04 |
MX2015017526A (es) | 2016-08-05 |
KR102048395B1 (ko) | 2019-11-25 |
RU2640865C2 (ru) | 2018-01-12 |
JP2016524016A (ja) | 2016-08-12 |
EP3617236B1 (en) | 2024-07-31 |
JP6434003B2 (ja) | 2018-12-05 |
US20180362670A1 (en) | 2018-12-20 |
US20160145357A1 (en) | 2016-05-26 |
US11702484B2 (en) | 2023-07-18 |
US20200247913A1 (en) | 2020-08-06 |
WO2014206500A1 (en) | 2014-12-31 |
CN109734825A (zh) | 2019-05-10 |
RU2016101734A (ru) | 2017-08-02 |
US20210214468A1 (en) | 2021-07-15 |
CN109734825B (zh) | 2022-01-28 |
US10077321B2 (en) | 2018-09-18 |
AU2013396752B2 (en) | 2018-11-08 |
EP3617236A1 (en) | 2020-03-04 |
CN105473622B (zh) | 2019-01-29 |
CA2916119A1 (en) | 2014-12-31 |
KR20160027095A (ko) | 2016-03-09 |
AU2013396752A1 (en) | 2016-02-18 |
CN105473622A (zh) | 2016-04-06 |
EP3013865B1 (en) | 2019-10-23 |
MX369409B (es) | 2019-11-07 |
HK1224314A1 (zh) | 2017-08-18 |
US10982016B2 (en) | 2021-04-20 |
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Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2462 DE 13/03/2018 POR TER SIDO INDEVIDA. |
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