BR0211737A - Derivados fenìlicos como inibidores do fator xa - Google Patents
Derivados fenìlicos como inibidores do fator xaInfo
- Publication number
- BR0211737A BR0211737A BR0211737-1A BR0211737A BR0211737A BR 0211737 A BR0211737 A BR 0211737A BR 0211737 A BR0211737 A BR 0211737A BR 0211737 A BR0211737 A BR 0211737A
- Authority
- BR
- Brazil
- Prior art keywords
- factor inhibitors
- phenolic derivatives
- inhibitors
- derivatives
- factor
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 title 1
- 108010039209 Blood Coagulation Factors Proteins 0.000 abstract 1
- 102000015081 Blood Coagulation Factors Human genes 0.000 abstract 1
- 229940123583 Factor Xa inhibitor Drugs 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000001435 Thromboembolism Diseases 0.000 abstract 1
- 239000003114 blood coagulation factor Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
"DERIVADOS FENìLICOS COMO INIBIDORES DO FATOR XA". A presente invenção refere-se a compostos da fórmula (I), na qual D, W, X, Y, T e R^ 1^ são como definidos na reivindicação 1, que são inibidores do fator de coagulação Xa e podem ser empregados para a profilaxia e/ou a terapia de doenças tromboembólicas e para o tratamento de tumores.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10139060A DE10139060A1 (de) | 2001-08-08 | 2001-08-08 | Phenylderivate |
PCT/EP2002/007798 WO2003013531A1 (de) | 2001-08-08 | 2002-07-12 | Phenylderivate als faktor xa inhibitoren |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0211737A true BR0211737A (pt) | 2004-09-28 |
Family
ID=7694867
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0211737-1A BR0211737A (pt) | 2001-08-08 | 2002-07-12 | Derivados fenìlicos como inibidores do fator xa |
Country Status (17)
Country | Link |
---|---|
US (1) | US7902223B2 (pt) |
EP (1) | EP1414456B1 (pt) |
JP (1) | JP4409941B2 (pt) |
KR (1) | KR20040020061A (pt) |
CN (1) | CN1538845A (pt) |
AT (1) | ATE538792T1 (pt) |
AU (1) | AU2002325882B2 (pt) |
BR (1) | BR0211737A (pt) |
CA (1) | CA2456717C (pt) |
DE (1) | DE10139060A1 (pt) |
ES (1) | ES2377497T3 (pt) |
HU (1) | HUP0401405A2 (pt) |
MX (1) | MXPA04001121A (pt) |
PL (1) | PL367960A1 (pt) |
RU (1) | RU2004106784A (pt) |
WO (1) | WO2003013531A1 (pt) |
ZA (1) | ZA200401800B (pt) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10238002A1 (de) * | 2002-08-20 | 2004-03-04 | Merck Patent Gmbh | Benzimidazolderivate |
EP1558606A4 (en) * | 2002-10-02 | 2008-05-07 | Bristol Myers Squibb Co | DIAMINOALKYL CONTAINING LACTAM, BETA AMINO ACIDS, ALPHA AMINO ACIDS AND DERIVATIVES THEREOF AS FACTOR XA INHIBITORS |
EP1594845A4 (en) * | 2003-02-11 | 2008-05-21 | Bristol Myers Squibb Co | BENZENE ACETAMIDE COMPOUNDS USEFUL AS SERINE PROTEASE INHIBITORS |
US7122559B2 (en) | 2003-02-11 | 2006-10-17 | Bristol-Myers Squibb Company | Phenylglycine derivatives useful as serine protease inhibitors |
TW200505894A (en) | 2003-08-08 | 2005-02-16 | Yamanouchi Pharma Co Ltd | Tetrahydro-2H-thiopyran-4-carboxamide derivative |
WO2006076246A2 (en) | 2005-01-10 | 2006-07-20 | Bristol-Myers Squibb Company | Phenylglycinamide derivatives useful as anticoagulants |
ATE455103T1 (de) * | 2005-06-24 | 2010-01-15 | Bristol Myers Squibb Co | Als antikoagulationsmittel geeignete phenylglycinamid- und pyridylglycinamidderivate |
EP1917245A1 (de) | 2005-08-21 | 2008-05-07 | Abbott GmbH & Co. KG | Heterocyclische verbindungen und ihre verwendung als bindungspartner für 5-ht5-rezeptoren |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3279880A (en) * | 1965-07-12 | 1966-10-18 | Eastman Kodak Co | Polyester textile material dyed with 1-hydroxy-4-n-p-(2'-pyrrolidonyl-1-) phenyl-amino anthraquinones |
