BR112015030822A2 - métodos e composições para reduzir a imunossupressão pelas células tumorais - Google Patents

métodos e composições para reduzir a imunossupressão pelas células tumorais

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Publication number
BR112015030822A2
BR112015030822A2 BR112015030822A BR112015030822A BR112015030822A2 BR 112015030822 A2 BR112015030822 A2 BR 112015030822A2 BR 112015030822 A BR112015030822 A BR 112015030822A BR 112015030822 A BR112015030822 A BR 112015030822A BR 112015030822 A2 BR112015030822 A2 BR 112015030822A2
Authority
BR
Brazil
Prior art keywords
methods
compositions
tumor cell
reducing tumor
cell immunosuppression
Prior art date
Application number
BR112015030822A
Other languages
English (en)
Other versions
BR112015030822B1 (pt
Inventor
Alvarez Arias Diana
SHAFFER Donald
Dranoff Glenn
I Cantor Harvey
W Wucherpfennig Kai
Hacohen Nir
Zhou Penghui
Original Assignee
Dana Farber Cancer Inst Inc
The General Hospital Corp D/B/A Massachusetts General Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dana Farber Cancer Inst Inc, The General Hospital Corp D/B/A Massachusetts General Hospital filed Critical Dana Farber Cancer Inst Inc
Publication of BR112015030822A2 publication Critical patent/BR112015030822A2/pt
Publication of BR112015030822B1 publication Critical patent/BR112015030822B1/pt

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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/0011—Cancer antigens
    • A61K39/001193—Prostate associated antigens e.g. Prostate stem cell antigen [PSCA]; Prostate carcinoma tumor antigen [PCTA]; PAP or PSGR
    • A61K39/001195—Prostate specific membrane antigen [PSMA]
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    • A61K39/46—Cellular immunotherapy
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    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
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    • A61K39/4643—Vertebrate antigens
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Abstract

1/1 resumo “métodos e composições para reduzir a imunossupressão pelas células tumorais” a presente divulgação fornece, em parte, métodos de descobrir alvos de imunoterapia in vivo, composições terapêuticas (por exemplo, shrna, células imunorresponsivas que expressam shrna e/ou um receptor de antígeno quimérico (car)), e métodos de uso dos mesmos.
BR112015030822-8A 2013-06-10 2014-06-10 Vetor, ácido nucleico isolado, composição, método para preparar uma célula t e molécula de ácido nucleico isolada BR112015030822B1 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201361833298P 2013-06-10 2013-06-10
US61/833,298 2013-06-10
US201361921303P 2013-12-27 2013-12-27
US61/921,303 2013-12-27
US201461929821P 2014-01-21 2014-01-21
US61/929,821 2014-01-21
PCT/US2014/041739 WO2014201021A2 (en) 2013-06-10 2014-06-10 Methods and compositions for reducing immunosupression by tumor cells

Publications (2)

Publication Number Publication Date
BR112015030822A2 true BR112015030822A2 (pt) 2017-12-12
BR112015030822B1 BR112015030822B1 (pt) 2023-05-23

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Also Published As

Publication number Publication date
JP2019176868A (ja) 2019-10-17
CN105431524B (zh) 2020-04-21
US10876120B2 (en) 2020-12-29
AU2020223762A1 (en) 2020-09-17
CN105431524A (zh) 2016-03-23
EA201592269A1 (ru) 2016-05-31
AU2014278323A1 (en) 2015-11-26
MX2020001450A (es) 2020-03-24
JP2016526883A (ja) 2016-09-08
US20160122766A1 (en) 2016-05-05
CA3051222A1 (en) 2014-12-18
CA2912389C (en) 2020-01-28
US20180327750A1 (en) 2018-11-15
US11597934B2 (en) 2023-03-07
ES2897579T3 (es) 2022-03-01
JP7219254B2 (ja) 2023-02-07
EP3008173B1 (en) 2021-09-15
JP2021040648A (ja) 2021-03-18
KR20210115051A (ko) 2021-09-24
KR20160018525A (ko) 2016-02-17
WO2014201021A2 (en) 2014-12-18
EP3008173A2 (en) 2016-04-20
EP3892293A1 (en) 2021-10-13
CA3051222C (en) 2023-01-24
US20230383298A1 (en) 2023-11-30
KR20230005422A (ko) 2023-01-09
AU2014278323B2 (en) 2020-05-28
KR102301464B1 (ko) 2021-09-14
MX2015016963A (es) 2016-08-08
US9944931B2 (en) 2018-04-17
US20210139914A1 (en) 2021-05-13
EA035475B1 (ru) 2020-06-23
CA2912389A1 (en) 2014-12-18
WO2014201021A3 (en) 2015-02-26
JP6546160B2 (ja) 2019-07-17

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