BR0209446A - Método para identificar inibidores de mieloperoxidase, e, uso de um método - Google Patents

Método para identificar inibidores de mieloperoxidase, e, uso de um método

Info

Publication number
BR0209446A
BR0209446A BR0209446-0A BR0209446A BR0209446A BR 0209446 A BR0209446 A BR 0209446A BR 0209446 A BR0209446 A BR 0209446A BR 0209446 A BR0209446 A BR 0209446A
Authority
BR
Brazil
Prior art keywords
myeloperoxidase
detector molecule
reacting
oxidized
inhibitors
Prior art date
Application number
BR0209446-0A
Other languages
English (en)
Inventor
Anthony Kettle
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/SE2001/001014 external-priority patent/WO2001085146A1/en
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Priority claimed from PCT/SE2002/000877 external-priority patent/WO2002090575A1/en
Publication of BR0209446A publication Critical patent/BR0209446A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0065—Oxidoreductases (1.) acting on hydrogen peroxide as acceptor (1.11)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/28—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving peroxidase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

"MéTODO PARA IDENTIFICAR INIBIDORES DE MIELOPEROXIDASE, E, USO DE UM MéTODO". Um método de ensaio para a detecção de inibidores da enzima mieloperoxidase, o citado método compreendendo as etapas de: reagir mieloperoxidase com peróxido de hidrogênio e uma fonte de cloreto para gerar ácido hipocloroso na presença de um inibidor potencial da citada mieloperoxidase; reagir qualquer ácido hipocloroso formado com uma amina adequada para formar a cloramina correspondente; opcionalmente remover qualquer peróxido de hidrogênio não reagido; reagir qualquer cloramina com uma molécula detectora apropriada na presença de iodeto para formar molécula detectora oxidada; determinar a quantidade de molécula detectora oxidada formada pela medição da absorbância ou da fluorescência em um comprimento de onda adequado; identificar como inibidores de mieloperoxidase aqueles compostos que causam a diminuição da quantidade de molécula detectora oxidada formada. E é descrito o uso em testes de diagnósticos para a atividade de mieloperoxidase.
BR0209446-0A 2001-05-08 2002-05-06 Método para identificar inibidores de mieloperoxidase, e, uso de um método BR0209446A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/SE2001/001014 WO2001085146A1 (en) 2000-05-12 2001-05-08 Pharmaceutical compounds for treating copd
SE0103766A SE0103766D0 (sv) 2001-11-09 2001-11-09 Novel assay
PCT/SE2002/000877 WO2002090575A1 (en) 2001-05-08 2002-05-06 An assay for detecting inhibitors of the enzyme mueloperokidase

Publications (1)

Publication Number Publication Date
BR0209446A true BR0209446A (pt) 2004-08-03

Family

ID=20285957

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0209446-0A BR0209446A (pt) 2001-05-08 2002-05-06 Método para identificar inibidores de mieloperoxidase, e, uso de um método

Country Status (10)

Country Link
US (1) US7108997B2 (pt)
KR (1) KR100879700B1 (pt)
BR (1) BR0209446A (pt)
CY (1) CY1107345T1 (pt)
HK (1) HK1061700A1 (pt)
MX (1) MXPA03010143A (pt)
NO (1) NO20034951D0 (pt)
PT (1) PT1387893E (pt)
SE (1) SE0103766D0 (pt)
ZA (1) ZA200308185B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR039385A1 (es) * 2002-04-19 2005-02-16 Astrazeneca Ab Derivados de tioxantina como inhibidores de la mieloperoxidasa
SE0302756D0 (sv) * 2003-10-17 2003-10-17 Astrazeneca Ab Novel Compounds
SE0402591D0 (sv) * 2004-10-25 2004-10-25 Astrazeneca Ab Novel use
MY140748A (en) * 2004-12-06 2010-01-15 Astrazeneca Ab Novel pyrrolo [3,2-d] pyrimidin-4-one derivatives and their use in therapy
TW200804383A (en) * 2006-06-05 2008-01-16 Astrazeneca Ab New compounds
WO2011133581A1 (en) 2010-04-19 2011-10-27 General Atomics Methods and compositions for assaying enzymatic activity of myeloperoxidase in blood samples
AU2012281172B2 (en) 2011-07-11 2016-11-17 Exoxemis, Inc. Eosinophil peroxidase compositions and methods of their use
US20150099010A1 (en) 2013-10-07 2015-04-09 Reoxcyn Discoveries Group, Inc Redox signaling gel formulation
US10485827B2 (en) 2016-01-19 2019-11-26 Rdg Holdings, Inc. Topical eye serum compositions, methods or preparing, and methods of use
US11857674B2 (en) 2016-05-18 2024-01-02 Reoxcyn, Llc Lubricant formulations
US9474768B1 (en) 2016-05-18 2016-10-25 Reoxcyn Discoveries Group, Inc. Lubricant formulations
US9833471B1 (en) 2016-09-15 2017-12-05 Reoxcyn Discoveries Group, Inc. Hypochlorous acid-based hand sanitizer
US20180200165A1 (en) 2017-01-16 2018-07-19 Reoxcyn Innovation Group, Llc Dentifrice formulations and methods of oral care

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6046019A (en) * 1991-07-09 2000-04-04 Goumeniouk; Alexander P. Diagnostic kits and methods for making granulocyte cell counts
US5976823A (en) * 1997-03-19 1999-11-02 Integrated Biomedical Technology, Inc. Low range total available chlorine test strip
GB2362101A (en) * 2000-05-12 2001-11-14 Astrazeneca Ab Treatment of chronic obstructive pulmonary disease
FR2819723B1 (fr) * 2001-01-23 2006-11-17 Arnaud Mainnemare Composition halogene, son procede de preparation et ses utilisations

Also Published As

Publication number Publication date
ZA200308185B (en) 2004-07-05
US20040142407A1 (en) 2004-07-22
MXPA03010143A (es) 2004-05-21
NO20034951D0 (no) 2003-11-06
KR20030094389A (ko) 2003-12-11
US7108997B2 (en) 2006-09-19
CY1107345T1 (el) 2012-12-19
SE0103766D0 (sv) 2001-11-09
KR100879700B1 (ko) 2009-01-21
PT1387893E (pt) 2007-02-28
HK1061700A1 (en) 2004-09-30

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 9A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2108 DE 31/05/2011.