BR112014003974A2 - processo aperfeiçoado para fazer um composto de piperazina alcoxilada - Google Patents

processo aperfeiçoado para fazer um composto de piperazina alcoxilada

Info

Publication number
BR112014003974A2
BR112014003974A2 BR112014003974A BR112014003974A BR112014003974A2 BR 112014003974 A2 BR112014003974 A2 BR 112014003974A2 BR 112014003974 A BR112014003974 A BR 112014003974A BR 112014003974 A BR112014003974 A BR 112014003974A BR 112014003974 A2 BR112014003974 A2 BR 112014003974A2
Authority
BR
Brazil
Prior art keywords
making
improved process
piperazine compound
alkoxylated
alkoxylated piperazine
Prior art date
Application number
BR112014003974A
Other languages
English (en)
Other versions
BR112014003974B1 (pt
Inventor
R Laroche Christophe
A Aguilar Daniel
Original Assignee
Dow Global Technologies Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Global Technologies Llc filed Critical Dow Global Technologies Llc
Publication of BR112014003974A2 publication Critical patent/BR112014003974A2/pt
Publication of BR112014003974B1 publication Critical patent/BR112014003974B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

resumo “processo aperfeiçoado para fazer um composto de piperazina alcoxilada” a presente invenção se refere a um processo aperfeiçoado para fazer compostos de piperazina mono- e di-alcoxilada, especialmente dihidroxietilpiperazina. o aperfeiçoamento compreende a adição de um ácido ao composto de piperazina antes da adição de um óxido de alquileno ao reator onde o composto de piperazina alcoxilada é preparado. tal aperfeiçoamento reduz a concentração de subprodutos de glicol éter indesejáveis que contribuem para cor e espumação indesejáveis dos compostos de piperazina alcoxilada. 1/1
BR112014003974-7A 2011-08-26 2012-08-24 Processo para fazer uma piperazina mono- ou di-alcoxilada através da alcoxilação de um composto de piperazina BR112014003974B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161527822P 2011-08-26 2011-08-26
US61/527,822 2011-08-26
PCT/US2012/052179 WO2013032874A1 (en) 2011-08-26 2012-08-24 Improved process for making alkoxylated piperazine compounds

Publications (2)

Publication Number Publication Date
BR112014003974A2 true BR112014003974A2 (pt) 2017-03-07
BR112014003974B1 BR112014003974B1 (pt) 2019-10-01

Family

ID=46829890

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014003974-7A BR112014003974B1 (pt) 2011-08-26 2012-08-24 Processo para fazer uma piperazina mono- ou di-alcoxilada através da alcoxilação de um composto de piperazina

Country Status (6)

Country Link
US (1) US9169222B2 (pt)
EP (1) EP2748152B1 (pt)
JP (1) JP5973574B2 (pt)
CN (1) CN104011030B (pt)
BR (1) BR112014003974B1 (pt)
WO (1) WO2013032874A1 (pt)

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US846795A (en) * 1905-09-30 1907-03-12 Gen Electric Shaft-bearing.
US2541260A (en) * 1949-06-10 1951-02-13 Colgate Palmolive Peet Co Di-n-alkoxy substituted piperazine derivatives and method of preparing same
JPS5159809A (pt) * 1974-11-15 1976-05-25 Tokuyama Soda Kk
JPS5251307A (en) * 1975-10-21 1977-04-25 Tokuyama Soda Co Ltd Process for preparatio of alkyleneglycolethers
US4757143A (en) * 1986-06-09 1988-07-12 Texaco Inc. Catalytic method for the manufacture of triethylenediamine
CN1067246A (zh) * 1992-05-26 1992-12-23 薛守礼 三乙撑二胺合成新工艺
US5395973A (en) 1993-04-22 1995-03-07 The Dow Chemical Company Processes for making ethanolamines
US5334763A (en) * 1993-04-22 1994-08-02 The Dow Chemical Company Processes for making ethanolamines
ES2111365T3 (es) * 1994-01-31 1998-03-01 Shell Int Research Procedimiento de alcoxilacion.
TW557313B (en) * 1998-02-02 2003-10-11 Ciba Sc Holding Ag Oxopiperazinyl derivatives and light stabilized compositions

Also Published As

Publication number Publication date
CN104011030B (zh) 2016-12-14
BR112014003974B1 (pt) 2019-10-01
JP5973574B2 (ja) 2016-08-23
US20140256944A1 (en) 2014-09-11
CN104011030A (zh) 2014-08-27
EP2748152B1 (en) 2018-03-14
EP2748152A1 (en) 2014-07-02
WO2013032874A1 (en) 2013-03-07
JP2014525415A (ja) 2014-09-29
US9169222B2 (en) 2015-10-27

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according art. 34 industrial property law
B07A Technical examination (opinion): publication of technical examination (opinion)
B15K Others concerning applications: alteration of classification

Free format text: A CLASSIFICACAO ANTERIOR ERA: C07D 241/04

Ipc: C07D 241/04 (1974.07), C07D 295/088 (1990.01)

B09A Decision: intention to grant
B16A Patent or certificate of addition of invention granted

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 24/08/2012, OBSERVADAS AS CONDICOES LEGAIS. (CO) 20 (VINTE) ANOS CONTADOS A PARTIR DE 24/08/2012, OBSERVADAS AS CONDICOES LEGAIS