BR0116723A - Derivados de tioéster de ácido tiazolil acético e seu uso na preparação de compostos de cefalosporina - Google Patents

Derivados de tioéster de ácido tiazolil acético e seu uso na preparação de compostos de cefalosporina

Info

Publication number
BR0116723A
BR0116723A BR0116723-5A BR0116723A BR0116723A BR 0116723 A BR0116723 A BR 0116723A BR 0116723 A BR0116723 A BR 0116723A BR 0116723 A BR0116723 A BR 0116723A
Authority
BR
Brazil
Prior art keywords
acetic acid
thioester derivatives
preparation
acid thioester
cephalosporin compounds
Prior art date
Application number
BR0116723-5A
Other languages
English (en)
Inventor
Pandurang Balwant Deshpande
Parven Kumar Luthra
Original Assignee
Orchid Chemicals & Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orchid Chemicals & Pharm Ltd filed Critical Orchid Chemicals & Pharm Ltd
Publication of BR0116723A publication Critical patent/BR0116723A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"DERIVADOS DE TIOéSTER DE áCIDO TIAZOLIL ACéTICO E SEU USO NA PREPARAçãO DE COMPOSTOS DE CEFALOSPORINA". A presente invenção refere-se a derivados de tioéster de ácido tiazolil acético da fórmula geral (I), também, a invenção proporciona um método de preparação dos derivados de tioéster e reação dos derivados de tioéster com ácido cefem carboxílicos para produzir compostos antibióticos de cefalosporina tendo a fórmula geral (II).
BR0116723-5A 2001-01-05 2001-02-28 Derivados de tioéster de ácido tiazolil acético e seu uso na preparação de compostos de cefalosporina BR0116723A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/754,302 US6388070B1 (en) 2001-01-05 2001-01-05 Thioester derivatives of thiazolyl acetic acid and their use in the preparation of cephalosporin compounds
PCT/IN2001/000028 WO2002053563A1 (en) 2001-01-05 2001-02-28 Novel thioester derivatives of thiazolyl acetic acid and their use in the preparation of cephalosporin compounds

Publications (1)

Publication Number Publication Date
BR0116723A true BR0116723A (pt) 2005-02-01

Family

ID=25034204

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0116723-5A BR0116723A (pt) 2001-01-05 2001-02-28 Derivados de tioéster de ácido tiazolil acético e seu uso na preparação de compostos de cefalosporina

Country Status (8)

Country Link
US (2) US6388070B1 (pt)
EP (1) EP1347970A1 (pt)
JP (1) JP2004520336A (pt)
KR (1) KR20030078882A (pt)
CN (1) CN1492867A (pt)
BR (1) BR0116723A (pt)
CA (1) CA2433783A1 (pt)
WO (1) WO2002053563A1 (pt)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20010635A1 (es) 1999-10-08 2001-08-15 Smithkline Beecham Corp Inhibidores de fab i utiles para el tratamiento de infecciones bacterianas
US6388070B1 (en) * 2001-01-05 2002-05-14 Orchid Chemicals & Pharmaceuticals Ltd. Thioester derivatives of thiazolyl acetic acid and their use in the preparation of cephalosporin compounds
CA2444597A1 (en) * 2001-04-06 2002-10-06 Affinium Pharmaceuticals, Inc. Fab i inhibitors
ITMI20020913A0 (it) * 2002-04-29 2002-04-29 Acs Dobfar Spa Nuova forma cristallina del cefdinir
US6800756B2 (en) * 2002-05-03 2004-10-05 Orchid Chemicals And Pharmaceuticals, Ltd. Method for the preparation of ceftiofur sodium and its intermediates
US6713625B2 (en) * 2002-05-23 2004-03-30 Orchid Chemicals & Pharmaceuticals Ltd. Process for the preparation of cefditoren using the thioester of thiazolylacetic acid
EP1842852A1 (en) * 2002-08-13 2007-10-10 Sandoz AG A cefdinir intermediate
EP1556388B1 (en) * 2002-10-29 2007-09-19 Lupin Limited A method for manufacture of ceftiofur
WO2004046154A1 (en) * 2002-11-15 2004-06-03 Orchid Chemicals & Pharmaceuticals Ltd Novel amorphous hydrate of a cephalosporin antibiotic
WO2004048387A1 (en) * 2002-11-22 2004-06-10 Orchid Chemicals & Pharmaceuticals Ltd An improved process for the preparation of cefpodoxime proxetil
US7790709B2 (en) 2002-12-06 2010-09-07 Affinium Pharmaceuticals, Inc. Heterocyclic compounds, methods of making them and their use in therapy
WO2004082586A2 (en) * 2003-03-17 2004-09-30 Affinium Pharmaceuticals, Inc. Phamaceutical compositions comprising inhibitors of fab i and further antibiotics
CN100357294C (zh) * 2003-03-24 2007-12-26 桑多斯股份公司 7－[2－(2－氨基噻唑－4－基)－2－羟基亚氨基乙酰胺－3－乙烯基－3－头孢烯－4－羧酸(顺式异构体)的新型晶体和其制备方法
US20060142261A1 (en) * 2004-03-16 2006-06-29 Devalina Law Crystalline anhydrous cefdinir and crystalline cefdinir hydrates
US20050209211A1 (en) * 2004-03-16 2005-09-22 Devalina Law Trihemihydrate, anhydrate and novel hydrate forms of Cefdinir
US20060211676A1 (en) * 2004-03-16 2006-09-21 Devalina Law Crystalline anhydrous cefdinir and crystalline cefdinir hydrates
US20060142563A1 (en) * 2004-03-16 2006-06-29 Devalina Law Crystalline anhydrous cefdinir and crystalline cefdinir hydrates
US20060029674A1 (en) * 2004-04-09 2006-02-09 Sever Nancy E Stable amorphous Cefdinir
WO2005105813A1 (en) * 2004-04-28 2005-11-10 Wockhardt Limited Improved process for the manufacture of ceftriaxone sodium
EP2848614A3 (en) * 2004-06-04 2015-07-29 Debiopharm International SA Acrylamide derivatives as antibiotic agents
ES2334685T3 (es) * 2005-03-29 2010-03-15 Hetero Drugs Limited Procedimiento mejorado de preparacion de cefixima.
JP2009518399A (ja) * 2005-12-05 2009-05-07 アフィニウム ファーマシューティカルズ， インク． Ｆａｂｉ阻害剤および抗菌剤としてのヘテロ環アクリルアミド化合物
US20070128268A1 (en) * 2005-12-07 2007-06-07 Herwig Jennewein Pharmaceutical compositions comprising an antibiotic
WO2008009122A1 (en) 2006-07-20 2008-01-24 Affinium Pharmaceuticals, Inc. Acrylamide derivatives as fab i inhibitors
WO2008098374A1 (en) * 2007-02-16 2008-08-21 Affinium Pharmaceuticals, Inc. Salts, prodrugs and polymorphs of fab i inhibitors
AU2013279021C1 (en) 2012-06-19 2017-03-16 Debiopharm International Sa Prodrug derivatives of (E)-N-methyl-N-((3-methylbenzofuran-2-yl)methyl)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide
CN104876948A (zh) * 2015-05-28 2015-09-02 华北制药河北华民药业有限责任公司 一种头孢曲松钠的制备方法
KR20180114177A (ko) 2016-02-26 2018-10-17 데비오팜 인터네셔날 에스 에이 당뇨병성 족부 감염의 치료제
CN107955021A (zh) * 2017-10-27 2018-04-24 苏州盖德精细材料有限公司 一种低杂质的头孢曲松钠的生产方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3165922D1 (en) * 1980-03-28 1984-10-18 Biochemie Gmbh New process for the production of cephalosporin antibiotics, and novel intermediates used in such process and their production
AU690482B2 (en) * 1996-03-18 1998-04-23 Ranbaxy Laboratories Limited Process for producing cephalosporin antibiotics
IN184690B (pt) * 1996-03-18 2000-09-23 Ranbaxy Lab Ltd
US6388070B1 (en) * 2001-01-05 2002-05-14 Orchid Chemicals & Pharmaceuticals Ltd. Thioester derivatives of thiazolyl acetic acid and their use in the preparation of cephalosporin compounds
US6555680B1 (en) * 2001-12-10 2003-04-29 Orchid Chemicals & Pharmaceuticals Ltd. Method for the preparation of ceftiofur sodium
US6610845B1 (en) * 2002-01-04 2003-08-26 Orchid Chemicals & Pharmaceuticals Limited, India Thioester derivatives of thiazolyl acetic acid and their use in the preparation of cephalosporin compounds

