BR1100939A - Conjugado veìculo-droga e conjugado proteìna-droga - Google Patents

Conjugado veìculo-droga e conjugado proteìna-droga

Info

Publication number
BR1100939A
BR1100939A BR1100939-0A BR1100939A BR1100939A BR 1100939 A BR1100939 A BR 1100939A BR 1100939 A BR1100939 A BR 1100939A BR 1100939 A BR1100939 A BR 1100939A
Authority
BR
Brazil
Prior art keywords
drug conjugate
protein
vehicle
conjugate
drug
Prior art date
Application number
BR1100939-0A
Other languages
English (en)
Inventor
William J Mcgahren
Martin L Sassiver
George A Ellestad
Original Assignee
William J. Mcgahren
Martin L. Sassiver
George A. Ellestad
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by William J. Mcgahren, Martin L. Sassiver, George A. Ellestad filed Critical William J. Mcgahren
Publication of BR1100939A publication Critical patent/BR1100939A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
    • A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
BR1100939-0A 1987-10-30 1997-05-14 Conjugado veìculo-droga e conjugado proteìna-droga BR1100939A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11494087A 1987-10-30 1987-10-30

Publications (1)

Publication Number Publication Date
BR1100939A true BR1100939A (pt) 1999-08-31

Family

ID=22358378

Family Applications (1)

Application Number Title Priority Date Filing Date
BR1100939-0A BR1100939A (pt) 1987-10-30 1997-05-14 Conjugado veìculo-droga e conjugado proteìna-droga

Country Status (19)

Country Link
EP (2) EP0313874B1 (pt)
JP (2) JP2720933B2 (pt)
KR (2) KR0133130B1 (pt)
AR (1) AR246083A1 (pt)
AT (2) ATE104309T1 (pt)
AU (2) AU618763B2 (pt)
BR (1) BR1100939A (pt)
CA (1) CA1321582C (pt)
DE (2) DE3889063T2 (pt)
DK (2) DK174739B1 (pt)
ES (2) ES2061586T3 (pt)
FI (2) FI95204C (pt)
HK (2) HK131897A (pt)
IE (2) IE65989B1 (pt)
IL (2) IL87946A (pt)
NO (2) NO176480C (pt)
NZ (2) NZ226727A (pt)
PT (2) PT88882B (pt)
ZA (2) ZA888127B (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5079233A (en) * 1987-01-30 1992-01-07 American Cyanamid Company N-acyl derivatives of the LL-E33288 antitumor antibiotics, composition and methods for using the same
US5606040A (en) * 1987-10-30 1997-02-25 American Cyanamid Company Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyl-trithio group
IL115770A (en) * 1989-04-14 1999-03-12 American Cyanamid Co Substituted disulfides of formula q-sp-ss-w their preparation and use for inhibiting the growth of tumours and for treating bacterial infections
GB9007384D0 (en) * 1990-04-02 1990-05-30 Duncan Ruth Coupling between polymers and other organic molecular entities utilising thiol-specific reactive groups
US5712374A (en) * 1995-06-07 1998-01-27 American Cyanamid Company Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates
US5714586A (en) * 1995-06-07 1998-02-03 American Cyanamid Company Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates
US20040009535A1 (en) 1998-11-27 2004-01-15 Celltech R&D, Inc. Compositions and methods for increasing bone mineralization
DK1133558T4 (en) 1998-11-27 2016-05-17 Ucb Sa Compositions and methods for increasing bone mineralization
NZ511705A (en) * 2001-05-14 2004-03-26 Horticulture & Food Res Inst Methods and rapid immunoassay device for detecting progesterone and other steroids
JP4688802B2 (ja) 2003-06-16 2011-05-25 セルテック アール アンド ディー， インコーポレイテッド 骨の鉱化作用を増大させるためのスクレロスチンに特異的な抗体および方法
WO2008028050A2 (en) * 2006-08-30 2008-03-06 Wisconsin Alumni Research Foundation Reversible natural product glycosyltransferase-catalyzed reactions, compounds and related methods
KR100979928B1 (ko) * 2008-07-16 2010-09-03 한주학 수직축형 부력풍차
RU2640197C1 (ru) * 2013-11-04 2017-12-27 Пфайзер Инк. Промежуточные соединения и способы синтеза производных калихеамицина
AU2018211561B2 (en) 2017-01-24 2020-04-30 Pfizer Inc. Calicheamicin derivatives and antibody drug conjugates thereof
BR112021015676A2 (pt) * 2019-02-15 2021-10-05 University Of Southern California Composições de anticorpo lym-1 e lym-2 e construções car aprimoradas
WO2022085762A1 (ja) * 2020-10-22 2022-04-28 富士フイルム株式会社 皮膚感作性測定試薬、化合物、及び皮膚感作性の測定方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2430943A1 (fr) * 1978-07-13 1980-02-08 Toyo Jozo Kk Nouveaux derives disulfures
EP0040506B1 (en) * 1980-05-21 1986-08-20 Teijin Limited Reactive polymer and process for the preparation thereof
US4530835A (en) * 1983-07-08 1985-07-23 Warner-Lambert Company CL-1577 Antibiotic compounds and their production
CA1314245C (en) * 1984-05-23 1993-03-09 Franz Jansen Process for the preparation of conjugates in which a monovalent carboxylic ionophore is associated by means of a covalent bond with a macromolecule, which are useful as immunotoxin potentiators
IL76878A (en) * 1984-11-16 1991-12-15 American Cyanamid Co Antitumor antibiotic ll-33288alpha-br complex and process for its preparation
EP0330874A3 (en) * 1988-02-29 1989-10-18 American Cyanamid Company Antibacterial and antitumor agents LL-E33288 epsilon-I and LL-E33288-epsilonBr, with processes and intermediates for producing said agents
EP0342341A3 (en) * 1988-05-17 1991-07-24 American Cyanamid Company Process for producing antitumor antibiotic ll-e33288gamma2

