BR102015030210A2 - an agrochemical composition, a preparation method and the use thereof - Google Patents
an agrochemical composition, a preparation method and the use thereof Download PDFInfo
- Publication number
- BR102015030210A2 BR102015030210A2 BR102015030210A BR102015030210A BR102015030210A2 BR 102015030210 A2 BR102015030210 A2 BR 102015030210A2 BR 102015030210 A BR102015030210 A BR 102015030210A BR 102015030210 A BR102015030210 A BR 102015030210A BR 102015030210 A2 BR102015030210 A2 BR 102015030210A2
- Authority
- BR
- Brazil
- Prior art keywords
- dipropylene
- glycol dibenzoate
- emulsifier
- composition
- diethylene glycol
- Prior art date
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- 239000012872 agrochemical composition Substances 0.000 title claims abstract description 11
- 238000002360 preparation method Methods 0.000 title abstract description 3
- 239000000203 mixture Substances 0.000 claims abstract description 148
- NXQMCAOPTPLPRL-UHFFFAOYSA-N 2-(2-benzoyloxyethoxy)ethyl benzoate Chemical compound C=1C=CC=CC=1C(=O)OCCOCCOC(=O)C1=CC=CC=C1 NXQMCAOPTPLPRL-UHFFFAOYSA-N 0.000 claims abstract description 133
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 73
- PZTAGFCBNDBBFZ-UHFFFAOYSA-N tert-butyl 2-(hydroxymethyl)piperidine-1-carboxylate Chemical group CC(C)(C)OC(=O)N1CCCCC1CO PZTAGFCBNDBBFZ-UHFFFAOYSA-N 0.000 claims abstract description 66
- 239000004480 active ingredient Substances 0.000 claims abstract description 50
- 238000009472 formulation Methods 0.000 claims abstract description 36
- 206010015946 Eye irritation Diseases 0.000 claims abstract description 30
- 231100000013 eye irritation Toxicity 0.000 claims abstract description 30
- 238000000034 method Methods 0.000 claims abstract description 30
- 206010022998 Irritability Diseases 0.000 claims abstract description 22
- 235000014666 liquid concentrate Nutrition 0.000 claims abstract description 12
- -1 alkyl polysaccharide Chemical class 0.000 claims description 37
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 12
- 239000005660 Abamectin Substances 0.000 claims description 10
- KIEDNEWSYUYDSN-UHFFFAOYSA-N clomazone Chemical compound O=C1C(C)(C)CON1CC1=CC=CC=C1Cl KIEDNEWSYUYDSN-UHFFFAOYSA-N 0.000 claims description 10
- 239000004495 emulsifiable concentrate Substances 0.000 claims description 10
- 239000005499 Clomazone Substances 0.000 claims description 9
- OMFRMAHOUUJSGP-IRHGGOMRSA-N bifenthrin Chemical compound C1=CC=C(C=2C=CC=CC=2)C(C)=C1COC(=O)[C@@H]1[C@H](\C=C(/Cl)C(F)(F)F)C1(C)C OMFRMAHOUUJSGP-IRHGGOMRSA-N 0.000 claims description 9
- 239000011575 calcium Substances 0.000 claims description 9
- 229910052791 calcium Inorganic materials 0.000 claims description 9
- 125000002091 cationic group Chemical group 0.000 claims description 9
- NHDHVHZZCFYRSB-UHFFFAOYSA-N pyriproxyfen Chemical compound C=1C=CC=NC=1OC(C)COC(C=C1)=CC=C1OC1=CC=CC=C1 NHDHVHZZCFYRSB-UHFFFAOYSA-N 0.000 claims description 9
- 239000005927 Pyriproxyfen Substances 0.000 claims description 8
- 150000001412 amines Chemical class 0.000 claims description 8
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 8
- 239000000194 fatty acid Substances 0.000 claims description 8
- 229930195729 fatty acid Natural products 0.000 claims description 8
- SILSDTWXNBZOGF-KUZBFYBWSA-N chembl111058 Chemical compound CCSC(C)CC1CC(O)=C(\C(CC)=N\OC\C=C\Cl)C(=O)C1 SILSDTWXNBZOGF-KUZBFYBWSA-N 0.000 claims description 7
- PWPJGUXAGUPAHP-UHFFFAOYSA-N lufenuron Chemical compound C1=C(Cl)C(OC(F)(F)C(C(F)(F)F)F)=CC(Cl)=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F PWPJGUXAGUPAHP-UHFFFAOYSA-N 0.000 claims description 7
- IBSREHMXUMOFBB-JFUDTMANSA-N 5u8924t11h Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O3)C=C[C@H](C)[C@@H](C(C)C)O4)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C.C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 IBSREHMXUMOFBB-JFUDTMANSA-N 0.000 claims description 6
- 229950008167 abamectin Drugs 0.000 claims description 6
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 5
- 239000002728 pyrethroid Substances 0.000 claims description 5
- ZPFAVCIQZKRBGF-UHFFFAOYSA-N 1,3,2-dioxathiolane 2,2-dioxide Chemical compound O=S1(=O)OCCO1 ZPFAVCIQZKRBGF-UHFFFAOYSA-N 0.000 claims description 4
- 239000005874 Bifenthrin Substances 0.000 claims description 4
- 229920002101 Chitin Polymers 0.000 claims description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 4
- VBIIFPGSPJYLRR-UHFFFAOYSA-M Stearyltrimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)C VBIIFPGSPJYLRR-UHFFFAOYSA-M 0.000 claims description 4
- RRZXIRBKKLTSOM-XPNPUAGNSA-N avermectin B1a Chemical compound C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 RRZXIRBKKLTSOM-XPNPUAGNSA-N 0.000 claims description 4
- PLUHAVSIMCXBEX-UHFFFAOYSA-N azane;dodecyl benzenesulfonate Chemical compound N.CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 PLUHAVSIMCXBEX-UHFFFAOYSA-N 0.000 claims description 4
- 230000015572 biosynthetic process Effects 0.000 claims description 4
- KRGHCRNCQJIODP-UHFFFAOYSA-N bis(2-chloroethyl)-ethylazanium;bromide Chemical compound [Br-].ClCC[NH+](CC)CCCl KRGHCRNCQJIODP-UHFFFAOYSA-N 0.000 claims description 4
- 239000004359 castor oil Substances 0.000 claims description 4
- 235000019438 castor oil Nutrition 0.000 claims description 4
- 150000002148 esters Chemical class 0.000 claims description 4
- QUSNBJAOOMFDIB-UHFFFAOYSA-O ethylaminium Chemical group CC[NH3+] QUSNBJAOOMFDIB-UHFFFAOYSA-O 0.000 claims description 4
- 150000004665 fatty acids Chemical class 0.000 claims description 4
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 4
- 239000003112 inhibitor Substances 0.000 claims description 4
- XYFMGGWVGACNEC-UHFFFAOYSA-N n-carbamoyl-n-phenylbenzamide Chemical compound C=1C=CC=CC=1N(C(=O)N)C(=O)C1=CC=CC=C1 XYFMGGWVGACNEC-UHFFFAOYSA-N 0.000 claims description 4
- 239000003921 oil Substances 0.000 claims description 4
- 150000002923 oximes Chemical class 0.000 claims description 4
- 229920001282 polysaccharide Polymers 0.000 claims description 4
- 239000005017 polysaccharide Substances 0.000 claims description 4
- 238000003786 synthesis reaction Methods 0.000 claims description 4
- 241000607479 Yersinia pestis Species 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims 6
- 239000012875 nonionic emulsifier Substances 0.000 claims 6
- 235000008504 concentrate Nutrition 0.000 abstract description 17
- 239000012141 concentrate Substances 0.000 abstract description 17
- 239000000839 emulsion Substances 0.000 abstract description 16
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 25
- 239000002904 solvent Substances 0.000 description 15
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 13
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical group OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 11
- UBTJXEAITXFMMC-UHFFFAOYSA-N benzoic acid;prop-1-ene Chemical compound CC=C.CC=C.OC(=O)C1=CC=CC=C1.OC(=O)C1=CC=CC=C1 UBTJXEAITXFMMC-UHFFFAOYSA-N 0.000 description 10
- UXRWLQVKULNEIR-UHFFFAOYSA-N pentacosa-3,9,11,15-tetraene Chemical compound CCCCCCCCCC=CCCC=CC=CCCCCC=CCC UXRWLQVKULNEIR-UHFFFAOYSA-N 0.000 description 10
- 231100000419 toxicity Toxicity 0.000 description 8
- 230000001988 toxicity Effects 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 7
- 239000004202 carbamide Substances 0.000 description 7
- 125000000129 anionic group Chemical group 0.000 description 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 5
- YEJRWHAVMIAJKC-UHFFFAOYSA-N 4-Butyrolactone Chemical compound O=C1CCCO1 YEJRWHAVMIAJKC-UHFFFAOYSA-N 0.000 description 4
- 210000003711 chorioallantoic membrane Anatomy 0.000 description 4
- 231100000344 non-irritating Toxicity 0.000 description 4
- 239000003960 organic solvent Substances 0.000 description 4
- DHXVGJBLRPWPCS-UHFFFAOYSA-N Tetrahydropyran Chemical compound C1CCOCC1 DHXVGJBLRPWPCS-UHFFFAOYSA-N 0.000 description 3
- 150000004945 aromatic hydrocarbons Chemical class 0.000 description 3
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 3
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 3
- 230000002209 hydrophobic effect Effects 0.000 description 3
- 239000002085 irritant Substances 0.000 description 3
- 231100000021 irritant Toxicity 0.000 description 3
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 3
- PBIJFSCPEFQXBB-UHFFFAOYSA-N 1,1-dimethylcyclopropane Chemical compound CC1(C)CC1 PBIJFSCPEFQXBB-UHFFFAOYSA-N 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- 239000005912 Lufenuron Substances 0.000 description 2
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 description 2
- 239000003905 agrochemical Substances 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- MRWHYFHNFINGHU-UHFFFAOYSA-N benzoic acid;ethene Chemical compound C=C.C=C.OC(=O)C1=CC=CC=C1.OC(=O)C1=CC=CC=C1 MRWHYFHNFINGHU-UHFFFAOYSA-N 0.000 description 2
- 150000008280 chlorinated hydrocarbons Chemical class 0.000 description 2
- 239000002917 insecticide Substances 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 229960000521 lufenuron Drugs 0.000 description 2
- YNKFZRGTXAPYFD-UHFFFAOYSA-N n-[[2-chloro-3,5-bis(trifluoromethyl)phenyl]carbamoyl]-2,6-difluorobenzamide Chemical compound FC1=CC=CC(F)=C1C(=O)NC(=O)NC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1Cl YNKFZRGTXAPYFD-UHFFFAOYSA-N 0.000 description 2
- 239000003495 polar organic solvent Substances 0.000 description 2
- 150000005846 sugar alcohols Polymers 0.000 description 2
