BR112013004514A2 - differentiation of human embryonic stem cells - Google Patents

differentiation of human embryonic stem cells

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Publication number
BR112013004514A2
BR112013004514A2 BR112013004514A BR112013004514A BR112013004514A2 BR 112013004514 A2 BR112013004514 A2 BR 112013004514A2 BR 112013004514 A BR112013004514 A BR 112013004514A BR 112013004514 A BR112013004514 A BR 112013004514A BR 112013004514 A2 BR112013004514 A2 BR 112013004514A2
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BR
Brazil
Prior art keywords
differentiation
stem cells
human embryonic
embryonic stem
cells
Prior art date
Application number
BR112013004514A
Other languages
Portuguese (pt)
Inventor
Alireza Rezania
Original Assignee
Janssen Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Biotech Inc filed Critical Janssen Biotech Inc
Publication of BR112013004514A2 publication Critical patent/BR112013004514A2/en

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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells

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  • Developmental Biology & Embryology (AREA)
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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

diferenciação das células-tronco embrionárias humanas. a presente invenção refere-se a métodos para promover a diferenciação das células-tronco pluripotentes nas células que produzem insulina. em particular, a presente invenção apresenta um método para produzir uma população de células, em que mais do que 85% das células na população expressam marcadores característicos da linhagem endodérmica definitiva.differentiation of human embryonic stem cells. The present invention relates to methods for promoting differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method for producing a cell population, wherein more than 85% of the cells in the population express characteristic markers of the definitive endodermal lineage.

BR112013004514A 2010-08-31 2011-08-17 differentiation of human embryonic stem cells BR112013004514A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37847210P 2010-08-31 2010-08-31
PCT/US2011/048129 WO2012030539A2 (en) 2010-08-31 2011-08-17 Differentiation of human embryonic stem cells

Publications (1)

Publication Number Publication Date
BR112013004514A2 true BR112013004514A2 (en) 2016-06-07

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BR112013004514A BR112013004514A2 (en) 2010-08-31 2011-08-17 differentiation of human embryonic stem cells

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US (2) US9528090B2 (en)
EP (3) EP2611910B1 (en)
JP (1) JP6218605B2 (en)
KR (1) KR101836850B1 (en)
CN (2) CN108517310B (en)
AR (1) AR082820A1 (en)
AU (1) AU2011296382B2 (en)
BR (1) BR112013004514A2 (en)
CA (1) CA2809303C (en)
ES (2) ES2659393T3 (en)
HK (1) HK1243729A1 (en)
MX (1) MX355077B (en)
PL (2) PL2611910T3 (en)
RU (1) RU2627168C2 (en)
SG (2) SG10201506852VA (en)
WO (1) WO2012030539A2 (en)

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