BR112014007405A2 - composto; forma farmacêutica; e hexasulfato de inositol - Google Patents
composto; forma farmacêutica; e hexasulfato de inositolInfo
- Publication number
- BR112014007405A2 BR112014007405A2 BR112014007405A BR112014007405A BR112014007405A2 BR 112014007405 A2 BR112014007405 A2 BR 112014007405A2 BR 112014007405 A BR112014007405 A BR 112014007405A BR 112014007405 A BR112014007405 A BR 112014007405A BR 112014007405 A2 BR112014007405 A2 BR 112014007405A2
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- pharmaceutical form
- opso22
- opo32
- oso3
- Prior art date
Links
- NBTMNFYXJYCQHQ-UHFFFAOYSA-N (2,3,4,5,6-pentasulfooxycyclohexyl) hydrogen sulfate Chemical compound OS(=O)(=O)OC1C(OS(O)(=O)=O)C(OS(O)(=O)=O)C(OS(O)(=O)=O)C(OS(O)(=O)=O)C1OS(O)(=O)=O NBTMNFYXJYCQHQ-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- CZRCFAOMWRAFIC-UHFFFAOYSA-N 5-(tetradecyloxy)-2-furoic acid Chemical compound CCCCCCCCCCCCCCOC1=CC=C(C(O)=O)O1 CZRCFAOMWRAFIC-UHFFFAOYSA-N 0.000 abstract 1
- 208000037384 Clostridium Infections Diseases 0.000 abstract 1
- 206010009657 Clostridium difficile colitis Diseases 0.000 abstract 1
- 206010054236 Clostridium difficile infection Diseases 0.000 abstract 1
- 239000002202 Polyethylene glycol Substances 0.000 abstract 1
- 229920000388 Polyphosphate Polymers 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- -1 cyclic polyols Chemical class 0.000 abstract 1
- 125000003827 glycol group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
- 229920005862 polyol Polymers 0.000 abstract 1
- 239000001205 polyphosphate Substances 0.000 abstract 1
- 235000011176 polyphosphates Nutrition 0.000 abstract 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
- A61K31/6615—Compounds having two or more esterified phosphorus acid groups, e.g. inositol triphosphate, phytic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/117—Esters of phosphoric acids with cycloaliphatic alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C305/00—Esters of sulfuric acids
- C07C305/20—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/093—Polyol derivatives esterified at least twice by phosphoric acid groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/207—Cyclohexane rings not substituted by nitrogen atoms, e.g. kasugamycins
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Emergency Medicine (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
resumo composto; forma farmacêutica; e hexasulfato de inositol a invenção se refere a um composto representado pela fórmula geral (1), em que cada x independentemente pode ser opo32-, opso22- ou oso3-; r1 compreende uma função de solubilidade tais como uma fração de polietilenoglicol e cada x independentemente pode ser opo32-, opso22-, ou oso3-; e z é uma cadeia de alquila compreendendo 1 a 3 carbonos e/ou heteroátomos. a invenção se refere ainda aos derivados de polissulfato ou derivados de polifosfato/sulfato mistos de polióis cíclicos com seis membros para uso na terapia da infecção por clostridium difficile.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11007935 | 2011-09-29 | ||
EP11007933.2 | 2011-09-29 | ||
EP11007933 | 2011-09-29 | ||
EP11007935.7 | 2011-09-29 | ||
