BR0209837A - Partìcula semelhante a vìrus isolada ou recombimante capaz de replicação, composição, e, método para inibir ou bloquear uma infecção com um coronavìrus ou partìcula semelhante a coronavìrus - Google Patents
Partìcula semelhante a vìrus isolada ou recombimante capaz de replicação, composição, e, método para inibir ou bloquear uma infecção com um coronavìrus ou partìcula semelhante a coronavìrusInfo
- Publication number
- BR0209837A BR0209837A BR0209837-7A BR0209837A BR0209837A BR 0209837 A BR0209837 A BR 0209837A BR 0209837 A BR0209837 A BR 0209837A BR 0209837 A BR0209837 A BR 0209837A
- Authority
- BR
- Brazil
- Prior art keywords
- particle
- coronavirus
- vlps
- deletion
- replicative
- Prior art date
Links
- 239000002245 particle Substances 0.000 title abstract 5
- 241000711573 Coronaviridae Species 0.000 title abstract 3
- 230000000903 blocking effect Effects 0.000 title abstract 2
- 208000015181 infectious disease Diseases 0.000 title abstract 2
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 230000010076 replication Effects 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 230000003362 replicative effect Effects 0.000 abstract 3
- 230000002238 attenuated effect Effects 0.000 abstract 2
- 238000012217 deletion Methods 0.000 abstract 2
- 230000037430 deletion Effects 0.000 abstract 2
- 230000001225 therapeutic effect Effects 0.000 abstract 2
- 229960005486 vaccine Drugs 0.000 abstract 2
- -1 REPLICABLE Substances 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000001476 gene delivery Methods 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 238000002372 labelling Methods 0.000 abstract 1
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Abstract
"PARTìCULA SEMELHANTE A VìRUS ISOLADA OU RECOMBINANTE CAPAZ DE REPLICAçãO, COMPOSIçãO, E, MéTODO PARA INIBIR OU BLOQUEAR UMA INFECçãO COM UM CORONAVìRUS OU PARTìCULA SEMELHANTE A CORONAVìRUS". A invenção refere-se ao campo dos coronavírus e ao diagnóstico, uso terapêutico e vacinas derivadas dos mesmos. A invenção proporciona coronavírus replicativos e partículas semelhantes a vírus (VLPS) replicativas de que grandes partes de seu genoma são deletadas (pelo menos funcionalmente) sem abolir suas capacidades replicativas. Referida deleção resulta, de preferência, numa deleção pelo menos funcional pelo fato de que o gene correspondente não é expresso ou só é expresso parcialmente, com o que o produto de gene resultante é disfuncional ou pelo menos funcionalmente distinto de um produto de gene de tipo selvagem. Um resultado notável observado com VLPs dotadas com deleções como proporcionado aqui é que referidas VLPs deletadas, embora capazes de replicação in vitro e in vivo, são geralmente bem atenuadas, pelo fato de que não causam doença no hospedeiro-alvo, o que as torna muito adequadas para uso terapêutico, tanto como um veículo de fornecimento para genes como para outras cargas (com o que se pode proporcionar marcação específica e também quando desejada), e para uso como uma vacina, sendo atenuadas ao mesmo tempo em que carregam importantes determinantes imunogênicos que auxiliam a obter uma resposta imunológica.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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EP01201861 | 2001-05-17 | ||
PCT/NL2002/000318 WO2002092827A2 (en) | 2001-05-17 | 2002-05-17 | Corona-virus-like particles comprising functionally deleted genomes |
Publications (1)
Publication Number | Publication Date |
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BR0209837A true BR0209837A (pt) | 2004-12-14 |
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BR0209837-7A BR0209837A (pt) | 2001-05-17 | 2002-05-17 | Partìcula semelhante a vìrus isolada ou recombimante capaz de replicação, composição, e, método para inibir ou bloquear uma infecção com um coronavìrus ou partìcula semelhante a coronavìrus |