- CJDWRQLODFKPEL-UHFFFAOYSA-N teflubenzuron Chemical compound FC1=CC=CC(F)=C1C(=O)NC(=O)NC1=CC(Cl)=C(F)C(Cl)=C1F CJDWRQLODFKPEL-UHFFFAOYSA-N 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- XAIPTRIXGHTTNT-UHFFFAOYSA-N triflumuron Chemical compound C1=CC(OC(F)(F)F)=CC=C1NC(=O)NC(=O)C1=CC=CC=C1Cl XAIPTRIXGHTTNT-UHFFFAOYSA-N 0.000 description 2
- ZXQYGBMAQZUVMI-RDDWSQKMSA-N (1S)-cis-(alphaR)-cyhalothrin Chemical compound CC1(C)[C@H](\C=C(/Cl)C(F)(F)F)[C@@H]1C(=O)O[C@@H](C#N)C1=CC=CC(OC=2C=CC=CC=2)=C1 ZXQYGBMAQZUVMI-RDDWSQKMSA-N 0.000 description 1
- BTYQXKURSPAXLT-UHFFFAOYSA-N 2,6-dichloro-n-[(4-chlorophenyl)carbamoyl]benzamide Chemical compound C1=CC(Cl)=CC=C1NC(=O)NC(=O)C1=C(Cl)C=CC=C1Cl BTYQXKURSPAXLT-UHFFFAOYSA-N 0.000 description 1
- JTHMHWAHAKLCKT-UHFFFAOYSA-N 2,6-difluoro-n-[[4-(trifluoromethyl)phenyl]carbamoyl]benzamide Chemical compound FC1=CC=CC(F)=C1C(=O)NC(=O)NC1=CC=C(C(F)(F)F)C=C1 JTHMHWAHAKLCKT-UHFFFAOYSA-N 0.000 description 1
- YPSCQJTUAKNUNF-UHFFFAOYSA-N 2-chloro-n-[(4-chlorophenyl)carbamoyl]benzamide Chemical compound C1=CC(Cl)=CC=C1NC(=O)NC(=O)C1=CC=CC=C1Cl YPSCQJTUAKNUNF-UHFFFAOYSA-N 0.000 description 1
- AZSNMRSAGSSBNP-UHFFFAOYSA-N 22,23-dihydroavermectin B1a Natural products C1CC(C)C(C(C)CC)OC21OC(CC=C(C)C(OC1OC(C)C(OC3OC(C)C(O)C(OC)C3)C(OC)C1)C(C)C=CC=C1C3(C(C(=O)O4)C=C(C)C(O)C3OC1)O)CC4C2 AZSNMRSAGSSBNP-UHFFFAOYSA-N 0.000 description 1
- ZOGDSYNXUXQGHF-UHFFFAOYSA-N 5-(3-butanoyl-2,4,6-trimethylphenyl)-2-(N-ethoxy-C-ethylcarbonimidoyl)-3-hydroxycyclohex-2-en-1-one Chemical compound CCCC(=O)C1=C(C)C=C(C)C(C2CC(=O)C(C(CC)=NOCC)=C(O)C2)=C1C ZOGDSYNXUXQGHF-UHFFFAOYSA-N 0.000 description 1
- SPBDXSGPUHCETR-JFUDTMANSA-N 8883yp2r6d Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O[C@@H]([C@@H](C)CC4)C(C)C)O3)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C.C1C[C@H](C)[C@@H]([C@@H](C)CC)O[C@@]21O[C@H](C\C=C(C)\[C@@H](O[C@@H]1O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C1)[C@@H](C)\C=C\C=C/1[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\1)O)C[C@H]4C2 SPBDXSGPUHCETR-JFUDTMANSA-N 0.000 description 1
- 241000532370 Atla Species 0.000 description 1
- FTTFCJDGMIRORE-UHFFFAOYSA-N C1CC(C(CC)=NOCC)=C(O)CC1C1=C(C)C=C(C)C=C1C Chemical compound C1CC(C(CC)=NOCC)=C(O)CC1C1=C(C)C=C(C)C=C1C FTTFCJDGMIRORE-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 239000005501 Cycloxydim Substances 0.000 description 1
- 239000005893 Diflubenzuron Substances 0.000 description 1
- 239000005894 Emamectin Substances 0.000 description 1
- KIWBPDUYBMNFTB-UHFFFAOYSA-N Ethyl hydrogen sulfate Chemical compound CCOS(O)(=O)=O KIWBPDUYBMNFTB-UHFFFAOYSA-N 0.000 description 1
- WPPOGHDFAVQKLN-UHFFFAOYSA-N N-Octyl-2-pyrrolidone Chemical compound CCCCCCCCN1CCCC1=O WPPOGHDFAVQKLN-UHFFFAOYSA-N 0.000 description 1
- 239000004721 Polyphenylene oxide Substances 0.000 description 1
- 239000005938 Teflubenzuron Substances 0.000 description 1
- 239000005942 Triflumuron Substances 0.000 description 1
- 230000000895 acaricidal effect Effects 0.000 description 1
- 239000000642 acaricide Substances 0.000 description 1
- 150000001338 aliphatic hydrocarbons Chemical class 0.000 description 1
- 150000004996 alkyl benzenes Chemical class 0.000 description 1
- 239000012874 anionic emulsifier Substances 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- VEMKTZHHVJILDY-UXHICEINSA-N bioresmethrin Chemical compound CC1(C)[C@H](C=C(C)C)[C@H]1C(=O)OCC1=COC(CC=2C=CC=CC=2)=C1 VEMKTZHHVJILDY-UXHICEINSA-N 0.000 description 1
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- GGWHBJGBERXSLL-NBVRZTHBSA-N chembl113137 Chemical compound C1C(=O)C(C(=N/OCC)/CCC)=C(O)CC1C1CSCCC1 GGWHBJGBERXSLL-NBVRZTHBSA-N 0.000 description 1
- UISUNVFOGSJSKD-UHFFFAOYSA-N chlorfluazuron Chemical compound FC1=CC=CC(F)=C1C(=O)NC(=O)NC(C=C1Cl)=CC(Cl)=C1OC1=NC=C(C(F)(F)F)C=C1Cl UISUNVFOGSJSKD-UHFFFAOYSA-N 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- GGWHBJGBERXSLL-UHFFFAOYSA-N cycloxydim Chemical compound C1C(=O)C(C(=NOCC)CCC)=C(O)CC1C1CSCCC1 GGWHBJGBERXSLL-UHFFFAOYSA-N 0.000 description 1
- ZXQYGBMAQZUVMI-UNOMPAQXSA-N cyhalothrin Chemical compound CC1(C)C(\C=C(/Cl)C(F)(F)F)C1C(=O)OC(C#N)C1=CC=CC(OC=2C=CC=CC=2)=C1 ZXQYGBMAQZUVMI-UNOMPAQXSA-N 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- QQQYTWIFVNKMRW-UHFFFAOYSA-N diflubenzuron Chemical compound FC1=CC=CC(F)=C1C(=O)NC(=O)NC1=CC=C(Cl)C=C1 QQQYTWIFVNKMRW-UHFFFAOYSA-N 0.000 description 1
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- 239000002270 dispersing agent Substances 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- QLFZZSKTJWDQOS-YDBLARSUSA-N doramectin Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O3)C=C[C@H](C)[C@@H](C3CCCCC3)O4)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C QLFZZSKTJWDQOS-YDBLARSUSA-N 0.000 description 1
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- CXEGAUYXQAKHKJ-NSBHKLITSA-N emamectin B1a Chemical compound C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](NC)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 CXEGAUYXQAKHKJ-NSBHKLITSA-N 0.000 description 1
- RYLHNOVXKPXDIP-UHFFFAOYSA-N flufenoxuron Chemical compound C=1C=C(NC(=O)NC(=O)C=2C(=CC=CC=2F)F)C(F)=CC=1OC1=CC=C(C(F)(F)F)C=C1Cl RYLHNOVXKPXDIP-UHFFFAOYSA-N 0.000 description 1
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- RGNPBRKPHBKNKX-UHFFFAOYSA-N hexaflumuron Chemical compound C1=C(Cl)C(OC(F)(F)C(F)F)=C(Cl)C=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F RGNPBRKPHBKNKX-UHFFFAOYSA-N 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
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- 150000002576 ketones Chemical class 0.000 description 1
- 150000002596 lactones Chemical class 0.000 description 1
- 239000005910 lambda-Cyhalothrin Substances 0.000 description 1
- 239000012669 liquid formulation Substances 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- JZMJDSHXVKJFKW-UHFFFAOYSA-M methyl sulfate(1-) Chemical compound COS([O-])(=O)=O JZMJDSHXVKJFKW-UHFFFAOYSA-M 0.000 description 1
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 description 1
- YTYGAJLZOJPJGH-UHFFFAOYSA-N noviflumuron Chemical compound FC1=C(Cl)C(OC(F)(F)C(C(F)(F)F)F)=C(Cl)C=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F YTYGAJLZOJPJGH-UHFFFAOYSA-N 0.000 description 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 description 1
- 239000003090 pesticide formulation Substances 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- 229920000570 polyether Polymers 0.000 description 1
- 229920000151 polyglycol Polymers 0.000 description 1
- 239000010695 polyglycol Substances 0.000 description 1
- KRQUFUKTQHISJB-UHFFFAOYSA-N profoxydim Chemical compound OC=1CC(C2CSCCC2)CC(=O)C=1C(CCC)=NOCC(C)OC1=CC=C(Cl)C=C1 KRQUFUKTQHISJB-UHFFFAOYSA-N 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- AFJYYKSVHJGXSN-KAJWKRCWSA-N selamectin Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1C(/C)=C/C[C@@H](O[C@]2(O[C@@H]([C@@H](C)CC2)C2CCCCC2)C2)C[C@@H]2OC(=O)[C@@H]([C@]23O)C=C(C)C(=N\O)/[C@H]3OC\C2=C/C=C/[C@@H]1C AFJYYKSVHJGXSN-KAJWKRCWSA-N 0.000 description 1
- 229960002245 selamectin Drugs 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/32—Ingredients for reducing the noxious effect of the active substances to organisms other than pests, e.g. toxicity reducing compositions, self-destructing compositions
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
- A01N35/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical at least one of the bonds to hetero atoms is to nitrogen
- A01N35/10—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical at least one of the bonds to hetero atoms is to nitrogen containing a carbon-to-nitrogen double bond
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/34—Nitriles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
- A01N47/34—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the groups, e.g. biuret; Thio analogues thereof; Urea-aldehyde condensation products
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N53/00—Biocides, pest repellants or attractants, or plant growth regulators containing cyclopropane carboxylic acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N2300/00—Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Agronomy & Crop Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Toxicology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
uma composição agroquímica, um método de preparação do mesmo e o uso da mesma. é provida uma composição agroquímica, a composição compreendendo pelo menos um dibenzoato de glicol de dipropileno/dietileno, pelo menos um ingrediente ativo e pelo menos um emulsificante. a presença do dibenzoato de glicol de dipropileno/dietileno reduz a irritabilidade da composição reduzindo especialmente a irritação dos olhos causada pelo ingrediente ativo e o emulsificante. a composição é preferencialmente um concentrado líquido, em particular uma formulação de concentrado de emulsão (ec).an agrochemical composition, a method of preparation thereof and the use thereof. An agrochemical composition is provided, the composition comprising at least one dipropylene / diethylene glycol dibenzoate, at least one active ingredient and at least one emulsifier. The presence of dipropylene / diethylene glycol dibenzoate reduces the irritability of the composition especially reducing eye irritation caused by the active ingredient and the emulsifier. the composition is preferably a liquid concentrate, in particular an emulsion concentrate (c) formulation.