FR2387219B1 (pt) * | 1977-04-15 | 1982-11-19 | Ciba Geigy Ag | |
ZA928276B (en) | 1991-10-31 | 1993-05-06 | Daiichi Seiyaku Co | Aromatic amidine derivates and salts thereof. |
IL115420A0 (en) | 1994-09-26 | 1995-12-31 | Zeneca Ltd | Aminoheterocyclic derivatives |
US5612353A (en) | 1995-06-07 | 1997-03-18 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Substituted (sulfinic acid, sulfonic acid, sulfonylamino or sulfinylamino) N-[(aminoiminomethyl)phenylalkyl]-azaheterocyclylamide compounds |
DE19530996A1 (de) | 1995-08-23 | 1997-02-27 | Boehringer Mannheim Gmbh | Cyclische Guanidine, Verfahren zu ihrer Herstellung und Arzneimittel |
EA003056B1 (ru) | 1996-12-23 | 2002-12-26 | Дюпон Фармасьютикалз Компани | АЗОТСОДЕРЖАЩИЕ ГЕТЕРОАРОМАТИЧЕСКИЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ ФАКТОРА Ха, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И СПОСОБ ЛЕЧЕНИЯ |
CA2374793A1 (en) | 1999-05-24 | 2000-11-30 | Penglie Zhang | Inhibitors of factor xa |
AU5283900A (en) | 1999-05-24 | 2000-12-12 | Cor Therapeutics, Inc. | Inhibitors of factor xa |
JP2003500390A (ja) | 1999-05-24 | 2003-01-07 | シーオーアール セラピューティクス インコーポレイテッド | Xa因子阻害剤 |
CA2374820A1 (en) | 1999-05-24 | 2000-11-30 | Cor Therapeutics, Inc. | Inhibitors of factor xa |
DE10102322A1 (de) * | 2001-01-19 | 2002-07-25 | Merck Patent Gmbh | Phenylderivate |
-
2001
- 2001-08-08 DE DE10139060A patent/DE10139060A1/de not_active Withdrawn
-
2002
- 2002-07-12 AU AU2002325882A patent/AU2002325882B2/en not_active Ceased
- 2002-07-12 CA CA2456717A patent/CA2456717C/en not_active Expired - Fee Related
- 2002-07-12 RU RU2004106784/04A patent/RU2004106784A/ru not_active Application Discontinuation
- 2002-07-12 EP EP02760242A patent/EP1414456B1/de not_active Expired - Lifetime
- 2002-07-12 MX MXPA04001121A patent/MXPA04001121A/es unknown
- 2002-07-12 US US10/486,238 patent/US7902223B2/en not_active Expired - Fee Related
- 2002-07-12 WO PCT/EP2002/007798 patent/WO2003013531A1/de active IP Right Grant
- 2002-07-12 JP JP2003518540A patent/JP4409941B2/ja not_active Expired - Fee Related
- 2002-07-12 ES ES02760242T patent/ES2377497T3/es not_active Expired - Lifetime
- 2002-07-12 CN CNA028154827A patent/CN1538845A/zh active Pending
- 2002-07-12 HU HU0401405A patent/HUP0401405A2/hu unknown
- 2002-07-12 PL PL02367960A patent/PL367960A1/xx unknown
- 2002-07-12 AT AT02760242T patent/ATE538792T1/de active
- 2002-07-12 BR BR0211737-1A patent/BR0211737A/pt not_active IP Right Cessation
- 2002-07-12 KR KR10-2003-7016957A patent/KR20040020061A/ko not_active Application Discontinuation
-
2004
- 2004-03-04 ZA ZA200401800A patent/ZA200401800B/en unknown
Also Published As
Publication number | Publication date |
---|---|
CN1538845A (zh) | 2004-10-20 |
US20040235828A1 (en) | 2004-11-25 |
PL367960A1 (en) | 2005-03-07 |
WO2003013531A1 (de) | 2003-02-20 |
CA2456717C (en) | 2012-01-03 |
ATE538792T1 (de) | 2012-01-15 |
KR20040020061A (ko) | 2004-03-06 |
ZA200401800B (en) | 2005-02-04 |
EP1414456B1 (de) | 2011-12-28 |
US7902223B2 (en) | 2011-03-08 |
JP4409941B2 (ja) | 2010-02-03 |
ES2377497T3 (es) | 2012-03-28 |
EP1414456A1 (de) | 2004-05-06 |
CA2456717A1 (en) | 2003-02-20 |
HUP0401405A2 (hu) | 2004-12-28 |
DE10139060A1 (de) | 2003-02-20 |
JP2005501075A (ja) | 2005-01-13 |
AU2002325882B2 (en) | 2007-05-17 |
MXPA04001121A (es) | 2004-05-20 |
RU2004106784A (ru) | 2005-07-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE 5A., 6A. E 7A. ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2029 DE 24/11/2009. |