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US (1) | US20040071709A1 (pt) |
EP (1) | EP1470218B1 (pt) |
JP (1) | JP4463481B2 (pt) |
CN (1) | CN100580080C (pt) |
AT (1) | ATE473274T1 (pt) |
AU (1) | AU2002311668B2 (pt) |
BR (1) | BR0209837A (pt) |
CA (1) | CA2447450C (pt) |
DE (1) | DE60236965D1 (pt) |
ES (1) | ES2348600T3 (pt) |
HU (1) | HU228121B1 (pt) |
MX (1) | MXPA03010427A (pt) |
NZ (1) | NZ529691A (pt) |
PL (1) | PL207933B1 (pt) |
WO (1) | WO2002092827A2 (pt) |
ZA (1) | ZA200309098B (pt) |
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US7556957B2 (en) | 2001-05-17 | 2009-07-07 | Stichting Voor De Technische Wetenschappen | Coronavirus-like particles comprising functionally deleted genomes |
JP4242607B2 (ja) * | 2002-07-04 | 2009-03-25 | 学校法人北里研究所 | ネコ伝染性腹膜炎ワクチン |
ES2333223T3 (es) * | 2003-03-03 | 2010-02-18 | Intervet International B.V. | Virus de la bronquitis infecciosa que contiene un gen punta modificado. |
US7151163B2 (en) * | 2003-04-28 | 2006-12-19 | Sequoia Pharmaceuticals, Inc. | Antiviral agents for the treatment, control and prevention of infections by coronaviruses |
CA2527296A1 (en) * | 2003-05-27 | 2004-12-09 | Anticancer, Inc. | Imageable animal model of sars infection |
WO2004110483A1 (en) * | 2003-05-31 | 2004-12-23 | Yiyou Chen | Method and composition of a novel vaccine design for the prevention and treatment of sars |
KR101206206B1 (ko) * | 2003-07-22 | 2012-11-29 | 크루셀 홀란드 비.브이. | 사스-코로나바이러스에 대한 결합분자 및 그것의 용도 |
CN1324049C (zh) * | 2003-08-04 | 2007-07-04 | 中国疾病预防控制中心病毒病预防控制所 | 人源抗sars冠状病毒基因工程抗体 |
JP2007502612A (ja) † | 2003-08-18 | 2007-02-15 | アムステルダム インスティチュ−ト オブ ヴァイラル ゲノミックス ベー.フェー. | コロナウイルス、核酸、蛋白質、ならびにワクチンの生成方法、薬剤および診断 |
DE602004028506D1 (de) * | 2003-12-02 | 2010-09-16 | Pasteur Institut | Neuer mit sars verbunden coronavirus stamm und seine verwendungen |
WO2005077103A2 (en) * | 2004-02-12 | 2005-08-25 | Regents Of The University Of Colorado | Compositions and methods for modification and prevention of sars coronavirus infectivity |
US20060199176A1 (en) * | 2004-07-15 | 2006-09-07 | Yeau-Ching Wang | Coronavirus S peptides |
WO2006024542A1 (en) * | 2004-09-03 | 2006-03-09 | Consejo Superior De Investigaciones Cientificas | Nucleic acid sequences encoding proteins capable of associating into a virus-like particle |
EP1650308A1 (en) * | 2004-09-03 | 2006-04-26 | Consejo Superior De Investigaciones Cientificas | Nucleic acid sequences encoding proteins capable of associating into a virus-like particle |
WO2006056103A1 (fr) * | 2004-11-26 | 2006-06-01 | Dna Shuttle Biopharm Co., Ltd. | Vecteur d'expression codant des particules de type coronavirus |
KR100915980B1 (ko) | 2004-11-26 | 2009-09-10 | 디엔에이 셔틀 바이오팜 컴퍼니, 엘티디. | 코로나바이러스-유사 입자를 인코딩하는 발현 벡터 |
EP1792996A1 (en) * | 2005-12-01 | 2007-06-06 | Consejo Superior de Investigaciones Cientificas | Nucleic acid sequences encoding vaccines against Porcine reproductive and respiratory syndrome virus (PRRSV) |
KR20120018783A (ko) * | 2009-05-01 | 2012-03-05 | 레드바이오텍 아게 | 다중 유전자 벡터에 의해 암호화된 재조합 바이러스-유사 입자 |
US20130183740A1 (en) * | 2010-06-02 | 2013-07-18 | Avir Green Hills Biotechnology Research Development Trade Ag | Novel method for generation of rna virus |
CN103316337B (zh) * | 2010-08-30 | 2014-08-13 | 中国人民解放军军事医学科学院微生物流行病研究所 | 痘苗病毒载体基因修饰***的建立及重组冠状病毒的应用 |
CN101948516B (zh) * | 2010-08-30 | 2013-05-01 | 中国人民解放军军事医学科学院微生物流行病研究所 | 一种以痘苗病毒载体为基础的反向遗传学***建立及应用 |
WO2012117045A1 (en) * | 2011-03-02 | 2012-09-07 | Intervet International B.V. | Infectious bronchitis virus (ibv) spike protein as subunit vaccine |
WO2013135655A1 (en) * | 2012-03-13 | 2013-09-19 | Universiteit Utrecht Holding B.V. | Bi-specific adapters |
WO2016022028A1 (en) | 2014-08-08 | 2016-02-11 | Universiteit Utrecht Holding B.V. | Mutant porcine epizootic diarrhea virus for use in a vaccine |
