BR0113439A - Processo para a manufatura de um imunógeno para vacina, derivado de maleimida de peptìdeo de ige, uso do mesmo, conjugado adequado para uso em uma vacina e composição de vacina - Google Patents
Processo para a manufatura de um imunógeno para vacina, derivado de maleimida de peptìdeo de ige, uso do mesmo, conjugado adequado para uso em uma vacina e composição de vacinaInfo
- Publication number
- BR0113439A BR0113439A BR0113439-6A BR0113439A BR0113439A BR 0113439 A BR0113439 A BR 0113439A BR 0113439 A BR0113439 A BR 0113439A BR 0113439 A BR0113439 A BR 0113439A
- Authority
- BR
- Brazil
- Prior art keywords
- vaccine
- peptide
- disulfide
- immunogens
- pharmaceutical compositions
- Prior art date
Links
- 229960005486 vaccine Drugs 0.000 title abstract 9
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 8
- 238000000034 method Methods 0.000 title abstract 6
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 title abstract 2
- 230000002163 immunogen Effects 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 4
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 abstract 3
- 102000001189 Cyclic Peptides Human genes 0.000 abstract 2
- 108010069514 Cyclic Peptides Proteins 0.000 abstract 2
- 206010020751 Hypersensitivity Diseases 0.000 abstract 2
- 208000026935 allergic disease Diseases 0.000 abstract 2
- 230000007815 allergy Effects 0.000 abstract 2
- 238000001311 chemical methods and process Methods 0.000 abstract 1
- 230000001268 conjugating effect Effects 0.000 abstract 1
- 230000021615 conjugation Effects 0.000 abstract 1
- 238000009169 immunotherapy Methods 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6068—Other bacterial proteins, e.g. OMP
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6081—Albumin; Keyhole limpet haemocyanin [KLH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
- A61K2039/627—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier characterised by the linker
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Analytical Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
"PROCESSO PARA A MANUFATURA DE UM IMUNóGENO PARA VACINA, DERIVADO DE MALEIMIDA DE PEPTìDEO DE IgE, USO DO MESMO, CONJUGADO ADEQUADO PARA USO EM UMA VACINA E COMPOSIçãO DE VACINA". A presente invenção refere-se a um novo processo químico para a conjugação covalente de peptídeos ciclisados por ponte de dissulfeto em moléculas veículo imunogênicas por ligações de tio-éter para formar imunógenos para vacina. Em particular, a nova química envolve a reação de um veículo tiolado com um peptídeo cíclico contendo uma ponte de dissulfeto, cujo peptídeo cíclico (aqui um peptídeo ciclisado por ponte de dissulfeto) tem ligado nele, usualmente via um ligador, um grupo reativo capaz de formar ligações de tio-éter com o veículo. A invenção refere-se em adição aos intermediários de peptídeo ativado do processo, aos medicamentos produzidos pelo processo, às composições farmacêuticas contendo os medicamentos, e ao uso das composições farmacêuticas na medicina. O processo da presente invenção é particularmente útil para a preparação de imunógenos elevadamente puros para vacinas, compreendendo peptídeos ciclisados por ponte de dissulfeto. Também novos imunógenos são proporcionados, baseados em peptídeos derivados da seq³ência da IgE humana, que são úteis em imunoterapia de alergia. Conseq³entemente, a invenção também se refere a um processo para a conjugação de peptídeos ciclisados por ponte de dissulfeto de IgE em veículos, aos imunógenos produzidos pelo processo e às vacinas e às composições farmacêuticas compreendendo-os e ao seu uso no tratamento de alergia.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0020717.5A GB0020717D0 (en) | 2000-08-22 | 2000-08-22 | Novel compounds and process |
PCT/EP2001/009576 WO2002016409A2 (en) | 2000-08-22 | 2001-08-17 | Vaccine immunogens comprising disulphide bridged cyclised peptide and use thereof in the treatment of allergies |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0113439A true BR0113439A (pt) | 2004-07-06 |
Family
ID=9898110
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0113439-6A BR0113439A (pt) | 2000-08-22 | 2001-08-17 | Processo para a manufatura de um imunógeno para vacina, derivado de maleimida de peptìdeo de ige, uso do mesmo, conjugado adequado para uso em uma vacina e composição de vacina |
