BR112014031282A2 - preparação líquida, métodos de produção da preparação líquida, de estabilização de uma preparação líquida, de supressão da produção de um produto de reação de um ingrediente farmaceuticamente ativo, preparação secada por congelamento, kit de injeção, uso de um sal, e, sal - Google Patents
preparação líquida, métodos de produção da preparação líquida, de estabilização de uma preparação líquida, de supressão da produção de um produto de reação de um ingrediente farmaceuticamente ativo, preparação secada por congelamento, kit de injeção, uso de um sal, e, salInfo
- Publication number
- BR112014031282A2 BR112014031282A2 BR112014031282A BR112014031282A BR112014031282A2 BR 112014031282 A2 BR112014031282 A2 BR 112014031282A2 BR 112014031282 A BR112014031282 A BR 112014031282A BR 112014031282 A BR112014031282 A BR 112014031282A BR 112014031282 A2 BR112014031282 A2 BR 112014031282A2
- Authority
- BR
- Brazil
- Prior art keywords
- liquid preparation
- salt
- production
- preparation
- active ingredient
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title abstract 10
- 239000007788 liquid Substances 0.000 title abstract 7
- 239000004480 active ingredient Substances 0.000 title abstract 5
- 150000003839 salts Chemical class 0.000 title abstract 5
- 238000004519 manufacturing process Methods 0.000 title abstract 4
- 239000007795 chemical reaction product Substances 0.000 title abstract 3
- -1 and Chemical class 0.000 title abstract 2
- 238000002347 injection Methods 0.000 title abstract 2
- 239000007924 injection Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 230000006641 stabilisation Effects 0.000 title abstract 2
- 238000011105 stabilization Methods 0.000 title abstract 2
- 230000001629 suppression Effects 0.000 title abstract 2
- 150000007524 organic acids Chemical class 0.000 abstract 2
- 150000001408 amides Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000000467 secondary amino group Chemical group [H]N([*:1])[*:2] 0.000 abstract 1
- 230000000087 stabilizing effect Effects 0.000 abstract 1
- 210000002268 wool Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01D—COMPOUNDS OF ALKALI METALS, i.e. LITHIUM, SODIUM, POTASSIUM, RUBIDIUM, CAESIUM, OR FRANCIUM
- C01D3/00—Halides of sodium, potassium or alkali metals in general
- C01D3/04—Chlorides
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01D—COMPOUNDS OF ALKALI METALS, i.e. LITHIUM, SODIUM, POTASSIUM, RUBIDIUM, CAESIUM, OR FRANCIUM
- C01D3/00—Halides of sodium, potassium or alkali metals in general
- C01D3/10—Bromides
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01F—COMPOUNDS OF THE METALS BERYLLIUM, MAGNESIUM, ALUMINIUM, CALCIUM, STRONTIUM, BARIUM, RADIUM, THORIUM, OR OF THE RARE-EARTH METALS
- C01F11/00—Compounds of calcium, strontium, or barium
- C01F11/20—Halides
- C01F11/24—Chlorides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Materials Engineering (AREA)
- Geology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
