BR0211130A - Plantas transgênicas que expressam proteìnas de ligação da cobalamina - Google Patents
Plantas transgênicas que expressam proteìnas de ligação da cobalaminaInfo
- Publication number
- BR0211130A BR0211130A BR0211130-6A BR0211130A BR0211130A BR 0211130 A BR0211130 A BR 0211130A BR 0211130 A BR0211130 A BR 0211130A BR 0211130 A BR0211130 A BR 0211130A
- Authority
- BR
- Brazil
- Prior art keywords
- binding proteins
- transgenic plants
- vitamin
- plants expressing
- cobalamin binding
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
- A01H1/00—Processes for modifying genotypes ; Plants characterised by associated natural traits
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/168—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
- A61K47/551—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds one of the codrug's components being a vitamin, e.g. niacinamide, vitamin B3, cobalamin, vitamin B12, folate, vitamin A or retinoic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/38—Vitamins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Nutrition Science (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Developmental Biology & Embryology (AREA)
- Environmental Sciences (AREA)
Abstract
"PLANTAS TRANSGêNICAS QUE EXPRESSAM PROTEìNAS DE LIGAçãO DA COBALAMINA". A presente invenção está relacionada com o uso de plantas transgênicas para a expressão das proteínas de ligação da vitamina B12 (cobalamina) . As células da planta são transformadas com seq³ências de nucleotídeos adaptadas para expressão e secreção das proteínas de ligação da vitamina B12. A presente invenção está relacionada também com o uso de proteínas de ligação da vitamina B12 recombinante de plantas em testes analíticos e tratamento de deficiência de vitamina B12. Também é apresentado um método para purificação de proteínas de ligação da vitamina B12 recombinante.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0117171A GB2377446B (en) | 2001-07-13 | 2001-07-13 | Expression of cobalamin binding proteins in transgenic plants |
PCT/GB2002/003227 WO2003006661A2 (en) | 2001-07-13 | 2002-07-12 | Transgenic plants expressing cobalamin binding proteins |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0211130A true BR0211130A (pt) | 2004-10-26 |
Family
ID=9918480
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0211130-6A BR0211130A (pt) | 2001-07-13 | 2002-07-12 | Plantas transgênicas que expressam proteìnas de ligação da cobalamina |
Country Status (16)
Country | Link |
---|---|
US (5) | US20040268440A1 (pt) |
EP (1) | EP1417320A2 (pt) |
JP (1) | JP2004533851A (pt) |
KR (1) | KR20040027876A (pt) |
CN (1) | CN1549862A (pt) |
BR (1) | BR0211130A (pt) |
CA (1) | CA2453574A1 (pt) |
EA (1) | EA200400174A1 (pt) |
GB (1) | GB2377446B (pt) |
HU (1) | HUP0400458A3 (pt) |
IL (1) | IL159817A0 (pt) |
MX (1) | MXPA04000377A (pt) |
NZ (1) | NZ531026A (pt) |
PL (1) | PL367827A1 (pt) |
WO (1) | WO2003006661A2 (pt) |
ZA (1) | ZA200400751B (pt) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1782063A2 (en) * | 2004-07-29 | 2007-05-09 | Cobento Biotech A/S | Methods for determining proteins and protein-bound compounds comprising enzymatic modification |
US7790363B2 (en) | 2005-02-07 | 2010-09-07 | Abbott Laboratories Inc. | Diagnostic test for vitamin B12 |
AU2015317016A1 (en) * | 2014-09-15 | 2017-02-02 | Société des Produits Nestlé S.A. | Method for determining vitamin B12 uptake |
US10716827B2 (en) | 2015-05-20 | 2020-07-21 | Syracuse University | Compositions and methods for enhancing peptide stability against protease digestion |
US20180154007A1 (en) * | 2015-05-20 | 2018-06-07 | Syracuse University | Glycemic Control Using Intrinsic Factor Bound to A Vitamin B12 Conjugate of a Glucagon-Like Peptide-1 Receptor Agonist |
US20220257805A1 (en) * | 2019-05-20 | 2022-08-18 | Syracuse University | Pharmaceutical formulations and methods for delivering a therapeutic, diagnostic, or imaging agent to cd206 |
CN114206367B (zh) * | 2019-08-09 | 2024-07-19 | 美国西门子医学诊断股份有限公司 | 抗猪tcn1单克隆抗体及其生产和使用方法 |
WO2023089616A1 (en) * | 2021-11-18 | 2023-05-25 | Imagindairy Ltd. | Food compositions comprising recombinant cells comprising transcobalamin |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3591678A (en) * | 1969-09-05 | 1971-07-06 | American Cyanamid Co | Method of purifying intrinsic factor |