Description
UMA COMPOSIÇÃO AGROQUÍMICA, UM MÉTODO DE PREPARAÇÃO DO MESMO E O USO DA MESMA Campo da Invenção [0001] As formulações de concentrados emulsif icáveis (EC) são um tipo de formulação muito comum para a preparação e uso de composições que compreendem componentes ativos agroquimicamente. No entanto, ditas formulações exigem quantidades substanciais de solventes orgânicos, tais como hidrocarbonetos aromáticos, hidrocarbonetos clorados, e similares, junto com emulsificantes aniônicos e não iônicos para estabilizar os ingredientes ativos nas formulações. Com essa combinação de componentes, os produtos formulados têm uma boa qualidade e geralmente têm um bom desempenho em aplicações de campo. No entanto, a maioria dos produtos formulados dessa maneira causam severe irritação grave de olhos aos usuários. Consequentemente, as ditas formulações são geralmente classificadas como sendo perigosas. Por exemplo, os concentrados emulsificáveis são classificados como Categoria de Toxicidade I (Cat I) no Brasil. Tendo o conhecimento de que as formulações rotuladas como "Categoria de Toxicidade I" podem causar irritação dos olhos, os fazendeiros e outros usuários finais ficam relutantes em comprar e em usar os ditos produtos.AN AGROCHEMICAL COMPOSITION, A METHOD FOR PREPARING THE SAME AND THE USE OF THE SAME Field of the Invention Emulsifiable Concentrate (EC) formulations are a very common type of formulation for the preparation and use of compositions comprising agrochemically active components. However, such formulations require substantial amounts of organic solvents such as aromatic hydrocarbons, chlorinated hydrocarbons, and the like, together with anionic and nonionic emulsifiers to stabilize the active ingredients in the formulations. With this combination of components, formulated products are of good quality and generally perform well in field applications. However, most products formulated in this manner cause severe severe eye irritation to users. Accordingly, said formulations are generally classified as being dangerous. For example, emulsifiable concentrates are classified as Toxicity Category I (Cat I) in Brazil. Knowing that formulations labeled "Toxicity Category I" can cause eye irritation, farmers and other end users are reluctant to purchase and use such products.
[0002] A técnica anterior não oferece uma solução para os problemas de se utilizar os solventes e emulsificantes em formulações de concentrados de emulsão (EC). Atualmente, as formulações de concentrados de emulsão comerciais causam irritação grave dos olhos. Consequentemente, foram feitas tentativas para evitar o uso de solventes orgânicos, tais como hidrocarbonetos clorados ou aromáticos, e ao invés disso usar solventes alternativos que tenham efeitos tóxicos reduzidos. Exemplos dos ditos solventes alternativos são hidrocarbonetos alifáticos, alcóois, glicóis, poliglicóis, éteres de glicol, cetonas, bem como solventes polares com um alto poder de solvente, tais como gama-butirolactona, Pirrolidona N-metila, e similares.The prior art does not offer a solution to the problems of using solvents and emulsifiers in emulsion concentrate (EC) formulations. Currently, commercial emulsion concentrate formulations cause severe eye irritation. Consequently, attempts have been made to avoid the use of organic solvents, such as chlorinated or aromatic hydrocarbons, and instead to use alternative solvents that have reduced toxic effects. Examples of said alternative solvents are aliphatic hydrocarbons, alcohols, glycols, polyglycols, glycol ethers, ketones, as well as polar solvents with a high solvent power, such as gamma butyrolactone, N-methyl pyrrolidone, and the like.
[0003] No entanto, a irritação dos olhos não é causada somente pelos solventes, porém pode ser causada também por ingrediente ativos e emulsificantes presentes na formulação. Os emulsificantes, por exemplo, emulsificantes aniônicos, são importantes para aumentar a dispersabilidade espontânea da formulação em água e a estabilidade da formulação diluida. Sulfonato de alquilbenzeno de cálcio é um tipo de emulsificante aniônico usado frequentemente em formulações de concentrados de emulsão. No entanto, esses tipos de emulsificantes aniônicos causam irritação grave dos olhos. Consequentemente, mesmo se a composição for formulada com solventes que são não-irritantes para os olhos, a formulação pode ainda causar irritação grave dos olhos por causa da presença de ingredientes ativos e emulsificantes .However, eye irritation is not only caused by solvents, but may also be caused by active ingredients and emulsifiers present in the formulation. Emulsifiers, for example anionic emulsifiers, are important for increasing the spontaneous dispersibility of the formulation in water and the stability of the diluted formulation. Calcium alkylbenzene sulfonate is a type of anionic emulsifier often used in emulsion concentrate formulations. However, these types of anionic emulsifiers cause severe eye irritation. Accordingly, even if the composition is formulated with solvents that are non-irritating to the eye, the formulation may still cause severe eye irritation due to the presence of active ingredients and emulsifiers.
[0004] WO 02/045507 descreve um concentrado microemulsificável que compreende um ingrediente ativo hidrofóbico e pelo menos um tensoativo dissolvido em um sistema de solvente que compreende um alcanolato hidrofóbico de alquila insolúvel em água, como um primeiro solvente, e um álcool polihidrico ou um condensado de alcóois polihidricos e misturas desses, como um segundo solvente. As formulações são relatadas exibindo reduzida irritação dos olhos.WO 02/045507 describes a microemulsifiable concentrate comprising a hydrophobic active ingredient and at least one surfactant dissolved in a solvent system comprising a water insoluble alkyl hydrophobic alkanolate as a first solvent, and a polyhydric alcohol or a condensate of polyhydric alcohols and mixtures thereof as a second solvent. Formulations are reported to exhibit reduced eye irritation.
[0005] WO 2006/002984 revela uma composição de concentrado liquido que compreende um ingrediente ativo insolúvel em água, pelo menos um solvente orgânico que tem uma solubilidade de água de pelo menos 10 g/L, e pelo menos um copolimero de bloco não-iônico que compreende pelo menos uma porção de óxido de polietileno e pelo menos uma porção de poliéter hidrofóbico. O solvente orgânico é capaz de dissolver o ingrediente ativo. O problema de irritação dos olhos não é discutido ou de alguma maneira tratado no WO 2006/002984.WO 2006/002984 discloses a liquid concentrate composition comprising a water-insoluble active ingredient, at least one organic solvent having a water solubility of at least 10 g / l, and at least one non-block block copolymer. which comprises at least a portion of polyethylene oxide and at least a portion of hydrophobic polyether. The organic solvent is capable of dissolving the active ingredient. The problem of eye irritation is not discussed or otherwise addressed in WO 2006/002984.
[0006] Existe uma necessidade continua para se descobrir componentes seguros, preferencialmente substancialmente inertes, componentes para formular os concentrados líquidos, com o intuito de prover uma formulação que não irrite os olhos. Seria vantajoso se os componentes da formulação pudessem reduzir também a irritabilidade por ingrediente ativos e por emulsificantes para os olhos dos usuários.There is a continuing need to find safe, preferably substantially inert, components for formulating liquid concentrates in order to provide a non-eye irritating formulation. It would be advantageous if the formulation components could also reduce irritability by active ingredients and emulsifiers to the users' eyes.
[0007] Foi descoberto de maneira surpreendente que determinados dibenzoatos de glicol de dipropileno/dietileno não somente não causam irritação aos olhos, como também reduzem a irritação dos olhos causada pelos ingredientes ativos e pelos emulsificantes presentes na formulação.It has been surprisingly found that certain dipropylene / diethylene glycol dibenzoates not only do not cause eye irritation, but also reduce eye irritation caused by the active ingredients and emulsifiers present in the formulation.
[0008] Consequentemente, em um primeiro aspecto, a presente invenção provê uma composição agroquímica que compreende pelo menos um dibenzoato de glicol de dipropileno/dietileno, pelo menos um ingrediente ativo e pelo menos um emulsificante.Accordingly, in a first aspect, the present invention provides an agrochemical composition comprising at least one dipropylene / diethylene glycol dibenzoate, at least one active ingredient and at least one emulsifier.
[0009] Dibenzoatos de glicol de dipropileno/dietileno são eles mesmos não irritantes. Foi descoberto que a presença do dibenzoato de glicol de dipropileno/dietileno na composição agroquímica reduz significativamente a toxicidade da formulação, em particular, reduz a irritabilidade da formulação aos olhos. Em particular, parece que o dibenzoato de glicol de dipropileno/dietileno reduz ou substancialmente anula a irritabilidade dos ingredientes ativos e dos emulsificantes aos olhos.Dipropylene / diethylene glycol dibenzoates are themselves non-irritating. The presence of dipropylene / diethylene glycol dibenzoate in the agrochemical composition has been found to significantly reduce the toxicity of the formulation, in particular, it reduces the irritability of the formulation to the eyes. In particular, it appears that dipropylene / diethylene glycol dibenzoate reduces or substantially nullifies the irritability of the active ingredients and emulsifiers to the eyes.
[0010] Conforme descrito em mais detalhes abaixo, foi descoberto que o dibenzoato de glicol de dipropileno/dietileno é eficaz na redução da irritabilidade das formulações de concentrados líquidos. Então, a inclusão de dibenzoato de glicol de dipropileno/dietileno em concentrados líquidos reduz a irritabilidade dos olhos da formulação. Além disso, foi descoberto que o uso de dibenzoato de glicol de dipropileno/dietileno em formulações de pesticidas de concentrados líquidos é amigável em termos de meio ambiente.As described in more detail below, it has been found that dipropylene / diethylene glycol dibenzoate is effective in reducing irritability of liquid concentrate formulations. Thus, the inclusion of dipropylene glycol dibenzoate / diethylene in liquid concentrates reduces the eye irritability of the formulation. In addition, it has been found that the use of dipropylene / diethylene glycol dibenzoate in liquid concentrate pesticide formulations is environmentally friendly.
[0011] O dibenzoato de glicol de dipropileno/dietileno está presente em uma composição da presente invenção em uma quantidade suficiente para reduzir a irritabilidade dos outros componentes em uma composição, em particular a irritação dos olhos por ingredientes ativos e emulsificantes presentes. A quantidade de dibenzoato de glicol de dipropileno/dietileno necessária será determinada pelos ingredientes ativos e pelos emulsificantes particulares empregados em uma composição e suas quantidades. A quantidade do dibenzoato de glicol de dipropileno/dietileno necessário para reduzir ou eliminar a irritabilidade dos olhos da formulação pode ser determinada sem experimentação indevida pela pessoa com habilidade, por exemplo por tentativa e erro.Dipropylene / diethylene glycol dibenzoate is present in a composition of the present invention in an amount sufficient to reduce irritability of the other components in a composition, in particular eye irritation by active ingredients and emulsifiers present. The amount of dipropylene / diethylene glycol dibenzoate required will be determined by the active ingredients and the particular emulsifiers employed in a composition and their amounts. The amount of dipropylene / diethylene glycol dibenzoate required to reduce or eliminate eye irritability of the formulation can be determined without undue experimentation by the skilled person, for example by trial and error.
[0012] O dibenzoato de glicol de dipropileno/dietileno é eficaz para reduzir a irritabilidade dos olhos pelo ingrediente ativo quando estiver presente em uma ampla faixa de razões de peso para o ingrediente ativo. 0 dibenzoato de glicol de dipropileno/dietileno está presente preferencialmente em uma quantidade pelo menos igual a ou, mais preferencialmente, que ultrapassa a quantidade do ingrediente ativo. A razão de peso do dibenzoato de glicol de dipropileno/dietileno para o ingrediente ativo é preferencialmente de pelo menos 1:1, em algumas modalidades preferidas de pelo menos 1:2, em outras modalidades preferidas de pelo menos 1:3. Em particular, o dibenzoato de glicol de dipropileno/dietileno está preferencialmente presente em uma quantidade para prover uma razão de peso do ingrediente ativo para o dibenzoato de glicol de dipropileno/dietileno a partir de 1:1 até 1:100, preferencialmente a partir de 1:1 até 1:90, mais preferencialmente a partir de 1:2 até 1:20, ainda mais preferencialmente a partir de 1:3 até 1:15.Dipropylene / diethylene glycol dibenzoate is effective in reducing eye irritability by the active ingredient when present in a wide range of weight ratios for the active ingredient. Dipropylene / diethylene glycol dibenzoate is preferably present in an amount at least equal to or more preferably greater than the amount of the active ingredient. The weight ratio of dipropylene / diethylene glycol dibenzoate to active ingredient is preferably at least 1: 1, in some preferred embodiments of at least 1: 2, in other preferred embodiments of at least 1: 3. In particular, dipropylene / diethylene glycol dibenzoate is preferably present in an amount to provide a weight ratio of the active ingredient to dipropylene / diethylene glycol dibenzoate from 1: 1 to 1: 100, preferably from 1: 1 to 1:90, more preferably from 1: 2 to 1:20, even more preferably from 1: 3 to 1:15.
