BR0213964A - regulated nucleic acid expression system - Google Patents
regulated nucleic acid expression systemInfo
- Publication number
- BR0213964A BR0213964A BRPI0213964-2A BR0213964A BR0213964A BR 0213964 A BR0213964 A BR 0213964A BR 0213964 A BR0213964 A BR 0213964A BR 0213964 A BR0213964 A BR 0213964A
- Authority
- BR
- Brazil
- Prior art keywords
- nucleic acid
- expression system
- acid expression
- regulated nucleic
- expression
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/635—Externally inducible repressor mediated regulation of gene expression, e.g. tetR inducible by tetracyline
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16051—Methods of production or purification of viral material
- C12N2740/16052—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
- C12N2740/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
- C12N2740/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
"SISTEMA DE EXPRESSãO DE áCIDO NUCLéICO REGULADA". A presente invenção refere-se a constructos de ácido nucléico, sistemas de expressão e métodos relatando a regulação de expressão de gene. A invenção pode ser aplicada para regular a expressão de qualquer seqüência de codificação de interesse, incluindo aquelas codificações para componentes virais necessários para o empacotamento de partículas virais."REGULATED NUCLEIC ACID EXPRESSION SYSTEM". The present invention relates to nucleic acid constructs, expression systems and methods relating to gene expression regulation. The invention may be applied to regulate the expression of any coding sequence of interest, including those coding for viral components required for packaging of viral particles.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/020,472 US6835568B2 (en) | 2001-10-30 | 2001-10-30 | Regulated nucleic acid expression system |
PCT/US2002/034932 WO2003054210A2 (en) | 2001-10-30 | 2002-10-30 | Regulated nucleic acid expression system |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0213964A true BR0213964A (en) | 2006-05-30 |
Family
ID=21798805
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0213964-2A BR0213964A (en) | 2001-10-30 | 2002-10-30 | regulated nucleic acid expression system |
Country Status (15)
Country | Link |
---|---|
US (2) | US6835568B2 (en) |
EP (1) | EP1446488A4 (en) |
JP (1) | JP2005512573A (en) |
KR (1) | KR100984268B1 (en) |
CN (1) | CN100591769C (en) |
AU (1) | AU2002365090B2 (en) |
BR (1) | BR0213964A (en) |
CA (1) | CA2464268C (en) |
CZ (1) | CZ2004546A3 (en) |
IL (2) | IL161495A0 (en) |
MX (1) | MXPA04003969A (en) |
NO (1) | NO20041763L (en) |
NZ (1) | NZ533132A (en) |
RU (1) | RU2004116319A (en) |
WO (1) | WO2003054210A2 (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7297536B2 (en) * | 2003-01-23 | 2007-11-20 | Wisconsin Alumni Research Foundation | Inducible protein expression system |
US20090123494A1 (en) * | 2007-07-31 | 2009-05-14 | William Staplin | Momlv-based pseudovirion packaging cell line |
US20110142880A1 (en) * | 2008-03-28 | 2011-06-16 | Franck Yann Lemiale | Lentivirus-based immunogenic vectors |
BR112012010755A2 (en) * | 2009-11-05 | 2015-09-22 | Proyecto Biomedicina Cima Sl | gene construct allowing inducible hepato-specific expression of a polynucleotide of interest in response to an inducing agent, vector, recombinant viral genome, virion, in vitro method for expression of a polynucleotide of interest in a cell of hepatic origin, composition pharmaceutical and inducible bi-directional promoter-operator suitable for the inducible hepato-specific expression of two polynucleotides of interest by an inducing agent |
CA2789539A1 (en) | 2011-09-12 | 2013-03-12 | International Aids Vaccine Initiative | Immunoselection of recombinant vesicular stomatitis virus expressing hiv-1 proteins by broadly neutralizing antibodies |
US9402894B2 (en) | 2011-10-27 | 2016-08-02 | International Aids Vaccine Initiative | Viral particles derived from an enveloped virus |
US9347065B2 (en) | 2012-03-29 | 2016-05-24 | International Aids Vaccine Initiative | Methods to improve vector expression and genetic stability |
