BR112013001257A2 - processo. - Google Patents

processo.

Info

Publication number
BR112013001257A2
BR112013001257A2 BR112013001257A BR112013001257A BR112013001257A2 BR 112013001257 A2 BR112013001257 A2 BR 112013001257A2 BR 112013001257 A BR112013001257 A BR 112013001257A BR 112013001257 A BR112013001257 A BR 112013001257A BR 112013001257 A2 BR112013001257 A2 BR 112013001257A2
Authority
BR
Brazil
Prior art keywords
formula
compound
compounds
dehydrating
intermediates
Prior art date
Application number
BR112013001257A
Other languages
English (en)
Inventor
Douglas Mans
Hao Yin
Joseph Sisko
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of BR112013001257A2 publication Critical patent/BR112013001257A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

processo. a presente invenção diz respeito a um processo que compreende a etapa de desidratar um composto da fórmula (i): com um reagente de desidratação adequado para formar um composto da fórmula (ii): em que r^ 1^-r^ 7^como aqui definido. os compostos da fórmula (ii) têm se mostrado promissores como intermediários para compostos úteis para tratar infecções bacterianas.
BR112013001257A 2010-07-20 2011-07-19 processo. BR112013001257A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36588010P 2010-07-20 2010-07-20
PCT/US2011/044489 WO2012012391A2 (en) 2010-07-20 2011-07-19 Process for preparing pyrano - [2,3-c]pyridine derivatives

Publications (1)

Publication Number Publication Date
BR112013001257A2 true BR112013001257A2 (pt) 2016-05-17

Family

ID=45497409

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013001257A BR112013001257A2 (pt) 2010-07-20 2011-07-19 processo.

Country Status (10)

Country Link
US (1) US8759523B2 (pt)
EP (1) EP2595994B1 (pt)
JP (1) JP5762538B2 (pt)
KR (1) KR20130129902A (pt)
CN (1) CN103492393A (pt)
BR (1) BR112013001257A2 (pt)
EA (1) EA201390016A1 (pt)
ES (1) ES2574179T3 (pt)
SG (1) SG187146A1 (pt)
WO (1) WO2012012391A2 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA41169A (fr) 2014-12-17 2017-10-24 Acraf Composés antibactériens à large spectre d'activité
CN105954913B (zh) 2016-06-24 2021-02-26 京东方科技集团股份有限公司 一种液晶显示器及显示装置
CN112830933A (zh) * 2021-02-04 2021-05-25 康化（上海）新药研发有限公司 一种3,4-二氢-2H-吡喃并[2,3-b]吡啶合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8613786D0 (en) 1986-06-06 1986-07-09 Beecham Group Plc Active compounds
DE10120619A1 (de) * 2001-04-26 2002-10-31 Merck Patent Gmbh 2-(5-(4-Fluorphenyl)-3-pyridylmethylaminomethyl-chroman
BR0214016A (pt) * 2001-11-09 2004-10-13 Upjohn Co Compostos azabicìclico-fenil-fundido heterocìclicos e seu uso como ligandos alfa 7 nachr
AR042486A1 (es) * 2002-12-18 2005-06-22 Glaxo Group Ltd Compuesto de quinolina y naftiridina halosustituido en la posicion 3, procedimiento para preparar el compuesto, composicion farmaceutica que lo comprende y su uso para preparar dicha composicion .

Also Published As

Publication number Publication date
EA201390016A1 (ru) 2013-09-30
US8759523B2 (en) 2014-06-24
EP2595994A2 (en) 2013-05-29
WO2012012391A3 (en) 2013-08-08
EP2595994A4 (en) 2014-12-10
CN103492393A (zh) 2014-01-01
WO2012012391A2 (en) 2012-01-26
US20130116436A1 (en) 2013-05-09
KR20130129902A (ko) 2013-11-29
JP5762538B2 (ja) 2015-08-12
SG187146A1 (en) 2013-02-28
ES2574179T3 (es) 2016-06-15
JP2013541498A (ja) 2013-11-14
EP2595994B1 (en) 2016-04-20

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]