Country Status (17)
Country | Link |
---|---|
US (1) | US20040030106A1 (pt) |
EP (1) | EP1311536A2 (pt) |
JP (1) | JP2004514655A (pt) |
KR (1) | KR20030062405A (pt) |
CN (1) | CN1471539A (pt) |
AR (1) | AR030458A1 (pt) |
AU (1) | AU2002214951A1 (pt) |
BR (1) | BR0113439A (pt) |
CA (1) | CA2420086A1 (pt) |
GB (1) | GB0020717D0 (pt) |
HU (1) | HUP0301725A3 (pt) |
IL (1) | IL154532A0 (pt) |
MX (1) | MXPA03001631A (pt) |
NO (1) | NO20030822L (pt) |
PL (1) | PL365788A1 (pt) |
WO (1) | WO2002016409A2 (pt) |
ZA (1) | ZA200301437B (pt) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0026334D0 (en) * | 2000-10-27 | 2000-12-13 | Smithkline Beecham Biolog | Vaccine |
GB0209878D0 (en) * | 2002-04-30 | 2002-06-05 | Glaxosmithkline Biolog Sa | Vaccine |
CN102702359A (zh) * | 2004-02-02 | 2012-10-03 | 泰勒公司 | 新的IgE表位的鉴别 |
CN101511861B (zh) * | 2006-07-21 | 2013-04-24 | 克里斯泰利亚化学药物产品有限公司 | 抗炎和抗过敏的环肽 |
CA2657338C (en) * | 2006-07-21 | 2013-10-22 | Cristalia Produtos Quimicos Farmaceuticos Ltda. | Anti-inflammatory and antiallergic cyclic peptides |
CA2659225A1 (en) * | 2006-07-26 | 2008-01-31 | Pepscan Systems B.V. | Immunogenic compounds and protein mimics |
EP2502072A1 (en) * | 2009-11-16 | 2012-09-26 | F. Hoffmann-La Roche AG | Calibration reagent and uses thereof |
EP2458467B1 (en) | 2010-11-26 | 2013-08-28 | ABB Research Ltd. | Method and system for monitoring an industrial system |
CN106366160B (zh) * | 2016-10-11 | 2019-06-14 | 厦门大学 | 基于二硫键精准配对构建富含二硫键多肽分子骨架的方法 |
EP3779443A4 (en) * | 2018-04-06 | 2022-05-04 | Slsbio Co., Ltd. | NEW IMMUNOGLOBULIN E EPITOPE, BINDING ANTIBODY AND KIT FOR THE ANALYSIS OF IMMUNOGLOBULIN E IN A SAMPLE CONTAINING IT |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4981979A (en) * | 1987-09-10 | 1991-01-01 | Neorx Corporation | Immunoconjugates joined by thioether bonds having reduced toxicity and improved selectivity |
CA2047078A1 (en) * | 1990-07-19 | 1992-01-20 | Steven S. Bondy | Cyclic hiv principal neutralizing determinant peptides |
TWI227241B (en) * | 1998-06-20 | 2005-02-01 | United Biomedical Inc | IgE-CH3 domain antigen peptide, peptide conjugate containing the same, and pharmaceutical composition for treating allergies containing the peptide conjugate |
-
2000
- 2000-08-22 GB GBGB0020717.5A patent/GB0020717D0/en not_active Ceased
-
2001
- 2001-08-17 CA CA002420086A patent/CA2420086A1/en not_active Abandoned
- 2001-08-17 JP JP2002521504A patent/JP2004514655A/ja active Pending
- 2001-08-17 IL IL15453201A patent/IL154532A0/xx unknown
- 2001-08-17 HU HU0301725A patent/HUP0301725A3/hu unknown
- 2001-08-17 US US10/362,527 patent/US20040030106A1/en not_active Abandoned
- 2001-08-17 WO PCT/EP2001/009576 patent/WO2002016409A2/en not_active Application Discontinuation
- 2001-08-17 MX MXPA03001631A patent/MXPA03001631A/es unknown
- 2001-08-17 PL PL01365788A patent/PL365788A1/xx not_active Application Discontinuation
- 2001-08-17 AU AU2002214951A patent/AU2002214951A1/en not_active Abandoned
- 2001-08-17 CN CNA018177778A patent/CN1471539A/zh active Pending
- 2001-08-17 BR BR0113439-6A patent/BR0113439A/pt not_active Application Discontinuation
- 2001-08-17 EP EP01983441A patent/EP1311536A2/en not_active Withdrawn
- 2001-08-17 KR KR10-2003-7002628A patent/KR20030062405A/ko not_active Application Discontinuation
- 2001-08-21 AR ARP010103969A patent/AR030458A1/es unknown
-
2003
- 2003-02-21 ZA ZA200301437A patent/ZA200301437B/en unknown
- 2003-02-21 NO NO20030822A patent/NO20030822L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JP2004514655A (ja) | 2004-05-20 |
WO2002016409A2 (en) | 2002-02-28 |
NO20030822L (no) | 2003-03-31 |
KR20030062405A (ko) | 2003-07-25 |
CA2420086A1 (en) | 2002-02-28 |
IL154532A0 (en) | 2003-09-17 |
US20040030106A1 (en) | 2004-02-12 |
GB0020717D0 (en) | 2000-10-11 |
CN1471539A (zh) | 2004-01-28 |
HUP0301725A3 (en) | 2004-11-29 |
ZA200301437B (en) | 2004-05-21 |
PL365788A1 (en) | 2005-01-10 |
AR030458A1 (es) | 2003-08-20 |
NO20030822D0 (no) | 2003-02-21 |
WO2002016409A3 (en) | 2002-08-29 |
HUP0301725A2 (hu) | 2003-08-28 |
AU2002214951A1 (en) | 2002-03-04 |
MXPA03001631A (es) | 2004-09-10 |
EP1311536A2 (en) | 2003-05-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |