BR112013013544A2 - "usos de poliânions que inibem a atividade citotóxica de histonas" - Google Patents

"usos de poliânions que inibem a atividade citotóxica de histonas"

Info

Publication number: BR112013013544A2
Authority: BR; Brazil
Prior art keywords: polyanions; cytotoxic activity; inhibit histone; histone; inhibit
Prior art date: 2010-12-01

Application number

BR112013013544A

Other languages

English (en)

Other versions

BR112013013544B1 (pt

Inventor

Christopher Richard Parish

Craig Geoffrey Freeman

Ross Wentworth Stephens

Timothy John Senden

Original Assignee

Univ Australian

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-12-01

Filing date

2011-11-29

Publication date

2016-10-11

2011-11-29 Application filed by Univ Australian filed Critical Univ Australian

2016-10-11 Publication of BR112013013544A2 publication Critical patent/BR112013013544A2/pt

2020-09-29 Publication of BR112013013544B1 publication Critical patent/BR112013013544B1/pt

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7016—Disaccharides, e.g. lactose, lactulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/724—Cyclodextrins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Molecular Biology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Dermatology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Virology (AREA)
Diabetes (AREA)
Hematology (AREA)
Tropical Medicine & Parasitology (AREA)
Toxicology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Saccharide Compounds (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)

BR112013013544-1A 2010-12-01 2011-11-29 Uso de um oligossacarídeo polianiônico na fabricação de um medicamento para o tratamento de sepse BR112013013544B1 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US41882610P	2010-12-01	2010-12-01
US61/418,826		2010-12-01
PCT/AU2011/001550 WO2012071611A1 (en)	2010-12-01	2011-11-29	Histone inhibition

Publications (2)

Publication Number	Publication Date
BR112013013544A2 true BR112013013544A2 (pt)	2016-10-11
BR112013013544B1 BR112013013544B1 (pt)	2020-09-29

Family

ID=46171086

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BR112013013544-1A BR112013013544B1 (pt)	2010-12-01	2011-11-29	Uso de um oligossacarídeo polianiônico na fabricação de um medicamento para o tratamento de sepse

Country Status (15)