PCT/EP2012/004088 WO2013045107A1 (en) | 2011-09-29 | 2012-09-28 | Pharmaceutical compounds for use in the therapy of clostridium difficile infection |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112014007405A2 true BR112014007405A2 (pt) | 2017-04-04 |
BR112014007405B1 BR112014007405B1 (pt) | 2021-07-13 |
Family
ID=47022623
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014007405-4A BR112014007405B1 (pt) | 2011-09-29 | 2012-09-28 | Composto, mio-inositol-pentaquisfosfato-2-peg(400) e forma farmacêutica |
Country Status (14)
Country | Link |
---|---|
US (1) | US9358243B2 (pt) |
EP (2) | EP3521294A1 (pt) |
JP (1) | JP5766884B2 (pt) |
CN (2) | CN105949234B (pt) |
AU (2) | AU2012314932B2 (pt) |
BR (1) | BR112014007405B1 (pt) |
CA (1) | CA2849426C (pt) |
DK (1) | DK2773648T3 (pt) |
EA (1) | EA024069B1 (pt) |
ES (1) | ES2727633T3 (pt) |
IL (1) | IL231698A (pt) |
MX (1) | MX347723B (pt) |
PL (1) | PL2773648T3 (pt) |
WO (1) | WO2013045107A1 (pt) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2054044B1 (de) * | 2006-08-02 | 2014-07-23 | Johannes Gutenberg-Universität Mainz | Arzneimittel gegen lct-vergiftungen |
PL3386994T3 (pl) | 2015-12-11 | 2020-05-18 | ETH Zürich | 4,6-di-(o-tiofosforano)-inozytolo-1,2,3,5-tetra-o-siarczan dla zakażenia c. difficile |
US11028112B2 (en) | 2015-12-11 | 2021-06-08 | Eth Zurich | Inositol derivatives for use in pathological crystallization |
EP3848053A1 (en) * | 2015-12-11 | 2021-07-14 | Universität Bern | Inositol derivatives for use in pathological crystallization |
US11707470B2 (en) | 2015-12-11 | 2023-07-25 | Eth Zurich | Inositol derivatives for use in pathological crystallization |
CN106474458B (zh) * | 2017-01-05 | 2020-03-24 | 重庆医科大学 | 白介素-27在治疗艰难梭菌感染中的应用 |
WO2020058321A1 (en) * | 2018-09-18 | 2020-03-26 | Inositec Ag | Calcium oxalate crystallization inhibitors for renal disorders |
KR102651652B1 (ko) | 2018-10-11 | 2024-03-26 | 사니핏 테라퓨틱스 에스.에이. | 이소성 석회화의 치료를 위한 이노시톨 포스페이트 |
KR20210148078A (ko) | 2019-01-30 | 2021-12-07 | 사니핏 테라퓨틱스 에스.에이. | 조직 관류 증가에 사용하기 위한 이노시톨 포스페이트 화합물 |
EP3818983A1 (en) | 2019-11-11 | 2021-05-12 | Sanifit Therapeutics S.A. | Inositol phosphate compounds for use in treating, inhibiting the progression, or preventing cardiovascular calcification |
US20230167140A1 (en) * | 2020-04-30 | 2023-06-01 | Shanghai Senhui Medicine Co., Ltd. | Inositol derivative and use thereof |
CA3199478A1 (en) | 2020-11-20 | 2022-05-27 | Vifor (International) Ag | Inositol hexakisphosphate analogues for treatment of calcification associated kidney diseases |
EP4015494A1 (en) | 2020-12-15 | 2022-06-22 | Sanifit Therapeutics S.A. | Processes for the preparation of soluble salts of inositol phosphates |
US20240100074A1 (en) | 2021-01-26 | 2024-03-28 | Vifor (International) Ag | Clinical Dosing Schedule of Inositol Phosphate Oligo(Ethylene Glycol) Compounds |
WO2024047037A1 (en) | 2022-08-30 | 2024-03-07 | ETH Zürich | Compositions for parenteral sustained release delivery of hydrophilic drugs |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5444901A (en) * | 1977-09-12 | 1979-04-09 | Ricoh Kk | Treating liquid for flat printing plate |
SE8605063D0 (sv) * | 1986-11-26 | 1986-11-26 | Matti Siren | Derivatives of cyclohexane |
