BR112013026755A2 - derivados da acadesina, produtos e composições que os compreendem, as respectivas utilizações terapêuticas e os respectivos processos de síntese - Google Patents

derivados da acadesina, produtos e composições que os compreendem, as respectivas utilizações terapêuticas e os respectivos processos de síntese

Info

Publication number
BR112013026755A2
BR112013026755A2 BR112013026755A BR112013026755A BR112013026755A2 BR 112013026755 A2 BR112013026755 A2 BR 112013026755A2 BR 112013026755 A BR112013026755 A BR 112013026755A BR 112013026755 A BR112013026755 A BR 112013026755A BR 112013026755 A2 BR112013026755 A2 BR 112013026755A2
Authority
BR
Brazil
Prior art keywords
derivatives
compositions
products
therapeutic uses
relates
Prior art date
Application number
BR112013026755A
Other languages
English (en)
Inventor
Puissant Alexandre
Robert Guillaume
Driowya Mohsine
Auberger Patrick
Benhida Rachid
Malnuit Vincent
Original Assignee
Centre Nat Rech Scient
Inst Nat Sante Rech Med
Univ Nice Sophia Antipolis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre Nat Rech Scient, Inst Nat Sante Rech Med, Univ Nice Sophia Antipolis filed Critical Centre Nat Rech Scient
Publication of BR112013026755A2 publication Critical patent/BR112013026755A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/056—Triazole or tetrazole radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

resumo patente de invenção: "derivados da acadesina, produtos e composições que os compreendem, as respectivas utilizações terapêuticas e os respectivos processos de síntese". a invenção refere-se aos derivados da acadesina a título de medicamento, assim como a esses derivados para o tratamento do câncer e, notadamente, para o tratamento da leucemia mieloide crônica (lmc). a invenção refere-se também a um produto contendo esses derivados e pelo menos a um segundo ativo, como produto de combinação para uma administração simultânea, separada ou aferida no tempo, no tratamento do câncer, assim como uma composição farmacêutica compreendendo esses derivados e um suporte farmaceuticamente aceitável. enfim, a invenção refere-se a um processo de inibição da proliferação celular in vitro, compreendendo a colocação em contato de uma célula in vitro com esses derivados e processos de síntese desses derivados.
BR112013026755A 2011-04-18 2012-04-17 derivados da acadesina, produtos e composições que os compreendem, as respectivas utilizações terapêuticas e os respectivos processos de síntese BR112013026755A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1101204A FR2974089B1 (fr) 2011-04-18 2011-04-18 Derives de l'acadesine, produits et compositions les comprenant, leurs utilisations therapeutiques et leurs procedes de synthese.
PCT/FR2012/000147 WO2012143624A2 (fr) 2011-04-18 2012-04-17 Dérivés de l'acadésine, produits et compositions les comprenant, leurs utilisations thérapeutiques et leurs procédés de synthèse

Publications (1)

Publication Number Publication Date
BR112013026755A2 true BR112013026755A2 (pt) 2017-08-08

Family

ID=46147469

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013026755A BR112013026755A2 (pt) 2011-04-18 2012-04-17 derivados da acadesina, produtos e composições que os compreendem, as respectivas utilizações terapêuticas e os respectivos processos de síntese

Country Status (15)

Country Link
US (1) US9173892B2 (pt)
EP (1) EP2699240B1 (pt)
JP (1) JP2014515026A (pt)
CN (1) CN103619332A (pt)
AU (1) AU2012246159A1 (pt)
BR (1) BR112013026755A2 (pt)
CA (1) CA2832866A1 (pt)
DK (1) DK2699240T3 (pt)
ES (1) ES2544542T3 (pt)
FR (1) FR2974089B1 (pt)
IL (1) IL228812A0 (pt)
PL (1) PL2699240T3 (pt)
PT (1) PT2699240E (pt)
WO (1) WO2012143624A2 (pt)
ZA (1) ZA201307451B (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2494744C1 (ru) * 2012-10-31 2013-10-10 Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов" (ФГУП "ГосНИИгенетика") Лечебное средство с противоопухолевой активностью на основе акадезина
CN107641141B (zh) * 2017-10-31 2021-03-23 天津大学 糖偶联-1,2,3-三氮唑取代的多环芳烃衍生物及制备方法
CN110372675B (zh) * 2019-07-18 2022-11-08 曲阜师范大学 一种n-1和n2-氧烷基取代1,2,3-三氮唑化合物的选择性制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002951247A0 (en) * 2002-09-06 2002-09-19 Alchemia Limited Compounds that interact with kinases
DK1943004T3 (en) * 2005-09-30 2015-08-31 Scripps Research Inst Ruthenium-catalyzed cycloaddition of alkynes and organic azides
EP1921072A1 (en) * 2006-11-10 2008-05-14 Laboratorios del Dr. Esteve S.A. 1,2,3-Triazole derivatives as cannabinoid-receptor modulators
GB0722077D0 (en) * 2007-11-09 2007-12-19 Smithkline Beecham Corp Compounds
EP2113508A1 (en) * 2008-04-30 2009-11-04 INSERM (Institut National de la Santé et de la Recherche Medicale) Novel triazole nucleoside derivatives, their preparation and their application in therapeutics
WO2011019799A2 (en) * 2009-08-11 2011-02-17 The Scripps Research Institute Copper catalyzed cycloaddition of organic azides and 1-haloalkynes