Country	Link
US (1)	US9226939B2 (pt)
EP (1)	EP2646037B1 (pt)
JP (2)	JP2014501730A (pt)
KR (1)	KR101956335B1 (pt)
CN (1)	CN103402526B (pt)
AU (1)	AU2011335881B2 (pt)
BR (1)	BR112013013544B1 (pt)
CA (1)	CA2819642C (pt)
DK (1)	DK2646037T3 (pt)
ES (1)	ES2710857T3 (pt)
HU (1)	HUE043546T2 (pt)
IL (1)	IL226667A (pt)
NZ (1)	NZ611316A (pt)
SG (1)	SG190438A1 (pt)
WO (1)	WO2012071611A1 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP7330893B2 (ja)	2017-03-10	2023-08-22	ザユニバーシティオブノースカロライナアットチャペルヒル	短時間作用型ヘパリンベースの抗凝集剤化合物及び方法
US11993627B2 (en)	2017-07-03	2024-05-28	The University Of North Carolina At Chapel Hill	Enzymatic synthesis of homogeneous chondroitin sulfate oligosaccharides
EP3691653A4 (en)	2017-11-03	2021-08-11	The University Of North Carolina At Chapel Hill	SULPHATED OLIGOSACCHARIDES SHOWING ANTI-INFLAMMATORY ACTIVITY
CN111479574B (zh) *	2017-12-15	2024-02-09	澳大利亚国立大学	用于治疗和预防细胞外组蛋白介导的病理的化合物
EP3810152A4 (en) *	2018-06-20	2022-04-27	The University of North Carolina at Chapel Hill	CELLULAR PROTECTION METHODS AND COMPOSITIONS
WO2020033824A1 (en) *	2018-08-09	2020-02-13	University Of Vermont And State Agricultural College	Inhibitors of acute severe inflammatory conditions
JP2022530732A (ja) *	2019-02-25	2022-07-01	ジ・オーストラリアン・ナショナル・ユニヴァーシティ	Ｎｅｔ関連合併症を処置及び予防するための化合物
CN116829157A (zh) *	2020-12-01	2023-09-29	远大医药（中国）有限公司	一种聚阴离子纤维二糖苷类化合物的应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4847338A (en) *	1985-03-28	1989-07-11	University Of Iowa Research Foundation	Low molecular weight heparin fragments as inhibitors of complement activation
DK505488D0 (da) *	1987-12-21	1988-09-09	Bar Shalom Daniel	Middel og anvendelse af samme
US5583121A (en) *	1994-01-12	1996-12-10	Michigan State University	Non-anticoagulant chemically modified heparinoids for treating hypovolemic shock and related shock syndromes
CA2158715C (en)	1994-09-21	2005-11-08	Rodney Browitt	A precipitator
AUPN261895A0 (en) *	1995-04-28	1995-05-18	Australian National University, The	Preparation and use of sulfated oligosaccharides
AU3532197A (en)	1997-07-24	1999-02-16	Australian National University, The	Method for detection of fibrin clots
ITMI20021294A1 (it) *	2002-06-12	2003-12-12	Inalco Spa	Polisaccaridi batterici o-solfatati e loro uso
US7468358B2 (en) *	2004-06-16	2008-12-23	Paringenix, Inc.	Method and medicament for sulfated polysaccharide treatment of heparin-induced thrombocytopenia (HIT) syndrome
US20050282775A1 (en)	2004-06-16	2005-12-22	Paringenix, Inc.	Method and medicament for sulfated polysaccharide treatment of inflammation without inducing platelet activation and heparin-induced thrombocytopenia syndrome
US20060229276A1 (en) *	2004-07-28	2006-10-12	Magnus Hook	Use of glycosoaminoglycans for the prevention and treatment of sepsis
JP5053260B2 (ja)	2005-04-29	2012-10-17	ジオーストラリアンナショナルユニバーシティ	炭素封入放射性微粒子の注射用放射性組成物の生成方法
EP1747785A1 (en) *	2005-07-28	2007-01-31	Istituto Clinico Humanitas	Cyclodextrins for blood detoxification
NZ568288A (en) *	2005-11-28	2012-02-24	Verrow Pharmaceuticals Inc	Compositions comprising a a cyclodextrin and a nephrotoxic anticancer drug
WO2007095688A1 (en) *	2006-02-23	2007-08-30	The Australian National University	Methods for increasing the number of circulating cells
GB2450087A (en) *	2007-06-11	2008-12-17	Diosamine Dev Corp	Use of sulphated saccharides in the treatment of inflammatory and/or auto-immune diseases
US8716218B2 (en) *	2007-11-06	2014-05-06	Oklahoma Medical Research Foundation	Extracellular histones as biomarkers for prognosis and molecular targets for therapy
AU2009240789B2 (en)	2008-04-24	2014-06-26	The Australian National University	Methods for radiolabelling macromolecules
JP2011256111A (ja) *	2008-10-03	2011-12-22	Hayashibara Biochem Lab Inc	敗血症の予防及び治療剤

2011
- 2011-11-29 WO PCT/AU2011/001550 patent/WO2012071611A1/en active Application Filing
- 2011-11-29 NZ NZ611316A patent/NZ611316A/en unknown
- 2011-11-29 DK DK11845528.6T patent/DK2646037T3/en active
- 2011-11-29 ES ES11845528T patent/ES2710857T3/es active Active
- 2011-11-29 HU HUE11845528A patent/HUE043546T2/hu unknown
- 2011-11-29 EP EP11845528.6A patent/EP2646037B1/en active Active
- 2011-11-29 KR KR1020137016013A patent/KR101956335B1/ko active IP Right Grant
- 2011-11-29 US US13/990,031 patent/US9226939B2/en active Active
- 2011-11-29 SG SG2013041579A patent/SG190438A1/en unknown
- 2011-11-29 BR BR112013013544-1A patent/BR112013013544B1/pt active IP Right Grant
- 2011-11-29 AU AU2011335881A patent/AU2011335881B2/en active Active
- 2011-11-29 JP JP2013541148A patent/JP2014501730A/ja active Pending
- 2011-11-29 CA CA2819642A patent/CA2819642C/en active Active
- 2011-11-29 CN CN201180066031.1A patent/CN103402526B/zh active Active
2013
- 2013-05-30 IL IL226667A patent/IL226667A/en active IP Right Grant
2016
- 2016-05-27 JP JP2016105792A patent/JP6142039B2/ja active Active

