BR0109413A - Processo para a preparação de derivados 9-deoxo-8a-aza(8a-alquil)-8a-homoeritromicina a a partir da 9-deoxo-9(z)hidroxiiminoeritromicina a - Google Patents

Processo para a preparação de derivados 9-deoxo-8a-aza(8a-alquil)-8a-homoeritromicina a a partir da 9-deoxo-9(z)hidroxiiminoeritromicina a

Info

Publication number
BR0109413A
BR0109413A BR0109413-0A BR0109413A BR0109413A BR 0109413 A BR0109413 A BR 0109413A BR 0109413 A BR0109413 A BR 0109413A BR 0109413 A BR0109413 A BR 0109413A
Authority
BR
Brazil
Prior art keywords
deoxo
aza
preparation
homoerythromycin
hydroxyiminoerythromycin
Prior art date
Application number
BR0109413-0A
Other languages
English (en)
Other versions
BRPI0109413B8 (pt
BRPI0109413B1 (pt
Inventor
Patrick Leon
Frederic Lhermitte
Gilles Oddon
Denis Pauze
Original Assignee
Merial Sas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merial Sas filed Critical Merial Sas
Publication of BR0109413A publication Critical patent/BR0109413A/pt
Publication of BRPI0109413B1 publication Critical patent/BRPI0109413B1/pt
Publication of BRPI0109413B8 publication Critical patent/BRPI0109413B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)

Abstract

"PROCESSO PARA A PREPARAçãO DE DERIVADOS 9-DEOXO-8A-AZA-(8A-ALQUIL)-8A-HOMOERITROMICINA A A PARTIR DA 9-DEOXO-9(Z)-HIDROXIIMINOERITROMICINA A". A invenção fornece um processo para a preparação da 9-deoxo8a-aza-8a-homoeritromicina A e de seus derivados 8a-alquilado, a partir da 9-deoxo-9(Z)-hidroxiiminoeritromicina A via um rearranjo estereoespecífico de Beckmann em um meio de reação que utiliza a piridina como solvente principal, que leva a intermediários imidatos que não são isolados do dito meio e que são diretamente captados em uma etapa de redução com o auxílio de uma quantidade suficiente de boridreto, depois de extração da piridina através de um hidrocarboneto miscível a essa última e no qual os ditos imidatos são insolúveis. O composto (V) pode ser diretamente N-alquilado na posição -8a, com o auxílio de um aldeído, sem ser isolado do meio de redução.
BRPI0109413A 2000-03-24 2001-03-23 processo para a preparação de derivados 9-deoxo-8a-aza(8a-alquil)-8a-homoeritromicina a a partir da 9-deoxo-9(z)hidroxiiminoeritromicina a BRPI0109413B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0003807A FR2806724B1 (fr) 2000-03-24 2000-03-24 Procede pour la preparation de derives 9-deoxo-8a-aza- (8a-alkyl)-8a-homoerythromycine a a partir de la 9-deoxo-9 (z)-hydroxyiminoerythromycine a
PCT/FR2001/000897 WO2001072763A1 (fr) 2000-03-24 2001-03-23 Procede pour la preparation de derives 9-deoxo-8a-aza-(8a-alkyl)-8a-homoerythromycine a a partir de la 9-deoxo-9(z)-hydroxyiminoerythromycine a

Publications (3)

Publication Number Publication Date
BR0109413A true BR0109413A (pt) 2002-12-10
BRPI0109413B1 BRPI0109413B1 (pt) 2015-08-04
BRPI0109413B8 BRPI0109413B8 (pt) 2021-05-25

Family

ID=8848497

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0109413A BRPI0109413B8 (pt) 2000-03-24 2001-03-23 processo para a preparação de derivados 9-deoxo-8a-aza(8a-alquil)-8a-homoeritromicina a a partir da 9-deoxo-9(z)hidroxiiminoeritromicina a

Country Status (17)