EP3380605A1 (en) | 2015-11-24 | 2018-10-03 | GlaxoSmithKline Intellectual Property Development Limited | Transient transfection method for retroviral production |
RU2752498C2 (en) | 2015-11-24 | 2021-07-28 | Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед | Stable cell lines for retroviruses production |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE183235T1 (en) | 1990-03-21 | 1999-08-15 | Wolf Hans Joachim Prof Dr | DNA SEQUENCES ENCODING MODIFIED RETROVIRAL GAG POLYPEPTIDES AND VACCINES OR AGGREGATES THEREOF CONTAINING SAME |
US6174666B1 (en) | 1992-03-27 | 2001-01-16 | The United States Of America As Represented By The Department Of Health And Human Services | Method of eliminating inhibitory/instability regions from mRNA |
US5750396A (en) | 1995-05-08 | 1998-05-12 | St. Judes Children's Research Hospital | Stable virus packaging cell lines |
US5885806A (en) | 1995-11-28 | 1999-03-23 | The Johns Hopkins University School Of Medicine | Methods to prepare conditionally replicating viral vectors |
US5888767A (en) | 1996-11-27 | 1999-03-30 | The Johns Hopkins University School Of Medicine | Method of using a conditionally replicating viral vector to express a gene |
US6133027A (en) * | 1996-08-07 | 2000-10-17 | City Of Hope | Inducible expression system |
GB9803351D0 (en) | 1998-02-17 | 1998-04-15 | Oxford Biomedica Ltd | Anti-viral vectors |
WO2000065076A2 (en) | 1999-04-26 | 2000-11-02 | K.U. Leuven Research & Development | Synthetic gene for expressing active retroviral protein in eukaryotes |
-
2001
- 2001-10-30 US US10/020,472 patent/US6835568B2/en not_active Expired - Fee Related
-
2002
- 2002-10-30 RU RU2004116319/13A patent/RU2004116319A/en not_active Application Discontinuation
- 2002-10-30 JP JP2003554911A patent/JP2005512573A/en active Pending
- 2002-10-30 BR BRPI0213964-2A patent/BR0213964A/en not_active Application Discontinuation
- 2002-10-30 AU AU2002365090A patent/AU2002365090B2/en not_active Ceased
- 2002-10-30 NZ NZ533132A patent/NZ533132A/en not_active IP Right Cessation
- 2002-10-30 MX MXPA04003969A patent/MXPA04003969A/en active IP Right Grant
- 2002-10-30 WO PCT/US2002/034932 patent/WO2003054210A2/en not_active Application Discontinuation
- 2002-10-30 CN CN02821442A patent/CN100591769C/en not_active Expired - Fee Related
- 2002-10-30 KR KR1020047006464A patent/KR100984268B1/en not_active IP Right Cessation
- 2002-10-30 EP EP20020802938 patent/EP1446488A4/en not_active Withdrawn
- 2002-10-30 IL IL16149502A patent/IL161495A0/en unknown
- 2002-10-30 CA CA2464268A patent/CA2464268C/en not_active Expired - Fee Related
- 2002-10-30 CZ CZ2004546A patent/CZ2004546A3/en unknown
-
2004
- 2004-04-19 IL IL161495A patent/IL161495A/en not_active IP Right Cessation
- 2004-04-29 NO NO20041763A patent/NO20041763L/en not_active Application Discontinuation
- 2004-12-13 US US11/011,264 patent/US8043611B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CZ2004546A3 (en) | 2004-10-13 |
WO2003054210A2 (en) | 2003-07-03 |
CN1578837A (en) | 2005-02-09 |
US20060121579A1 (en) | 2006-06-08 |
KR100984268B1 (en) | 2010-09-30 |
WO2003054210A3 (en) | 2003-12-24 |
US8043611B2 (en) | 2011-10-25 |
AU2002365090A1 (en) | 2003-07-09 |
CA2464268A1 (en) | 2003-07-03 |
IL161495A (en) | 2009-06-15 |
AU2002365090B2 (en) | 2007-12-20 |
EP1446488A4 (en) | 2004-12-22 |
KR20040066799A (en) | 2004-07-27 |
EP1446488A2 (en) | 2004-08-18 |
WO2003054210B1 (en) | 2004-02-26 |
MXPA04003969A (en) | 2004-07-08 |
JP2005512573A (en) | 2005-05-12 |
NO20041763L (en) | 2004-04-29 |
US6835568B2 (en) | 2004-12-28 |
IL161495A0 (en) | 2004-09-27 |
RU2004116319A (en) | 2005-03-27 |
NZ533132A (en) | 2008-04-30 |
CN100591769C (en) | 2010-02-24 |
US20030087419A1 (en) | 2003-05-08 |
CA2464268C (en) | 2012-03-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B11E | Dismissal acc. art. 34 of ipl - requirements for examination incomplete | ||
B11T | Dismissal of application maintained [chapter 11.20 patent gazette] |