BR0110481A - Método para remover seletivamente células neoplásticas de uma composição celular mista, composição de células não neoplásticas viáveis, e, kit - Google Patents
Método para remover seletivamente células neoplásticas de uma composição celular mista, composição de células não neoplásticas viáveis, e, kitInfo
- Publication number
- BR0110481A BR0110481A BR0110481-0A BR0110481A BR0110481A BR 0110481 A BR0110481 A BR 0110481A BR 0110481 A BR0110481 A BR 0110481A BR 0110481 A BR0110481 A BR 0110481A
- Authority
- BR
- Brazil
- Prior art keywords
- cell composition
- neoplastic
- neoplastic cells
- kit
- selectively removing
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0081—Purging biological preparations of unwanted cells
- C12N5/0093—Purging against cancer cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
- A61K35/765—Reovirus; Rotavirus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0693—Tumour cells; Cancer cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/70—Undefined extracts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
- C12N2720/00011—Details
- C12N2720/12011—Reoviridae
- C12N2720/12211—Orthoreovirus, e.g. mammalian orthoreovirus
- C12N2720/12232—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
- C12N2720/00011—Details
- C12N2720/12011—Reoviridae
- C12N2720/12211—Orthoreovirus, e.g. mammalian orthoreovirus
- C12N2720/12241—Use of virus, viral particle or viral elements as a vector
- C12N2720/12243—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Developmental Biology & Embryology (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Mycology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"MéTODO PARA REMOVER SELETIVAMENTE CéLULAS NEOPLáSTICAS DE UMA COMPOSIçãO CELULAR MISTA, COMPOSIçãO DE CéLULAS NãO NEOPLáSTICAS VIáVEIS, E, KIT". A presente invenção diz respeito a um método para remover células neoplásticas de uma composição celular mista, que está fora de um organismo vivo, usando-se um vírus que seletivamente infecta e mata a célula neoplástica. Uma variedade de vírus podem ser usados neste método para remover células neoplásticas para propósitos diferentes, por exemplo, purgar células tronco hematopoéticas antes de transplante. Também são fornecidas composições preparadas de acordo com este método e kits que compreendem uma combinação de vírus que são úteis nesta invenção.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20199000P | 2000-05-03 | 2000-05-03 | |
US20538900P | 2000-05-19 | 2000-05-19 | |
US26805401P | 2001-02-13 | 2001-02-13 | |
US27678201P | 2001-03-16 | 2001-03-16 | |
PCT/CA2001/000609 WO2001083710A2 (en) | 2000-05-03 | 2001-05-01 | Clearance of neoplastic cells from mixed cellular compositions using viruses |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0110481A true BR0110481A (pt) | 2003-04-08 |
Family
ID=27498447
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0110481-0A BR0110481A (pt) | 2000-05-03 | 2001-05-01 | Método para remover seletivamente células neoplásticas de uma composição celular mista, composição de células não neoplásticas viáveis, e, kit |
Country Status (14)
Country | Link |
---|---|
US (3) | US20010048919A1 (pt) |
EP (1) | EP1278823B1 (pt) |
JP (2) | JP4509455B2 (pt) |
AR (1) | AR028040A1 (pt) |
AT (1) | ATE517983T1 (pt) |
