BR0209564A - Animal transgênico, embrião, camundongo transgênico, modelo animal para o estudo da modulação da densidade óssea, célula isolada, ácido nucleico para marcar o gene pela recombinação homóloga, e, métodos para estudar determinantes da massa óssea, para estudar moduladores de massa óssea, para estudar a massa óssea, para estudar um efeito hbm sobre os distúrbios ósseos, para identificar marcadores substitutos da formação/reabsorção ósseas, para estudar efeitos de hbm sobre os distúrbios cardìacos, para avaliar tratamentos cárdio-protetores quanto aos efeitos de modulação da massa óssea, para modular a densidade óssea, para produzir um camundongo transgênico e para identificar genes associados com a massa óssea - Google Patents

Animal transgênico, embrião, camundongo transgênico, modelo animal para o estudo da modulação da densidade óssea, célula isolada, ácido nucleico para marcar o gene pela recombinação homóloga, e, métodos para estudar determinantes da massa óssea, para estudar moduladores de massa óssea, para estudar a massa óssea, para estudar um efeito hbm sobre os distúrbios ósseos, para identificar marcadores substitutos da formação/reabsorção ósseas, para estudar efeitos de hbm sobre os distúrbios cardìacos, para avaliar tratamentos cárdio-protetores quanto aos efeitos de modulação da massa óssea, para modular a densidade óssea, para produzir um camundongo transgênico e para identificar genes associados com a massa óssea

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Publication number
BR0209564A
BR0209564A BR0209564-5A BR0209564A BR0209564A BR 0209564 A BR0209564 A BR 0209564A BR 0209564 A BR0209564 A BR 0209564A BR 0209564 A BR0209564 A BR 0209564A
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BR
Brazil
Prior art keywords
study
bone
bone mass
hbm
mass
Prior art date
Application number
BR0209564-5A
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English (en)
Inventor
Philip Babij
Frederick James Bex Iii
Peter Van Nest Bodine
G Roger Askew
Original Assignee
Wyeth Corp
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Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of BR0209564A publication Critical patent/BR0209564A/pt

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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Abstract

"ANIMAL TRANSGêNICO, EMBRIãO, CAMUNDONGO TRANSGêNICO, MODELO ANIMAL PARA O ESTUDO DA MODULAçãO DA DENSIDADE óSSEA, CéLULA ISOLADA , áCIDO NUCLEICO PARA MARCAR O GENE PELA RECOMBINAçãO HOMóLOGA, E, MéTODOS PARA ESTUDAR DETERMINANTES DA MASSA óSSEA, PARA ESTUDAR MODULADORES DE MASSA óSSEA, PARA ESTUDAR A MASSA óSSEA, PARA ESTUDAR UM EFEITO DE HBM SOBRE OS DISTúRBIOS óSSEOS, PARA IDENTIFICAR MARCADORES SUBSTITUTOS DA FORMAçãO/REABSORçãO óSSEAS, PARA ESTUDAR EFEITOS DE HBM SOBRE OS DISTúRBIOS CARDìACOS, PARA AVALIAR TRATAMENTOS CáRDIO-PROTETORES QUANTO AOS EFEITOS DE MODULAçãO DA MASSA óSSEA, PARA MODULAR A DENSIDADE óSSEA, PARA PRODUZIR UM CAMUNDONGO TRANSGêNICO E PARA IDENTIFICAR GENES ASSOCIADOS COM A MASSA óSSEA". A presente invenção diz respeito a métodos e materiais usados para expressar a proteina HBM em células de animal e animais transgênicos. A presente invenção também diz respeito aos animais transgênicos que expressam o gene da massa óssea alta, o gene do tipo selvagem correspondente e mutantes destes. A invenção fornece ácidos nucleicos, incluindo seq³ências codificadoras, iniciadores de oligonucleotídeo e sondas, proteinas, vetores de clonagem, vetores de expressão, hospedeiros transformados, métodos de desenvolver composições farmacêuticas, métodos de identificar moléculas envolvidas no desenvolvimento ósseo e métodos de diagnosticar e tratar doenças envolvidas no desenvolvimento ósseo. Em formas de realização preferidas, a presente invenção está direcionada a métodos para tratar, diagnosticar e prevenir a osteoporose.
BR0209564-5A 2001-05-11 2002-05-13 Animal transgênico, embrião, camundongo transgênico, modelo animal para o estudo da modulação da densidade óssea, célula isolada, ácido nucleico para marcar o gene pela recombinação homóloga, e, métodos para estudar determinantes da massa óssea, para estudar moduladores de massa óssea, para estudar a massa óssea, para estudar um efeito hbm sobre os distúrbios ósseos, para identificar marcadores substitutos da formação/reabsorção ósseas, para estudar efeitos de hbm sobre os distúrbios cardìacos, para avaliar tratamentos cárdio-protetores quanto aos efeitos de modulação da massa óssea, para modular a densidade óssea, para produzir um camundongo transgênico e para identificar genes associados com a massa óssea BR0209564A (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US29007101P 2001-05-11 2001-05-11
US29131101P 2001-05-17 2001-05-17
US35305802P 2002-02-01 2002-02-01
US36129302P 2002-03-04 2002-03-04
PCT/US2002/014876 WO2002092764A2 (en) 2001-05-11 2002-05-13 Transgenic animal model of bone mass modulation

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BR0209564A true BR0209564A (pt) 2004-10-26

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ID=27501520

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BR0209563-7A BR0209563A (pt) 2001-05-11 2002-05-13 ácido nucleico, polipeptìdeo, vetor, célula, anticorpo, métodos de diagnosticar um fenótipo e um paciente como expressando um ácido nucleico e de identificar agentes que modulam a atividade de um ácido nucleico e de uma proteìna e lrp5, lrp6, ou hbm e compostos que modulam a interação de dkk com o caminho de sinalização wnt, composição para modular a massa óssea e/ou os nìveis de lipìdeo em um paciente, animal transgênico, embrião e modelo de animal, e, agente
BR0209564-5A BR0209564A (pt) 2001-05-11 2002-05-13 Animal transgênico, embrião, camundongo transgênico, modelo animal para o estudo da modulação da densidade óssea, célula isolada, ácido nucleico para marcar o gene pela recombinação homóloga, e, métodos para estudar determinantes da massa óssea, para estudar moduladores de massa óssea, para estudar a massa óssea, para estudar um efeito hbm sobre os distúrbios ósseos, para identificar marcadores substitutos da formação/reabsorção ósseas, para estudar efeitos de hbm sobre os distúrbios cardìacos, para avaliar tratamentos cárdio-protetores quanto aos efeitos de modulação da massa óssea, para modular a densidade óssea, para produzir um camundongo transgênico e para identificar genes associados com a massa óssea

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BR0209563-7A BR0209563A (pt) 2001-05-11 2002-05-13 ácido nucleico, polipeptìdeo, vetor, célula, anticorpo, métodos de diagnosticar um fenótipo e um paciente como expressando um ácido nucleico e de identificar agentes que modulam a atividade de um ácido nucleico e de uma proteìna e lrp5, lrp6, ou hbm e compostos que modulam a interação de dkk com o caminho de sinalização wnt, composição para modular a massa óssea e/ou os nìveis de lipìdeo em um paciente, animal transgênico, embrião e modelo de animal, e, agente

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US (2) US7416849B2 (pt)
EP (2) EP1401269A4 (pt)
JP (3) JP2004537289A (pt)
AU (2) AU2002316095A1 (pt)
BR (2) BR0209563A (pt)
CA (2) CA2446859A1 (pt)
WO (2) WO2002092764A2 (pt)

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US6770461B1 (en) 1998-10-23 2004-08-03 Genome Therapeutics Corporation High bone mass gene of 11q13.3
US6780609B1 (en) * 1998-10-23 2004-08-24 Genome Therapeutics Corporation High bone mass gene of 1.1q13.3
WO2001092891A2 (en) * 2000-05-26 2001-12-06 Genome Therapeutics Corporation Regulating lipid levels via the zmax1 or hbm gene
CA2446859A1 (en) 2001-05-11 2002-11-21 Wyeth Transgenic animal model of bone mass modulation
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