1 / 1 resumo âpreparaãão lãquida, mãtodos de produãão da preparaãão lãquida, de estabilizaãão de uma preparaãão lãquida, de supressão da produãão de um produto de reaãão de um ingrediente farmaceuticamente ativo, preparaãão secada por congelamento, kit de injeãão, uso de um sal, e, salâ sã£o fornecidos uma preparaã§ã£o lãquida na qual o ingrediente farmaceuticamente ativo estã¡ estabilizado, e um mã©todo de estabilizar o mesmo. uma preparaã§ã£o lãquida compreendendo um ingrediente farmaceuticamente ativo tendo um grupo amino primã¡rio ou secundã¡rio (em que o grupo amino nã£o constitui uma parte da estrutura de amida), um ã¡cido orgã¢nico e um sal, que estã¡ substancialmente isenta de um produto de reaã§ã£o do ingrediente farmaceuticamente ativo e o ã¡cido orgã¢nico.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012144750 | 2012-06-27 | ||
| PCT/JP2013/068192 WO2014003199A1 (en) | 2012-06-27 | 2013-06-26 | Liquid preparations of amines and organic acids stabilized by salts |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112014031282A2 true BR112014031282A2 (pt) | 2017-06-27 |
Family
ID=48795873
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112014031282A BR112014031282A2 (pt) | 2012-06-27 | 2013-06-26 | preparação líquida, métodos de produção da preparação líquida, de estabilização de uma preparação líquida, de supressão da produção de um produto de reação de um ingrediente farmaceuticamente ativo, preparação secada por congelamento, kit de injeção, uso de um sal, e, sal |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US20150165027A1 (pt) |
| EP (1) | EP2866788B1 (pt) |
| JP (1) | JP6216338B2 (pt) |
| KR (1) | KR102206928B1 (pt) |
| CN (3) | CN104582687A (pt) |
| AR (1) | AR091567A1 (pt) |
| AU (1) | AU2013281626A1 (pt) |
| BR (1) | BR112014031282A2 (pt) |
| CA (1) | CA2877619C (pt) |
| HK (1) | HK1209338A1 (pt) |
| IL (1) | IL236187A0 (pt) |
| MX (1) | MX2014015269A (pt) |
| NZ (1) | NZ703528A (pt) |
| PH (1) | PH12014502863A1 (pt) |
| RU (1) | RU2015102333A (pt) |
| SG (1) | SG11201408511QA (pt) |
| TW (1) | TWI623327B (pt) |
| UY (1) | UY34880A (pt) |
| WO (1) | WO2014003199A1 (pt) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105982867A (zh) * | 2015-02-27 | 2016-10-05 | 江苏柯菲平医药股份有限公司 | 一种h009冻干粉针及其制备方法 |
| CN104814964B (zh) * | 2015-04-16 | 2018-07-31 | 广东赛烽医药科技有限公司 | 一种抗胃幽门螺旋杆菌的药物组合物、制备方法及其应用 |
| CN106265535A (zh) * | 2015-06-23 | 2017-01-04 | 中美华世通生物医药科技（武汉）有限公司 | 富马酸沃诺拉赞冻干粉针制剂及其制备方法 |
| CN104926790B (zh) * | 2015-06-29 | 2017-07-07 | 江苏奥赛康药业股份有限公司 | 一种高纯度Vonoprazan Fumarate化合物及其中间体、杂质以及它们的制备方法 |
| CN106511344A (zh) * | 2015-09-14 | 2017-03-22 | 王虹 | 一种胃酸分泌抑制剂的新用途 |
| RU2657833C2 (ru) | 2015-12-01 | 2018-06-15 | Общество С Ограниченной Ответственностью "Остерос Биомедика" | Стабилизированная лекарственная форма конъюгата этидроната с цитарабином и её применение |
| CN105640877A (zh) * | 2016-01-26 | 2016-06-08 | 北京阜康仁生物制药科技有限公司 | 一种含有沃诺拉赞的液体制剂 |
| CN107525877B (zh) * | 2016-06-20 | 2021-08-03 | 重庆医药工业研究院有限责任公司 | 一种采用液相色谱法分离测定依匹哌唑及其杂质的方法 |