Also Published As

Publication number Publication date
DK602488A (da) 1989-05-01
FI884984A0 (fi) 1988-10-28
AU2448988A (en) 1989-05-04
NO884833L (no) 1989-05-02
EP0313874B1 (en) 1994-04-13
IL87946A0 (en) 1989-03-31
DE3851682D1 (de) 1994-11-03
ATE104309T1 (de) 1994-04-15
NZ226727A (en) 1991-12-23
IE65989B1 (en) 1995-11-29
JPH0296599A (ja) 1990-04-09
JP2820256B2 (ja) 1998-11-05
EP0313873A1 (en) 1989-05-03
IL87946A (en) 1995-06-29
HK131897A (en) 1997-10-03
DK174739B1 (da) 2003-10-13
ES2061586T3 (es) 1994-12-16
DK602488D0 (da) 1988-10-28
EP0313874A2 (en) 1989-05-03
FI884983A0 (fi) 1988-10-28
KR890006244A (ko) 1989-06-12
EP0313873B1 (en) 1994-09-28
NO884834L (no) 1989-05-02
FI95204B (fi) 1995-09-29
NO884834D0 (no) 1988-10-28
FI95204C (fi) 1996-01-10
FI884983A (fi) 1989-05-01
CA1321582C (en) 1993-08-24
IL87947A0 (en) 1989-03-31
IE883261L (en) 1989-04-30
NO176480B (no) 1995-01-02
NO173506B (no) 1993-09-13
HK131997A (en) 1997-10-03
JPH01193282A (ja) 1989-08-03
PT88882B (pt) 1993-01-29
EP0313874A3 (en) 1990-05-09
AR246083A1 (es) 1994-03-30
PT88881B (pt) 1993-01-29
FI91262B (fi) 1994-02-28
NO176480C (no) 1995-04-12
AU2449488A (en) 1989-05-04
ES2059464T3 (es) 1994-11-16
DE3889063T2 (de) 1994-12-01
AU618763B2 (en) 1992-01-09
DE3889063D1 (de) 1994-05-19
NO884833D0 (no) 1988-10-28
KR890006245A (ko) 1989-06-12
IL87947A (en) 1995-05-26
KR0133130B1 (ko) 1998-04-17
IE883262L (en) 1989-04-30
AU612714B2 (en) 1991-07-18
KR970011385B1 (ko) 1997-07-10
FI91262C (fi) 1994-06-10
JP2720933B2 (ja) 1998-03-04
IE65053B1 (en) 1995-10-04
ATE112172T1 (de) 1994-10-15
ZA888123B (en) 1989-07-26
DE3851682T2 (de) 1995-05-04
NZ226726A (en) 1991-08-27
NO173506C (no) 1993-12-22
DK602588A (da) 1989-05-01
FI884984A (fi) 1989-05-01
DK602588D0 (da) 1988-10-28
ZA888127B (en) 1989-07-26

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Legal Events

Date Code Title Description
AN Processing applications according to articles 230 and 231 of law 9279/96: notification of filing an application
HHFK Processing applications according to articles 230 and 231 of law 9.279/96: republication
MT Patent procedure suspended until requirement met - articles 230 and 231 of law 9279/96
FGAN Processing applications according to articles 230 and 231 of law 9.279/96: granting
NB Patent issued - articles 230 and 231 of law 9279/96
B25D Requested change of name of applicant approved