[0013] O dibenzoato de glicol de dipropileno/dietileno é eficaz na redução da irritabilidade dos olhos por emulsificantes em uma ampla faixa de razões de peso. Em muitas modalidades, o dibenzoato de glicol de dipropileno/dietileno está presente em uma composição em uma quantidade pelo menos igual a, mais preferencialmente que ultrapassa a quantidade total do emulsificante presente. A razão de peso do dibenzoato de glicol de dipropileno/dietileno para o conteúdo total de emulsificante de uma composição é preferencialmente pelo menos de 0,1, mais preferencialmente de pelo menos 0,2. A razão de peso do dibenzoato de glicol de dipropileno/dietileno para o conteúdo total de emulsif icante de uma composição pode ser a partir de 0,1 até 60, preferencialmente a partir de 0,2 até 60. Em uma série de modalidades, uma razão de peso a partir de 0,3 até 10, mais particularmente a partir de 0,4 até 8 foi descoberta como sendo eficaz. Quantidades superiores do dibenzoato de glicol de dipropileno/dietileno podem ser empregadas, por exemplo em razões de peso para o conteúdo de emulsificante a partir de 10 até 50. Em muitas modalidades, uma razão de peso de dibenzoato de glicol de dipropileno/dietileno para o conteúdo de emulsificante de menos de 15, mais preferencialmente menos de 10 é eficaz.Dipropylene / diethylene glycol dibenzoate is effective in reducing eye irritability by emulsifiers over a wide range of weight ratios. In many embodiments, dipropylene / diethylene glycol dibenzoate is present in a composition in an amount at least equal to, more preferably exceeding the total amount of emulsifier present. The weight ratio of dipropylene / diethylene glycol dibenzoate to the total emulsifier content of a composition is preferably at least 0.1, more preferably at least 0.2. The weight ratio of dipropylene glycol dibenzoate / diethylene to the total emulsifier content of a composition may be from 0.1 to 60, preferably from 0.2 to 60. In a number of embodiments, a Weight ratio from 0.3 to 10, more particularly from 0.4 to 8 has been found to be effective. Higher amounts of dipropylene / diethylene glycol dibenzoate may be employed, for example in weight ratios of emulsifier content from 10 to 50. In many embodiments, a weight ratio of dipropylene / diethylene glycol dibenzoate to Emulsifier content of less than 15, more preferably less than 10 is effective.
[0014] O dibenzoato de glicol de dipropileno/dietileno pode estar presente em uma composição em uma quantidade de pelo menos 2% por peso, preferencialmente a partir de 10% por peso, mais preferencialmente a partir de 20% por peso. Em modalidades preferidas, o dibenzoato de glicol de dipropileno/dietileno está presente em uma composição em uma quantidade a partir de 2 até 90% por peso, preferencialmente a partir de 10 até 80% por peso, mais preferencialmente a partir de 20 até 70% por peso de uma composição.Dipropylene / diethylene glycol dibenzoate may be present in a composition in an amount of at least 2% by weight, preferably from 10% by weight, more preferably from 20% by weight. In preferred embodiments, dipropylene / diethylene glycol dibenzoate is present in a composition in an amount from 2 to 90% by weight, preferably from 10 to 80% by weight, more preferably from 20 to 70% by weight. by weight of a composition.
[0015] A composição pode compreender dibenzoato glicol de dipropileno, dibenzoato glicol de dietileno ou uma combinação de dibenzoato glicol de dipropileno e de dibenzoato glicol de dietileno.The composition may comprise dipropylene glycol dibenzoate, diethylene glycol dibenzoate or a combination of dipropylene glycol dibenzoate and diethylene glycol dibenzoate.
[0016] Cconforme mencionado acima, a presente invenção provê uma composição agroquimica que compreende pelo menos um ingrediente agroquimicamente ativo. Foi descoberto que a presença de um ou mais dibenzoatos de glicol de dipropileno/dietileno é eficaz para reduzir a irritabilidade de uma faixa de ingredientes ativos. Os ingredientes ativos adequados paa uso em uma composição da presente invenção são bem conhecidos na técnica e estão disponíveis comercialmente.As mentioned above, the present invention provides an agrochemical composition comprising at least one agrochemically active ingredient. The presence of one or more dipropylene / diethylene glycol dibenzoates has been found to be effective in reducing the irritability of a range of active ingredients. Suitable active ingredients for use in a composition of the present invention are well known in the art and are commercially available.
[0017] Conforme observado acima, os dibenzoatos de glicol de dipropileno/dietileno foram descobertos como sendo eficazes na redução da toxicidade, em particular de uma irritabilidade dos olhos, de uma faixa de ingredientes ativos. Em uma modalidade, a composição da presente invenção compreende, como um ingrediente ativo clomazona (2-(2-clorobenzil)- 4,4-dimetil-l,2-oxazolidin-3-ona) .As noted above, dipropylene / diethylene glycol dibenzoates have been found to be effective in reducing the toxicity, in particular of eye irritability, of a range of active ingredients. In one embodiment, the composition of the present invention comprises as an active ingredient clomazone (2- (2-chlorobenzyl) -4,4-dimethyl-1,2-oxazolidin-3-one).
[0018] Foi descoberto também que os dibenzoatos de glicol de dipropileno/dietileno são eficazes na redução da toxicidade, em particular a irritabilidade dos olhos, de acaricidas e inseticidas de éster de piretróide. Ditos piretróides são conhecidos na técnica e incluem, por exemplo, cihalotrina ( (RS)-cx-ciano-3-fenoxibenzil ( Z)- (1RS,3RS)-3-(2-cloro- 3,3,3-triflúorprop- 1- enil)-2,2-carboxilato de dimetilciclopropano), cipermetrina ((RS)- a-ciano-3-fenoxibenzil (1RS,3RS;1RS,3SR)-3-(2,2-diclorovinil)-2,2-carboxilato de dimetil ciclopropano), deltametrina ((S)-a-ciano-3-fenoxibenzil (lR,3R)-3- (2,2-dibromovinil)-2,2-carboxilato de dimetilciclopropano), lambda-cihalotrina ( (S)-a- ciano-3-fenoxibenzil (Z)-(IR,3R)-3-(2-cloro-3,3,3-triflúorprop-1-enil)-2,2- carboxilato de dimetilciclopropano e (R)—ciano-3-fenoxibenzil (Z)- (IS,3S)-3- (2-cloro-3,3,3-triflúorprop-1-enil)-2,2-carboxilato de dimetilciclopropano). Um piretróide particularmente adequado é bifentrina.Dipropylene / diethylene glycol dibenzoates have also been found to be effective in reducing toxicity, in particular eye irritability, to pyrethroid ester acaricides and insecticides. Said pyrethroids are known in the art and include, for example, cyhalothrin ((RS) -Cx-cyano-3-phenoxybenzyl (Z) - (1RS, 3RS) -3- (2-chloro-3,3,3-trifluoropropyl). Dimethylcyclopropane-1-enyl) -2,2-carboxylate) ((RS) -α-cyano-3-phenoxybenzyl) (1RS, 3RS; 1RS, 3SR) -3- (2,2-dichlorovinyl) -2,2-carboxylate dimethylcyclopropane-carboxylate), ((S) -α-cyano-3-phenoxybenzyl (1R, 3R) -3- (2,2-dibromovinyl) -2,2-carboxylate of dimethylcyclopropane), lambda-cyhalothrin (( Dimethylcyclopropane S) -Acyan-3-phenoxybenzyl (Z) - (IR, 3R) -3- (2-chloro-3,3,3-trifluorprop-1-enyl) -2,2-carboxylate and (R ) —Cyano-3-phenoxybenzyl (Z) - (IS, 3S) -3- (2-chloro-3,3,3-trifluorprop-1-enyl) -2,2-carboxylate). A particularly suitable pyrethroid is bifenthrin.
[0019] Em uma modalidade, a composição da presente invenção compreende, como um ingrediente ativo piriproxifena (4-fenoxifenil (RS)-2-(2-piridiloxi)propil éter).In one embodiment, the composition of the present invention comprises as an active ingredient pyriproxyphene (4-phenoxyphenyl (RS) -2- (2-pyridyloxy) propyl ether).
[0020] Foi descoberto também que os dibenzoatos de glicol de dipropileno/dietileno são eficazes na redução da toxicidade, em particular uma irritabilidade dos olhos, de herbicidas de oxima de ciclohexima, incluindo carboxilato de aloxidima (metil (1RS)-3-[(E)-1 - (aliloxiimino)butil]-4-hidroxi-6,6-dimetil-2-oxociclohex-3-eno), butroxidima ((5RS)-5-(3-butiril-2,4,6-trimetilfenil)- 2- [(EZ)-1-(etoxiimino)propil]-3-hidroxiciclohex-2-en-l- ona) , cletodima ( (5RS)-2-{ (1EZ)-1-[ (2E)-3-cloroaliloxi imino]propil}-5-[(2RS)-2-(etiltio)propil]-3- hidroxiciclohex-2-en-l-ona), cloproxidim ((5RS)-2-{(EZ)-ΙΕ (2EZ)-3-cloroaliloxiimino]butil}-5-[(2RS)-2-(etil tio)propil]-3-hidroxiciclohex-2-en-l-ona), cicloxidim ( {5RS)-2-[ (EZ)-1-(etoxi imino)butil]-3-hidroxi-5-[(3RS)-tian-3-il]ciclohex-2-en-l-ona), profoxidim ((5RS)-2 —{ (EZ)—1— [ (2RS)-2-(4-clorofenoxi)propoxiimino]butil}-3- hidroxi-5-[(3RS)-tian-3- il]ciclohex-2-en-l-ona), setoxidim ((5RS)-2-[(EZ)-1-(etoxiimino)butil]-5-[(2RS)- 2- (etiltio)propil]-3-hidroxiciclohex-2-en-l-ona), tepraloxidim ((5RS)-2-{(EZ)-1- [ (2E)-3- cloroaliloxiimino]propil}-3-hidroxi-5-perhidropiran-4-ilciclohex-2-en-l-ona) , e tralkoxidlm ( (RS)-2-[ (EZ)-1- (etoxiimino)propil]-3-hidroxi-5-mesitilciclohex-2-en-l-ona). Os dibenzoatos de glicol de dipropileno/dietileno são particularmente eficazes na redução da irritabilidade por cletodima.Dipropylene / diethylene glycol dibenzoates have also been found to be effective in reducing the toxicity, in particular eye irritability, of cyclohexime oxime herbicides, including aloxidime (methyl (1RS) -3 - [( E) -1- (allyloxyimino) butyl] -4-hydroxy-6,6-dimethyl-2-oxocyclohex-3-ene), butroxydime ((5RS) -5- (3-butyryl-2,4,6-trimethylphenyl ) - 2 - [(EZ) -1- (ethoxyimino) propyl] -3-hydroxycyclohex-2-en-1-one), clethodime ((5RS) -2 - {(1EZ) -1 - [(2E) - 3-chloroalyloxyimino] propyl} -5 - [(2RS) -2- (ethylthio) propyl] -3-hydroxycyclohex-2-en-1-one), cloproxidim ((5RS) -2 - {(EZ) -ΙΕ (2EZ) -3-chloroalyloxyimino] butyl} -5 - [(2RS) -2- (ethylthio) propyl] -3-hydroxycyclohex-2-en-1-one), cycloxydim ({5RS) -2 - [( EZ) -1- (ethoxyimino) butyl] -3-hydroxy-5 - [(3RS) -thian-3-yl] cyclohex-2-en-1-one), profoxidim ((5RS) -2 - {( EZ) —1— [(2RS) -2- (4-chlorophenoxy) propoxyimino] butyl} -3-hydroxy-5 - [(3RS) -thian-3-yl] cyclohex-2-en-1-one), methoxydim ((5RS) -2 - [(EZ) -1- (ethoxyimino) butyl] -5 - [(2RS) -2- (et ylthio) propyl] -3-hydroxycyclohex-2-en-1-one), tepraloxidim ((5RS) -2 - {(EZ) -1 - [(2E) -3-chloroalyloxyimino] propyl} -3-hydroxy-5 -perhydropyran-4-ylcyclohex-2-en-1-one), and tralkoxidyl ((RS) -2 - [(EZ) -1- (ethoxyimino) propyl] -3-hydroxy-5-mesitylcyclohex-2-ene) canvas). Dipropylene / diethylene glycol dibenzoates are particularly effective in reducing irritation by clethodime.