Country Link
EP (1) EP1265908B1 (pt)
JP (1) JP4975933B2 (pt)
CN (1) CN1174992C (pt)
AR (1) AR027706A1 (pt)
AT (1) ATE281463T1 (pt)
AU (2) AU2001246636C1 (pt)
BR (1) BRPI0109413B8 (pt)
CA (1) CA2399634C (pt)
DE (1) DE60106882T2 (pt)
DK (1) DK1265908T3 (pt)
ES (1) ES2232609T3 (pt)
FR (1) FR2806724B1 (pt)
NZ (1) NZ520878A (pt)
PL (1) PL206683B1 (pt)
PT (1) PT1265908E (pt)
WO (1) WO2001072763A1 (pt)
ZA (1) ZA200207443B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2358732T3 (pl) * 2008-10-24 2013-11-29 Merial Inc Sposób syntetyzowania związków makrolidowych
CN103833807B (zh) * 2012-11-21 2016-12-07 洛阳惠中兽药有限公司 一种加米霉素中间体的制备方法
CN103965273B (zh) 2013-08-23 2016-05-25 普莱柯生物工程股份有限公司 一种大环内酯类化合物
WO2015098716A1 (ja) * 2013-12-26 2015-07-02 住友化学株式会社 ハロゲン置換フタリドの製造方法
CN109970827A (zh) * 2017-12-27 2019-07-05 洛阳惠中兽药有限公司 加米霉素中间体化合物i的晶型及其制备方法和应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5912331A (en) * 1991-03-15 1999-06-15 Merck & Co., Inc. Process for the preparation of 9-deoxo-9(Z)-hydroxyiminoerythromycin A
DE69227713D1 (de) * 1991-03-15 1999-01-14 Merck & Co Inc 9-Deoxo-9(Z)-hydroxyiminoerythromycin A und O-Derivate hiervon
CA2064634C (en) * 1991-04-04 1998-08-04 James V. Heck 9-deoxo-8a-aza-8a-homoerythromycin a derivatives modified at the 4"- and8a-positions
CA2064985A1 (en) * 1991-04-05 1992-10-06 Robert R. Wilkening 8a-aza-8a-homoertyhromycin cyclic lactams
CA2065222A1 (en) * 1991-04-09 1992-10-10 Robert R. Wilkening Process for the preparation of 8a-aza-8a-homoerythromycin cyclic iminoethers
EP0508795A1 (en) * 1991-04-10 1992-10-14 Merck & Co. Inc. 8a-aza-8a-homoerythromycin cyclic iminoethers
CA2065218A1 (en) * 1991-04-11 1992-10-12 Robert R. Wilkening Process for the preparation of 9-deoxo-8a-aza-8a-homoerythromycin a and its 8a-alkyl derivatives
CA2068951A1 (en) * 1991-05-20 1992-11-21 Robert R. Wilkening Process for the preparation of 8a-aza-8a-homoerythromycin cyclic lactams
EP0549040A1 (en) * 1991-12-20 1993-06-30 Merck & Co. Inc. Methods of making 4" derivatives of 9-deoxo-8a-aza-8a-alkyl-8a-homoerythromycin A
PT102006B (pt) * 1997-05-19 2000-06-30 Hovione Sociedade Quimica S A Novo processo de preparacao de azitromicina
FR2791680B1 (fr) * 1999-03-29 2001-06-29 Merial Sas Procede utile pour reduire les intermediaires imidates issus d'un rearrangement de beckmann d'un macrocycle 8a-azalide

Also Published As

Publication number Publication date
BRPI0109413B8 (pt) 2021-05-25
AU4663601A (en) 2001-10-08
AU2001246636B2 (en) 2005-04-21
DK1265908T3 (da) 2005-03-14
ES2232609T3 (es) 2005-06-01
DE60106882T2 (de) 2005-12-01
PT1265908E (pt) 2005-03-31
CA2399634C (en) 2011-05-24
AR027706A1 (es) 2003-04-09
EP1265908B1 (fr) 2004-11-03
NZ520878A (en) 2004-05-28
WO2001072763A1 (fr) 2001-10-04
CN1174992C (zh) 2004-11-10
FR2806724B1 (fr) 2003-12-05
CN1425022A (zh) 2003-06-18
BRPI0109413B1 (pt) 2015-08-04
ZA200207443B (en) 2003-10-17
PL206683B1 (pl) 2010-09-30
ATE281463T1 (de) 2004-11-15
AU2001246636C1 (en) 2006-02-23
CA2399634A1 (en) 2001-10-04
PL361225A1 (en) 2004-09-20
FR2806724A1 (fr) 2001-09-28
EP1265908A1 (fr) 2002-12-18
JP2003528882A (ja) 2003-09-30
DE60106882D1 (de) 2004-12-09
JP4975933B2 (ja) 2012-07-11

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