BR112014027957A8 - métodos e composições para infusão de populações selecionadas de enxerto transitório de linfócitos alogênicos para tratar câncer" - Google Patents
métodos e composições para infusão de populações selecionadas de enxerto transitório de linfócitos alogênicos para tratar câncer"Info
- Publication number
- BR112014027957A8 BR112014027957A8 BR112014027957A BR112014027957A BR112014027957A8 BR 112014027957 A8 BR112014027957 A8 BR 112014027957A8 BR 112014027957 A BR112014027957 A BR 112014027957A BR 112014027957 A BR112014027957 A BR 112014027957A BR 112014027957 A8 BR112014027957 A8 BR 112014027957A8
- Authority
- BR
- Brazil
- Prior art keywords
- cells
- cell
- graft
- allogeneic
- infusion
- Prior art date
Links
- 230000000735 allogeneic effect Effects 0.000 title abstract 8
- 238000001802 infusion Methods 0.000 title abstract 6
- 210000004698 lymphocyte Anatomy 0.000 title abstract 6
- 206010028980 Neoplasm Diseases 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 4
- 201000011510 cancer Diseases 0.000 title abstract 2
- 230000001052 transient effect Effects 0.000 title abstract 2
- 210000004027 cell Anatomy 0.000 abstract 7
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 6
- 239000012636 effector Substances 0.000 abstract 4
- 210000003289 regulatory T cell Anatomy 0.000 abstract 4
- 230000002459 sustained effect Effects 0.000 abstract 4
- 208000009329 Graft vs Host Disease Diseases 0.000 abstract 2
- 230000000259 anti-tumor effect Effects 0.000 abstract 2
- 230000005809 anti-tumor immunity Effects 0.000 abstract 2
- 238000002659 cell therapy Methods 0.000 abstract 2
- 230000003750 conditioning effect Effects 0.000 abstract 2
- 208000024908 graft versus host disease Diseases 0.000 abstract 2
- 230000001506 immunosuppresive effect Effects 0.000 abstract 2
- 210000000130 stem cell Anatomy 0.000 abstract 2
- 238000011476 stem cell transplantation Methods 0.000 abstract 2
- 230000007423 decrease Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/664—Amides of phosphorus acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
- A61K39/4621—Cellular immunotherapy characterized by the effect or the function of the cells immunosuppressive or immunotolerising
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/46434—Antigens related to induction of tolerance to non-self
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0081—Purging biological preparations of unwanted cells
- C12N5/0087—Purging against subsets of blood cells, e.g. purging alloreactive T cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/26—Universal/off- the- shelf cellular immunotherapy; Allogenic cells or means to avoid rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
abstract of the invention the invention provides methods and compositions for administration of allogeneic lymphocytes as an an exogenous source of cd4+ t cell help for endogenous, tumor-reactive cd8+ t cells. depletion of cd8+ t cells from the donor lymphocyte infusion reduces the risk of sustained engraftment and graft-versus-host disease. removal of regulatory t cells from the infused population may augment the ability of non-regulatory t cells to provide help for endogenous effectors of anti-tumor immunity. allogeneic t cell therapy is typically given in the context of allogeneic stem cell transplantation, in which the patient receives highly immunosuppressive conditioning followed by an infusion of a stem cell graft containing unselected populations of mature t cells. in the treatment described here, the graft is engineered to minimize the possibility of sustained donor cell engraftment, and the anti-tumor effector t cells derive from the