BR112015000232A8 - Método para a síntese de ?,d-dihidroxi-isoleucina, composto, kit e método para sintetizar uma amatoxina - Google Patents
Método para a síntese de ?,d-dihidroxi-isoleucina, composto, kit e método para sintetizar uma amatoxinaInfo
- Publication number
- BR112015000232A8 BR112015000232A8 BR112015000232A BR112015000232A BR112015000232A8 BR 112015000232 A8 BR112015000232 A8 BR 112015000232A8 BR 112015000232 A BR112015000232 A BR 112015000232A BR 112015000232 A BR112015000232 A BR 112015000232A BR 112015000232 A8 BR112015000232 A8 BR 112015000232A8
- Authority
- BR
- Brazil
- Prior art keywords
- synthesis
- isoleucine
- dihydroxy
- amatoxin
- kit
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
- C07K1/065—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for hydroxy functions, not being part of carboxy functions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/10—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using coupling agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Peptides Or Proteins (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
método para a síntese de y,b-dihidroxi-isoleucina, composto, kit e método para sintetizar uma amatoxina. a invenção refere-se a novos métodos para a síntese de um sínton para y,b-dihidroxi-isoleucina 1 (n° cas 55399-94-5] como bloco de construção para a síntese de amatoxinas, e para novos métodos para a síntese de amatoxinas utilizando tais blocos de construção.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12005173.5 | 2012-07-13 | ||
EP12005173.5A EP2684865A1 (en) | 2012-07-13 | 2012-07-13 | Methods for synthesizing amatoxin building block and amatoxins |
PCT/EP2013/002084 WO2014009025A1 (en) | 2012-07-13 | 2013-07-12 | Methods for synthesizing amatoxin building block and amatoxins |
Publications (3)
Publication Number | Publication Date |
---|---|
BR112015000232A2 BR112015000232A2 (pt) | 2017-06-27 |
BR112015000232A8 true BR112015000232A8 (pt) | 2022-08-23 |
BR112015000232B1 BR112015000232B1 (pt) | 2022-09-06 |
Family
ID=48793164
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015000232-3A BR112015000232B1 (pt) | 2012-07-13 | 2013-07-12 | Método para a síntese de gama, delta-dihidroxi-isoleucina, composto, kit e método para sintetizar uma amatoxina |
Country Status (25)
Country | Link |
---|---|
US (1) | US9676702B2 (pt) |
EP (2) | EP2684865A1 (pt) |
JP (2) | JP2015528799A (pt) |
KR (1) | KR102122575B1 (pt) |
CN (1) | CN104470891B (pt) |
AU (1) | AU2013289555B2 (pt) |
BR (1) | BR112015000232B1 (pt) |
CA (1) | CA2878081C (pt) |
CY (1) | CY1117950T1 (pt) |
DK (1) | DK2872479T3 (pt) |
ES (1) | ES2589306T3 (pt) |
HK (1) | HK1209723A1 (pt) |
HR (1) | HRP20160984T1 (pt) |
HU (1) | HUE029538T2 (pt) |
IL (1) | IL236129A (pt) |
MX (1) | MX361116B (pt) |
NZ (1) | NZ702752A (pt) |
PL (1) | PL2872479T3 (pt) |
PT (1) | PT2872479T (pt) |
RU (1) | RU2637924C2 (pt) |
SG (1) | SG11201500225WA (pt) |
SI (1) | SI2872479T1 (pt) |
UA (1) | UA116991C2 (pt) |
