BR112012019881A2 - proteínas de domínio estrutural baseadas na fibronectina que ligam-se à il-23 - Google Patents

proteínas de domínio estrutural baseadas na fibronectina que ligam-se à il-23

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Publication number
BR112012019881A2
BR112012019881A2 BR112012019881A BR112012019881A BR112012019881A2 BR 112012019881 A2 BR112012019881 A2 BR 112012019881A2 BR 112012019881 A BR112012019881 A BR 112012019881A BR 112012019881 A BR112012019881 A BR 112012019881A BR 112012019881 A2 BR112012019881 A2 BR 112012019881A2
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Brazil
Prior art keywords
fibronectin
proteins
structural domain
based structural
bind
Prior art date
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BR112012019881A
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English (en)
Inventor
Bush Alex
Engle Linda
Schneeweis Lumelle
Dasgupta Ruchira
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Bristol Myers Squibb Co
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43901183&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112012019881(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of BR112012019881A2 publication Critical patent/BR112012019881A2/pt

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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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    • C12N15/1034—Isolating an individual clone by screening libraries
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    • C07K2318/00—Antibody mimetics or scaffolds
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction

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Abstract

proteínas de domínio estrutural baseadas na fibronectina que ligam-se à il-23. a presente invenção refere-se à proteína de domínio estrutural baseada na fibronectina que se liga à interleucina 23 (il-23), especificamente à subunidade p19 da il-23. a invenção também refere-se ao uso das proteínas inovadoras em aplicações terapêuticas para o tratamento de doenças autoimunes. a invenção refere-se ainda a células compreendendo tais proteínas, polinucleotídeos codificando tais proteínas ou seus fragmentos, e a vetores que compreendem os polinucleotídeos que codificam as proteínas inovadoras.
BR112012019881A 2010-02-18 2011-02-16 proteínas de domínio estrutural baseadas na fibronectina que ligam-se à il-23 BR112012019881A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30556610P 2010-02-18 2010-02-18
US33070610P 2010-05-03 2010-05-03
PCT/US2011/024959 WO2011103105A1 (en) 2010-02-18 2011-02-16 Fibronectin based scaffold domain proteins that bind il-23

Publications (1)

Publication Number Publication Date
BR112012019881A2 true BR112012019881A2 (pt) 2017-06-27

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ID=43901183

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012019881A BR112012019881A2 (pt) 2010-02-18 2011-02-16 proteínas de domínio estrutural baseadas na fibronectina que ligam-se à il-23

Country Status (19)

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US (2) US8927693B2 (pt)
EP (1) EP2536757B1 (pt)
JP (1) JP2013520426A (pt)
KR (1) KR20130010461A (pt)
CN (1) CN102762591A (pt)
AR (1) AR080229A1 (pt)
AU (1) AU2011218243A1 (pt)
BR (1) BR112012019881A2 (pt)
CA (1) CA2790329A1 (pt)
CL (1) CL2012002296A1 (pt)
EA (1) EA201270713A1 (pt)
HK (1) HK1179276A1 (pt)
MX (1) MX2012009050A (pt)
PE (1) PE20130041A1 (pt)
SG (1) SG183215A1 (pt)
TN (1) TN2012000372A1 (pt)
TW (1) TWI508736B (pt)
WO (1) WO2011103105A1 (pt)
ZA (1) ZA201206969B (pt)

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AR080229A1 (es) 2012-03-21
US8927693B2 (en) 2015-01-06
TW201130501A (en) 2011-09-16
CN102762591A (zh) 2012-10-31
SG183215A1 (en) 2012-09-27
HK1179276A1 (en) 2013-09-27
KR20130010461A (ko) 2013-01-28
TWI508736B (zh) 2015-11-21
EA201270713A1 (ru) 2013-01-30
EP2536757A1 (en) 2012-12-26
AU2011218243A1 (en) 2012-10-04
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US20130012436A1 (en) 2013-01-10
JP2013520426A (ja) 2013-06-06
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MX2012009050A (es) 2012-09-07
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ZA201206969B (en) 2015-06-24
CL2012002296A1 (es) 2013-01-11
US9714281B2 (en) 2017-07-25
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WO2011103105A1 (en) 2011-08-25
CA2790329A1 (en) 2011-08-25

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