BR0312736A - Associação de um inibidor carboxìlico alostérico da metaloproteinase-13 de matriz com celecoxib ou valdecoxib - Google Patents

Associação de um inibidor carboxìlico alostérico da metaloproteinase-13 de matriz com celecoxib ou valdecoxib

Info

Publication number
BR0312736A
BR0312736A BR0312736-2A BR0312736A BR0312736A BR 0312736 A BR0312736 A BR 0312736A BR 0312736 A BR0312736 A BR 0312736A BR 0312736 A BR0312736 A BR 0312736A
Authority
BR
Brazil
Prior art keywords
pharmaceutically acceptable
acceptable salt
valdecoxib
celecoxib
combination
Prior art date
Application number
BR0312736-2A
Other languages
English (en)
Inventor
William Howard Roark
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of BR0312736A publication Critical patent/BR0312736A/pt

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract

"ASSOCIAçãO DE UM INIBIDOR CARBOXìLICO ALOSTéRICO DA METALOPROTEINASE-13 DE MATRIZ COM CELECOXIB OU VALDECOXIB". Esta invenção proporciona urna associação, compreendendo um inibidor carboxílico alostédco da MMP-13, ou um seu sal farmaceuticamente aceitável, com celecoxib, ou um seu sal farmaceuticamente aceitável, ou com valdecoxib, ou um seu sal farmaceuticamente aceitável. Esta invenção proporciona também um método de tratamento da uma doença que reage à inibição da MMP-13 e da ciclooxigenase-2, compreendendo a administração, a um paciente que sofra dessa doença, da associação da invenção compreendendo um inibidor carboxílico alostérico da MMP-13, ou um seu sal farmaceuticamente aceitável, com celecoxib, ou um seu sal farmaceuticamente aceitável, ou com valdecoxib, ou um seu sal farmaceuticamente aceitável. Esta invenção proporciona também uma formulação farmacêutica, compreendendo a associação da invenção compreendendo um inibidor carboxílico alostérico da MMP-13, ou um seu sal farmaceuticamente aceitável, com celecoxib, ou um seu sal farmaceuticamente aceitável, ou com valdecoxib, ou um seu sal farmaceuticamente aceitável, e um veículo, diluente ou excipiente farmaceuticamente aceitável.A associação da invenção pode ser ainda combinada com outros agentes farmacêuticos dependendo da doença a ser tratada.
BR0312736-2A 2002-07-17 2003-07-07 Associação de um inibidor carboxìlico alostérico da metaloproteinase-13 de matriz com celecoxib ou valdecoxib BR0312736A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39690302P 2002-07-17 2002-07-17
PCT/IB2003/003044 WO2004006912A2 (en) 2002-07-17 2003-07-07 Combination of an allosteric carboxylic inhibitor of matrix metalloproteinase-13 with celecoxib or valdecoxib

Publications (1)

Publication Number Publication Date
BR0312736A true BR0312736A (pt) 2005-04-26

Family

ID=30116069

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0312736-2A BR0312736A (pt) 2002-07-17 2003-07-07 Associação de um inibidor carboxìlico alostérico da metaloproteinase-13 de matriz com celecoxib ou valdecoxib

Country Status (8)

Country Link
US (1) US20040019053A1 (pt)
EP (1) EP1530467A2 (pt)
JP (1) JP2006503811A (pt)
AU (1) AU2003281169A1 (pt)
BR (1) BR0312736A (pt)
CA (1) CA2495432A1 (pt)
MX (1) MXPA05000754A (pt)
WO (1) WO2004006912A2 (pt)

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AU2003281169A1 (en) 2004-02-02
WO2004006912A2 (en) 2004-01-22
MXPA05000754A (es) 2005-04-19
CA2495432A1 (en) 2004-01-22
EP1530467A2 (en) 2005-05-18
US20040019053A1 (en) 2004-01-29
WO2004006912A3 (en) 2004-06-03

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