WO (1) | WO2014009025A1 (pt) |
ZA (1) | ZA201409384B (pt) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3215519A1 (en) | 2014-11-06 | 2017-09-13 | Novartis AG | Amatoxin derivatives and conjugates thereof as inhibitors of rna polymerase |
US10723766B2 (en) | 2015-11-27 | 2020-07-28 | Heidelberg Pharma Research Gmbh | Derivatives of gamma-amanitin |
EP3222292A1 (en) * | 2016-03-03 | 2017-09-27 | Heidelberg Pharma GmbH | Amanitin conjugates |
EP3452492A1 (en) | 2016-05-05 | 2019-03-13 | Novartis AG | Amatoxin derivatives and conjugates thereof as inhibitors of rna polymerase |
AU2017204125B1 (en) | 2016-06-17 | 2017-10-26 | Crispr Therapeutics Ag | Compositions and methods for the depletion of cd117+ cells |
AU2017204139B2 (en) | 2016-06-17 | 2018-08-09 | Magenta Therapeutics, Inc. | Compositions and methods for the depletion of cells |
BR112019012937A2 (pt) * | 2016-12-23 | 2019-12-10 | Heidelberg Pharma Res Gmbh | novo conjugado de amanitina |
US10576161B2 (en) | 2017-01-20 | 2020-03-03 | Magenta Therapeutics, Inc. | Compositions and methods for the depletion of CD137+ cells |
WO2019030173A1 (en) | 2017-08-07 | 2019-02-14 | Heidelberg Pharma Gmbh | NOVEL METHOD FOR SYNTHESIZING AMANITINES |
US11420971B2 (en) | 2017-08-07 | 2022-08-23 | Heidelberg Pharma Research Gmbh | Method for synthesizing amanitins |
US20210030887A1 (en) * | 2017-08-18 | 2021-02-04 | Sichuan Baili Pharmaceutical Co. Ltd. | Non-natural amatoxin-type antibody conjugate |
AU2018329066B2 (en) * | 2017-09-08 | 2022-02-17 | Baili-Bio (Chengdu) Pharmaceutical Co., Ltd. | Amanitin antibody conjugate |
KR20190043031A (ko) * | 2017-10-17 | 2019-04-25 | 한국화학연구원 | 아마톡신 유도체 및 이의 제조방법 |
EP3546447A1 (en) | 2018-03-29 | 2019-10-02 | Heidelberg Pharma GmbH | Synthesis of (2s,3r,4r)-4,5-dihydroxyisoleucine and derivatives |
EP3958908A1 (en) | 2019-04-24 | 2022-03-02 | Heidelberg Pharma Research GmbH | Amatoxin antibody-drug conjugates and uses thereof |
EP3792250A1 (en) * | 2019-09-13 | 2021-03-17 | Pure Bioorganics SIA | Synthesis of alpha-amanitin and its derivatives |
EP3994146A1 (en) * | 2019-07-05 | 2022-05-11 | Pure Bioorganics SIA | Synthesis of a-amanitin and its derivatives |
KR102092817B1 (ko) * | 2019-08-22 | 2020-03-24 | 한국화학연구원 | 아마톡신 유도체 및 이의 제조방법 |
CN112552196B (zh) * | 2020-11-23 | 2024-02-02 | 蚌埠丰原医药科技发展有限公司 | 一种制备赖氨匹林的方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1585076A (en) * | 1976-07-13 | 1981-02-25 | Roche Products Ltd | Peptides of phosphonic and phosphinic acids |
DE4104024A1 (de) * | 1991-02-09 | 1992-08-13 | Merck Patent Gmbh | Aminosaeurederivate |
JPH0959228A (ja) * | 1995-08-17 | 1997-03-04 | Hokuriku Seiyaku Co Ltd | 光学活性なアミノアルコール及びその製造方法 |
EP0934923B1 (en) * | 1996-09-13 | 2003-04-02 | Nippon Kayaku Kabushiki Kaisha | Optically active erythro-3-amino-2-hydroxybutyric esters and process for preparing said esters |
JPH11137291A (ja) * | 1997-11-12 | 1999-05-25 | Mori Sangyo Kk | アマニチン類の製造法 |
