BR112015005081A8 - Método para produzir um polissacarídeo capsular tendo um sorotipo de pneumococo - Google Patents
Método para produzir um polissacarídeo capsular tendo um sorotipo de pneumococoInfo
- Publication number
- BR112015005081A8 BR112015005081A8 BR112015005081A BR112015005081A BR112015005081A8 BR 112015005081 A8 BR112015005081 A8 BR 112015005081A8 BR 112015005081 A BR112015005081 A BR 112015005081A BR 112015005081 A BR112015005081 A BR 112015005081A BR 112015005081 A8 BR112015005081 A8 BR 112015005081A8
- Authority
- BR
- Brazil
- Prior art keywords
- producing
- serotype
- capsular polysaccharide
- pneumococus
- present
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials Engineering (AREA)
- Molecular Biology (AREA)
- Polymers & Plastics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
MÉTODO PARA PRODUZIR UM POLISSACARÍDEO CAPSULAR TENDO UM SOROTIPO DE PNEUMOCOCO. A presente invenção provê um método melhorado de produção de um polissacarídeo capsular contendo um serotipo de pneumococo. O método de acordo com a presente invenção inclui uma etapa de cultura adicional de células bacterianas produzindo um serotipo pneumococo sem ajuste do pH, assim removendo um processo de precipitação de proteína por meio da acidificação com um regulador de pH.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2012-0099348 | 2012-09-07 | ||
| KR20120099348 | 2012-09-07 | ||
| PCT/KR2013/008048 WO2014038879A1 (ko) | 2012-09-07 | 2013-09-06 | 폐렴 구균 혈청형을 갖는 협막 다당류의 제조방법 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR112015005081A2 BR112015005081A2 (pt) | 2017-07-04 |
| BR112015005081A8 true BR112015005081A8 (pt) | 2018-07-31 |
| BR112015005081B1 BR112015005081B1 (pt) | 2021-10-26 |
Family
ID=50237413
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112015005081-6A BR112015005081B1 (pt) | 2012-09-07 | 2013-09-06 | Método para produzir um polissacarídeo capsular tendo um sorotipo de pneumococo |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9636392B2 (pt) |
| EP (1) | EP2894225B1 (pt) |
| JP (1) | JP5905649B2 (pt) |
| KR (1) | KR101944960B1 (pt) |
| CN (1) | CN104781413B (pt) |
| AU (1) | AU2013313794B2 (pt) |
| BR (1) | BR112015005081B1 (pt) |
| CA (1) | CA2884241C (pt) |
| CO (1) | CO7400875A2 (pt) |
| ES (1) | ES2651415T3 (pt) |
| MX (1) | MX363051B (pt) |
| PH (1) | PH12015500497B1 (pt) |
| RU (1) | RU2606022C2 (pt) |
| WO (1) | WO2014038879A1 (pt) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105934251A (zh) * | 2014-01-21 | 2016-09-07 | 辉瑞大药厂 | 肺炎链球菌荚膜多糖及其缀合物 |
| IL297740A (en) | 2015-05-04 | 2022-12-01 | Pfizer | Protein-polysaccharide conjugates of group b streptococcus, methods for preparing the conjugates, immunogenic preparations containing conjugates and their uses |
| WO2016204265A1 (ja) * | 2015-06-18 | 2016-12-22 | 一般財団法人阪大微生物病研究会 | 肺炎球菌補体依存性殺菌能測定方法 |
| CN105131139B (zh) * | 2015-07-31 | 2018-02-13 | 兰州生物制品研究所有限责任公司 | 一种肺炎链球菌荚膜多糖的纯化方法 |
| CN107936128B (zh) * | 2017-11-22 | 2020-07-03 | 成都欧林生物科技股份有限公司 | 一种简便有效的细菌疫苗纯化方法 |
| CN109336989B (zh) * | 2018-10-22 | 2022-05-13 | 北京智飞绿竹生物制药有限公司 | 一种通过粘度控制制备肺炎球菌荚膜多糖的方法 |
| JP7239509B6 (ja) * | 2019-02-22 | 2023-03-28 | ファイザー・インク | 細菌多糖類を精製するための方法 |
| CN112608392B (zh) * | 2020-12-23 | 2023-03-31 | 北京民海生物科技有限公司 | 肺炎球菌荚膜多糖的制备 |
| CN114106209A (zh) * | 2021-11-09 | 2022-03-01 | 北京智飞绿竹生物制药有限公司 | 一种纯化17f型肺炎球菌多糖的方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2059693C (en) * | 1991-01-28 | 2003-08-19 | Peter J. Kniskern | Polysaccharide antigens from streptococcus pneumoniae |
| CN104815327A (zh) | 2005-04-08 | 2015-08-05 | 惠氏有限责任公司 | 多价肺炎球菌多糖-蛋白质缀合物组合物 |
| PL1866342T3 (pl) * | 2005-04-08 | 2019-04-30 | Wyeth Llc | Oddzielanie zanieczyszczeń od polisacharydu Streptococcus pneumoniae przez manipulację pH |
| US7709001B2 (en) * | 2005-04-08 | 2010-05-04 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| MX2009003730A (es) | 2006-10-10 | 2009-04-22 | Wyeth Corp | Purificacion de polisacaridos de streptococcus pneumoniae tipo 3. |
| SI2436700T1 (sl) * | 2007-03-23 | 2018-09-28 | Wyeth Llc | Skrajšan postopek čiščenja za proizvodnjo kapsularnih polisaharidov streptococcusa pneumoniae |
| KR101045881B1 (ko) * | 2008-09-11 | 2011-07-01 | 전남대학교산학협력단 | 연쇄상구균으로부터의 협막다당 생산 배지, 생산 방법 및 정제 방법 |
| RU2511404C2 (ru) * | 2008-12-18 | 2014-04-10 | УАЙТ ЭлЭлСи | Способ получения раствора, содержащего высокомолекулярные изолированные капсульные полисахариды streptococcus pneumoniae серотипа 19а (варианты) |
| WO2011151841A1 (en) | 2010-05-31 | 2011-12-08 | Panacea Biotec Limited | Fermentation process for streptococcus pneumoniae |
-
2013
- 2013-09-06 BR BR112015005081-6A patent/BR112015005081B1/pt active IP Right Grant
- 2013-09-06 WO PCT/KR2013/008048 patent/WO2014038879A1/ko active Application Filing
- 2013-09-06 US US14/426,585 patent/US9636392B2/en active Active
- 2013-09-06 CA CA2884241A patent/CA2884241C/en active Active
- 2013-09-06 AU AU2013313794A patent/AU2013313794B2/en active Active
- 2013-09-06 MX MX2015002950A patent/MX363051B/es unknown
- 2013-09-06 KR KR1020130106993A patent/KR101944960B1/ko active IP Right Grant
- 2013-09-06 ES ES13834636.6T patent/ES2651415T3/es active Active
- 2013-09-06 EP EP13834636.6A patent/EP2894225B1/en active Active
- 2013-09-06 JP JP2015531010A patent/JP5905649B2/ja active Active
- 2013-09-06 CN CN201380058019.5A patent/CN104781413B/zh active Active
- 2013-09-06 RU RU2015109997A patent/RU2606022C2/ru active
-
2015
- 2015-03-06 PH PH12015500497A patent/PH12015500497B1/en unknown
- 2015-03-30 CO CO15072525A patent/CO7400875A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CO7400875A2 (es) | 2015-09-30 |
| CN104781413B (zh) | 2018-01-23 |
| PH12015500497A1 (en) | 2015-04-27 |
| WO2014038879A1 (ko) | 2014-03-13 |
| CA2884241C (en) | 2018-11-20 |
| CA2884241A1 (en) | 2014-03-13 |
| ES2651415T3 (es) | 2018-01-26 |
| KR20140032912A (ko) | 2014-03-17 |
| RU2015109997A (ru) | 2016-10-27 |
| BR112015005081A2 (pt) | 2017-07-04 |
| EP2894225A4 (en) | 2016-04-27 |
| AU2013313794B2 (en) | 2016-10-20 |
| CN104781413A (zh) | 2015-07-15 |
| EP2894225B1 (en) | 2017-11-22 |
| US20150231225A1 (en) | 2015-08-20 |
| PH12015500497B1 (en) | 2015-04-27 |
| MX363051B (es) | 2019-03-06 |
| RU2606022C2 (ru) | 2017-01-10 |
| JP2015527079A (ja) | 2015-09-17 |
| EP2894225A1 (en) | 2015-07-15 |
| BR112015005081B1 (pt) | 2021-10-26 |
| US9636392B2 (en) | 2017-05-02 |
| JP5905649B2 (ja) | 2016-04-20 |
| KR101944960B1 (ko) | 2019-02-07 |
| AU2013313794A1 (en) | 2015-04-23 |
| MX2015002950A (es) | 2016-04-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06I | Publication of requirement cancelled [chapter 6.9 patent gazette] |
Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2462 DE 13/03/2018 POR TER SIDO INDEVIDA. |
|
| B25D | Requested change of name of applicant approved |
Owner name: SK DISCOVERY CO., LTD. (KR) |
|
| B25G | Requested change of headquarter approved |
Owner name: SK DISCOVERY CO., LTD. (KR) |
|
| B25A | Requested transfer of rights approved |
Owner name: SK CHEMICALS CO., LTD. (KR) |
|
| B25A | Requested transfer of rights approved |
Owner name: SK BIOSCIENCE CO., LTD. (KR) |
|
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 06/09/2013, OBSERVADAS AS CONDICOES LEGAIS. |