AU (2) | AU5807701A (pt) |
BR (1) | BR0110481A (pt) |
CA (1) | CA2408251C (pt) |
DK (1) | DK1278823T3 (pt) |
HK (1) | HK1050217A1 (pt) |
IL (1) | IL152391A (pt) |
MX (1) | MXPA02010743A (pt) |
NZ (1) | NZ522180A (pt) |
WO (1) | WO2001083710A2 (pt) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7306902B2 (en) * | 2002-06-28 | 2007-12-11 | Oncolyties Biotech Inc. | Oncolytic viruses as phenotyping agents for neoplasms |
US8491884B2 (en) | 2000-05-03 | 2013-07-23 | Oncolytics Biotech Inc. | Virus clearance of neoplastic cells from mixed cellular compositions |
AR028039A1 (es) * | 2000-05-03 | 2003-04-23 | Oncolytics Biotech Inc | Remocion de reovirus de celulas neoplasticas intermediadas por ras a partir de composiciones celulares mixtas |
JP5208343B2 (ja) | 2000-06-26 | 2013-06-12 | ウェルスタット バイオロジクス コーポレイション | ウイルスを用いる細胞の浄化 |
KR100492017B1 (ko) * | 2002-06-24 | 2005-05-30 | 학교법인고려중앙학원 | 인간 간엽줄기 세포를 이용한 항암치료방법 |
US20050214266A1 (en) * | 2004-03-12 | 2005-09-29 | Oncolytics Biotech Inc. | Combination of transplantation and oncolytic virus treatment |
US10668119B2 (en) | 2005-08-01 | 2020-06-02 | Virocure, Inc. | Attenuated reovirus |
WO2007099401A2 (en) | 2005-08-01 | 2007-09-07 | University Technologies International, Inc. | Oncolytic attenuated reoviruses for treatment of proliferative disorders |
DE202006020393U1 (de) | 2006-12-12 | 2008-07-17 | Labes, Holger | Handschelle |
US10369171B2 (en) | 2007-03-13 | 2019-08-06 | Virocure, Inc. | Attenuated reoviruses for selection of cell populations |
US9623096B2 (en) * | 2011-11-09 | 2017-04-18 | Celverum Inc. | Virally infected hematopoietic cells and uses thereof |
CN110117577B (zh) * | 2018-02-05 | 2023-10-24 | 中国科学院武汉物理与数学研究所 | 低毒单纯疱疹病毒***及其构建方法和应用 |
KR102141496B1 (ko) | 2018-04-27 | 2020-08-06 | 한국화학연구원 | 투명화된 거대조직의 면역염색용 조성물 및 이를 이용한 투명화된 거대 생체 조직의 면역염색 방법 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1221307A (en) * | 1982-12-02 | 1987-05-05 | Nobutaka Tani | Adsorbent and process for preparing the same |
US5061620A (en) * | 1990-03-30 | 1991-10-29 | Systemix, Inc. | Human hematopoietic stem cell |
US5846945A (en) * | 1993-02-16 | 1998-12-08 | Onyx Pharmaceuticals, Inc. | Cytopathic viruses for therapy and prophylaxis of neoplasia |
WO1995016464A1 (en) * | 1993-12-14 | 1995-06-22 | Johns Hopkins University School Of Medicine | Controlled release of pharmaceutically active substances for immunotherapy |
US5514340A (en) * | 1994-01-24 | 1996-05-07 | Magnetix Biotechnology, Inc. | Device for separating magnetically labelled cells |
WO1995032300A1 (en) * | 1994-05-23 | 1995-11-30 | University Of Medicine & Dentistry Of New Jersey | Selective biological destruction of tumor cells |
US5585096A (en) * | 1994-06-23 | 1996-12-17 | Georgetown University | Replication-competent herpes simplex virus mediates destruction of neoplastic cells |
US5840502A (en) * | 1994-08-31 | 1998-11-24 | Activated Cell Therapy, Inc. | Methods for enriching specific cell-types by density gradient centrifugation |
US6136307A (en) | 1997-08-13 | 2000-10-24 | Oncolytics Biotech Inc. | Reovirus for the treatment of cellular proliferative disorders |
US7780962B2 (en) * | 1997-10-09 | 2010-08-24 | Wellstat Biologics Corporation | Treatment of neoplasms with RNA viruses |