[0021] Foi ainda descoberto que os dibenzoatos de glicol de dipropileno/dietileno são eficazes na redução da toxicidade, em particular de uma irritabilidade dos olhos, de inibidores de síntese de quitina de benzoilfeniluréia, incluindo bistrifluron (1-[2-cloro-3,5-bis(triflúormetil)fenil]-3-(2,6-diflúorbenzoil)uréia), clorbenzuron (1- (2-clorobenzoil)-3-(4-clorofenil)uréia) , clorfluazuron (1-[3,5-dicloro-4-(3-cloro-5-triflúormetil-2-piridiloxi)fenil]-3-(2,6-diflúorbenzoil) uréia), diclorbenzuron (1- (4-clorofenil)-3-(2,6- diclorobenzoil)uréia) , diflubenzuron (1-(4-clorofenil)-3-(2,6-dif lúorbenzoil) uréia) , f lucicloxuron (1-{ qí-[ (EZ)-4- cloro-a-ciclopropilbenzilidenoaminooxi]-p-tolil}-3-(2 , 6-diflúor benzoil) uréia (razão de 50 até 80% (E) - e 50 -20% de (Z)-isômeros), flufenoxuron (1-[4-(2-cloro-a,a,a- triflúor-p-toliloxi)-2-flúorfenil]-3-(2,6-diflúor benzoil)uréia) , hexaflumuron (1-[3,5-dicloro-4-(1,1,2,2- tetraflúoretoxi)fenil] -3- (2,6-diflúorbenzoil)uréia), lufenuron ( (RS)-1-[2,5-dicloro-4- (1,1,2,3,3,3-hexa flúorpropoxi)fenil]-3-(2,6-diflúorbenzoil)uréia), novaluron ((RS)-1-[3-cloro-4-(1,l,2-triflúor-2-triflúormetoxietoxi)fenil]-3-(2,6-diflúorbenzoil)uréia), noviflumuron (1-{3,5-dicloro-2-flúor-4-[ (RS )-1,1,2,3,3,3-hexaflúorpropoxi]fenil}-3- (2,6-diflúorbenzoil)uréia) , penfluron (1-(2,6-diflúorbenzoil)-3-(a,a,a-triflúor-p-tolil)uréia), teflubenzuron (1-(3,5-dicloro-2,4- diflúorfenil)-3-(2,6-diflúorbenzoil) uréia), e triflumuron (1-(2-clorobenzoil)-3-(4-triflúornetoxifenil)uréia) . Os dibenzoatos de glicol de dipropileno/dietileno são particularmente eficazes na redução de uma irritabilidade por lufenuron.Dipropylene / diethylene glycol dibenzoates have also been found to be effective in reducing the toxicity, in particular of an eye irritability, of benzoylphenylurea chitin synthesis inhibitors, including bistrifluron (1- [2-chloro-3 , 5-bis (trifluoromethyl) phenyl] -3- (2,6-difluorobenzoyl) urea), chlororbenzuron (1- (2-chlorobenzoyl) -3- (4-chlorophenyl) urea), chlorfluazuron (1- [3,5 -dichloro-4- (3-chloro-5-trifluoromethyl-2-pyridyloxy) phenyl] -3- (2,6-difluorenzoyl) urea), dichlorenzuron (1- (4-chlorophenyl) -3- (2,6- dichlorobenzoyl) urea), diflubenzuron (1- (4-chlorophenyl) -3- (2,6-difluorenzoyl) urea), flucicloxuron (1- {q- [(EZ) -4-chloro-α-cyclopropylbenzylidenoaminooxy] - p-tolyl} -3- (2,6-difluoro benzoyl) urea (50 to 80% (E) - and 50 -20% (Z) -isomers) ratio, flufenoxuron (1- [4- (2- chloro-a, α, α-trifluoro-p-tolyloxy) -2-fluorophenyl] -3- (2,6-difluoro benzoyl) urea), hexaflumuron (1- [3,5-dichloro-4- (1,1 2,2-tetrafluoroethoxy) phenyl] -3- (2,6-difluorbenz oil) urea), lufenuron ((RS) -1- [2,5-dichloro-4- (1,1,2,3,3,3-hexa fluoropropoxy) phenyl] -3- (2,6-difluoroenzoyl) urea), novaluron ((RS) -1- [3-chloro-4- (1,1,2-trifluoro-2-trifluoromethoxyethoxy) phenyl] -3- (2,6-difluoroenzoyl) urea), noviflumuron (1- {3,5-dichloro-2-fluoro-4 - [(RS) -1,1,2,3,3,3-hexafluoropropoxy] phenyl} -3- (2,6-difluoroenzoyl) urea), penfluron (1 - (2,6-difluoroenzoyl) -3- (α, α, α-trifluoro-p-tolyl) urea), teflubenzuron (1- (3,5-dichloro-2,4-difluorophenyl) -3- (2, 6-difluorobenzoyl) urea), and triflumuron (1- (2-chlorobenzoyl) -3- (4-trifluoromethoxyphenyl) urea). Dipropylene / diethylene glycol dibenzoates are particularly effective in reducing lufenuron irritability.
[0022] Foi ainda descoberto que os dibenzoatos de glicol de dipropileno/dietileno são eficazes na redução da toxicidade, em particular uma irritabilidade dos olhos, por inseticidas, acaracidas e nematacidas de avermectina, incluindo abamectina (mistura de > 80% de (10E,14E,16E)-(IR,4S,5'S,6S,6'R,8R,12S,13S,20R,21R,24S)-6'- [(S)-sec-butil]-21,24-dihidroxi-5',11,13,22-tetrametil-2-oxo-(3,7,19-trioxa tetra ciclo [15.6.1.14'8.020,24] pentacosa- 10,14,16,22-tetraeno)-6-spiro-2' -(5',6'-dihidro-2'H-piran)-12-il 2,6-dideoxi-4-0-(2,6-dideoxi-3-0-metil-a-L-arabino- hexopiranosil) -3-O-metil-a-L-arabino-hexopiranosida e b 20% de (10E,14E,16E) - (IR,4S,5'S,6S,6'R,8R,12S,13S,20R,21R,24S)-21,24-dihidroxi-6'-isopropil-5',11,13,22-tetrametil-2-oxo-(3,7,19-tr roxa tetra ciclo [15.6.1.14'8.020,24] pentacosa-10,14 , 16,22-tetraeno )-6-spiro-2'-(5',6'-dihidro-2'H-piran)-12-il 2,6- dideoxi-4-Ο-(2,6-dideoxi- 3-O-metil-a-L-arabino- hexopiranosil)-3-O-metil-a-L-arabino-hexopiranosida), doramectina ( {10E, 14E,16E)- (1R,4 S,5'S,6S,6' R,8R,12S,13S,20R,21R,24S)-6'- ciclohexil-21,24-dihidroxi-5',11,13,22-tetrametil-2-oxo-(3,7 , 19-trioxa tetra ciclo [15.6.1.14'8.020,24] pentacosa-10,14,16,22-tetraeno)-6-spiro-2'-(5',6'-dihidro-2'H-piran)- 12-il 2,6- dideoxi-4-0-(2,6-dideoxi-3-0-metil-a-L-arabino-hexopiranosil)-3-0- metil-a-L-arabino-hexopiranosida) , emamectina (mistura de 2 90% de (10E,14E,16E)- (IR,4S,5'S,6S,6'R,8R,12S,13S,20R,21R,24S)-6'-[(S)-sec-butil]-21,24-dihidroxi-5',11,13,22-tetrametil-2-oxo-(3,7,19-trioxatetraciclo [15.6.1.14'8.020,24] pentacosa- 10.14.16.22- tetraeno)-6-spiro-2' -(5',6'-dihidro-2'H-piran)- 12-il 2,6-dideoxi- 3-0-metil-4-0-(2,4,6-trideoxi-3-0-metil-4-metilamino-a-L-lyxo-hexapiranosil)-oí-L-arabino-hexapiranosida e d 10% de (10E,14E,16E)- (IR,4S,5'S,6S,6'R,8R,12S,13S,20R,21R,24S)-21,24-dihidroxi- 6'-isopropil-5',11,13,22-tetrametil-2-oxo-(3,7,19-trioxatetraciclo [15.6.1.14'8.020,24] pentacosa-10,14,16,22-tetraeno )-6-spiro-2'-(5',6'-dihidro-2'H-piran)-12-il 2,6- dideoxi-3-0-metil-4-O- (2,4,6-trideoxi-3-0-metil-4- metilamino-a-L-lyxo-hexapiranosil)-a-L-arabino-hexapiranosida), eprinomectiona (mistura de (10E,14E,16E)-(1R,4S,5'S,6S,6'R,8R, 12S,13S,20R,21R,24S)-6'-[(S)-sec- butil]-21,24-dihidroxi-5',11,13,22-tetrametil-2-oxo-(3,7,19-trioxatetraciclo [15.6.1.14'8.020,24] pentacosa- 10.14.16.22- tetraeno)-6-spiro-2'-(5',6'-dihidro-2'H-piran)- 12-il 4-0-(4-acetamido-2,4,6-trideoxi-3-0-metil- a-L-lyxo- hexopiranosil)-2,6-dideoxi-3-0-metil-a-L-arabino-hexopiranosida (componente maior) e de (10E,14E,16E)-(IR,4S,5'S,6S,6'R,8R,12S,13S,20R, 21R,24S)-21,24-dihidroxi- 6'-isopropil-5',11,13,22-tetrametil-2-oxo-(3,7,19-trioxatetraciclo [15.6.1.14'8.020,24] pentacosa-10,14 , 16,22-tetraeno) -6-spiro-2' - (5',6'-dihidro-2'H-piran)-12-il 4-0- (4-acetamido-2,4,6-trideoxi-3-0-metil-a-L-lyxo-hexopiranosil)-2,6-dideoxi-3-0-metil-a-L-arabino-hexopiranosida (componente menor)), ivermectina (mistura de (10E,14E,16E)-(IR,4S,5'S,6R,6' R,8R,12S,13S,20R,2 IR,24S)-6'-[ (S)-sec-butil]-21,24-dihidroxi-5',11,13,22-tetrametil-2-oxo- (3,7,19-trioxatetraciclo [15.6.1.14'8.020,24] pentacosa- 10.14.16.22- tetraeno)-6-spiro-2' -(tetrahidropiran)-12-il 2.6- dideoxi-4-O-(2,6-dideoxi-3-0-netil-a-L-arabino- hexopiranosil)-3-0-metil-a-L-arabino-hexopiranosida e (10E,14E,16E)-(IR,4S,5'S,6R,6 'R,8R,12S,13S,2OR,2 IR,24S)- 21,24-dihidroxi-6'-isopropil-5',11,13,22-tetrametil-2-oxo-(3,7,19-trioxatetraciclo [15.6.1.14,8.020,24] pentacosa- 10.14.16.22- tetraeno)-6-spiro-2' -(tetrahidropiran)-12-il 2.6- dideoxi-4-0-(2,6-dideoxi-3-0-netil-a-L-arabino- hexopiranosil)-3-O-metil-a-L-arabino-hexopiranosida) , e selamectina ((10E,14E,16E,21Z)- (1R,4 S,5'S,6R,6'S,8R,12S,13S,20R,2IR,24S)-6'-ciclohexil-2 4-hidroxi-21-hidroxiimino-5',11,13,22-tetrametil-2-oxo-(3,7,19-trioxatetraciclo [15.6.1.14,8.020,24] pentacosa- 10.14.16.22- tetraeno)-6-spiro-2'-(tetrahidropiran)-12-il 2.6- dideoxi-3-0-metil-a-L-arabino-hexopiranosida). Os dibenzoatos de glicol de dipropileno/dietileno são particularmente eficazes na redução de uma irritabilidade por abamectina.It has further been found that dipropylene / diethylene glycol dibenzoates are effective in reducing toxicity, in particular eye irritability, by avermectin insecticides, acaracides and nematacides including abamectin (> 80% mixture of (10E, 14E, 16E) - (IR, 4S, 5'S, 6S, 6'R, 8R, 12S, 13S, 20R, 21R, 24S) -6'- [(S) -sec-butyl] -21,24-dihydroxy- 5 ', 11,13,22-tetramethyl-2-oxo- (3,7,19-trioxa