BR0208510A - Métodos de sìntese de compostos contendo fenol - Google Patents

Métodos de sìntese de compostos contendo fenol

Info

Publication number
BR0208510A
BR0208510A BR0208510-0A BR0208510A BR0208510A BR 0208510 A BR0208510 A BR 0208510A BR 0208510 A BR0208510 A BR 0208510A BR 0208510 A BR0208510 A BR 0208510A
Authority
BR
Brazil
Prior art keywords
phenol
containing compounds
synthesis methods
synthesis
methods
Prior art date
Application number
BR0208510-0A
Other languages
English (en)
Inventor
Michael R Palovich
Katherine L Widdowson
Original Assignee
Smithkline Beecham Corporatiio
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corporatiio filed Critical Smithkline Beecham Corporatiio
Publication of BR0208510A publication Critical patent/BR0208510A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
    • C07C311/47—Y being a hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
    • C07C311/43—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"MéTODOS DE SìNTESE DE COMPOSTOS CONTENDO FENOL". A presente invenção se refere ao método de colocação de um grupo sulfona ou sulfonamida orto a um fenol em uma substância de droga a fim de aumentar a estabilidade metabólica e a meia-vida do composto, enquanto mantém-se a acidez do fenol. Métodos de síntese de compostos contendo fenol são também descritos.
BR0208510-0A 2001-03-30 2002-03-27 Métodos de sìntese de compostos contendo fenol BR0208510A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28041101P 2001-03-30 2001-03-30
PCT/US2002/010038 WO2002079122A2 (en) 2001-03-30 2002-03-27 Methods of synthesizing phenol-containing compounds

Publications (1)

Publication Number Publication Date
BR0208510A true BR0208510A (pt) 2005-04-19

Family

ID=23072962

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0208510-0A BR0208510A (pt) 2001-03-30 2002-03-27 Métodos de sìntese de compostos contendo fenol

Country Status (16)

Country Link
US (1) US20040110954A1 (pt)
EP (1) EP1383488A2 (pt)
JP (1) JP2005507366A (pt)
KR (1) KR20030088044A (pt)
CN (1) CN1529591A (pt)
AR (1) AR034299A1 (pt)
BR (1) BR0208510A (pt)
CA (1) CA2442480A1 (pt)
CZ (1) CZ20032639A3 (pt)
HU (1) HUP0500644A3 (pt)
IL (1) IL158014A0 (pt)
MX (1) MXPA03008946A (pt)
NO (1) NO20034288L (pt)
PL (1) PL373510A1 (pt)
WO (1) WO2002079122A2 (pt)
ZA (1) ZA200307443B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY149050A (en) * 2001-04-16 2013-07-15 Merck Sharp & Dohme 3,4 di-substituted cyclobutene-1,2-diones as cxc-chemokine receptor ligands
MY143477A (en) * 2002-10-29 2011-05-31 Smithkline Beecham Corp Il-8 receptor antagonists
WO2006043950A1 (en) * 2004-10-20 2006-04-27 Smithkline Beecham Corporation Il-8 receptor antagonists
CN101495113A (zh) * 2006-04-21 2009-07-29 史密丝克莱恩比彻姆公司 Il-8受体拮抗剂
CL2007001142A1 (es) * 2006-04-21 2008-01-25 Smithkline Beecham Corp Compuestos derivados de sulfona, antagonistas del receptor il-8; procedimiento de preparacion;compuestos intermediarios;composicion farmaceutica; combinacion farmaceutica; y uso en el tratamiento de asma, enfermedad pulmonar obstructiva cronica, dermatitis, psoriasis, alzheimer, aterosclerosis, osteoporosis.
AR061571A1 (es) * 2006-06-23 2008-09-03 Smithkline Beecham Corp Compuesto sal del acido toluenosulfonico de 4-{[6-cloro-3-({[(2- cloro-3-fluorofenil) amino]carbonil} amino)- 2- hidroxifenil]sulfonil] -1- piperazinacarbxilato de 1.1-dimetiletilo, composicion farmaceutica que lo comprende su uso para la fabricacion de un medicamento combinacion farmaceutica con un
UA103198C2 (en) 2008-08-04 2013-09-25 Новартис Аг Squaramide derivatives as cxcr2 antagonists
CA2783696A1 (en) 2009-12-17 2011-06-23 Galderma Research & Development Use of compounds in the treatment or prevention of skin disorders
KR102024955B1 (ko) 2011-09-02 2019-09-24 노파르티스 아게 치환된 시클로부텐디온 항염 화합물의 콜린 염
AU2018318075B2 (en) 2017-08-14 2023-04-13 Allergan, Inc. 3,4-disubstituted 3-cyclobutene-1,2-diones and use thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3714232A (en) * 1969-06-25 1973-01-30 Merck & Co Inc 5-arylphenyl sulfonic acids
US3691185A (en) * 1970-04-20 1972-09-12 Lewis H Sarett 5-aryl and arylphenyl sulfonic acids in treating inflammation
DE3208189A1 (de) * 1982-03-06 1983-09-08 Hoechst Ag, 6230 Frankfurt 2-aminomethyl-6-sulfamoylphenolderivate, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen
UY25842A1 (es) * 1998-12-16 2001-04-30 Smithkline Beecham Corp Antagonistas de receptores de il-8

Also Published As

Publication number Publication date
CN1529591A (zh) 2004-09-15
WO2002079122A3 (en) 2002-11-28
JP2005507366A (ja) 2005-03-17
CA2442480A1 (en) 2002-10-10
IL158014A0 (en) 2004-03-28
EP1383488A2 (en) 2004-01-28
HUP0500644A3 (en) 2005-11-28
PL373510A1 (en) 2005-09-05
US20040110954A1 (en) 2004-06-10
NO20034288D0 (no) 2003-09-25
CZ20032639A3 (cs) 2004-04-14
KR20030088044A (ko) 2003-11-15
WO2002079122A2 (en) 2002-10-10
NO20034288L (no) 2003-12-01
ZA200307443B (en) 2004-10-29
HUP0500644A2 (hu) 2005-09-28
AR034299A1 (es) 2004-02-18
MXPA03008946A (es) 2004-05-21

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A,6A E 7A ANUIDADES

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2029 DE 24/11/2009.