| EA030671B1 (ru) * | 2016-07-20 | 2018-09-28 | Общество С Ограниченной Ответственностью "Остерос Биомедика" | Препарат для лечения костных поражений, вызванных злокачественными новообразованиями |
| CN107536801B (zh) * | 2017-08-18 | 2019-08-06 | 常州兰陵制药有限公司 | 氯化钙溴化钠注射液的制备工艺 |
| CN108689991B (zh) * | 2018-06-11 | 2019-12-20 | 杭州中美华东制药有限公司 | 沃诺拉赞新晶型盐及其制备方法 |
| CN110917201A (zh) * | 2019-12-02 | 2020-03-27 | 吉林省博大伟业制药有限公司 | 聚普瑞锌在制备治疗萎缩性胃炎伴随胃粘膜上皮异型增生的药物中的应用 |
| CN113350271A (zh) * | 2020-03-04 | 2021-09-07 | 广东东阳光药业有限公司 | 一种质子泵抑制剂的组合物及其制备方法 |
| BR112022025613A2 (pt) * | 2020-06-17 | 2023-01-17 | Ildong Pharmaceutical Co Ltd | Novo inibidor de secreção de ácido e uso do mesmo |
| CN111943932B (zh) * | 2020-08-06 | 2023-07-14 | 四川国康药业有限公司 | 一种可以治疗消化性溃疡的3-吡啶磺酰-1-n-杂吡咯衍生物及其制备方法和用途 |
| CN116270443A (zh) * | 2022-10-27 | 2023-06-23 | 广州白云山天心制药股份有限公司 | 富马酸伏诺拉生注射液及其制备方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19833119A1 (de) * | 1998-07-23 | 2000-01-27 | Roche Diagnostics Gmbh | Spritzfertige Injektionslösungen enthaltend Carvedilol |
| DK1277471T3 (da) * | 2000-04-24 | 2008-08-11 | Daiichi Sankyo Co Ltd | Stabilt væskepræparat omfattende sitafloxacin |
| MY137726A (en) * | 2000-11-22 | 2009-03-31 | Nycomed Gmbh | Freeze-dried pantoprazole preparation and pantoprazole injection |
| US6310094B1 (en) * | 2001-01-12 | 2001-10-30 | Baxter International Inc. | Ready-to-use esmolol solution |
| CA2473412A1 (en) * | 2004-07-08 | 2006-01-08 | Laboratoires Omega Ltee | Liquid pharmaceutical injectable formulation of octreotide |
| CA2582777A1 (en) | 2004-09-30 | 2006-04-06 | Takeda Pharmaceutical Company Limited | Proton pump inhibitors |
| US20070191306A1 (en) * | 2005-08-17 | 2007-08-16 | Bristol-Myers Squibb Company | FACTOR Xa INHIBITOR FORMULATION AND METHOD |
| ME00610B (me) * | 2005-08-30 | 2011-12-20 | Takeda Pharmaceuticals Co | 1 –heterociklilsulfonil, 2 –aminometil, 5– (hetero–) aril supstituisan 1–h–pirol derivati kao inhibitori lučenja kiseline |
| JP5207964B2 (ja) | 2006-03-31 | 2013-06-12 | 武田薬品工業株式会社 | 酸分泌抑制薬 |
| US8933105B2 (en) | 2007-02-28 | 2015-01-13 | Takeda Pharmaceutical Company Limited | Pyrrole compounds |
| US8658183B2 (en) * | 2007-08-09 | 2014-02-25 | Taigen Biotechnology Company, Ltd. | Antimicrobial parenteral formulation |
| WO2009041447A1 (ja) | 2007-09-28 | 2009-04-02 | Takeda Pharmaceutical Company Limited | ５員複素環化合物 |
| WO2009041705A2 (en) | 2007-09-28 | 2009-04-02 | Takeda Pharmaceutical Company Limited | 5-membered heterocyclic compounds as proton pump inhibitors |
| ES2660962T3 (es) | 2008-07-28 | 2018-03-26 | Takeda Pharmaceutical Company Limited | Composición farmacéutica fotoestabilizada |
| MY152008A (en) | 2008-08-27 | 2014-08-15 | Takeda Pharmaceutical | Pyrrole compounds |
| US8895588B2 (en) | 2009-03-26 | 2014-11-25 | Takeda Pharmaceutical Company Limited | Pyrazole compound |
-
2013
- 2013-06-26 WO PCT/JP2013/068192 patent/WO2014003199A1/en active Application Filing
- 2013-06-26 MX MX2014015269A patent/MX2014015269A/es unknown
- 2013-06-26 TW TW102122662A patent/TWI623327B/zh active
- 2013-06-26 KR KR1020157002034A patent/KR102206928B1/ko active IP Right Grant
