BR112015022263A2 - N-acil-n’-(piridin-2-il) uréias e análogos apresentando atividades anticâncer e antiproliferativas, seus usos, e composição farmacêutica - Google Patents

N-acil-n’-(piridin-2-il) uréias e análogos apresentando atividades anticâncer e antiproliferativas, seus usos, e composição farmacêutica

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Publication number
BR112015022263A2
BR112015022263A2 BR112015022263A BR112015022263A BR112015022263A2 BR 112015022263 A2 BR112015022263 A2 BR 112015022263A2 BR 112015022263 A BR112015022263 A BR 112015022263A BR 112015022263 A BR112015022263 A BR 112015022263A BR 112015022263 A2 BR112015022263 A2 BR 112015022263A2
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BR
Brazil
Prior art keywords
ureas
pyridin
anticancer
fms
kit
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BR112015022263A
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English (en)
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BR112015022263A8 (pt
BR112015022263B1 (pt
Inventor
L Flynn Daniel
M Yates Karen
Vogeti Lakshminarayana
D Kaufman Michael
Samarakoon Thiwanka
Malcolm Caldwell Timothy
C Patt William
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Deciphera Pharmaceuticals Llc
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Application filed by Deciphera Pharmaceuticals Llc filed Critical Deciphera Pharmaceuticals Llc
Publication of BR112015022263A2 publication Critical patent/BR112015022263A2/pt
Publication of BR112015022263A8 publication Critical patent/BR112015022263A8/pt
Publication of BR112015022263B1 publication Critical patent/BR112015022263B1/pt

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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Abstract

abstract described are compounds of formula i formula i which find utility in the treatment of cancer, autoimmune diseases and metabolic bone disorders through inhibition of c-fms (csf-1r), c-kit, and/or pdgfr kinases. these compounds also find utility in the treatment of other mammalian diseases mediated by c-fms, c-kit, or pdgfr kinases. ______________________________________________________ resumo n-acil-n'-(piridin-2-il) ureias e análogos apresentando atividades anticâncer e antiproliferativas são descritos compostos de fórmula i fórmula i que encontram utilidade no tratamento de câncer, doenças autoimunes e distúrbios metabólicas do osso, através da inibição de c-fms (csf-ir), c-kit, e/ou quinases pdgfr. estes compostos também encontram utilidade no tratamento de outras doenças de mamíferos mediadas por c-fms, c-kit, ou quinases pdgfr.
BR112015022263-3A 2013-03-15 2014-03-14 N-acil-n-(piridin-2-il) uréias e análogos apresentando atividades anticâncer e antiproliferativas, seus usos, e composição farmacêutica BR112015022263B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361789971P 2013-03-15 2013-03-15
US61/789,971 2013-03-15
PCT/US2014/029664 WO2014145028A2 (en) 2013-03-15 2014-03-14 N-acyl-n'-(pyridin-2-yl) ureas and analogs exhibiting anti-cancer and anti-proliferative activities

Publications (3)

Publication Number Publication Date
BR112015022263A2 true BR112015022263A2 (pt) 2017-10-10
BR112015022263A8 BR112015022263A8 (pt) 2018-01-23
BR112015022263B1 BR112015022263B1 (pt) 2023-01-03

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BR112015022263-3A BR112015022263B1 (pt) 2013-03-15 2014-03-14 N-acil-n-(piridin-2-il) uréias e análogos apresentando atividades anticâncer e antiproliferativas, seus usos, e composição farmacêutica

Country Status (16)

Country Link
US (1) US9382228B2 (pt)
EP (1) EP2968287B1 (pt)
JP (3) JP6364472B2 (pt)
KR (2) KR102333718B1 (pt)
CN (3) CN105228620B (pt)
AU (2) AU2014233414B2 (pt)
BR (1) BR112015022263B1 (pt)
CA (1) CA2903288C (pt)
ES (1) ES2817902T3 (pt)
HK (1) HK1220400A1 (pt)
IL (2) IL241523B (pt)
MX (2) MX366429B (pt)
PH (1) PH12015502336A1 (pt)
RU (1) RU2769607C2 (pt)
SG (1) SG11201508532VA (pt)
WO (1) WO2014145028A2 (pt)

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TWI747873B (zh) 2016-02-01 2021-12-01 美商百歐克斯製藥公司 苯并吡唑化合物及其類似物
KR101691954B1 (ko) * 2016-04-26 2017-01-02 고려대학교 산학협력단 신규 n-아실유레아 유도체 및 이를 함유하는 심혈관질환의 예방 또는 치료용 조성물
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HUE064734T2 (hu) 2019-02-06 2024-04-28 Eli Lilly And Company 1-((2-(2,2,2-trifluoretoxi)piridin-4-il)metil)karbamid származékok mint KCNQ potenciátorok
EP3966207B1 (en) 2019-05-10 2023-11-01 Deciphera Pharmaceuticals, LLC Phenylaminopyrimidine amide autophagy inhibitors and methods of use thereof
LT3966206T (lt) 2019-05-10 2023-11-10 Deciphera Pharmaceuticals, Llc Heteroarilaminopirimidino amido autofagijos inhibitoriai ir jų naudojimo būdai
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RS65058B1 (sr) 2019-12-30 2024-02-29 Deciphera Pharmaceuticals Llc Formulacije inhibitora amorfne kinaze i postupci njihove primene
BR112022013169A2 (pt) 2019-12-30 2022-09-13 Deciphera Pharmaceuticals Llc Composições de 1-(4-bromo-5-(1-etil-7-(metilamino)-2-oxo-1,2-diidro-1,6-naftiridin-3-il)-2-fluorofeil)-3-fenilurea
US11912668B2 (en) 2020-11-18 2024-02-27 Deciphera Pharmaceuticals, Llc GCN2 and perk kinase inhibitors and methods of use thereof
CN115385896A (zh) * 2021-05-24 2022-11-25 上海和誉生物医药科技有限公司 一种csf-1r抑制剂中间体或其酸式盐的制备方法
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