BR112015028026A2 - method for measuring cancer-related substance by raman spectroscopy - Google Patents

method for measuring cancer-related substance by raman spectroscopy

Info

Publication number
BR112015028026A2
BR112015028026A2 BR112015028026A BR112015028026A BR112015028026A2 BR 112015028026 A2 BR112015028026 A2 BR 112015028026A2 BR 112015028026 A BR112015028026 A BR 112015028026A BR 112015028026 A BR112015028026 A BR 112015028026A BR 112015028026 A2 BR112015028026 A2 BR 112015028026A2
Authority
BR
Brazil
Prior art keywords
cancer
related substance
raman
raman spectroscopy
biochip
Prior art date
Application number
BR112015028026A
Other languages
Portuguese (pt)
Inventor
Ito Hiroaki
Hasegawa Katsuyuki
Hasegawa Yuki
Original Assignee
Ito Hiroaki
Mytech Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51867292&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112015028026(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ito Hiroaki, Mytech Co Ltd filed Critical Ito Hiroaki
Publication of BR112015028026A2 publication Critical patent/BR112015028026A2/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N21/658—Raman scattering enhancement Raman, e.g. surface plasmons
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
    • C01G5/00—Compounds of silver
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G01N33/553—Metal or metal coated
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57496—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving intracellular compounds
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2002/00—Crystal-structural characteristics
    • C01P2002/60—Compounds characterised by their crystallite size

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

resumo método para medir substância relacionada ao câncer por espectroscopia de raman esta invenção se refere a fornecer um método para medir substância relacionada ao câncer que inclui dna isento de célula derivada de câncer por espectroscopia raman. esse método de medição é caracterizado por envolver etapas para preparar um biochip que tem uma região de mesocristal de óxidos de prata que contêm peróxido de prata, adicionar soro sanguíneo ou solução de amostra biológica na forma de gotas na região de mesocristal do dito biochip, capturar de modo seletivo a substância relacionada ao câncer que tem uma carga positiva na amostra, irradiar a substância relacionada ao câncer capturada com uma luz a laser de excitação e detectar uma difusão aprimorada de superfície de raman da mesma, em que as doenças cancerígenas são avaliadas com base na intensidade da difusão aprimorada de superfície de raman (sers). na faixa d e na faixa g específicas de carbono no espectro de difusão de raman, um espectro de pico característico da substância relacionada ao câncer pode ser detectado na proximidade da característica do grupo metila de 2.900 cm-1. 1/1Abstract Method for Measuring Cancer-Related Substance by Raman Spectroscopy This invention relates to providing a method for measuring cancer-related substance that includes cancer-free cell-derived DNA by Raman spectroscopy. This measurement method is characterized by involving steps for preparing a biochip which has a mesocrystal region of silver oxides containing silver peroxide, adding blood serum or biological sample solution in the form of droplets in the mesocrystalline region of said biochip, capturing selectively select the cancer-related substance that has a positive charge in the sample, radiate the cancer-related substance captured with an excitation laser light, and detect enhanced raman surface diffusion thereof, where cancerous diseases are evaluated with based on the enhanced raman surface diffusion intensity (sers). In the carbon-specific d and g-band in the Raman diffusion spectrum, a characteristic peak spectrum of the cancer-related substance can be detected in the vicinity of the 2,900 cm-1 methyl group characteristic. 1/1

BR112015028026A 2013-05-08 2014-05-08 method for measuring cancer-related substance by raman spectroscopy BR112015028026A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2013098608 2013-05-08
PCT/JP2014/062318 WO2014181816A1 (en) 2013-05-08 2014-05-08 Raman quantification method of cancer-related substance

Publications (1)

Publication Number Publication Date
BR112015028026A2 true BR112015028026A2 (en) 2017-07-25

Family

ID=51867292

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015028026A BR112015028026A2 (en) 2013-05-08 2014-05-08 method for measuring cancer-related substance by raman spectroscopy

Country Status (16)

Country Link
US (2) US10365222B2 (en)
EP (2) EP3054285A4 (en)
JP (5) JP6294614B2 (en)
KR (1) KR102162706B1 (en)
CN (2) CN105452850B (en)
AU (1) AU2014263556A1 (en)
BR (1) BR112015028026A2 (en)
CA (1) CA2911744C (en)
CL (1) CL2015003261A1 (en)
EA (1) EA037886B1 (en)
IL (1) IL242470B (en)
MX (1) MX2015015476A (en)
MY (1) MY174717A (en)
PH (2) PH12015502537B1 (en)
SG (1) SG11201509034XA (en)
WO (2) WO2014181816A1 (en)