- 2013-06-26 EP EP13737879.0A patent/EP2866788B1/en active Active
- 2013-06-26 US US14/407,174 patent/US20150165027A1/en not_active Abandoned
- 2013-06-26 JP JP2014561221A patent/JP6216338B2/ja active Active
- 2013-06-26 NZ NZ703528A patent/NZ703528A/en not_active IP Right Cessation
- 2013-06-26 CN CN201380044649.7A patent/CN104582687A/zh active Pending
- 2013-06-26 AR ARP130102255 patent/AR091567A1/es unknown
- 2013-06-26 SG SG11201408511QA patent/SG11201408511QA/en unknown
- 2013-06-26 CA CA2877619A patent/CA2877619C/en active Active
- 2013-06-26 AU AU2013281626A patent/AU2013281626A1/en not_active Abandoned
- 2013-06-26 UY UY0001034880A patent/UY34880A/es not_active Application Discontinuation
- 2013-06-26 BR BR112014031282A patent/BR112014031282A2/pt not_active IP Right Cessation
- 2013-06-26 CN CN201910298076.XA patent/CN110200903B/zh active Active
- 2013-06-26 CN CN201911035338.XA patent/CN110917130A/zh active Pending
- 2013-06-26 RU RU2015102333A patent/RU2015102333A/ru not_active Application Discontinuation
-
2014
- 2014-12-11 IL IL236187A patent/IL236187A0/en unknown
- 2014-12-22 PH PH12014502863A patent/PH12014502863A1/en unknown
-
2015
- 2015-10-15 HK HK15110093.8A patent/HK1209338A1/xx unknown
-
2022
- 2022-12-16 US US18/082,799 patent/US20230143246A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| HK1209338A1 (en) | 2016-04-01 |
| CA2877619C (en) | 2020-09-22 |
| MX2014015269A (es) | 2015-02-20 |
| KR20150023883A (ko) | 2015-03-05 |
| KR102206928B1 (ko) | 2021-01-22 |
| AR091567A1 (es) | 2015-02-11 |
| JP2015521986A (ja) | 2015-08-03 |
| RU2015102333A (ru) | 2016-08-20 |
| US20150165027A1 (en) | 2015-06-18 |
| TW201406399A (zh) | 2014-02-16 |
| CA2877619A1 (en) | 2014-01-03 |
| WO2014003199A1 (en) | 2014-01-03 |
| NZ703528A (en) | 2016-08-26 |
| IL236187A0 (en) | 2015-01-29 |
| EP2866788B1 (en) | 2020-12-16 |
| AU2013281626A1 (en) | 2015-01-22 |
| CN104582687A (zh) | 2015-04-29 |
| SG11201408511QA (en) | 2015-01-29 |
| CN110200903A (zh) | 2019-09-06 |
| CN110917130A (zh) | 2020-03-27 |
| UY34880A (es) | 2014-01-31 |
| EP2866788A1 (en) | 2015-05-06 |
| JP6216338B2 (ja) | 2017-10-18 |
| US20230143246A1 (en) | 2023-05-11 |
| TWI623327B (zh) | 2018-05-11 |
| PH12014502863A1 (en) | 2015-02-23 |
| CN110200903B (zh) | 2022-07-29 |
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| Date | Code | Title | Description |
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| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06I | Publication of requirement cancelled [chapter 6.9 patent gazette] |
Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2462 DE 13/03/2018 POR TER SIDO INDEVIDA. |
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| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
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| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A ANUIDADE. |
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| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO ARQUIVAMENTO PUBLICADO NA RPI 2520 DE 25/04/2019. |