US20030044384A1 (en) * | 1997-10-09 | 2003-03-06 | Pro-Virus, Inc. | Treatment of neoplasms with viruses |
US6475481B2 (en) * | 1997-11-18 | 2002-11-05 | Canji Inc | Purging of stem cell products |
DE69929986T2 (de) * | 1998-08-31 | 2006-10-19 | Ambrus, Julian L. | Verfahren zur entfernung von hiv und anderen viren aus blut |
CA2720361A1 (en) * | 1999-11-12 | 2001-05-25 | Oncolytics Biotech, Inc. | Viruses for the treatment of cellular proliferative disorders |
AR028039A1 (es) * | 2000-05-03 | 2003-04-23 | Oncolytics Biotech Inc | Remocion de reovirus de celulas neoplasticas intermediadas por ras a partir de composiciones celulares mixtas |
JP5208343B2 (ja) * | 2000-06-26 | 2013-06-12 | ウェルスタット バイオロジクス コーポレイション | ウイルスを用いる細胞の浄化 |
EP1648233A4 (en) * | 2003-07-08 | 2006-08-23 | Univ Arizona | VACCINE VACCINE MUTANTS INSTEAD OF ONCOLYTIC AGENTS |
-
2001
- 2001-04-25 AR ARP010101937A patent/AR028040A1/es not_active Application Discontinuation
- 2001-05-01 JP JP2001580319A patent/JP4509455B2/ja not_active Expired - Lifetime
- 2001-05-01 WO PCT/CA2001/000609 patent/WO2001083710A2/en active IP Right Grant
- 2001-05-01 AU AU5807701A patent/AU5807701A/xx active Pending
- 2001-05-01 MX MXPA02010743A patent/MXPA02010743A/es active IP Right Grant
- 2001-05-01 DK DK01931242.0T patent/DK1278823T3/da active
- 2001-05-01 NZ NZ522180A patent/NZ522180A/en unknown
- 2001-05-01 CA CA002408251A patent/CA2408251C/en not_active Expired - Lifetime
- 2001-05-01 BR BR0110481-0A patent/BR0110481A/pt not_active Application Discontinuation
- 2001-05-01 IL IL152391A patent/IL152391A/en active IP Right Grant
- 2001-05-01 EP EP01931242A patent/EP1278823B1/en not_active Expired - Lifetime
- 2001-05-01 AU AU2001258077A patent/AU2001258077B2/en not_active Expired
- 2001-05-01 AT AT01931242T patent/ATE517983T1/de not_active IP Right Cessation
- 2001-05-03 US US09/847,355 patent/US20010048919A1/en not_active Abandoned
-
2003
- 2003-04-01 HK HK03102325.9A patent/HK1050217A1/xx not_active IP Right Cessation
-
2004
- 2004-08-31 US US10/931,728 patent/US20050026289A1/en not_active Abandoned
-
2007
- 2007-05-30 US US11/807,921 patent/US20080038822A1/en not_active Abandoned
-
2008
- 2008-06-25 JP JP2008166112A patent/JP2008283982A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
WO2001083710A3 (en) | 2002-05-02 |
IL152391A0 (en) | 2003-05-29 |
HK1050217A1 (en) | 2003-06-13 |
IL152391A (en) | 2010-11-30 |
ATE517983T1 (de) | 2011-08-15 |
US20010048919A1 (en) | 2001-12-06 |
WO2001083710A2 (en) | 2001-11-08 |
EP1278823B1 (en) | 2011-07-27 |
CA2408251A1 (en) | 2001-11-08 |
US20050026289A1 (en) | 2005-02-03 |
JP2003531605A (ja) | 2003-10-28 |
AR028040A1 (es) | 2003-04-23 |
DK1278823T3 (da) | 2011-09-05 |
JP2008283982A (ja) | 2008-11-27 |
EP1278823A2 (en) | 2003-01-29 |
CA2408251C (en) | 2008-01-22 |
NZ522180A (en) | 2004-11-26 |
MXPA02010743A (es) | 2003-05-14 |
JP4509455B2 (ja) | 2010-07-21 |
AU2001258077B2 (en) | 2006-07-20 |
AU5807701A (en) | 2001-11-12 |
US20080038822A1 (en) | 2008-02-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B11E | Dismissal acc. art. 34 of ipl - requirements for examination incomplete | ||
B15K | Others concerning applications: alteration of classification |
Ipc: C12N 5/00 (2006.01), A61K 35/28 (2015.01), A61K 35 |
|
B11T | Dismissal of application maintained [chapter 11.20 patent gazette] |