BR112013012950A2 - Benzoxazepinas asn inhibidoras de p13k/m tor e métodos de seu uso e fabricação - Google Patents

Benzoxazepinas asn inhibidoras de p13k/m tor e métodos de seu uso e fabricação

Info

Publication number
BR112013012950A2
BR112013012950A2 BR112013012950A BR112013012950A BR112013012950A2 BR 112013012950 A2 BR112013012950 A2 BR 112013012950A2 BR 112013012950 A BR112013012950 A BR 112013012950A BR 112013012950 A BR112013012950 A BR 112013012950A BR 112013012950 A2 BR112013012950 A2 BR 112013012950A2
Authority
BR
Brazil
Prior art keywords
methods
benzoxazepines
asn
manufacture
tor inhibitors
Prior art date
Application number
BR112013012950A
Other languages
English (en)
Inventor
Rice Kenneth
Original Assignee
Exelixis Inc 210
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exelixis Inc 210 filed Critical Exelixis Inc 210
Publication of BR112013012950A2 publication Critical patent/BR112013012950A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

BENZOXAZEPINAS ASN INIBIDORAS DE P13K/M TOR E MÉTODOS DE SEU USO E FABRICAÇÃO. A invenção é direcionada para inibidores de mTOR e sais e solvatos farmaceuticamente aceitáveis destes, tanto quanto métodos de seus usos. Os inibidores são geralmente da fórmula da estrutura I e sais farmaceuticamente aceitáveis destes, caracterizado por: as variáveis serem como definidas neste documento.
BR112013012950A 2010-11-24 2011-11-23 Benzoxazepinas asn inhibidoras de p13k/m tor e métodos de seu uso e fabricação BR112013012950A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41716510P 2010-11-24 2010-11-24
PCT/US2011/062025 WO2012071501A1 (en) 2010-11-24 2011-11-23 Benzoxazepines asn inhibitors of p13k/m tor and methods of their use and manufacture

Publications (1)

Publication Number Publication Date
BR112013012950A2 true BR112013012950A2 (pt) 2017-08-29

Family

ID=45099217

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013012950A BR112013012950A2 (pt) 2010-11-24 2011-11-23 Benzoxazepinas asn inhibidoras de p13k/m tor e métodos de seu uso e fabricação

Country Status (12)

Country Link
US (1) US20140073628A1 (pt)
EP (1) EP2643315A1 (pt)
JP (1) JP2013544826A (pt)
KR (1) KR20130119951A (pt)
CN (1) CN103384667A (pt)
AU (1) AU2011332849A1 (pt)
BR (1) BR112013012950A2 (pt)
CA (1) CA2818898A1 (pt)
EA (1) EA201390757A1 (pt)
MX (1) MX2013005821A (pt)
WO (1) WO2012071501A1 (pt)
ZA (1) ZA201303855B (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI642670B (zh) 2010-09-14 2018-12-01 伊塞利克斯公司 Ｐｉ３ｋ-德爾塔抑制劑以及其應用和生產方法
EA201490905A1 (ru) 2011-11-01 2014-11-28 Экселиксис, Инк. N-(3-{[(3-{[2-хлор-5-(метокси)фенил]амино}хиноксалин-2-ил)амино]сульфонил}фенил)-2-метилаланинамид как ингибитор фосфатидилинозитол-3-киназы для лечения лимфопролиферативных злокачественных заболеваний
CN102786512A (zh) * 2012-05-31 2012-11-21 中国人民解放军军事医学科学院毒物药物研究所 N-芳基不饱和稠环叔胺类化合物及其制备方法和抗肿瘤应用
US10807951B2 (en) * 2017-10-13 2020-10-20 The Regents Of The University Of California mTORC1 modulators

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090233926A1 (en) * 2006-09-14 2009-09-17 Astrazeneca 2-benzimidazolyl-6-morpholino-4-piperidin-4-ylpyrimidine derivatives as pi3k and mtor inhibitors for the treatment of proliferative disorders
MX2011012345A (es) * 2009-05-22 2012-01-31 Exelixis Inc Inhibidores de pi3k/mtor basados en benzoxazepinas contra enfermedades proliferativas.
WO2010135568A1 (en) * 2009-05-22 2010-11-25 Exelixis, Inc. Benzoxazepines as inhibitors of mtor and their use to treat cancer

Also Published As

Publication number Publication date
KR20130119951A (ko) 2013-11-01
EA201390757A1 (ru) 2013-11-29
MX2013005821A (es) 2013-08-27
AU2011332849A1 (en) 2013-06-20
CN103384667A (zh) 2013-11-06
CA2818898A1 (en) 2012-05-31
ZA201303855B (en) 2014-01-29
WO2012071501A1 (en) 2012-05-31
JP2013544826A (ja) 2013-12-19
EP2643315A1 (en) 2013-10-02
US20140073628A1 (en) 2014-03-13

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Legal Events

Date Code Title Description
B15I Others concerning applications: loss of priority
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]