GB201601498D0 (en) | 2016-01-27 | 2016-03-09 | Pirbright Inst The | Coronavirus |
CN112300251B (zh) * | 2020-02-24 | 2022-04-05 | 成都威斯克生物医药有限公司 | 抗SARS-CoV-2感染的蛋白及疫苗 |
WO2021232067A1 (en) * | 2020-05-15 | 2021-11-18 | Glg Pharma, Llc | Stats3 inhibition for treatment and prevention of human coronavirus infection |
CN111732637B (zh) * | 2020-05-25 | 2022-03-01 | 上海交通大学 | 抑制新型冠状病毒SARS-CoV-2感染宿主细胞的多肽及其应用 |
IL300905A (en) * | 2020-08-27 | 2023-04-01 | Univ Leland Stanford Junior | Immunogenic fusion proteins from the corona virus, preparations containing them and their uses |
CN112250738B (zh) * | 2020-09-02 | 2023-05-12 | 兰州大学 | 严重急性呼吸综合征冠状病毒2病毒样颗粒的制备、纯化和鉴定方法 |
US11479582B2 (en) | 2020-10-16 | 2022-10-25 | King Faisal University | Anti-SARS-CoV-2 fusion peptides |
WO2022103797A1 (en) * | 2020-11-10 | 2022-05-19 | Massachusetts Institute Of Technology | Engineered protein for rapid, efficient capture of pathogen-specific antibodies |
CN113151359A (zh) * | 2020-12-25 | 2021-07-23 | 广州医科大学 | 一种冠状病毒的缺陷型嵌合病毒模型的包装体系及其应用 |
CN112852762B (zh) | 2021-04-02 | 2021-09-10 | 青岛海华生物医药技术有限公司 | 新型冠状病毒肺炎副粘病毒疫苗株及其构建方法 |
CN113713122A (zh) * | 2021-08-24 | 2021-11-30 | 华中科技大学 | 一种与新冠病毒竞争性结合细胞表面受体的超分子 |
CN116042538B (zh) * | 2022-11-24 | 2024-05-07 | 华中农业大学 | 一株猫冠状病毒及其应用 |
CN116808193B (zh) * | 2023-08-29 | 2023-11-14 | 成都导飞科技有限公司 | 一种用于预防猫传染性腹膜炎的重组蛋白疫苗及其应用 |
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AU7350798A (en) * | 1997-04-29 | 1998-11-24 | Universiteit Utrecht | Corona virus-like particles as tools for vaccination and therapy |
ES2170622B1 (es) * | 1999-12-03 | 2004-05-16 | Consejo Superior De Investigaciones Cientificas | Clones y vectores infectivos derivados de coronavirus y sus aplicaciones. |
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2002
- 2002-05-17 MX MXPA03010427A patent/MXPA03010427A/es active IP Right Grant
- 2002-05-17 EP EP02738952A patent/EP1470218B1/en not_active Expired - Lifetime
- 2002-05-17 CA CA2447450A patent/CA2447450C/en not_active Expired - Lifetime
- 2002-05-17 ES ES02738952T patent/ES2348600T3/es not_active Expired - Lifetime
- 2002-05-17 HU HU0400042A patent/HU228121B1/hu unknown
- 2002-05-17 WO PCT/NL2002/000318 patent/WO2002092827A2/en active Application Filing
- 2002-05-17 NZ NZ529691A patent/NZ529691A/en not_active IP Right Cessation
- 2002-05-17 JP JP2002589693A patent/JP4463481B2/ja not_active Expired - Fee Related
- 2002-05-17 DE DE60236965T patent/DE60236965D1/de not_active Expired - Lifetime
- 2002-05-17 AU AU2002311668A patent/AU2002311668B2/en not_active Expired
- 2002-05-17 PL PL374582A patent/PL207933B1/pl unknown
- 2002-05-17 BR BR0209837-7A patent/BR0209837A/pt not_active IP Right Cessation
- 2002-05-17 AT AT02738952T patent/ATE473274T1/de not_active IP Right Cessation
- 2002-05-17 CN CN02814378A patent/CN100580080C/zh not_active Expired - Lifetime
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Also Published As
Publication number | Publication date |
---|---|
CA2447450C (en) | 2011-12-20 |
CN100580080C (zh) | 2010-01-13 |
PL207933B1 (pl) | 2011-02-28 |
HUP0400042A3 (en) | 2011-07-28 |
PL374582A1 (en) | 2005-10-31 |
EP1470218A2 (en) | 2004-10-27 |
EP1470218B1 (en) | 2010-07-07 |
DE60236965D1 (de) | 2010-08-19 |
WO2002092827A2 (en) | 2002-11-21 |
MXPA03010427A (es) | 2004-12-06 |
JP2005503132A (ja) | 2005-02-03 |
CN1620500A (zh) | 2005-05-25 |
CA2447450A1 (en) | 2002-11-21 |
AU2002311668B2 (en) | 2007-10-04 |
NZ529691A (en) | 2007-12-21 |
ZA200309098B (en) | 2005-04-26 |
WO2002092827A3 (en) | 2004-05-27 |
US20040071709A1 (en) | 2004-04-15 |
HUP0400042A2 (hu) | 2004-04-28 |
ES2348600T3 (es) | 2010-12-09 |
HU228121B1 (en) | 2012-11-28 |
ATE473274T1 (de) | 2010-07-15 |
JP4463481B2 (ja) | 2010-05-19 |
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