US4279886A (en) * | 1979-01-02 | 1981-07-21 | University Patents, Inc. | Test for pancreatic exocrine function |
SU1751207A1 (ru) | 1990-04-20 | 1992-07-30 | Институт общей генетики им.Н.И.Вавилова | Рекомбинантна плазмидна ДНК pST20, кодирующа альфа-интерферон человека в растени х табака |
JPH0549478A (ja) * | 1991-06-06 | 1993-03-02 | Kanegafuchi Chem Ind Co Ltd | ヒト内因子をコードするdna配列 |
US5548064A (en) * | 1993-05-24 | 1996-08-20 | Biotech Australia Pty Limited | Vitamin B12 conjugates with EPO, analogues thereof and pharmaceutical compositions |
US5939288A (en) * | 1995-06-07 | 1999-08-17 | Iowa State University Research Foundation, Inc. | Plant secretory signal peptides and nectarins |
US5959187A (en) * | 1996-09-26 | 1999-09-28 | Bailey; James E. | Expression of oxygen-binding proteins in plants |
WO2000037610A2 (en) * | 1998-12-23 | 2000-06-29 | Boyce Thompson Institute For Plant Research At Cornell | Expression of immunogenic hepatitis b surface antigens in transgenic plants |
JP4890712B2 (ja) * | 1999-10-26 | 2012-03-07 | スティヒティング ディーンスト ランドバウクンディフ オンデルズーク | 植物における哺乳類型グリコシレーション |
CN1301718A (zh) * | 1999-12-27 | 2001-07-04 | 上海博德基因开发有限公司 | 一种新的多肽——钴胺素结合蛋白10和编码这种多肽的多核苷酸 |
WO2002064750A2 (en) * | 2001-02-14 | 2002-08-22 | Ventria Bioscience | Expression system for seed proteins |
PT1904636E (pt) * | 2005-07-12 | 2010-09-14 | Greenovation Biotech Gmbh | Melhoramentos na ou relacionados com a produção de proteínas |
-
2001
- 2001-07-13 GB GB0117171A patent/GB2377446B/en not_active Expired - Fee Related
-
2002
- 2002-07-12 JP JP2003512418A patent/JP2004533851A/ja active Pending
- 2002-07-12 PL PL02367827A patent/PL367827A1/xx not_active Application Discontinuation
- 2002-07-12 EA EA200400174A patent/EA200400174A1/ru unknown
- 2002-07-12 WO PCT/GB2002/003227 patent/WO2003006661A2/en active IP Right Grant
- 2002-07-12 KR KR10-2004-7000558A patent/KR20040027876A/ko not_active Application Discontinuation
- 2002-07-12 NZ NZ531026A patent/NZ531026A/en unknown
- 2002-07-12 US US10/483,849 patent/US20040268440A1/en not_active Abandoned
- 2002-07-12 CA CA002453574A patent/CA2453574A1/en not_active Abandoned
- 2002-07-12 EP EP02745627A patent/EP1417320A2/en not_active Withdrawn
- 2002-07-12 BR BR0211130-6A patent/BR0211130A/pt not_active IP Right Cessation
- 2002-07-12 CN CNA028168984A patent/CN1549862A/zh active Pending
- 2002-07-12 HU HU0400458A patent/HUP0400458A3/hu unknown
- 2002-07-12 IL IL15981702A patent/IL159817A0/xx unknown
- 2002-07-12 MX MXPA04000377A patent/MXPA04000377A/es not_active Application Discontinuation
-
2004
- 2004-01-29 ZA ZA200400751A patent/ZA200400751B/xx unknown
-
2009
- 2009-01-22 US US12/357,622 patent/US9751918B2/en active Active
-
2015
- 2015-02-19 US US14/625,922 patent/US20150158920A1/en not_active Abandoned
- 2015-02-19 US US14/625,914 patent/US20150158922A1/en not_active Abandoned
- 2015-02-19 US US14/625,916 patent/US20150157731A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US9751918B2 (en) | 2017-09-05 |
IL159817A0 (en) | 2004-06-20 |
ZA200400751B (en) | 2005-04-29 |
EP1417320A2 (en) | 2004-05-12 |
GB0117171D0 (en) | 2001-09-05 |
PL367827A1 (en) | 2005-03-07 |
MXPA04000377A (es) | 2005-03-07 |
JP2004533851A (ja) | 2004-11-11 |
US20150158922A1 (en) | 2015-06-11 |
HUP0400458A2 (hu) | 2004-11-29 |
KR20040027876A (ko) | 2004-04-01 |
GB2377446B (en) | 2005-06-29 |
NZ531026A (en) | 2005-09-30 |
US20150157731A1 (en) | 2015-06-11 |
US20100184642A1 (en) | 2010-07-22 |
US20150158920A1 (en) | 2015-06-11 |
US20040268440A1 (en) | 2004-12-30 |
GB2377446A (en) | 2003-01-15 |
HUP0400458A3 (en) | 2005-06-28 |
CN1549862A (zh) | 2004-11-24 |
WO2003006661A3 (en) | 2003-07-24 |
CA2453574A1 (en) | 2003-01-23 |
WO2003006661A2 (en) | 2003-01-23 |
EA200400174A1 (ru) | 2005-06-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B25D | Requested change of name of applicant approved |
Owner name: COBENTO BIOTECH A/S (DK) Free format text: ALTERADO DE: COBENTO BIOTECH APS |
|
B25A | Requested transfer of rights approved |
Owner name: COBENTO A/S (DK) Free format text: TRANSFERIDO DE: COBENTO BIOTECH A/S |
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B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A E 9A A NUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2108 DE 31/05/2011. |