Also Published As

Publication number	Publication date
EP2646037B1 (en)	2019-01-09
AU2011335881B2 (en)	2016-07-14
JP2016193917A (ja)	2016-11-17
US9226939B2 (en)	2016-01-05
NZ611316A (en)	2014-12-24
CN103402526B (zh)	2016-01-20
KR101956335B1 (ko)	2019-03-08
EP2646037A1 (en)	2013-10-09
WO2012071611A1 (en)	2012-06-07
HUE043546T2 (hu)	2019-08-28
BR112013013544B1 (pt)	2020-09-29
CA2819642A1 (en)	2012-06-07
KR20130121877A (ko)	2013-11-06
SG190438A1 (en)	2013-07-31
JP6142039B2 (ja)	2017-06-07
IL226667A (en)	2017-02-28
CA2819642C (en)	2019-07-16
ES2710857T3 (es)	2019-04-29
JP2014501730A (ja)	2014-01-23
EP2646037A4 (en)	2015-03-18
DK2646037T3 (en)	2019-03-04
CN103402526A (zh)	2013-11-20
AU2011335881A1 (en)	2013-06-20
US20130338097A1 (en)	2013-12-19

Legal Events

Date	Code	Title	Description
2018-01-16	B07D	Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
2018-04-03	B06F	Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
2018-07-31	B07E	Notice of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
2019-01-15	B06T	Formal requirements before examination [chapter 6.20 patent gazette]
2019-07-16	B06A	Patent application procedure suspended [chapter 6.1 patent gazette]
2020-05-05	B09A	Decision: intention to grant [chapter 9.1 patent gazette]
2020-09-29	B16A	Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]	Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 29/11/2011, OBSERVADAS AS CONDICOES LEGAIS.

Publication	Publication Date	Title
BR112013013544A2 (pt)	2016-10-11	"usos de poliânions que inibem a atividade citotóxica de histonas"
BR112013006785A2 (pt)	2016-07-05	conjunto de cateter com meio de seurança aperfeiçoado
BR112013002845A2 (pt)	2016-06-07	combinação de susbtâncias ativas
IL222888A0 (en)	2012-12-31	Anchored cardiac ablation catheter
LT2836491T (lt)	2017-03-27	Žmogaus histono metiltransferazės ezh2 slopiklio druskos forma
EP2544642A4 (en)	2014-02-05	WATERPROOF MEDICAL ASSOCIATION PRODUCT
BR112013030398A2 (pt)	2016-12-13	cateter de ablação com balão
EP2509568A4 (en)	2015-12-30	SKIN CARE COMPOSITIONS
GT201200303A (es)	2014-04-29	Formulaciones farmacéuticas
ZA201208286B (en)	2013-07-31	Use of formulations having insecticidal activity
EP2552197A4 (en)	2013-09-25	USE OF A COPOLYMER TO INCREASE THE ACTIVITY OF A PESTICIDE
BR112013015428A2 (pt)	2016-08-02	formulações de aerossol com melhores propriedades de pulverização
HK1179553A1 (en)	2013-10-04	Intercardiac defibrillation catheter system
EE201300004A (et)	2013-08-15	Kombineeritud ravimkoostis sdame-veresoonkonnaga seotud haiguste v?i seisundite raviks
DK2881108T3 (da)	2024-03-11	Forbedrede medicinske aerosolformuleringer
ZA201205128B (en)	2013-03-27	Guarding of livestock
PL2658374T3 (pl)	2016-05-31	Hepatoochronne działanie garcinolu
FR2967657B1 (fr)	2012-11-16	Distributeur unitaire de capsules de beaute
IT1399609B1 (it)	2013-04-26	Ifi16 extracellulare come agente terapeutico
DK2563375T3 (da)	2014-08-18	Farmaceutiske sammensætninger med phosphonium-antimikrobielle midler
ES1075720Y (es)	2012-02-21	Aposito para cubrir el punto de puncion de un cateter
BRPI1014069A2 (pt)	2016-04-12	exoterma controlada de formulações de cianocrilato
DK2593381T3 (da)	2017-01-02	Medicinsk forbrugsvare-emballage
BR112013008937A2 (pt)	2016-06-28	dispositivo ativo estimulador da área perineal
TWM390652U (en)	2010-10-21	Structure to prevent the sprawl of weeds of weeds