Also Published As

Publication number Publication date
WO2002053563A1 (en) 2002-07-11
EP1347970A1 (en) 2003-10-01
KR20030078882A (ko) 2003-10-08
US20040087787A1 (en) 2004-05-06
JP2004520336A (ja) 2004-07-08
CA2433783A1 (en) 2002-07-11
US6388070B1 (en) 2002-05-14
CN1492867A (zh) 2004-04-28

Similar Documents

Publication Publication Date Title
BR0116723A (pt) Derivados de tioéster de ácido tiazolil acético e seu uso na preparação de compostos de cefalosporina
BR0213380A (pt) Derivados propiÈnicos alfa-oxissubstituìdos por beta-fenila: processo para sua preparação e seu uso na preparação de compostos farmaceuticamente importantes
FI894477A0 (fi) Menetelmä terapeuttisesti aktiivisten 7-substituoitujen 3,5-dihydroksihept-6-yynihappojen ja niiden johdannaisten valmistamiseksi ja välituotteina käyttökelpoiset yhdisteet
BR1100445A (pt) Derivados imino cìclicos, composições farmacêuticas contendo estes compostos e processo para sua preparação
BR0211701A (pt) Processo para a preparação conjunta de ácido fórmico, assim como de um ácido carboxìlico tendo pelo menos dois átomos de carbono e/ou seus derivados.
HU9302007D0 (en) Method for producing pharmaceutical preparatives containing 2-|n-(2-amino-ethyl)-amino¨-acetic acid derivatives
ES2105362T3 (es) Nuevos derivados de acidos quinolon- y naftiridoncarboxilicos.
YU86792A (sh) Rastvor sparfloksacina, njegovo dobijanje i so sparfloksacina kao komponenta rastvora
ATE144778T1 (de) 9a-n-(n'-carbamoyl)-und 9a-n-(n'thiocarbamoyl)- derivate von 9-deoxo-9a-aza-9a-homoerythromycin a
AU1951392A (en) Naphthylamine polycarboxylic acids
KR910005871A (ko) 세팔로스포린계 주사용 제제
PT94347A (pt) Processo para a preparacao de sais cristalinos de adicao a acidos da cefalosporina
FI893677A0 (fi) Menetelmä terapeuttisesti käyttökelpoisten 6-fluori-3,5-dihydroksikarboksyylihappojen ja niiden johdannaisten valmistamiseksi
AU636178B2 (en) 7 (alanylaminothiazol-iminoacetamide) substituted cephalosporin derivatives
KR960000893A (ko) 세팔로스포린 염의 정제 방법
DE69717583T2 (de) 9-N-Ethenylderivate von 9(S)-Erythromycylamin
PT927722E (pt) Derivados beta beta-dissubstituidos de 9-desoxo-9a-n-etenil-9a-aza-9aza-9a-homoeritromicina
EP0397048A3 (de) Verfahren zur Herstellung von 2-Mercapto-4-methyl-1,3-thiazol-5-yl-essigsäure und deren Ester
BRPI0007593B8 (pt) processo para preparar uma aza-macrolida com 4"(r)-nh2"
LT2241B (lt) (alpha-(tret-butilaminometil)-3,4-dichlorbenzil)-tioacetamido ir jo drusku gavimo budas
TH18619A (th) ไอโซควินโนลีน
EE200200280A (et) Amükomütsiin, meetod selle valmistamiseks, kasutamine ravimina ja seda sisaldav farmatseutiline kompositsioon
AU2001250636A1 (en) Novel thioester derivatives of thiazolyl acetic acid and their use in the preparation of cephalosporin compounds
CA2373291A1 (en) Antibacterial optically pure benzoquinolizine carboxylic acids, processes, compositions and methods of treatment
RU94019970A (ru) Водный раствор спарфлоксацина, способ его получения и соль спарфлоксацина и фармацевтическая композиция

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE 6A., 7A., E 8A. ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2021 DE 29/09/2009.