host. ********************************* tradução do resumo resumo patente de invenção: "métodos e composições para infusão de populações selecionadas de enxertia transiente de linfócitos alogênicos para tratamento de câncer". a invenção fornece métodos e composições para administração de linfócitos alogênicos como uma fonte exógena de auxílio de células t cd4+ para células t cd8+ endógenas reativas a tumor. a depleção de células t cd8+ da infusão de linfócito de doador reduz o risco de doença enxerto contra hospedeiro e enxertia sustentada. a remoção de células t regulatórias da população infundida pode aumentar a habilidade de células t não regulatórias para fornecer auxílio para efetores endógenos de imunidade anti-tumoral. a terapia de célula t alogênica é tipicamente dada no contexto de transplante de célula-tronco alogênica, em que o paciente recebe um condicionamento altamente imunosupressivo sucedido por uma infusão de um enxerto de célula-tronco que contém populações não selecionadas de células t maduras. no tratamento descrito aqui, o enxerto é modificado para minimizar a possibilidade de enxertia sustentada de célula de doador, e as células t efetoras antitumorais são derivadas do hospedeiro. 23020494v1 1/1 23020494v1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261644126P | 2012-05-08 | 2012-05-08 | |
| PCT/US2013/032129 WO2013169386A1 (en) | 2012-05-08 | 2013-03-15 | Methods and compositions for infusion of transiently engrafting, selected populations of allogeneic lymphocytes to treat cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112014027957A2 BR112014027957A2 (pt) | 2017-06-27 |
| BR112014027957A8 true BR112014027957A8 (pt) | 2018-01-16 |
Family
ID=49551134
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112014027957A BR112014027957A8 (pt) | 2012-05-08 | 2013-03-15 | métodos e composições para infusão de populações selecionadas de enxerto transitório de linfócitos alogênicos para tratar câncer" |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US9931359B2 (pt) |
| EP (2) | EP3144008B1 (pt) |
| CN (1) | CN104394877B (pt) |
| AU (1) | AU2013260132B2 (pt) |
| BR (1) | BR112014027957A8 (pt) |
| CA (2) | CA2872643C (pt) |
| DK (1) | DK2846816T3 (pt) |
| ES (1) | ES2607148T3 (pt) |
| WO (1) | WO2013169386A1 (pt) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10144778B2 (en) | 2014-03-12 | 2018-12-04 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
| US9394365B1 (en) | 2014-03-12 | 2016-07-19 | Yeda Research And Development Co., Ltd | Reducing systemic regulatory T cell levels or activity for treatment of alzheimer's disease |
| US10519237B2 (en) | 2014-03-12 | 2019-12-31 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
| US10618963B2 (en) | 2014-03-12 | 2020-04-14 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
| WO2016183153A1 (en) * | 2015-05-12 | 2016-11-17 | Memorial Sloan Kettering Cancer Center | Methods of treating epstein-barr virus-associated lymphoproliferative disorders by t cell therapy |
| BR122023022076A2 (pt) | 2015-05-28 | 2024-01-16 | Kite Pharma, Inc. | Agente pré-condicionantes, seus usos e métodos para identificar uma dose de um ou mais agentes de pré-condicionamento e para verificar a eficácia dos mesmos |
| JP7197979B2 (ja) | 2015-05-28 | 2022-12-28 | カイト ファーマ インコーポレイテッド | Ｔ細胞療法のために患者をコンディショニングする方法 |
| US11090333B2 (en) | 2015-09-14 | 2021-08-17 | Baylor College Of Medicine | Immune stimulatory function and anti-tumor activity of TGF-β primed myeloid derived suppressor cells (MDSC) |
| MX2019003768A (es) | 2016-10-03 | 2019-06-24 | Juno Therapeutics Inc | Moleculas de enlace especificas de hpv. |