JP2002516337A (ja) * | 1998-05-22 | 2002-06-04 | アボット・ラボラトリーズ | ガン、関節炎および網膜症を処置するための抗血管形成薬 |
JP2003528072A (ja) * | 2000-03-17 | 2003-09-24 | ブリストル−マイヤーズ スクイブ ファーマ カンパニー | マトリックスメタロプロテアーゼおよびTNF−αの阻害剤としての環状β−アミノ酸誘導体 |
BR0109968A (pt) * | 2000-04-18 | 2003-05-27 | Lilly Co Eli | Processo para a preparação de lipìdeo ii |
ES2371085T3 (es) | 2006-05-27 | 2011-12-27 | Faulstich, Heinz, Dr. | Utilización de conjugados de amatoxinas o falotoxinas con macromoléculas para la terapia tumoral y de la inflamación. |
MX2011010469A (es) | 2009-04-08 | 2012-03-14 | Deutsches Krebsforsch | Radicales de enlace al objetivo, armados con amatoxina para el tratamiento del cancer. |
AU2010234334B2 (en) | 2009-04-08 | 2014-10-09 | Deutsches Krebsforschungszentrum | Amatoxin-armed therapeutic cell surface binding components designed for tumour therapy |
-
2012
- 2012-07-13 EP EP12005173.5A patent/EP2684865A1/en not_active Withdrawn
-
2013
- 2013-07-12 NZ NZ702752A patent/NZ702752A/en unknown
- 2013-07-12 RU RU2015104802A patent/RU2637924C2/ru active
- 2013-07-12 CN CN201380037459.2A patent/CN104470891B/zh active Active
- 2013-07-12 US US14/414,143 patent/US9676702B2/en active Active
- 2013-07-12 BR BR112015000232-3A patent/BR112015000232B1/pt active IP Right Grant
- 2013-07-12 EP EP13737145.6A patent/EP2872479B1/en active Active
- 2013-07-12 ES ES13737145.6T patent/ES2589306T3/es active Active
- 2013-07-12 JP JP2015520852A patent/JP2015528799A/ja active Pending
- 2013-07-12 PT PT137371456T patent/PT2872479T/pt unknown
- 2013-07-12 PL PL13737145.6T patent/PL2872479T3/pl unknown
- 2013-07-12 MX MX2015000479A patent/MX361116B/es active IP Right Grant
- 2013-07-12 WO PCT/EP2013/002084 patent/WO2014009025A1/en active Application Filing
- 2013-07-12 KR KR1020157003282A patent/KR102122575B1/ko active IP Right Grant
- 2013-07-12 SG SG11201500225WA patent/SG11201500225WA/en unknown
- 2013-07-12 CA CA2878081A patent/CA2878081C/en active Active
- 2013-07-12 SI SI201330268A patent/SI2872479T1/sl unknown
- 2013-07-12 HU HUE13737145A patent/HUE029538T2/en unknown
- 2013-07-12 AU AU2013289555A patent/AU2013289555B2/en active Active
- 2013-07-12 UA UAA201501155A patent/UA116991C2/uk unknown
- 2013-07-12 DK DK13737145.6T patent/DK2872479T3/en active
-
2014
- 2014-12-08 IL IL236129A patent/IL236129A/en active IP Right Grant
- 2014-12-19 ZA ZA2014/09384A patent/ZA201409384B/en unknown
-
2015
- 2015-10-22 HK HK15110372.0A patent/HK1209723A1/xx unknown
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2016
- 2016-08-02 HR HRP20160984TT patent/HRP20160984T1/hr unknown
- 2016-08-22 CY CY20161100827T patent/CY1117950T1/el unknown
-
2018
- 2018-02-16 JP JP2018025844A patent/JP6560382B2/ja active Active
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 12/07/2013, OBSERVADAS AS CONDICOES LEGAIS |
|
B25D | Requested change of name of applicant approved |
Owner name: HEIDELBERG PHARMA RESEARCH GMBH (DE) |
|
B25G | Requested change of headquarter approved |
Owner name: HEIDELBERG PHARMA RESEARCH GMBH (DE) |