tetra-cyclo [15.6.1.14'8.020,24] pentacosa-10,14,16,22-tetraene) -6-spiro -2 '- (5', 6'-dihydro-2'H-pyran) -12-yl 2,6-dideoxy-4-0- (2,6-dideoxy-3-0-methyl-α-L-arabino- hexopyranosyl) -3-O-methyl-α-L-arabinohexopyranoside and 20% (10E, 14E, 16E) - (IR, 4S, 5'S, 6S, 6'R, 8R, 12S, 13S, 20R, 21R, 24S ) -21,24-dihydroxy-6'-isopropyl-5 ', 11,13,22-tetramethyl-2-oxo- (3,7,19-tr purple tetra-cyclo [15.6.1.14'8.020,24] pentacosa- 10.14,16,22-tetraene) -6-spiro-2 '- (5', 6'-dihydro-2'H-pyran) -12-yl 2,6-dideoxy-4-Ο- (2, 6-Dideoxy-3-O-methyl-α-L-arabinohexopyranosyl) -3-O-methyl-α-L-arabinohexopyranoside), doramectin ({10E , 14E, 16E) - (1R, 4S, 5'S, 6S, 6'R, 8R, 12S, 13S, 20R, 21R, 24S) -6'-cyclohexyl-21,24-dihydroxy-5 ', 11,13 , 22-tetramethyl-2-oxo- (3,7,19-trioxa tetracyclo [15.6.1.14'8.020,24] pentacosa-10,14,16,22-tetraene) -6-spiro-2 '- (5 ', 6'-dihydro-2'H-pyran) -12-yl 2,6-dideoxy-4-0- (2,6-dideoxy-3-O-methyl-Î ± -Araninohexopyranosyl) -3-0 - methyl-ΔL-arabinohexopyranoside), emamectin (mixture of 2 90% (10E, 14E, 16E) - (IR, 4S, 5'S, 6S, 6'R, 8R, 12S, 13R, 21R, 24S ) -6 '- [(S) -sec-butyl] -21,24-dihydroxy-5', 11,13,22-tetramethyl-2-oxo- (3,7,19-trioxatetracyclo [15.6.1.14'8.020 24] pentacosa-10.14.16.22-tetraene) -6-spiro-2 '- (5', 6'-dihydro-2'H-pyran) -12-yl 2,6-dideoxy-3-O-methyl 4-0- (2,4,6-trideoxy-3-0-methyl-4-methylamino-ΔL-lyxohexapyranosyl) -o-L-arabinohexapyranoside ed 10% (10E, 14E, 16E) - ( IR, 4S, 5'S, 6S, 6'R, 8R, 12S, 13S, 20R, 21R, 24S) -21,24-dihydroxy-6'-isopropyl-5 ', 11,13,22-tetramethyl-2-oxo - (3,7,19-trioxatetracyclo [15.6.1.14'8.020,24] pentacosa-10,14,16,22-tetraene) -6-spiro-2 '- (5', 6'-dihydro-2'H -pyran) -12-yl 2,6- dideoxy-3-O-methyl-4-O- (2,4,6-trideoxy-3-O-methyl-4-methylamino-ΔL-lyxo-hexapyranosyl) -α-L-arabinohexapyranoside), eprinomectiona (mixture of ( 10E, 14E, 16E) - (1R, 4S, 5'S, 6S, 6'R, 8R, 12S, 13S, 20R, 21R, 24S) -6 '- [(S) -secryl] -21,24- dihydroxy-5 ', 11,13,22-tetramethyl-2-oxo- (3,7,19-trioxatetracyclo [15.6.1.14'8.020,24] pentacosa-10.14.16.22-tetraene) -6-spiro-2'- (5 ', 6'-Dihydro-2'H-pyran) -12-yl 4-0- (4-acetamido-2,4,6-trideoxy-3-O-methyl-α-L-hexoxyheanosyl) -2 , 6-dideoxy-3-O-methyl-α-L-arabinohexopyranoside (major component) and (10E, 14E, 16E) - (IR, 4S, 5'S, 6S, 6'R, 8R, 12S, 13S, 20R , 21R, 24S) -21,24-dihydroxy-6'-isopropyl-5 ', 11,13,22-tetramethyl-2-oxo- (3,7,19-trioxatetracyclo [15.6.1.14'8.020,24] pentacosa -10,14,16,22-tetraene) -6-spiro-2 '- (5', 6'-dihydro-2'H-pyran) -12-yl 4-0- (4-acetamido-2,4 , 6-trideoxy-3-O-methyl-αL-lyxohexopyranosyl) -2,6-dideoxy-3-O-methyl-αL-arabinhexopyranoside (minor component)), ivermectin (mixture of (10E, 14E, 16E) - (IR, 4S, 5'S, 6R, 6'R, 8R, 12S, 13S, 20R, 2 IR, 24S) -6 '- [(S) -sec-butyl] -21,24-dihydroxy-5 ', 11,13,22-tetramethyl-2-oxo- (3,7,19-trioxatetracyclo [15.6.1.14'8.020,24] pentacosa-10.14.16.22- tetraene) -6-spiro-2 '- (tetrahydropyran) -12-yl 2,6-dideoxy-4-O- (2,6-dideoxy-3-0-netyl-α-arabinohexopyranyl) -3-0-methyl -α-L-arabinohexopyranoside and (10E, 14E, 16E) - (IR, 4S, 5'S, 6R, 6'R, 8R, 12S, 13S, 2OR, 2 IR, 24S) - 21,24-dihydroxy-6 ' -isopropyl-5 ', 11,13,22-tetramethyl-2-oxo- (3,7,19-trioxatetracyclo [15.6.1.14,8.020,24] pentacosa-10.14.16.22-tetraene) -6-spiro-2' - (tetrahydropyran) -12-yl 2,6-dideoxy-4-0- (2,6-dideoxy-3-O-netyl-α-L-arabinohexopyranosyl) -3-O-methyl-α-L-arabinohexopyranoside), and selamectin ((10E, 14E, 16E, 21Z) - (1R, 4S, 5S, 6R, 6S, 8R, 12S, 13S, 20R, 2IR, 24S) -6'-cyclohexyl-2-4-hydroxy-21-hydroxyimino -5 ', 11,13,22-tetramethyl-2-oxo- (3,7,19-trioxatetracyclo [15.6.1.14,8.020,24] pentacosa-10.14.16.22-tetraene) -6-spiro-2' - ( tetrahydropyran) -12-yl 2.6-dideoxy-3-O-methyl-α-L-arabinohexopyranide). Dipropylene / diethylene glycol dibenzoates are particularly effective in reducing abamectin irritability.
[0023] Foi descoberto que a composição da presente invenção é particularmente eficaz quando o ingrediente ativo é selecionado a partir de clomazona, bifentrina, piriproxifena, cletodima, lufenurona, abamectina e misturas desses.It has been found that the composition of the present invention is particularly effective when the active ingredient is selected from clomazone, bifenthrin, pyriproxyfen, clethodime, lufenurone, abamectin and mixtures thereof.
[0024] A presente invenção provê uma composição agroquímica que ainda compreende pelo menos um emulsificante. Os emulsificantes adequados para uso em uma composição são bem conhecidos na técnica e estão disponíveis comercialmente. O emulsificante ou a mistura emulsificante é selecionada para ter boas capacidades de emulsificantes, dispersantes e umectantes na formulação empregada. O emulsificante pode ser selecionado a partir de emulsificantes não iônicos, emulsificantes iônicos, emulsificantes catiônicos e misturas desses.The present invention provides an agrochemical composition which further comprises at least one emulsifier. Suitable emulsifiers for use in a composition are well known in the art and are commercially available. The emulsifier or emulsifier mixture is selected to have good emulsifier, dispersant and wetting capabilities in the formulation employed. The emulsifier may be selected from nonionic emulsifiers, ionic emulsifiers, cationic emulsifiers and mixtures thereof.
[0025] Os emulsificantes não iônicos preferidos são aqueles selecionados a partir de alcoxilatos de álcool, etoxilatos de alquilfenol, alquilpolissacarideos, etoxilatos de amina, etoxilatos de óleo de rícino, etoxilatos de éster de ácidos graxos de sorbitano, e ácidos graxos de polioxietileno.Preferred nonionic emulsifiers are those selected from alcohol alkoxylates, alkylphenol ethoxylates, alkyl polysaccharides, amine ethoxylates, castor oil ethoxylates, sorbitan fatty acid ester ethoxylates, and polyoxyethylene fatty acids.
[0026] Os emulsificantes aniônicos preferidos são sabões solúveis em água bem como emulsificantes sintéticos solúveis em água. Os exemplos típicos de emulsificantes aniônicos são selecionados a partir de alquilbenzenossulfonato de amina, sulfonato de dodecilbenzeno de amônio, alquilssulfonato de cálcio, e alquilbenzenossulfonato de cálcio.Preferred anionic emulsifiers are water soluble soaps as well as water soluble synthetic emulsifiers. Typical examples of anionic emulsifiers are selected from amine alkylbenzenesulfonate, ammonium dodecylbenzene sulfonate, calcium alkylsulfonate, and calcium alkylbenzenesulfonate.
[0027] Os emulsificantes catiônicos preferidos em uma composição da presente invenção podem ser sais de amônio quaternário que tenham a seguinte fórmula geral: [0028] na qual Ri, R2, R3 ou R4 cada um representa pelo menos um radical de alquila Ce até C22 r ou Ri, R2, R3 ou R4 cada um representa uma alquila, benzila inferior não substituída ou halogenada, ou radicais de alquila inferior de hidroxila; e X representa um haleto, por exemplo um íon de cloro, sulfato de metila ou sulfato de etila. Os exemplos de emulsificantes catiônicos preferidos são etossulfato de etilamônio de óleo de polioxietileno e quaternário de polioxietileno, cloreto de esteariltrimetilamônio, brometo de benzila bis (2-cloroetil)etilamônio.Preferred cationic emulsifiers in a composition of the present invention may be quaternary ammonium salts having the following general formula: wherein R 1, R 2, R 3 or R 4 each represent at least one C 1 to C 22 alkyl radical. R1 or R2, R2, R3 or R4 each represent an unsubstituted or halogenated lower alkyl, benzyl, or hydroxyl lower alkyl radicals; and X represents a halide, for example a chlorine ion, methyl sulfate or ethyl sulfate. Examples of preferred cationic emulsifiers are polyoxyethylene and polyoxyethylene quaternary ethylammonium ethosulfate, stearyltrimethylammonium chloride, bis (2-chloroethyl) ethylammonium bromide.
[0029] O emulsificante ou mistura de emulsificante pode estar presente em uma composição em qualquer quantidade adequada. Preferencialmente, o emulsificante está presente em uma composição em uma quantidade de pelo menos 5% por peso, mais preferencialmente pelo menos 10% por peso, ainda mais preferencialmente pelo menos 15% por peso. Preferencialmente, um ou mais emulsificantes estão presentes em uma quantidade na faixa a partir de 5 até 40% por peso, mais preferencialmente a partir de 5 até 35% por peso, ainda mais preferencialmente a partir de 10 até 30% por peso de uma composição. Uma quantidade de um ou mais emulsif icantes a partir de 20 até 30% por peso de uma composição foi descoberta como sendo particularmente adequada em muitas modalidades.The emulsifier or emulsifier mixture may be present in a composition in any suitable amount. Preferably, the emulsifier is present in a composition in an amount of at least 5 wt%, more preferably at least 10 wt%, even more preferably at least 15 wt%. Preferably, one or more emulsifiers are present in an amount in the range of from 5 to 40% by weight, more preferably from 5 to 35% by weight, even more preferably from 10 to 30% by weight of a composition. . An amount of one or more emulsifiers from 20 to 30% by weight of a composition has been found to be particularly suitable in many embodiments.
[0030] Além de dibenzoato glicol de dietileno/diproprileno, pelo menos um ingrediente ativo e pelo menos um emulsificante, as composições da presente invenção podem compreender também outros componentes como é conhecido na técnica, dependendo do tipo de formulação sendo empregada.In addition to diethylene glycol dibenzoate / diproprylene, at least one active ingredient and at least one emulsifier, the compositions of the present invention may also comprise other components as is known in the art, depending on the type of formulation being employed.
[0031] Por exemplo, a composição pode compreender um ou mais solventes, em particular um ou mais solventes orgânicos polares ou não polares. Os solventes adequados são conhecidos na técnica e estão disponíveis comercialmente. Os solventes orgânicos polares ou não polares adequados incluem alcóois, tais como álcool benzílico, pirrolidonas de alquila, tais como N- metilpirrolidona, N-octilpirrolidona, ou uma ou mais lactonas, tais como γ-butírolactona; hidrocarbonetos aromáticos e misturas desses, tais como as composições de solvente disponíveis comercialmente SOLVESSO™100 e S0LVESS0™200, e sulfóxido de dimetila.For example, the composition may comprise one or more solvents, in particular one or more polar or non-polar organic solvents. Suitable solvents are known in the art and are commercially available. Suitable polar or non-polar organic solvents include alcohols, such as benzyl alcohol, alkyl pyrrolidones, such as N-methylpyrrolidone, N-octylpyrrolidone, or one or more lactones, such as γ-butyrolactone; aromatic hydrocarbons and mixtures thereof, such as commercially available solvent compositions SOLVESSO ™ 100 and SOLVESS0 ™ 200, and dimethyl sulfoxide.
[0032] Os componentes adicionais que podem estar incluídos em uma composição são bem conhecidos na técnica e incluem um ou mais estabilizantes, um ou mais espessantes, e similares. Ditos componentes estão disponíveis comercialmente e seus usos na formulação das composições agroquímicas são reconhecidos e compreendidos pela pessoa com habilidade na técnica.Additional components that may be included in a composition are well known in the art and include one or more stabilizers, one or more thickeners, and the like. Such components are commercially available and their uses in the formulation of agrochemical compositions are recognized and understood by one of ordinary skill in the art.
[0033] A composição da presente invenção pode ser preparada de qualquer forma adequada. A composição da presente invenção é preferencialmente um concentrado líquido, em particular uma formulação de concentrado emulsificável (EC). As formulações de concentrados líquidos podem compreender ingredientes ativos que sejam comedidamente solúveis em água ou insolúveis em água. As formulações de concentrados líquidos são preferencialmente aquelas para dispersão em água, antes de usar.The composition of the present invention may be prepared in any suitable manner. The composition of the present invention is preferably a liquid concentrate, in particular an emulsifiable concentrate (EC) formulation. Liquid concentrate formulations may comprise active ingredients that are sparingly soluble in water or insoluble in water. Liquid concentrate formulations are preferably those for dispersion in water prior to use.
[0034] Em um aspecto adicional, a presente invenção provê uma composição líquida concentrada que compreende pelo menos um dibenzoato de glicol de dipropileno/dietileno, pelo menos um ingrediente ativo e pelo menos um emulsificante.In a further aspect, the present invention provides a concentrated liquid composition comprising at least one dipropylene / diethylene glycol dibenzoate, at least one active ingredient and at least one emulsifier.
[0035] A presente invenção também provê, em um aspecto adicional, um método para preparar uma composição agroquímica, o método que compreende combinar pelo menos um dibenzoato de glicol de dipropileno/dietileno com pelo menos um ingrediente ativo e pelo menos um emulsificante.The present invention also provides, in a further aspect, a method for preparing an agrochemical composition, the method comprising combining at least one dipropylene / diethylene glycol dibenzoate with at least one active ingredient and at least one emulsifier.
[0036] As composições da presente invenção podem ser preparadas utilizando técnicas conhecidas na técnica. Um método particularmente preferido para preparar a composição de concentrado liquido é conforme se segue: [0037] Cada componente é provido de acordo com a fração de peso necessária na composição final. Primeiro, um solvente e dibenzoato de glicol de dipropileno/dietileno são adicionados em um recipiente de mistura adequado, por exemplo um tanque de mistura, e misturado para formar uma mistura. O ingrediente ativo é então adicionado à mistura e misturado continuamente (tipicamente por cerca de 30 minutos) até que o ingrediente ativo dissolva completamente no solvente. Após isso, um ou mais emulsif icantes e os componentes adicionais, se presentes, são adicionados à mistura e misturados (tipicamente por cerca de uma hora) para garantir a homogeneidade.The compositions of the present invention may be prepared using techniques known in the art. A particularly preferred method for preparing the liquid concentrate composition is as follows: Each component is provided according to the weight fraction required in the final composition. First, a solvent and dipropylene / diethylene glycol dibenzoate are added in a suitable mixing vessel, for example a mixing tank, and mixed to form a mixture. The active ingredient is then added to the mixture and mixed continuously (typically for about 30 minutes) until the active ingredient dissolves completely in the solvent. Thereafter, one or more emulsifiers and additional components, if present, are added to the mixture and mixed (typically for about one hour) to ensure homogeneity.
[0038] Em um aspecto adicional, a presente invenção provê o uso de pelo menos um dibenzoato de glicol de dipropileno/dietileno para reduzir a irritabilidade dos olhos por um ingrediente ativo e um emulsif icante em uma formulação agroquímica.In a further aspect, the present invention provides the use of at least one dipropylene / diethylene glycol dibenzoate to reduce eye irritability by an active ingredient and an emulsifier in an agrochemical formulation.
[0039] Em um aspecto adicional, a presente invenção provê um método para reduzir a irritação dos olhos de formulações liquidas causada pelos ingredientes ativos e emulsificantes, o método que compreende adicionar pelo menos um dibenzoato de glicol de dipropileno/dietileno à formulação em uma quantidade suficiente para reduzir a irritabilidade de olhos da formulação.In a further aspect, the present invention provides a method for reducing eye irritation of liquid formulations caused by the active ingredients and emulsifiers, the method comprising adding at least one dipropylene / diethylene glycol dibenzoate to the formulation in an amount sufficient to reduce eye irritability of the formulation.
[0040] Em um aspecto ainda adicional, a presente invenção provê um método para tratar pragas em um local que compreende empregar ao local uma composição conforme descrito doravante.In a still further aspect, the present invention provides a method for treating pests at a site comprising employing a composition as described hereinafter.
[0041] As modalidades da presente invenção serão descritas agora, para fins de ilustração somente, por meio dos seguintes exemplos.Embodiments of the present invention will now be described, for illustration purposes only, by way of the following examples.
EXEMPLOSEXAMPLES
[0042] Em cada um dos seguintes exemplos, a composição foi preparada de acordo com a seguinte metodologia geral: [0043] Em geral, cada componente foi adicionado a um recipiente em uma quantidade baseada na indicativo da receita de composição particular. Mais particularmente, primeiro, o solvente e o dibenzoato de glicol de dipropileno/dietileno mais foram adicionados em um tanque de mistura nas quantidades especificadas e misturados para formar uma mistura. Pelo menos um ingrediente ativo foi adicionado à mistura e misturado continuamente por cerca de 30 minutos até que o ingrediente ativo estivesse completamente dissolvido. Após isso, o emulsificante foi adicionado ao tanque de mistura e a mistura misturada resultante continuamente por cerca de uma hora até que a mistura ficasse uniforme, após o que a mistura foi interrompida. Finalmente, a mistura foi descarregada do tanque de mistura.In each of the following examples, the composition was prepared according to the following general methodology: In general, each component was added to a container in an amount based on the particular composition recipe indicative. More particularly, first, the solvent and more dipropylene / diethylene glycol dibenzoate were added to a mixing tank in the specified amounts and mixed to form a mixture. At least one active ingredient was added to the mixture and mixed continuously for about 30 minutes until the active ingredient was completely dissolved. Thereafter, the emulsifier was added to the mixing tank and the resulting mixed mixture continuously for about one hour until mixing became uniform, after which time mixing was stopped. Finally, the mixture was discharged from the mixing tank.
[0044] A irritação potencial dos olhos de cada formulação foi determinada de acordo com o método descrito por N. P. Luepke: 'Hen's Egg Chorio Allantoic Membrane Test for Irritation Potential', Fd. Chem. Toxic. 23 (1985), páginas 287 a 291, (doravante o 'Teste HET-CAM' ) , que foi modificado de acordo com o método de H. Spielmann (H. Spielmann: Methods in Molecular Biology 43 (1995) páginas 199 a 204, e H. Spielmann et al. ATLA 24 (1996), páginas 741 a 858) .Potential eye irritation of each formulation was determined according to the method described by N. P. Luepke: 'Hen's Egg Chorio Allantoic Membrane Test for Irritation Potential', Fd. Chem. Toxic 23 (1985), pages 287 to 291, (hereinafter the 'HET-CAM Test'), which was modified according to the method of H. Spielmann (H. Spielmann: Methods in Molecular Biology 43 (1995) pages 199 to 204 and H. Spielmann et al., ATLA 24 (1996), pages 741 to 858).
[0045] No Teste HET-CAM, uma membrana corioalantóica (CAM) foi tratada com amostras de cada composição. A membrana corioalantóica foi então observada por 5 minutos. A severidade da hemorragia, lise e coagulação foram examinadas. As amostras foram categorizadas conforme se segue: [0046] Categoria 0 (Cat 0): fortemente irritante [0047] Categoria I (Cat I): irritante [0048] Categoria II (Cat II): irritante moderado [0049] Categoria III (Cat III): não irritante [0050] As amostras e controles foram preparados para cada formulação. A irritação potencial dos olhos das amostras e controles foram examinadas cconforme mencionado acima. Em cada exemplo, a composição de controle é idêntica à composição da amostra, com a exceção de que o dibenzoato de glicol de dipropileno/dietileno foi omitido.In the HET-CAM Test, a chorioallantoic membrane (CAM) was treated with samples of each composition. The chorioallantoic membrane was then observed for 5 minutes. The severity of bleeding, lysis and coagulation were examined. Samples were categorized as follows: [0046] Category 0 (Cat 0): strongly irritating [0047] Category I (Cat I): irritating [0048] Category II (Cat II): moderate irritant [0049] Category III (Cat III): non-irritating Samples and controls were prepared for each formulation. Potential eye irritation of samples and controls was examined as mentioned above. In each example, the control composition is identical to the sample composition except that dipropylene / diethylene glycol dibenzoate was omitted.