| EP4215543A3 (en) | 2017-10-03 | 2023-10-11 | Juno Therapeutics, Inc. | Hpv-specific binding molecules |
| US20210048429A1 (en) * | 2017-10-23 | 2021-02-18 | Vipin Kumar Chaturvedi | Plzf+ regulatory cd8 t cells for control of inflammation |
| WO2019084273A1 (en) * | 2017-10-25 | 2019-05-02 | Actinium Pharmaceuticals, Inc. | METHODS OF ANTI-CD45-BASED LYMPHODEPPLICATION AND USES THEREOF IN COMBINATION WITH ACT-BASED ANTICANCER THERAPIES |
| EP3773908A1 (en) | 2018-04-05 | 2021-02-17 | Juno Therapeutics, Inc. | T cell receptors and engineered cells expressing same |
| EP3725370A1 (en) | 2019-04-19 | 2020-10-21 | ImmunoBrain Checkpoint, Inc. | Modified anti-pd-l1 antibodies and methods and uses for treating a neurodegenerative disease |
| JP2023512670A (ja) * | 2020-02-10 | 2023-03-28 | ザ・ジョンズ・ホプキンス・ユニバーシティ | 同種異系、腫瘍特異的なｃｄ４＋ ｔ細胞の注射移植を用いたがん免疫療法 |
| CN111537424B (zh) * | 2020-04-26 | 2022-10-28 | 北京市神经外科研究所 | 基于外周血细胞评估脊髓胶质瘤患者预后性的*** |
| CN111643525A (zh) * | 2020-06-16 | 2020-09-11 | 济宁医学院 | 引发免疫排斥反应在肿瘤治疗中的应用及其方法 |
| CN114452388A (zh) * | 2022-03-07 | 2022-05-10 | 北京大学第一医院 | 一种降低血循环***中eb病毒拷贝数的方法和*** |
| WO2024073529A1 (en) * | 2022-09-29 | 2024-04-04 | Iyuda Therapeutics, Llc | Methods and compositions for localized production and delivery of biological molecules |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7361332B2 (en) * | 1995-03-17 | 2008-04-22 | The Regents Of The University Of California | Treating tumors using implants comprising combinations of allogeneic cells |
| CA2280156C (en) * | 1997-02-11 | 2007-10-02 | William H. Hildebrand | Class i sequence based typing of hla-a, -b, and -c alleles by direct dna sequencing |
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2013
- 2013-03-15 ES ES13788469.8T patent/ES2607148T3/es active Active
- 2013-03-15 EP EP16190858.7A patent/EP3144008B1/en active Active
- 2013-03-15 CA CA2872643A patent/CA2872643C/en active Active
- 2013-03-15 EP EP13788469.8A patent/EP2846816B1/en active Active
- 2013-03-15 CA CA3132353A patent/CA3132353A1/en active Pending
- 2013-03-15 BR BR112014027957A patent/BR112014027957A8/pt not_active Application Discontinuation
- 2013-03-15 US US14/398,724 patent/US9931359B2/en active Active
- 2013-03-15 CN CN201380030373.7A patent/CN104394877B/zh active Active
- 2013-03-15 WO PCT/US2013/032129 patent/WO2013169386A1/en active Application Filing
- 2013-03-15 AU AU2013260132A patent/AU2013260132B2/en active Active
- 2013-03-15 DK DK13788469.8T patent/DK2846816T3/en active
-
2018
- 2018-03-28 US US15/939,059 patent/US20180280439A1/en not_active Abandoned
-
2021
- 2021-11-12 US US17/525,714 patent/US20220143090A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DK2846816T3 (en) | 2017-01-16 |
| EP3144008B1 (en) | 2018-01-17 |
| AU2013260132A1 (en) | 2014-11-27 |
| US20150132290A1 (en) | 2015-05-14 |
| EP2846816A4 (en) | 2015-11-04 |
| CN104394877B (zh) | 2017-11-28 |
| EP2846816A1 (en) | 2015-03-18 |
| CA3132353A1 (en) | 2013-11-14 |
| CA2872643A1 (en) | 2013-11-14 |
| EP3144008A1 (en) | 2017-03-22 |
| EP2846816B1 (en) | 2016-09-28 |
| AU2013260132B2 (en) | 2017-12-14 |
| US20220143090A1 (en) | 2022-05-12 |
| ES2607148T3 (es) | 2017-03-29 |
| US9931359B2 (en) | 2018-04-03 |
| CA2872643C (en) | 2021-11-16 |
| BR112014027957A2 (pt) | 2017-06-27 |
| US20180280439A1 (en) | 2018-10-04 |
| WO2013169386A1 (en) | 2013-11-14 |
| CN104394877A (zh) | 2015-03-04 |
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| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
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| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] | ||
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Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |