BR0113376A - Uso de um éster de testosterona, método de tratamento de distúrbios de insuficiência de androgênio, e, sistema de liberação de droga para contracepção masculina - Google Patents

Uso de um éster de testosterona, método de tratamento de distúrbios de insuficiência de androgênio, e, sistema de liberação de droga para contracepção masculina

Info

Publication number
BR0113376A
BR0113376A BR0113376-4A BR0113376A BR0113376A BR 0113376 A BR0113376 A BR 0113376A BR 0113376 A BR0113376 A BR 0113376A BR 0113376 A BR0113376 A BR 0113376A
Authority
BR
Brazil
Prior art keywords
testosterone
drug release
release system
testosterone ester
male contraceptive
Prior art date
Application number
BR0113376-4A
Other languages
English (en)
Inventor
Henrik De Nijs
Wendy Margaretha Kersemaekers
Stephanus Cornelis Schutte
Johann Gerhard Corneli Bruggen
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Publication of BR0113376A publication Critical patent/BR0113376A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

"USO DE UM éSTER DE TESTOSTERONA, MéTODO DE TRATAMENTO DE DISTúRBIOS DE INSUFICIêNCIA DE ANDROGêNIO, E, SISTEMA DE LIBERAçãO DE DROGA PARA CONTRACEPçãO MASCULINA". é revelada uma formulação de decanoato de testosterona para uso no tratamento de humanos. Ao contrário das formulações conhecidas compreendendo decanoato de testosterona, verificou-se que quaisquer outros esteres de testosterona, normalmente presentes juntos com o decanoato de testosterona, podem ser omitidos e a formulação, assim, compreende decanoato de testosterona como o único éster de testosterona.
BR0113376-4A 2000-08-23 2001-08-17 Uso de um éster de testosterona, método de tratamento de distúrbios de insuficiência de androgênio, e, sistema de liberação de droga para contracepção masculina BR0113376A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00202939 2000-08-23
PCT/EP2001/009569 WO2002015938A2 (en) 2000-08-23 2001-08-17 Testosterone ester formulation for human use

Publications (1)

Publication Number Publication Date
BR0113376A true BR0113376A (pt) 2003-07-15

Family

ID=8171940

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0113376-4A BR0113376A (pt) 2000-08-23 2001-08-17 Uso de um éster de testosterona, método de tratamento de distúrbios de insuficiência de androgênio, e, sistema de liberação de droga para contracepção masculina

Country Status (15)

Country Link
US (1) US20050101517A1 (pt)
EP (1) EP1313511B1 (pt)
JP (1) JP2004506698A (pt)
CN (1) CN1248738C (pt)
AT (1) ATE311201T1 (pt)
AU (2) AU9177501A (pt)
BR (1) BR0113376A (pt)
CA (1) CA2415349A1 (pt)
CY (1) CY1106064T1 (pt)
DE (1) DE60115464T2 (pt)
DK (1) DK1313511T3 (pt)
ES (1) ES2253423T3 (pt)
IL (2) IL153648A0 (pt)
MX (1) MXPA03001147A (pt)
WO (1) WO2002015938A2 (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200404552A (en) * 2002-05-30 2004-04-01 Akzo Nobel Nv Self administered contraception
JO2505B1 (en) 2003-03-14 2009-10-05 باير شيرنغ فارما اكتنجيسيلشافت Pharmacy methods and formulations for obtaining acceptable serum testosterone levels
IL157535A0 (en) * 2003-08-21 2004-03-28 Topimed Ltd Preparations for the prevention of skin atrophy
US8541413B2 (en) * 2004-10-01 2013-09-24 Ramscor, Inc. Sustained release eye drop formulations
EP2452670A1 (en) * 2004-10-01 2012-05-16 Ramscor, Inc. Conveniently implantable sustained release drug compositions
US20080038316A1 (en) * 2004-10-01 2008-02-14 Wong Vernon G Conveniently implantable sustained release drug compositions
US9993558B2 (en) 2004-10-01 2018-06-12 Ramscor, Inc. Sustained release eye drop formulations
US8492369B2 (en) 2010-04-12 2013-07-23 Clarus Therapeutics Inc Oral testosterone ester formulations and methods of treating testosterone deficiency comprising same
AU2006236564B2 (en) 2005-04-15 2011-02-17 Tolmar, Inc. Pharmaceutical delivery systems for hydrophobic drugs and compositions comprising same
PL2519230T3 (pl) 2009-12-31 2019-05-31 Marius Pharmaceuticals Llc Modulacja rozpuszczalności, stabilności, absorpcji, metabolizmu i profilu farmakokinetycznego leków lipofilowych przez sterole
US9034858B2 (en) 2010-11-30 2015-05-19 Lipocine Inc. High-strength testosterone undecanoate compositions
US20180153904A1 (en) 2010-11-30 2018-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US9358241B2 (en) 2010-11-30 2016-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US20120148675A1 (en) 2010-12-10 2012-06-14 Basawaraj Chickmath Testosterone undecanoate compositions
TW201521731A (zh) * 2013-03-15 2015-06-16 利波辛股份有限公司 用於口服之脂平衡的長鏈睪固酮酯
EP2968137B1 (en) 2013-03-15 2021-11-10 Marius Pharmaceuticals LLC Emulsion formulations
US10245273B2 (en) 2013-12-26 2019-04-02 Clarus Therapeutics, Inc. Oral pharmaceutical products and methods of use combining testosterone esters with hypolipidemic agents
WO2016033556A1 (en) 2014-08-28 2016-03-03 Lipocine Inc. BIOAVAILABLE SOLID STATE (17-β)-HYDROXY-4-ANDROSTEN-3-ONE ESTERS
US20170246187A1 (en) 2014-08-28 2017-08-31 Lipocine Inc. (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE
WO2018064556A1 (en) 2016-09-29 2018-04-05 Gesea Biosciences Inc. Bioerodible implant for long-term drug delivery and associated methods of manufacture and use
CA3078723A1 (en) 2016-11-28 2018-05-31 Nachiappan Chidambaram Oral testosterone undecanoate therapy

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB465331A (en) * 1935-10-05 1937-05-05 Chem Ind Basel Manufacture of new esters of polynuclear cyclic oxyketones
NL189235C (nl) * 1974-02-28 1993-02-16 Akzo Nv Werkwijze voor de bereiding van een oraal toe te dienen farmaceutisch preparaat met androgene werking.
US4098802A (en) * 1975-02-18 1978-07-04 Akzona Incorporated Oral pharmaceutical preparation having androgenic activity
US4147783A (en) * 1974-02-28 1979-04-03 Akzona Incorporated Oral pharmaceutical preparation
NL7506407A (nl) * 1975-05-30 1976-12-02 Akzo Nv Werkwijze ter bereiding van een oraal werkzaam far- maceutisch preparaat.
GB1567515A (en) * 1976-05-28 1980-05-14 Akzo Nv Esters of testo-sterone and 5 -dihydro-testosterone
ATE86484T1 (de) * 1987-08-08 1993-03-15 Akzo Nv Kontrazeptives implantat.
US6063395A (en) * 1998-11-12 2000-05-16 Leiras Oy Drug delivery device especially for the delivery of progestins and estrogens
US7025979B2 (en) * 2000-02-15 2006-04-11 Schering Ag Male contraceptive formulation comprising norethisterone

Also Published As

Publication number Publication date
ATE311201T1 (de) 2005-12-15
CA2415349A1 (en) 2002-02-28
EP1313511B1 (en) 2005-11-30
US20050101517A1 (en) 2005-05-12
AU9177501A (en) 2002-03-04
DE60115464T2 (de) 2006-06-14
DK1313511T3 (da) 2006-03-20
AU2001291775B2 (en) 2005-09-08
WO2002015938A3 (en) 2002-08-15
DE60115464D1 (de) 2006-01-05
WO2002015938A2 (en) 2002-02-28
JP2004506698A (ja) 2004-03-04
CN1248738C (zh) 2006-04-05
IL153648A (en) 2009-02-11
MXPA03001147A (es) 2003-10-06
EP1313511A2 (en) 2003-05-28
IL153648A0 (en) 2003-07-06
CN1443078A (zh) 2003-09-17
CY1106064T1 (el) 2011-06-08
ES2253423T3 (es) 2006-06-01
WO2002015938A8 (en) 2004-03-04

Similar Documents

Publication Publication Date Title
BR0113376A (pt) Uso de um éster de testosterona, método de tratamento de distúrbios de insuficiência de androgênio, e, sistema de liberação de droga para contracepção masculina
IS2354B (is) Lyfjasamsetning sem mögulegt er að hleypa
Grecomoro et al. Intra-articular treatment with sodium hyaluronate in gonarthrosis: a controlled clinical trial versus placebo
BR9715022A (pt) Método para tratar de doenças prostáticas usando formulações de vitamina d por liberação sistemática e/ou prolongada
GT199900151A (es) Sistema de entrega controlado de droga administrado oralmente, que provee control temporal y espacial.
AU7998682A (en) Continuous release pharmaceutical compositions
CY1106107T1 (el) Φαρμακολογικες μορφοποιησεις που πepιλαμβανουν ρεσβepατρολη και χρηση αυτων
BR0014928A (pt) Dispositivo e processo para distribuição de medicamento para um olho humano
DE60105448D1 (de) Feste dispersionen mit nitrataktiven wirkstoffen
PE20040068A1 (es) Decanoato, undecanoato y dodecanoato de etonogestrel
AR015933A1 (es) Esmalte para unas con actividad antipsoriasica y procedimiento para su preparacion
PT881891E (pt) Implante contaceptivo masculino
CA2216887A1 (en) Budesonide alone or in combination with ursodeoxycholic acid in the therapy of cholestatic liver diseases
ES2166988T3 (es) Terapia de administracion uniforme de farmacos.
AR026655A1 (es) Nuevos esteroides con actividad androgenica y su uso como antinconceptivos masculinos y para tratar la insuficiencia androgenica
AR001765A1 (es) Una formulación de liberación prolongada un procedimiento para su preparación una forma cristalina de cisaprida-(l)-tartrato y un medicamento util para el tratamiento de trastornos gastrointestinales
CO4960657A1 (es) Composicion farmaceutica
DK0753300T3 (da) Anvendelse af steroider med antioxidative egenskaber til fremstilling af farmaceutiske præparater til medikamentøs substitu
AR003001A1 (es) Composicion farmaceutica estimuladora de la osteogenesis.
BR9814136A (pt) Conjunto contraceptivo, processos de fabricação do mesmo e de tratamento de sangramento, usos de anti-progestogênio, de progestogênio e de anti-progestogênio, e, de um composto.
AR011707A1 (es) Composicion farmaceutica que comprende tirosina y un alergeno opcionalmente modificado, procedimiento para su preparacion y el uso de la misma para la manufactura de un medicamento.
BR0311248A (pt) Kit de contracepção e/ou de hrt, usos de um éster de etonogestrel de ação prolongada, de um éster de etonogestrel de ação prolongada em conjunto com um éster de andrógeno de ação prolongada e de um éster de etonogestrel de ação prolongada em conjunto com um estrogênio, e, métodos de contracepção e /ou de hrt e de tratamento e/ou de prevenção de um distúrbio ginecológico feminino
GR3034803T3 (en) Low-dose steroid tablets containing gallic acid esters as antioxidant agent, process for the manufacture of said tablets, and uses of said tablets
DE59911381D1 (de) Verwendung von testosteronestern und/oder testosteron zur herstellung von bukkal applizierbaren bioadhasiven systemen mit zeitgesteuerter arzneistoffwirkung
ES2172172T3 (es) Composiciones farmaceuticas solidas para la administracion por via oral que permiten la liberacion modulada de nicorandil y su procedimiento de preparacion.

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE 9A. ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2077 DE 26/10/2010.