[0051] Exemplo 1 [0052] As composições de concentrados de emulsão da Amostra 1 e Controle 1 foram preparadas de acordo com a receita especificada na Tabela 1 abaixo. A razão de bifentrina e de dibenzoato glicol de dipropileno da Amostra 1 foi de aproximadamente 1:13. A irritabilidade dos olhos da Amostra 1 foi comparada com aquela do Controle 1 (que é uma composição da Amostra 1 sem a adição de dibenzoato glicol de dipropileno).Example 1 The emulsion concentrate compositions of Sample 1 and Control 1 were prepared according to the recipe specified in Table 1 below. The ratio of bifentrin and dipropylene glycol dibenzoate of Sample 1 was approximately 1:13. Eye irritability of Sample 1 was compared with that of Control 1 (which is a composition of Sample 1 without the addition of dipropylene dibenzoate glycol).
[0053] Tabela 1 [0054] Exemplo 2 [0055] As composições de concentrados de emulsão da Amostra 2 e Controle 2 foram preparadas de acordo com a receita definida na Tabela 2 abaixo. A razão de bifentrina e de dibenzoato glicol de dietileno da Amostra 2 foi de aproximadamente 1:1. A irritação dos olhos da Amostra 2 foi comparada com aquela do Controle 2 (sem a adição de dibenzoato glicol de dietileno).[0053] Table 1 Example 2 The emulsion concentrate compositions of Sample 2 and Control 2 were prepared according to the recipe defined in Table 2 below. The ratio of bifentrin and diethylene glycol dibenzoate of Sample 2 was approximately 1: 1. Eye irritation from Sample 2 was compared to that of Control 2 (without the addition of diethylene glycol dibenzoate).
[0056] Tabela 2 [0057] Exemplo 3 [0058] As composições de concentrado de emulsão da Amostra 3 e Controle 3 foram preparadas com componentes de acordo com a Tabela 3 abaixo. A razão de bifentrina e de dibenzoato glicol de dipropileno da Amostra 3 foi de aproximadamente 1:2. A irritação dos olhos da Amostra 3 foi comparada com aquela de Controle 3 (sem a adição de dibenzoato glicol de dipropileno).Table 2 Example 3 The emulsion concentrate compositions of Sample 3 and Control 3 were prepared with components according to Table 3 below. The ratio of bifentrin and dipropylene glycol dibenzoate of Sample 3 was approximately 1: 2. Eye irritation from Sample 3 was compared to that of Control 3 (without the addition of dipropylene dibenzoate glycol).
[0059] Tabela 3 [0060] Exemplo 4 [0061] As composições de concentrado de emulsão da Amostra 4 e Controle 4 foram preparadas com componentes conforme definido na Tabela 4 abaixo. A razão de cletodima e de dibenzoato glicol de dietileno da Amostra 4 foi de aproximadamente 1:3. A irritação dos olhos da Amostra 4 foi comparada com aquela do Controle 4 (sem a adição de dibenzoato glicol de dietileno).Table 4 Example 4 The emulsion concentrate compositions of Sample 4 and Control 4 were prepared with components as defined in Table 4 below. The ratio of clethodime and diethylene glycol dibenzoate of Sample 4 was approximately 1: 3. Eye irritation from Sample 4 was compared to that of Control 4 (without the addition of diethylene glycol dibenzoate).
[0062] Tabela 4 [0063] Exemplo 5 [0064] As composições de concentrado de emulsão da Amostra 5 e Controle 5 foram preparadas com os componentes de acordo com a Tabela 5. A razão de clomazona e dibenzoato glicol de dipropileno da Amostra 5 foi de aproximadamente 1:6. A irritação dos olhos da Amostra 5 foi comparada com aquela do Controle 5 (sem a adição de dibenzoato glicol de dipropileno).Example 5 The emulsion concentrate compositions of Sample 5 and Control 5 were prepared with the components according to Table 5. The clomazone and dipropylene glycol dibenzoate ratio of Sample 5 was approximately 1: 6. Eye irritation from Sample 5 was compared to that of Control 5 (without the addition of dipropylene dibenzoate glycol).
[0065] Tabela 5 [0066] Exemplo 6 [0067] As composições de concentrado de emulsão da Amostra 6 e Controle 6 foram preparadas com os componentes de acordo com a Tabela 6 abaixo. A razão de piriproxifena e de dibenzoato glicol de dipropileno da Amostra 6 foi de aproximadamente 1:5. A irritação dos olhos da Amostra 6 foi comparada com aquela do Controle 6 (sem a adição de dibenzoato glicol de dipropileno).Example 6 The emulsion concentrate compositions of Sample 6 and Control 6 were prepared with the components according to Table 6 below. The ratio of pyriproxyfen and dipropylene glycol dibenzoate from Sample 6 was approximately 1: 5. Eye irritation from Sample 6 was compared with that of Control 6 (without the addition of dipropylene dibenzoate glycol).
[0068] Tabela 6 [0069] Exemplo 7 [0070] As composições de concentrado de emulsão da Amostra 7 e Controle 7 foram preparados com componentes conforme definido na Tabela 7 abaixo. A razão de piriproxifena e de dibenzoato glicol de dietileno of Amostra 7 foi de aproximadamente 1:10. A irritação dos olhos da Amostra 7 foi comparada com aquela do Controle 7 (sem a adição de dibenzoato glicol de dietileno).[0068] Example 6 The emulsion concentrate compositions of Sample 7 and Control 7 were prepared with components as defined in Table 7 below. The ratio of pyriproxyfen and diethylene glycol dibenzoate of Sample 7 was approximately 1:10. Eye irritation from Sample 7 was compared with that of Control 7 (without the addition of diethylene glycol dibenzoate).
[0071] Tabela 7 [0072] Exemplo 8 [0073] As composições de concentrado de emulsão da Amostra 8 e do Controle 8 foram preparadas com componentes de acordo com a Tabela 8 abaixo. A razão de piriproxifena e dibenzoato glicol de dipropileno da Amostra 7 foi de aproximadamente 1:16. A irritação dos olhos da Amostra 8 foi comparada com aquela do Controle 8 (sem a adição de dibenzoato glicol de dipropileno).Example 8 The emulsion concentrate compositions of Sample 8 and Control 8 were prepared with components according to Table 8 below. The ratio of pyriproxyfen and dipropylene glycol dibenzoate from Sample 7 was approximately 1:16. Eye irritation from Sample 8 was compared to that of Control 8 (without the addition of dipropylene dibenzoate glycol).
[0074] Tabela 8 [0075] Exemplo 9 [0076] As composições de concentrado de emulsão da Amostra 9 e do Controle 9 foram preparadas de acordo com a receita da Tabela 9. A razão de piriproxifena e de dibenzoato glicol de dipropíleno da Amostra 9 foi de aproximadamente 1:20. A irritação dos olhos da Amostra 9 foi comparada com aquela do Controle 9 (sem a adição de dibenzoato glicol de dipropileno).Example 9 The emulsion concentrate compositions of Sample 9 and Control 9 were prepared according to the recipe of Table 9. The ratio of pyriproxyfen and dipropylene dibenzoate glycol of Sample 9 it was about 1:20. Eye irritation from Sample 9 was compared to that of Control 9 (without the addition of dipropylene dibenzoate glycol).
[0077] Tabela 9 [0078] Exemplo 10 [0079] As composições de concentrado de emulsão da Amostra 10 e do Controle 10 foram preparadas de acordo com a receita da Tabela 10 abaixo. A razão de lufenurona e de dibenzoato glicol de dipropileno da Amostra 10 foi de aproximadamente 1:30. A irritação dos olhos da Amostra 10 foi comparada com aquela do Controle 10 (sem a adição de dibenzoato glicol de dipropileno).Example 9 The emulsion concentrate compositions of Sample 10 and Control 10 were prepared according to the recipe of Table 10 below. The ratio of lufenurone and dipropylene glycol dibenzoate in Sample 10 was approximately 1:30. Eye irritation from Sample 10 was compared to that of Control 10 (without the addition of dipropylene glycol dibenzoate).
[0080] Tabela 10 [0081] Exemplo 11 [0082] As composições de concentrado de emulsão da Amostra 11 e de Controle 11 foram preparadas de acordo com a receita da Tabela 11. A razão de abmectina e de dibenzoato glicol de dipropileno da Amostra 11 foi de aproximadamente 1:90. A irritação dos olhos da Amostra 11 foi comparada com aquela do Controle 11 (sem a adição de dibenzoato glicol de dipropileno).Example 11 The emulsion concentrate compositions of Sample 11 and Control 11 were prepared according to the recipe in Table 11. The ratio of abmectin and dipropylene glycol dibenzoate from Sample 11 it was about 1:90. Eye irritation from Sample 11 was compared with that of Control 11 (without the addition of dipropylene dibenzoate glycol).
[0083] Tabela 11 [0084] Exemplo 12 [0085] As composições de concentrado de emulsão da Amostra 12 e de Controle 12 foram preparadas de acordo com a receita da tabela 12. A razão entre bifentrina e o dibenzoato glicol de dipropileno e o dibenzoato glicol de dietileno combinado da Amostra 12 foi de aproximadamente 1:5. A irritação dos olhos da Amostra 12 foi comparada com aquela do Controle 12 (sem a adição de dibenzoato glicol de dipropileno e de dibenzoato glicol de dietileno).Example 12 The emulsion concentrate compositions of Sample 12 and Control 12 were prepared according to the recipe in Table 12. The ratio of bifenthrin to dipropylene glycol dibenzoate and dibenzoate combined diethylene glycol from Sample 12 was approximately 1: 5. Eye irritation from Sample 12 was compared to that of Control 12 (without the addition of dipropylene dibenzoate glycol and diethylene dibenzoate glycol).
[0086] Tabela 12 [0087] Exemplo 13 [0088] A irritação potencial dos olhos de uma composições das Amostras e Controles dos Exemplos 1 até 12 foi determinada conforme descrito acima. O desempenho das composições das Amostras e Controles foi categorizada conforme se segue: [0089] Categoria 0 (Cat 0) : fortemente irritante [0090] Categoria I (Cat I): irritante [0091] Categoria II (Cat II): irritante moderado [0092] Categoria III (Cat III): não irritante [0093] Os resultados estão listados na Tabela 13 abaixo.[0086] Table 12 Example 13 The potential eye irritation of a Sample and Control compositions of Examples 1 through 12 was determined as described above. The performance of the Sample and Control compositions was categorized as follows: Category 0 (Cat 0): Strongly irritating [0090] Category I (Cat I): irritant [0091] Category II (Cat II): Moderate irritant [ 0092] Category III (Cat III): non-irritating [0093] Results are listed in Table 13 below.
[0094] Tabela 13 [0095] A partir dos resultados definidos na Tabela 13, pode ser visto que o dibenzoato glicol de dipropileno e o dibenzoato glicol de dietileno, se usados sozinhos ou combinados, foram muito eficazes para reduzir significativamente a irritação potencial dos olhos das composições.From the results defined in Table 13, it can be seen that dipropylene dibenzoate glycol and diethylene dibenzoate glycol, if used alone or in combination, were very effective in significantly reducing potential eye irritation. of the compositions.
REIVINDICAÇÕES
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