Also Published As

Publication number Publication date
EP2699240B1 (fr) 2015-05-27
ES2544542T3 (es) 2015-09-01
FR2974089A1 (fr) 2012-10-19
AU2012246159A1 (en) 2013-10-31
ZA201307451B (en) 2014-05-28
EP2699240A2 (fr) 2014-02-26
WO2012143624A2 (fr) 2012-10-26
AU2012246159A2 (en) 2014-01-23
JP2014515026A (ja) 2014-06-26
FR2974089B1 (fr) 2014-04-25
CN103619332A (zh) 2014-03-05
US20140179626A1 (en) 2014-06-26
DK2699240T3 (en) 2015-08-24
PT2699240E (pt) 2015-09-11
CA2832866A1 (fr) 2012-10-26
IL228812A0 (en) 2013-12-31
US9173892B2 (en) 2015-11-03
PL2699240T3 (pl) 2015-10-30
WO2012143624A3 (fr) 2012-12-20

Similar Documents

Publication Publication Date Title
MX359989B (es) Fármacos antivirales para el tratamiento de la infección por arenavirus.
WO2012142511A3 (en) Orthomolecular compositions and their use in stabilizing the extracellular matrix
BR112013021537A2 (pt) derivados de tiazolilpenil-benzenosulfonamido como inibidores da quinase
CU20110208A7 (es) Derivados de la piridina de tieno (2,3-b) como inhibidores virales de la réplica
MA37206B1 (fr) Nouveaux derives de pyrrole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
BR112017023764A2 (pt) derivados de ciclohexano substituído por amido
BR112015028879A8 (pt) compostos derivados heterocíclicos, composição farmacêutica compreendendo os referidos compostos e usos dos mesmos
MX2010002278A (es) Farmacos antivirales para el tratamiento de una infeccion por arenavirus.
TW201613593A (en) Molecules for administration to ROS1 mutant cancer cells
BR122019010200B8 (pt) compostos de pirazol-quinazolina, seus sais, produtos ou kits e composições farmacêuticas
CR10056A (es) [(1h-indol-5-il)-heteroariloxi]-(1-aza-biciclo[3.3.1]nonanos como ligandos colinérgicos del n-achr para el tratamiento de trastornos piscóticos y neurodegenerativos
CL2009000780A1 (es) Compuestos derivados de heterociclil-pirano-heterociclilo, heterociclil-oxepina-heterociclilo, benzopirano-heterociclilo y benzoxepina-heterociclilo sustituidos; composicion farmaceutica; procedimiento de preparacion de la composicion; kit farmaceutico; y su uso en el tratamiento del cancer, mediado por la inhibicion de pi3k.
EA200901138A1 (ru) Производные дианилинопиримидина как ингибиторы киназы wee1, фармацевтическая композиция и применение
BR112019024747A2 (pt) formulações de dose fixa
DOP2010000012A (es) Derivados de morfolino pirimidina utilizados en enfermedades relacionadas con mtor quinasa y/o pi3k
UA93673C2 (ru) Фармацевтическая композиция, которая содержит омега-карбоксиарилзамещенную дифенилмочевину, для лечения paka
BRPI0411863A (pt) derivados de pirazolil-indol como inibidores de cinase, processo para seu preparo e composições farmacêuticas compreendendo os mesmos
CL2012003211A1 (es) Compuestos derivados de lactamas sustituidas con piperidinilo, moduladores de gpr119; proceso para preparar los compuestos; composicion farmaceutica que comprende a los compuestos; y uso de los compuestos en la preparacion de medicamentos para el tratamiento o prevencion de diabetes tipo 2, obesidad y condiciones relacionadas
BR112015021856A2 (pt) processos e intermediários para a preparação de um medicamento
MX357780B (es) Derivados policíclicos, proceso para su preparación y su uso farmacéutico.
GB2511685A (en) Muscarinic m1 receptor agonists
UA104988C2 (uk) Похідні піроніндолу та спосіб їх отримання
MX2013003635A (es) Compuestos de n-heteroarilo.
UY32673A (es) Nuevas pirimidinas, composiciones farmaceuticas que las contienen, procedimientos de preparaciones y su aplicacion como medicamentos
BR112018007128A2 (pt) compostos para a inibição de câncer e epigênese

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]