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JP6312393B2 (en) * 2013-09-25 2018-04-18 有限会社マイテック Discrimination method of pluripotent stem cells
JP2015182923A (en) * 2014-03-25 2015-10-22 有限会社マイテック Silver oxide meso crystal containing silver peroxide and production method thereof
KR102232197B1 (en) 2014-05-08 2021-03-25 유겐가이샤 마이테크 Plasmonic chip, and cancer disease diagnosis methods respectively employing fluorescent image and raman spectroscopy and each using same
WO2017049000A1 (en) * 2015-09-15 2017-03-23 Massachusetts Institute Of Technology Systems and methods for diagnosis of middle ear conditions and detection of analytes in the tympanic membrane
US20170354950A1 (en) * 2016-06-14 2017-12-14 Mytech Co., Ltd. Silver oxide meso crystal containing silver peroxide and manufacturing method therefor
GB201704128D0 (en) * 2017-03-15 2017-04-26 Univ Swansea Method and apparatus for use in diagnosis and monitoring of colorectal cancer
KR102086583B1 (en) * 2018-03-20 2020-03-09 (주)광림정공 A biosensor chip and diagnostic system for cancers
JP2021156576A (en) * 2018-06-21 2021-10-07 有限会社マイテック Liquid biopsy method by autofluorescence targeting disease-related protein conjugate
RU2723160C1 (en) * 2019-08-15 2020-06-09 Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) Method of detecting and determining dna with a given sequence using giant raman scattering spectroscopy
KR20210131078A (en) 2020-04-23 2021-11-02 동아대학교 산학협력단 Method for the quantification of carbon nanomaterials in organs
CN112461810A (en) * 2020-11-19 2021-03-09 河南科技大学第一附属医院 Method for detecting gliclazide tablets based on SERS technology
KR20220134419A (en) 2021-03-26 2022-10-05 삼성전자주식회사 Chiroptical spectroscopy platform, and Raman data acquiring method using the same
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JP2023074685A (en) * 2021-11-18 2023-05-30 浜松ホトニクス株式会社 Specimen analysis method
KR102559438B1 (en) * 2022-08-18 2023-07-26 주식회사 엑소퍼트 System of Providing Artigicial Intelligence-Based Multiple Cancer Diagnosis Using Exosome SERS signals And Method Thereof

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Also Published As

Publication number Publication date
CN105452850B (en) 2018-12-28
KR102162706B1 (en) 2020-10-07
JP6294614B2 (en) 2018-03-14
EA201592123A1 (en) 2016-06-30
WO2014181816A1 (en) 2014-11-13
EP2995935A4 (en) 2017-03-15
JP2014238382A (en) 2014-12-18
JP2017223678A (en) 2017-12-21
US10365222B2 (en) 2019-07-30
MY174717A (en) 2020-05-10
JP6294621B2 (en) 2018-03-14
WO2014181814A1 (en) 2014-11-13
US9535069B2 (en) 2017-01-03
PH12015502537A1 (en) 2016-02-22
CN105452850A (en) 2016-03-30
JPWO2014181814A1 (en) 2017-02-23
CA2911744A1 (en) 2014-11-13
MX2015015476A (en) 2016-07-07
JP6457935B2 (en) 2019-01-23
EP2995935B1 (en) 2020-09-23
JP6529015B2 (en) 2019-06-12
EP3054285A1 (en) 2016-08-10
EA037886B1 (en) 2021-06-01
EP2995935A1 (en) 2016-03-16
AU2014263556A1 (en) 2015-11-26
CN107202786A (en) 2017-09-26
US20170248523A1 (en) 2017-08-31
PH12015502537B1 (en) 2016-02-22
US20160187344A1 (en) 2016-06-30
JPWO2014181816A1 (en) 2017-02-23
IL242470B (en) 2020-09-30
SG11201509034XA (en) 2016-01-28
KR20160019419A (en) 2016-02-19
JP2014238384A (en) 2014-12-18
CA2911744C (en) 2021-04-27
EP3054285A4 (en) 2017-09-06
CN107202786B (en) 2019-10-25
PH12019502307A1 (en) 2021-02-15
CL2015003261A1 (en) 2016-05-27

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]