GB8705811D0 (en) * | 1987-03-11 | 1987-04-15 | Research Corp Ltd | Inositol derivatives |
EP2054044B1 (de) * | 2006-08-02 | 2014-07-23 | Johannes Gutenberg-Universität Mainz | Arzneimittel gegen lct-vergiftungen |
DE102006062250A1 (de) * | 2006-12-22 | 2008-06-26 | Roland Saur-Brosch | Verwendung einer Zusammensetzung aus Mineralstoffen und/oder Vitaminen und gegebenenfalls acetogenen und/oder butyrogenen Bakterien zur oralen oder rektalen Verabreichung für die Behandlung und Vorbeugung von abdominalen Beschwerden |
US8809392B2 (en) * | 2008-03-28 | 2014-08-19 | Ecolab Usa Inc. | Sulfoperoxycarboxylic acids, their preparation and methods of use as bleaching and antimicrobial agents |
WO2010049921A1 (en) * | 2008-10-31 | 2010-05-06 | Alimentary Health Limited | Disaccharides |
WO2012138963A1 (en) * | 2011-04-06 | 2012-10-11 | The Board Of Regents Of The University Of Texas System | Inositol hexakisphosphate analogs and uses thereof |
-
2012
- 2012-09-28 CN CN201610286773.XA patent/CN105949234B/zh active Active
- 2012-09-28 AU AU2012314932A patent/AU2012314932B2/en active Active
- 2012-09-28 JP JP2014532277A patent/JP5766884B2/ja active Active
- 2012-09-28 ES ES12772882T patent/ES2727633T3/es active Active
- 2012-09-28 EP EP19162400.6A patent/EP3521294A1/en not_active Withdrawn
- 2012-09-28 WO PCT/EP2012/004088 patent/WO2013045107A1/en active Application Filing
- 2012-09-28 EP EP12772882.2A patent/EP2773648B1/en active Active
- 2012-09-28 DK DK12772882.2T patent/DK2773648T3/da active
- 2012-09-28 US US14/347,649 patent/US9358243B2/en active Active
- 2012-09-28 CA CA2849426A patent/CA2849426C/en active Active
- 2012-09-28 MX MX2014003771A patent/MX347723B/es active IP Right Grant
- 2012-09-28 EA EA201490726A patent/EA024069B1/ru not_active IP Right Cessation
- 2012-09-28 PL PL12772882T patent/PL2773648T3/pl unknown
- 2012-09-28 BR BR112014007405-4A patent/BR112014007405B1/pt active IP Right Grant
- 2012-09-28 CN CN201280058049.1A patent/CN103958535A/zh active Pending
-
2014
- 2014-03-25 IL IL231698A patent/IL231698A/en active IP Right Grant
-
2017
- 2017-04-12 AU AU2017202419A patent/AU2017202419B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
CN103958535A (zh) | 2014-07-30 |
CA2849426C (en) | 2020-03-24 |
AU2017202419B2 (en) | 2017-08-31 |
JP2014532049A (ja) | 2014-12-04 |
AU2017202419A1 (en) | 2017-05-11 |
WO2013045107A1 (en) | 2013-04-04 |
EP3521294A1 (en) | 2019-08-07 |
EP2773648A1 (en) | 2014-09-10 |
US20140235590A1 (en) | 2014-08-21 |
AU2012314932B2 (en) | 2017-01-19 |
CN105949234A (zh) | 2016-09-21 |
DK2773648T3 (da) | 2019-05-20 |
EA024069B1 (ru) | 2016-08-31 |
MX2014003771A (es) | 2015-03-20 |
BR112014007405B1 (pt) | 2021-07-13 |
MX347723B (es) | 2017-05-10 |
EP2773648B1 (en) | 2019-03-13 |
NZ624189A (en) | 2015-05-29 |
IL231698A (en) | 2017-06-29 |
ES2727633T3 (es) | 2019-10-17 |
EA201490726A1 (ru) | 2014-08-29 |
AU2012314932A1 (en) | 2014-05-15 |
CN105949234B (zh) | 2018-07-10 |
US9358243B2 (en) | 2016-06-07 |
CA2849426A1 (en) | 2013-04-04 |
PL2773648T3 (pl) | 2020-03-31 |
JP5766884B2 (ja) | 2015-08-19 |
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B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 28/09/2012, OBSERVADAS AS CONDICOES LEGAIS. |